Angel Nadal
@anadaln.bsky.social
Professor of Physiology, UMH, Spain
Preventing Diabetes by Caring for the Environment
https://isletcellsignal.umh.es/
Preventing Diabetes by Caring for the Environment
https://isletcellsignal.umh.es/
Pinned
Angel Nadal
@anadaln.bsky.social
· Dec 10
Consensus on the key characteristics of metabolism disruptors - Nature Reviews Endocrinology
This Consensus Statement uses available mechanistic knowledge on pharmaceutical, chemical, physical and biological agents to identify the key characteristics (KCs) of metabolism-disrupting agents (MDA...
www.nature.com
We have recently published the key characteristics of metabolism disruptors. They can be used to organize and use mechanistic data to help to identify metabolism-disrupting agents. #diabetogens #obesogens #EDCs @natureportfolio.bsky.social
www.nature.com/articles/s41...
Reposted by Angel Nadal
Analysis of human pancreas indicates that the molecular mechanisms driving #pregnancy induced #islet adaptations in humans differ from those in mice, highlighting the need for human-based studies @natcomms.nature.com www.nature.com/articles/s41...
A new paradigm of islet adaptations in human pregnancy: insights from immunohistochemistry and proteomics - Nature Communications
Here the authors show that human pancreatic islets adapt during pregnancy with increased α-cell area and GLP-1 abundance, while key differences from islet adaptations in mouse pregnancy include unchan...
www.nature.com
July 21, 2025 at 10:37 AM
Analysis of human pancreas indicates that the molecular mechanisms driving #pregnancy induced #islet adaptations in humans differ from those in mice, highlighting the need for human-based studies @natcomms.nature.com www.nature.com/articles/s41...
Endocrine-disrupting chemicals in 2025 @natrevendo.nature.com www.nature.com/articles/s41...
The hidden health effects of endocrine-disrupting chemicals - Nature Reviews Endocrinology
The quest to understand the adverse health outcomes linked to endocrine-disrupting chemicals continued in 2025. Insights have been gained regarding their effects on metabolic health, their key charact...
www.nature.com
December 13, 2025 at 5:54 AM
Endocrine-disrupting chemicals in 2025 @natrevendo.nature.com www.nature.com/articles/s41...
Reposted by Angel Nadal
A new report “Chemical Pollution and Men’s Health: A Hidden Crisis in Europe commissioned by the Health and Environment Alliance highlights the severe risks of #EndocrineDisruptors for men’s health 👉 lnkd.in/ehQZKrFb
#MensHealthAwarenessMonth #BecauseHormonesMatter
#MensHealthAwarenessMonth #BecauseHormonesMatter
November 21, 2025 at 1:38 PM
A new report “Chemical Pollution and Men’s Health: A Hidden Crisis in Europe commissioned by the Health and Environment Alliance highlights the severe risks of #EndocrineDisruptors for men’s health 👉 lnkd.in/ehQZKrFb
#MensHealthAwarenessMonth #BecauseHormonesMatter
#MensHealthAwarenessMonth #BecauseHormonesMatter
Reposted by Angel Nadal
🔴 #PFAS Alert: ESE, ESPE & @endocrinesociety.bsky.social urge the EU to adopt a universal restriction with limited exemptions. “Forever chemicals” pose serious risks to #endocrinehealth. 📢 Read ow.ly/9Vqp50XkaO5 / #EDCs #EURegulation #BecauseHormonesMatter #PublicHealth
October 30, 2025 at 8:17 PM
🔴 #PFAS Alert: ESE, ESPE & @endocrinesociety.bsky.social urge the EU to adopt a universal restriction with limited exemptions. “Forever chemicals” pose serious risks to #endocrinehealth. 📢 Read ow.ly/9Vqp50XkaO5 / #EDCs #EURegulation #BecauseHormonesMatter #PublicHealth
Reposted by Angel Nadal
New HEAL report!
Chemical pollution is fuelling a growing men’s health crisis in Europe.
Prostate cancer, testicular cancer, male infertility are on the rise, and parental exposure can even mean health impacts in the next generation.
