Andi Brunner
@andibrunner.bsky.social
PostDoc @EllenbergLab @EMBL working on Genome Organization. Interested in Cell Biology, Climate Change & Politics
Reposted by Andi Brunner
Our work on NPC biogenesis is now out! Wanlu Zhang investigated the role of FG-Nups in NPC reassembly, pore dilation, and the nuclear envelope remodelling using acute depletions, correlative EM, and MINFLUX imaging 💫.
Thanks, Wanlu and all the collaborators!
Thanks, Wanlu and all the collaborators!
Excited to share the preprint from my postdoc work @ellenberglab.bsky.social! 🌟
During mitotic exit, cells rebuild thousands of nuclear pores within minutes. How do tiny holes expand to selective channels, and how is this coordinated with the nuclear envelope remodeling? 🔗 doi.org/10.1101/2025...
During mitotic exit, cells rebuild thousands of nuclear pores within minutes. How do tiny holes expand to selective channels, and how is this coordinated with the nuclear envelope remodeling? 🔗 doi.org/10.1101/2025...
Hydrophobic interactions of FG-nucleoporins are required for dilating nuclear membrane pores into selective transport channels after mitosis
Nuclear envelope (NE) reformation after mitosis is essential for daughter cell viability and requires tightly coordinated nuclear pore complex (NPC) assembly and nuclear membrane reformation. To revea...
doi.org
September 10, 2025 at 1:14 PM
Our work on NPC biogenesis is now out! Wanlu Zhang investigated the role of FG-Nups in NPC reassembly, pore dilation, and the nuclear envelope remodelling using acute depletions, correlative EM, and MINFLUX imaging 💫.
Thanks, Wanlu and all the collaborators!
Thanks, Wanlu and all the collaborators!
Congratulations Wanlu!! 🚀🚀
Excited to share the preprint from my postdoc work @ellenberglab.bsky.social! 🌟
During mitotic exit, cells rebuild thousands of nuclear pores within minutes. How do tiny holes expand to selective channels, and how is this coordinated with the nuclear envelope remodeling? 🔗 doi.org/10.1101/2025...
During mitotic exit, cells rebuild thousands of nuclear pores within minutes. How do tiny holes expand to selective channels, and how is this coordinated with the nuclear envelope remodeling? 🔗 doi.org/10.1101/2025...
Hydrophobic interactions of FG-nucleoporins are required for dilating nuclear membrane pores into selective transport channels after mitosis
Nuclear envelope (NE) reformation after mitosis is essential for daughter cell viability and requires tightly coordinated nuclear pore complex (NPC) assembly and nuclear membrane reformation. To revea...
doi.org
September 10, 2025 at 7:13 AM
Congratulations Wanlu!! 🚀🚀
Reposted by Andi Brunner
Just got round to watching Mario Draghi's speech in Rimini in the original Italian. It is easily the most important speech on Europe so far this year and I hope someone (@grandcontinent.bsky.social?) publishes it in English and other EU languages soon.
www.youtube.com/watch?v=YMME...
www.youtube.com/watch?v=YMME...
Mario Draghi’s Full Speech: Europe’s Harsh Reality — Powerless on the Global Stage! -ITALIAN-
YouTube video by EU Debates | eudebates.tv
www.youtube.com
August 24, 2025 at 6:44 PM
Just got round to watching Mario Draghi's speech in Rimini in the original Italian. It is easily the most important speech on Europe so far this year and I hope someone (@grandcontinent.bsky.social?) publishes it in English and other EU languages soon.
www.youtube.com/watch?v=YMME...
www.youtube.com/watch?v=YMME...
Reposted by Andi Brunner
Our new non-denaturing nanoscale 3D DNA tracing technology provides single-cell (and sister-chromatid specific!) readout of chromatin structure with 10kb genomic resolution - Check it out!
www.nature.com/articles/s41...
Congratulations to Kai and Oyvind!!
www.nature.com/articles/s41...
Congratulations to Kai and Oyvind!!
Nanoscale 3D DNA tracing in non-denatured cells resolves the Cohesin-dependent loop architecture of the genome in situ - Nature Communications
A nanoscale 3D DNA tracing workflow visualizes Cohesin-dependent loops in single, structurally well-preserved cells. Computer simulations based on the tracing data give further insight into how Cohesi...
www.nature.com
July 21, 2025 at 10:53 AM
Our new non-denaturing nanoscale 3D DNA tracing technology provides single-cell (and sister-chromatid specific!) readout of chromatin structure with 10kb genomic resolution - Check it out!
www.nature.com/articles/s41...
