Using a dynamic polymer constrained only by available quantitative Condensin chromatin-binding data, we could recapitulate the formation of native mitotic chromosome rods!

Two features were essential for that ->

We found that Condensins are also responsible for the backfolding of DNA at much larger genomic distances: up to 6-8 megabases.

Analyzing these traces, we found evidence for continuously growing loops, and our degron-based experiments showed that these loops are built by the Condensin complexes.

Kai and I used the recently established LoopTrace technology to trace the structure of single mitotic chromosomes in human cells in a very mild & structure pre-serving manner.

Mitotic chromosomes form through long, overlapping and self-repelling DNA loops, generated by the Condensin complexes!

Check out our newest paper here, and see below for a short Bluetorial!
www.cell.com/cell/fulltex...

In today‘s talk on „Autocracy vs Democracy“ in Heidelberg, Prof. Dr. Aurel Croissant said that 7/9 landmark developments towards #autocracy have been made in the US.

A change back to more #democracy becomes increasingly unlikely.

At the same time, the white house posted this on X, citing #Trump.