Read the report: ➡️ www.env-health.org/new-report-c...
Chemical pollution is fuelling a growing men’s health crisis in Europe.
Prostate cancer, testicular cancer, male infertility are on the rise, and parental exposure can even mean health impacts in the next generation.
Read the report: ➡️ www.env-health.org/new-report-c...
November 5, 2025 at 11:02 AM
New HEAL report!
Chemical pollution is fuelling a growing men’s health crisis in Europe.
Prostate cancer, testicular cancer, male infertility are on the rise, and parental exposure can even mean health impacts in the next generation.
Read the report: ➡️ www.env-health.org/new-report-c...
Chemical pollution is fuelling a growing men’s health crisis in Europe.
Prostate cancer, testicular cancer, male infertility are on the rise, and parental exposure can even mean health impacts in the next generation.
Read the report: ➡️ www.env-health.org/new-report-c...
Reposted by Angel Nadal
🚨 Delighted to share our latest paper, from
@asharpmedonc.bsky.social team in collaboration with Johann de Bono’s team at @icr.ac.uk and international colleagues, published in Nature Communications @natureportfolio.nature.com
Read here: bit.ly/477pYt7
🧵1/4
@asharpmedonc.bsky.social team in collaboration with Johann de Bono’s team at @icr.ac.uk and international colleagues, published in Nature Communications @natureportfolio.nature.com
Read here: bit.ly/477pYt7
🧵1/4
October 15, 2025 at 1:48 PM
🚨 Delighted to share our latest paper, from
@asharpmedonc.bsky.social team in collaboration with Johann de Bono’s team at @icr.ac.uk and international colleagues, published in Nature Communications @natureportfolio.nature.com
Read here: bit.ly/477pYt7
🧵1/4
@asharpmedonc.bsky.social team in collaboration with Johann de Bono’s team at @icr.ac.uk and international colleagues, published in Nature Communications @natureportfolio.nature.com
Read here: bit.ly/477pYt7
🧵1/4
Reposted by Angel Nadal
„Obesity rates continue to rise globally, and the pressure exerted by food systems on planetary boundaries shows no signs of abating.“
Plastics are the key enabler of globalized food systems…
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)01201-2/
Plastics are the key enabler of globalized food systems…
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)01201-2/
The EAT–Lancet Commission on healthy, sustainable, and just food systems
The global context has shifted dramatically since publication of the first EAT–Lancet
Commission in 2019, with increased geopolitical instability, soaring food prices,
and the COVID-19 pandemic exacer...
www.thelancet.com
October 5, 2025 at 8:22 AM
„Obesity rates continue to rise globally, and the pressure exerted by food systems on planetary boundaries shows no signs of abating.“
Plastics are the key enabler of globalized food systems…
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)01201-2/
Plastics are the key enabler of globalized food systems…
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)01201-2/
Reposted by Angel Nadal
ESE #SpotlightOnScience 'Uncovering the functional roles of #FSHR oligomerisation in young and ageing ovaries'.
📅20 November 18:00-19:30 CET
Chairs: Manuel Gahete and Lina Paschou
Sign up for free now! 👇
ow.ly/6J9w50WlPWO
#ReproductiveScience
📅20 November 18:00-19:30 CET
Chairs: Manuel Gahete and Lina Paschou
Sign up for free now! 👇
ow.ly/6J9w50WlPWO
#ReproductiveScience
September 12, 2025 at 1:02 PM
ESE #SpotlightOnScience 'Uncovering the functional roles of #FSHR oligomerisation in young and ageing ovaries'.
📅20 November 18:00-19:30 CET
Chairs: Manuel Gahete and Lina Paschou
Sign up for free now! 👇
ow.ly/6J9w50WlPWO
#ReproductiveScience
📅20 November 18:00-19:30 CET
Chairs: Manuel Gahete and Lina Paschou
Sign up for free now! 👇
ow.ly/6J9w50WlPWO
#ReproductiveScience
Reposted by Angel Nadal
Excellent reporting on endocrine disrupting chemicals in plastics. Some of them suggested for a global ban under a future #plasticstreaty.