Congratulations to Kai and Oyvind!!
www.nature.com/articles/s41...
Congratulations to Kai and Oyvind!!
Reposted by Andi Brunner
"Nicht einen Millimeter überlassen..."
Ich habe das jetzt erst gesehen und was soll ich sagen, was Igor Levit da anlässlich des Todes von Margot Friedländer aus dem Stand heraus sagt, ist das Berührendste, Wahrste und Richtigste, was ich seit ewig im deutschen Fernsehen gehört habe.
Ich habe das jetzt erst gesehen und was soll ich sagen, was Igor Levit da anlässlich des Todes von Margot Friedländer aus dem Stand heraus sagt, ist das Berührendste, Wahrste und Richtigste, was ich seit ewig im deutschen Fernsehen gehört habe.
Igor Levit über Margot Friedländer beim Deutschen Filmpreis 2025 -
YouTube video by Rederei FM
www.youtube.com
May 10, 2025 at 4:23 PM
"Nicht einen Millimeter überlassen..."
Ich habe das jetzt erst gesehen und was soll ich sagen, was Igor Levit da anlässlich des Todes von Margot Friedländer aus dem Stand heraus sagt, ist das Berührendste, Wahrste und Richtigste, was ich seit ewig im deutschen Fernsehen gehört habe.
Ich habe das jetzt erst gesehen und was soll ich sagen, was Igor Levit da anlässlich des Todes von Margot Friedländer aus dem Stand heraus sagt, ist das Berührendste, Wahrste und Richtigste, was ich seit ewig im deutschen Fernsehen gehört habe.
Reposted by Andi Brunner
🎉 Excited to share our new work: “Adhesion-driven tissue rigidification triggers epithelial cell polarity”, now on @biorxivpreprint.bsky.social !
A huge thank you to @nicolettapetridou.bsky.social, Bernat, @crisp-c.bsky.social, Adrián, and everyone involved! 🙌
🧵⤵️
A huge thank you to @nicolettapetridou.bsky.social, Bernat, @crisp-c.bsky.social, Adrián, and everyone involved! 🙌
🧵⤵️
March 27, 2025 at 2:16 PM
🎉 Excited to share our new work: “Adhesion-driven tissue rigidification triggers epithelial cell polarity”, now on @biorxivpreprint.bsky.social !
A huge thank you to @nicolettapetridou.bsky.social, Bernat, @crisp-c.bsky.social, Adrián, and everyone involved! 🙌
🧵⤵️
A huge thank you to @nicolettapetridou.bsky.social, Bernat, @crisp-c.bsky.social, Adrián, and everyone involved! 🙌
🧵⤵️
Reposted by Andi Brunner
DWD-Fakten zur aktuellen #Trockenheit in #Deutschland: Noch nie seit Beginn der Auswertung 1931 war es in Deutschland im Zeitraum von Anfang Februar bis Mitte April so trocken wie 2025. Mehr Details auch zu #Europa in der heutigen Pressemitteilung unter www.dwd.de/presse
April 15, 2025 at 1:07 PM
DWD-Fakten zur aktuellen #Trockenheit in #Deutschland: Noch nie seit Beginn der Auswertung 1931 war es in Deutschland im Zeitraum von Anfang Februar bis Mitte April so trocken wie 2025. Mehr Details auch zu #Europa in der heutigen Pressemitteilung unter www.dwd.de/presse
Reposted by Andi Brunner
Spoiler: It is absolutely market manipulation
Rep. Steven Horsford to Greer: "So the trade representative hasn't spoken to the POTUS about a global reordering of trade, but yet he announced it on a tweet? WTF! Who is in charge? It looks like your boss just pulled the rug out from under you. There is no strategy ... is this market manipulation?"
April 9, 2025 at 6:52 PM
Spoiler: It is absolutely market manipulation
Reposted by Andi Brunner
Our new findings on how chromosomes get ready for cell division are now published in @cellpress.bsky.social!
Congratulations, Kai, @andibrunner.bsky.social and everyone else involved! 🤩
www.sciencedirect.com/science/arti...
Congratulations, Kai, @andibrunner.bsky.social and everyone else involved! 🤩
www.sciencedirect.com/science/arti...
March 24, 2025 at 3:29 PM
Our new findings on how chromosomes get ready for cell division are now published in @cellpress.bsky.social!
