We use very small doses. Enough to activate the immune system, but not so much that they harm the animals.

This opens a path to acid-switched / sweeping antibodies that recycle and neutralise multiple antigens without changing the paratope.

#sweeping #toxins #mAbs #acidswitching

Thanks to all co-authors & funders for making this possible!

Also a big thanks to our generous funders, Villum Fonden, European Research Council (ERC), Wellcome Trust, and Consejo Nacional de Ciencia y Tecnología!

Johannes R. Loeffler, Andrew B. Ward, Kim Boddum, Jens Preben Morth, and Esperanza Rivera de Torre from @dtu.dk, Universidad Nacional Autónoma de México, Sophion Bioscience, and Scripps Research.

Thanks to great co-authors, including Anna Damsbo Jensen, Nick J. Burlet, Monica L. Fernández-Quintero, Melisa Benard-Valle, Max Overath, Alid Guadarrama-Martínez, Anneline Vlamynck, Ida Bisbo, César Noé Villalobos Carrizosa, Tulika Laprade, Alejandro Alagon...

While the work has immediate implications for snakebite envenoming, the methodologies developed here are generally useful for developing broadly-neutralising antibodies.

Read article here: www.nature.com/articles/s42...

Thanks also to our generous funders, Villum Fonden, European Research Council, Wellcome Trust, and Consejo Nacional de Ciencia y Tecnología!

Thanks to my fantastic co-authors, Anna Damsbo Jensen,
Melisa Benard-Valle, Tom Jansen, Nick J. Burlet, Max Overath, Alid Guadarrama-Martínez, Kim Boddum, Alejandro Alagon, and Esperanza Rivera de Torre from
DTU, UNAM, and Sophion Biosciences.
.

... Sandra Wingaard Thrane & Nuria Canibe.

Thanks to GUDP - Grønt Udviklings- & Demonstrationsprogram for the financial support to make this happen!

The work was done by researchers from
Bactolife, Aarhus University, Technical University of Denmark, and Università degli Studi di Parma, including Jiajia Xu, Melania Andrani, Rikke Brødsgaard Kjærup, Tina Sørensen Dalgaard, Carsten Eriksen, Susanne Brix Pedersen...

The Binding Proteins developed here retain full functionality when subjected to the very harsh process of pelleting, as part of admixing them into piglet feed, as can be seen in the figure.