For the last several months, I've been digging through endless scientific literature on what happens when pregnant mothers are exposed to plastic chemicals in their food, water, and everyday household products.
The result is this story.
I hope you'll take the time to read.
wapo.st/4g3ZoFc
The result is this story.
I hope you'll take the time to read.
wapo.st/4g3ZoFc
The health risks from plastics almost nobody knows about
Researchers have linked phthalates, chemicals found in plastics, to premature birth, infertility and ADHD.
wapo.st
September 4, 2025 at 3:50 PM
Excellent reporting on endocrine disrupting chemicals in plastics. Some of them suggested for a global ban under a future #plasticstreaty.
Reposted by Angel Nadal
Our members, @leotrasande.bsky.social, MPP; Thomas Zoeller, PhD; @elleenvy.bsky.social; and @jmuncke.bsky.social, joined a panel of experts to discuss how science supports action at all governance levels to address and minimize exposure to EDCs: bit.ly/2simKTL @genevaenvironmentnetwork.org
September 3, 2025 at 10:20 PM
Our members, @leotrasande.bsky.social, MPP; Thomas Zoeller, PhD; @elleenvy.bsky.social; and @jmuncke.bsky.social, joined a panel of experts to discuss how science supports action at all governance levels to address and minimize exposure to EDCs: bit.ly/2simKTL @genevaenvironmentnetwork.org
Reposted by Angel Nadal
Our members, Drs. @leotrasande.bsky.social, @smbrander.bsky.social, and @jmuncke.bsky.social, attended INC5.2 to educate European delegates about the health effects of EDCs and how they interfere with the endocrine system. Learn about our EDCs: bit.ly/2LCRwAr #EDCs #PlasticsTreaty (1/4)
August 19, 2025 at 6:38 PM
Our members, Drs. @leotrasande.bsky.social, @smbrander.bsky.social, and @jmuncke.bsky.social, attended INC5.2 to educate European delegates about the health effects of EDCs and how they interfere with the endocrine system. Learn about our EDCs: bit.ly/2LCRwAr #EDCs #PlasticsTreaty (1/4)
Reposted by Angel Nadal
Don’t trust the experts”? That’s not democracy, that’s recklessness.
On a plane, I want a pilot.
In a hospital, I want doctors and scientists who understand the evidence.
Expertise isn’t religion or authoritarianism — it’s training, accountability, and data.
Ignore it and we all pay the price.
On a plane, I want a pilot.
In a hospital, I want doctors and scientists who understand the evidence.
Expertise isn’t religion or authoritarianism — it’s training, accountability, and data.
Ignore it and we all pay the price.
RFK Jr: We need to stop trusting the experts... Trusting the experts is not a feature of science or democracy, it's a feature of religion and totalitarianism.
August 29, 2025 at 10:07 PM
Don’t trust the experts”? That’s not democracy, that’s recklessness.
On a plane, I want a pilot.
In a hospital, I want doctors and scientists who understand the evidence.
Expertise isn’t religion or authoritarianism — it’s training, accountability, and data.
Ignore it and we all pay the price.
On a plane, I want a pilot.
In a hospital, I want doctors and scientists who understand the evidence.
Expertise isn’t religion or authoritarianism — it’s training, accountability, and data.
Ignore it and we all pay the price.
Reposted by Angel Nadal
Over 20 years after Julius’s lab and mine cloned TRPM8, it is rewarding to see this science helping patients. The TRPM8 agonist Tryptyr treats dry eye by increasing tear production. A reminder that NIH-funded curiosity-driven research translates to medicines.
tryptyr.myalcon.com?gad_source=1...
tryptyr.myalcon.com?gad_source=1...
TRYPTYR (acoltremon ophthalmic solution) 0.003% eye drops | Alcon US
TRYPTYR is a prescription eye drop used for the treatment of the signs and symptoms of dry eye disease. See prescribing information, how to save, and more.
tryptyr.myalcon.com
August 13, 2025 at 9:17 PM
Over 20 years after Julius’s lab and mine cloned TRPM8, it is rewarding to see this science helping patients. The TRPM8 agonist Tryptyr treats dry eye by increasing tear production. A reminder that NIH-funded curiosity-driven research translates to medicines.
tryptyr.myalcon.com?gad_source=1...
tryptyr.myalcon.com?gad_source=1...