Congratulations, Kai, @andibrunner.bsky.social and everyone else involved! 🤩
www.sciencedirect.com/science/arti...
Congratulations, Kai, @andibrunner.bsky.social and everyone else involved! 🤩
www.sciencedirect.com/science/arti...
Reposted by Andi Brunner
Did you know that DNA must form overlapping loops to give rise to the well-known X-shape of chromosomes? 🧬🧪
New research from EMBL's Ellenberg Group provides new insights into the process of chromosome formation.
@ellenberglab.bsky.social
@andibrunner.bsky.social
www.embl.org/news/science...
New research from EMBL's Ellenberg Group provides new insights into the process of chromosome formation.
@ellenberglab.bsky.social
@andibrunner.bsky.social
www.embl.org/news/science...
How chromosomes shape up for cell division | EMBL
EMBL scientists have shown how overlapping loops of DNA stack upon each other in dividing cells to give rise to rod-shaped chromosomes
www.embl.org
March 24, 2025 at 3:10 PM
Did you know that DNA must form overlapping loops to give rise to the well-known X-shape of chromosomes? 🧬🧪
New research from EMBL's Ellenberg Group provides new insights into the process of chromosome formation.
@ellenberglab.bsky.social
@andibrunner.bsky.social
www.embl.org/news/science...
New research from EMBL's Ellenberg Group provides new insights into the process of chromosome formation.
@ellenberglab.bsky.social
@andibrunner.bsky.social
www.embl.org/news/science...
Mitotic chromosomes form through long, overlapping and self-repelling DNA loops, generated by the Condensin complexes!
Check out our newest paper here, and see below for a short Bluetorial!
www.cell.com/cell/fulltex...
Check out our newest paper here, and see below for a short Bluetorial!
www.cell.com/cell/fulltex...
March 24, 2025 at 3:47 PM
Mitotic chromosomes form through long, overlapping and self-repelling DNA loops, generated by the Condensin complexes!
Check out our newest paper here, and see below for a short Bluetorial!
www.cell.com/cell/fulltex...
Check out our newest paper here, and see below for a short Bluetorial!
www.cell.com/cell/fulltex...
SO excited to see this out!
Did you know that DNA must form overlapping loops to give rise to the well-known X-shape of chromosomes? 🧬🧪
New research from EMBL's Ellenberg Group provides new insights into the process of chromosome formation.
@ellenberglab.bsky.social
@andibrunner.bsky.social
www.embl.org/news/science...
New research from EMBL's Ellenberg Group provides new insights into the process of chromosome formation.
@ellenberglab.bsky.social
@andibrunner.bsky.social
www.embl.org/news/science...
How chromosomes shape up for cell division | EMBL
EMBL scientists have shown how overlapping loops of DNA stack upon each other in dividing cells to give rise to rod-shaped chromosomes
www.embl.org
March 24, 2025 at 3:36 PM
SO excited to see this out!
Reposted by Andi Brunner
We are #hiring!
We have two open postdoc/research scientist positions to join our #ERC funded project MITOFOLD to resolve the organization of mitotic chromosomes!
1) experimental biologist shorturl.at/LjGEM
2) data scientist shorturl.at/nDdhQ
Please share! 🙌
We look forward to your application! 🤩
We have two open postdoc/research scientist positions to join our #ERC funded project MITOFOLD to resolve the organization of mitotic chromosomes!
1) experimental biologist shorturl.at/LjGEM
2) data scientist shorturl.at/nDdhQ
Please share! 🙌
We look forward to your application! 🤩
March 19, 2025 at 11:50 AM
We are #hiring!
We have two open postdoc/research scientist positions to join our #ERC funded project MITOFOLD to resolve the organization of mitotic chromosomes!
1) experimental biologist shorturl.at/LjGEM
2) data scientist shorturl.at/nDdhQ
Please share! 🙌
We look forward to your application! 🤩
We have two open postdoc/research scientist positions to join our #ERC funded project MITOFOLD to resolve the organization of mitotic chromosomes!
1) experimental biologist shorturl.at/LjGEM
2) data scientist shorturl.at/nDdhQ
Please share! 🙌
We look forward to your application! 🤩
Reposted by Andi Brunner
History will remember this day— when an American President and Vice President abandoned all we stand for.
February 28, 2025 at 6:38 PM
History will remember this day— when an American President and Vice President abandoned all we stand for.
Reposted by Andi Brunner
Zwei Tage vor der der Wahl haben Friedrich Merz und die Union eine Anfrage gestellt, die man in dieser Form sonst nur von der AfD kannte. In 551 (!) Fragen stellen sie die Gemeinnützigkeit zahlreicher NGOs in Frage, darunter auch des @netzwerkrecherche.org. dserver.bundestag.de/btd/20/150/2...
February 25, 2025 at 2:53 PM
Zwei Tage vor der der Wahl haben Friedrich Merz und die Union eine Anfrage gestellt, die man in dieser Form sonst nur von der AfD kannte. In 551 (!) Fragen stellen sie die Gemeinnützigkeit zahlreicher NGOs in Frage, darunter auch des @netzwerkrecherche.org. dserver.bundestag.de/btd/20/150/2...
Reposted by Andi Brunner
🇩🇪 ist die drittgrößte Volkswirtschaft der Welt. Morgen wählen wir - entweder für eine moderne, klimaneutrale Wirtschaft, oder für die Rückkehr zu Technologien des letzten Jahrhunderts. Lasst euch nicht für dumm verkaufen mit Scheinlösungen, die nur das fossile Geschäftsmodell noch etwas verlängern.
February 22, 2025 at 12:42 PM
🇩🇪 ist die drittgrößte Volkswirtschaft der Welt. Morgen wählen wir - entweder für eine moderne, klimaneutrale Wirtschaft, oder für die Rückkehr zu Technologien des letzten Jahrhunderts. Lasst euch nicht für dumm verkaufen mit Scheinlösungen, die nur das fossile Geschäftsmodell noch etwas verlängern.
In today‘s talk on „Autocracy vs Democracy“ in Heidelberg, Prof. Dr. Aurel Croissant said that 7/9 landmark developments towards #autocracy have been made in the US.
A change back to more #democracy becomes increasingly unlikely.
At the same time, the white house posted this on X, citing #Trump.
A change back to more #democracy becomes increasingly unlikely.
At the same time, the white house posted this on X, citing #Trump.
February 19, 2025 at 9:36 PM
In today‘s talk on „Autocracy vs Democracy“ in Heidelberg, Prof. Dr. Aurel Croissant said that 7/9 landmark developments towards #autocracy have been made in the US.
A change back to more #democracy becomes increasingly unlikely.
At the same time, the white house posted this on X, citing #Trump.
A change back to more #democracy becomes increasingly unlikely.
At the same time, the white house posted this on X, citing #Trump.
Reposted by Andi Brunner
Ich rechne damit, dass heute, Vorwürfe gegen meine Doktorarbeit, die ich vor 25 Jahren geschrieben habe, veröffentlicht werden. Ich habe mich entschieden, das Ganze transparent zu machen. Denn ich kenne die Vorwürfe – und konnte sie vorab prüfen lassen.
www.youtube.com/watch?v=mYyA...
www.youtube.com/watch?v=mYyA...
Zu meiner Dissertation | Robert Habeck
YouTube video by Robert Habeck
www.youtube.com
February 10, 2025 at 10:35 AM
Ich rechne damit, dass heute, Vorwürfe gegen meine Doktorarbeit, die ich vor 25 Jahren geschrieben habe, veröffentlicht werden. Ich habe mich entschieden, das Ganze transparent zu machen. Denn ich kenne die Vorwürfe – und konnte sie vorab prüfen lassen.
www.youtube.com/watch?v=mYyA...
www.youtube.com/watch?v=mYyA...
Reposted by Andi Brunner
Erasure.
At the National Institute of Health, posters of women and scientists of color have been taken down. Shared by @ivancalcantara.bsky.social
At the National Institute of Health, posters of women and scientists of color have been taken down. Shared by @ivancalcantara.bsky.social
February 8, 2025 at 7:05 PM
Erasure.
At the National Institute of Health, posters of women and scientists of color have been taken down. Shared by @ivancalcantara.bsky.social
At the National Institute of Health, posters of women and scientists of color have been taken down. Shared by @ivancalcantara.bsky.social
Reposted by Andi Brunner
Doing a report on AfD campaigning on Facebook and it really is striking the sheer level of AI images and videos. Smiling white (often blonde) Germans contrasted against glowering dark skinned men. Shameless stuff, but perhaps I shouldn't be surprised
February 7, 2025 at 1:22 PM
Doing a report on AfD campaigning on Facebook and it really is striking the sheer level of AI images and videos. Smiling white (often blonde) Germans contrasted against glowering dark skinned men. Shameless stuff, but perhaps I shouldn't be surprised
Reposted by Andi Brunner
Congratulations to @andibrunner.bsky.social
and the team, and many thanks to the lab of Jan-Michael Peters for support!