Reposted by Angel Nadal
🔬 Evidence from international scientific experts highlights the importance of addressing chemicals of concern, plastic production, and developing essential use, transparency, safety and sustainability criteria for plastics.
ℹ️ See our latest statement ahead of INC 👇
drive.google.com/file/d/1ZSWd...
ℹ️ See our latest statement ahead of INC 👇
drive.google.com/file/d/1ZSWd...
July 31, 2025 at 12:41 PM
🔬 Evidence from international scientific experts highlights the importance of addressing chemicals of concern, plastic production, and developing essential use, transparency, safety and sustainability criteria for plastics.
ℹ️ See our latest statement ahead of INC 👇
drive.google.com/file/d/1ZSWd...
ℹ️ See our latest statement ahead of INC 👇
drive.google.com/file/d/1ZSWd...
Reposted by Angel Nadal
ESE joins with @endocrinesociety.bsky.social, the European Society for Paediatric Endocrinology and national endocrine societies, in an open letter to EU Member States outlining the endocrine community’s priorities for a future regulatory framework on #EDCs.
👉 ow.ly/thFE50WjKeM
👉 ow.ly/thFE50WjKeM
July 3, 2025 at 12:29 PM
ESE joins with @endocrinesociety.bsky.social, the European Society for Paediatric Endocrinology and national endocrine societies, in an open letter to EU Member States outlining the endocrine community’s priorities for a future regulatory framework on #EDCs.
👉 ow.ly/thFE50WjKeM
👉 ow.ly/thFE50WjKeM
Reposted by Angel Nadal
Plenty of fun is going on at ESE Summer School 2025, coupled with cutting-edge scientific presentations.
And who won the volleyball? No matter, it's about getting to know your #endocrine colleagues from across Europe.
#OurEndocrineCommunity #WeGrowTogether
@ese-eyes.bsky.social
And who won the volleyball? No matter, it's about getting to know your #endocrine colleagues from across Europe.
#OurEndocrineCommunity #WeGrowTogether
@ese-eyes.bsky.social
June 24, 2025 at 1:49 PM
Plenty of fun is going on at ESE Summer School 2025, coupled with cutting-edge scientific presentations.
And who won the volleyball? No matter, it's about getting to know your #endocrine colleagues from across Europe.
#OurEndocrineCommunity #WeGrowTogether
@ese-eyes.bsky.social
And who won the volleyball? No matter, it's about getting to know your #endocrine colleagues from across Europe.
#OurEndocrineCommunity #WeGrowTogether
@ese-eyes.bsky.social
Reposted by Angel Nadal
“In America, we don’t do kings!” Come out and make your voice heard today: www.nokings.org
June 14, 2025 at 2:58 PM
“In America, we don’t do kings!” Come out and make your voice heard today: www.nokings.org
Reposted by Angel Nadal
The 2025 klotz meeting just finished, 2 days of highly informative talks on "Hormones & Environment" , a timely topic. All abstracts and mini reviews from each talks are now free to download 👇👇👇
www.sciencedirect.com/journal/anna...
www.sciencedirect.com/journal/anna...
Annales d'Endocrinologie | 67th International Meeting of Clinical Endocrinology – Henri-Pierre Klotz : Hormones & Environment | ScienceDirect.com by ElsevierScienceDirect
Read the latest articles of Annales d'Endocrinologie at ScienceDirect.com, Elsevier’s leading platform of peer-reviewed scholarly literature
www.sciencedirect.com
June 13, 2025 at 5:42 PM
The 2025 klotz meeting just finished, 2 days of highly informative talks on "Hormones & Environment" , a timely topic. All abstracts and mini reviews from each talks are now free to download 👇👇👇
www.sciencedirect.com/journal/anna...
www.sciencedirect.com/journal/anna...