We found that the interphase and mitotic chromatin loop organization have more in common than previously thought:
In both stages big loops are built first, small ones second
and the team, and many thanks to the lab of Jan-Michael Peters for support!
We found that the interphase and mitotic chromatin loop organization have more in common than previously thought:
In both stages big loops are built first, small ones second
@andibrunner.bsky.social et al. @ellenberglab.bsky.social show that interphase organization into Cohesin-driven loops occurs in a sequential and hierarchical manner - just like the mitotic organization by Condensins. https://buff.ly/426gIEu
@wanluzhang.bsky.social
@wanluzhang.bsky.social
January 9, 2025 at 9:57 PM
Congratulations to @andibrunner.bsky.social
and the team, and many thanks to the lab of Jan-Michael Peters for support!
We found that the interphase and mitotic chromatin loop organization have more in common than previously thought:
In both stages big loops are built first, small ones second
and the team, and many thanks to the lab of Jan-Michael Peters for support!
We found that the interphase and mitotic chromatin loop organization have more in common than previously thought:
In both stages big loops are built first, small ones second
My first own project is published:
Despite major differences in chromosome shape during #interphase and #mitosis, the underlying #loop-extruder based organization is highly similar
A new data resource and new insights into human chromatin biology! 🧬🥳
Despite major differences in chromosome shape during #interphase and #mitosis, the underlying #loop-extruder based organization is highly similar
A new data resource and new insights into human chromatin biology! 🧬🥳
@andibrunner.bsky.social et al. @ellenberglab.bsky.social show that interphase organization into Cohesin-driven loops occurs in a sequential and hierarchical manner - just like the mitotic organization by Condensins. https://buff.ly/426gIEu
@wanluzhang.bsky.social
@wanluzhang.bsky.social
January 9, 2025 at 7:19 PM
My first own project is published:
Despite major differences in chromosome shape during #interphase and #mitosis, the underlying #loop-extruder based organization is highly similar
A new data resource and new insights into human chromatin biology! 🧬🥳
Despite major differences in chromosome shape during #interphase and #mitosis, the underlying #loop-extruder based organization is highly similar
A new data resource and new insights into human chromatin biology! 🧬🥳
Reposted by Andi Brunner
@andibrunner.bsky.social et al. @ellenberglab.bsky.social show that interphase organization into Cohesin-driven loops occurs in a sequential and hierarchical manner - just like the mitotic organization by Condensins. https://buff.ly/426gIEu
@wanluzhang.bsky.social
@wanluzhang.bsky.social
January 9, 2025 at 6:37 PM
@andibrunner.bsky.social et al. @ellenberglab.bsky.social show that interphase organization into Cohesin-driven loops occurs in a sequential and hierarchical manner - just like the mitotic organization by Condensins. https://buff.ly/426gIEu
@wanluzhang.bsky.social
@wanluzhang.bsky.social
Highly recommend to check that out! #CellBio24
Our excellent postdoc Wanlu Zhang is at #CellBio24 and will talk about her unpublished NPC biogensis work tomorrow!
Check it out and say hello 🙌🏼
Check it out and say hello 🙌🏼
December 16, 2024 at 5:37 PM
Highly recommend to check that out! #CellBio24
Reposted by Andi Brunner
We are now on Bluesky!
Follow us for exciting #Science around #CellDivision and nuclear organization, illuminated using advanced #imaging #technology - like our last preprint on mitotic chromosome structure and organization: tinyurl.com/yaznnkku
Follow us for exciting #Science around #CellDivision and nuclear organization, illuminated using advanced #imaging #technology - like our last preprint on mitotic chromosome structure and organization: tinyurl.com/yaznnkku
November 25, 2024 at 1:08 PM
We are now on Bluesky!
Follow us for exciting #Science around #CellDivision and nuclear organization, illuminated using advanced #imaging #technology - like our last preprint on mitotic chromosome structure and organization: tinyurl.com/yaznnkku
Follow us for exciting #Science around #CellDivision and nuclear organization, illuminated using advanced #imaging #technology - like our last preprint on mitotic chromosome structure and organization: tinyurl.com/yaznnkku