Reposted by Angel Nadal
ICYMI: New content online: Endocrine-disrupting chemicals and female reproductive health: a growing concern
Endocrine-disrupting chemicals and female reproductive health: a growing concern
Nature Reviews Endocrinology, Published online: 22 May 2025; doi:10.1038/s41574-025-01131-xThis article outlines evidence pointing to an important contribution of endocrine-disrupting chemicals to increasing rates of female reproductive disorders such as abnormal puberty, impaired fertility, premature menopause or polycystic ovarian syndrome reported over the past half a century.
www.nature.com
May 24, 2025 at 3:35 PM
ICYMI: New content online: Endocrine-disrupting chemicals and female reproductive health: a growing concern
Reposted by Angel Nadal
"there is sufficient evidence to suggest that bisphenols, a group of common chemicals found in plastics, may contribute to an increased risk of obesity and diabetes in human cohorts."
Article by Dr. Angel Nadal @anadaln.bsky.social
www.sciencedirect.com/science/arti...
Article by Dr. Angel Nadal @anadaln.bsky.social
www.sciencedirect.com/science/arti...
Diabetes from plastics: Role of endocrine disruptors in β-cell physiology
www.sciencedirect.com
May 27, 2025 at 2:40 PM
"there is sufficient evidence to suggest that bisphenols, a group of common chemicals found in plastics, may contribute to an increased risk of obesity and diabetes in human cohorts."
Article by Dr. Angel Nadal @anadaln.bsky.social
www.sciencedirect.com/science/arti...
Article by Dr. Angel Nadal @anadaln.bsky.social
www.sciencedirect.com/science/arti...
Endocrine-disrupting chemicals and female reproductive health: a growing concern @natrevendo.nature.com www.nature.com/articles/s41...
Endocrine-disrupting chemicals and female reproductive health: a growing concern - Nature Reviews Endocrinology
This article outlines evidence pointing to an important contribution of endocrine-disrupting chemicals to increasing rates of female reproductive disorders such as abnormal puberty, impaired fertility...
www.nature.com
May 23, 2025 at 5:30 AM
Endocrine-disrupting chemicals and female reproductive health: a growing concern @natrevendo.nature.com www.nature.com/articles/s41...
Health impacts of exposure to synthetic chemicals in food @foodpackagingforum.org @leotrasande.bsky.social @naturemedicine.bsky.social www.nature.com/articles/s41...
Health impacts of exposure to synthetic chemicals in food - Nature Medicine
This Review summarizes the current knowledge on sources, types and health effects of synthetic chemical contaminants in foods, particularly ultra-processed foods, and discusses regulatory shortcomings...
www.nature.com
May 23, 2025 at 5:26 AM
Health impacts of exposure to synthetic chemicals in food @foodpackagingforum.org @leotrasande.bsky.social @naturemedicine.bsky.social www.nature.com/articles/s41...
Endocrine-disrupting chemicals and female reproductive health: a growing concern www.nature.com/articles/s41...
Endocrine-disrupting chemicals and female reproductive health: a growing concern - Nature Reviews Endocrinology
This article outlines evidence pointing to an important contribution of endocrine-disrupting chemicals to increasing rates of female reproductive disorders such as abnormal puberty, impaired fertility...
www.nature.com
May 23, 2025 at 5:22 AM
Endocrine-disrupting chemicals and female reproductive health: a growing concern www.nature.com/articles/s41...
Reposted by Angel Nadal
Today with ESPE we welcomed leading endocrinologists, policymakers, NGOs and industry representatives to discuss the most pressing scientific and policy issues for #EndocrineDisruptors.
Full recording available soon lnkd.in/eqUUWz9y
@martinhojsik.bsky.social
Full recording available soon lnkd.in/eqUUWz9y
@martinhojsik.bsky.social
May 14, 2025 at 1:16 PM
Today with ESPE we welcomed leading endocrinologists, policymakers, NGOs and industry representatives to discuss the most pressing scientific and policy issues for #EndocrineDisruptors.
Full recording available soon lnkd.in/eqUUWz9y
@martinhojsik.bsky.social
Full recording available soon lnkd.in/eqUUWz9y
@martinhojsik.bsky.social