Anabel Chang
@anabelcjw.bsky.social
PhD student | Infectious Disease & Cell Biology | ASTAR IDLabs & NTU
Spreading ideas, not bacteria 🦠
Spreading ideas, not bacteria 🦠
Reposted by Anabel Chang
micromorph: a Python toolkit for measurement of microbial morphology https://www.biorxiv.org/content/10.64898/2025.12.05.692496v1
December 6, 2025 at 10:15 AM
micromorph: a Python toolkit for measurement of microbial morphology https://www.biorxiv.org/content/10.64898/2025.12.05.692496v1
Reposted by Anabel Chang
Spotlight: Freeman and Grinstein discuss a study from Riederer et al. (rupress.org/jcb/article/...) questioning whether TMEM175 contributes to #Parkinsons disease by serving as a pH-regulatory H⁺ channel or a K⁺ channel. rupress.org/jcb/article/...
November 26, 2025 at 6:02 PM
Spotlight: Freeman and Grinstein discuss a study from Riederer et al. (rupress.org/jcb/article/...) questioning whether TMEM175 contributes to #Parkinsons disease by serving as a pH-regulatory H⁺ channel or a K⁺ channel. rupress.org/jcb/article/...
Reposted by Anabel Chang
Studying trapped antimatter could help to explain why our world is so full of matter
go.nature.com/4pAySqA
go.nature.com/4pAySqA
Laser cooling traps more antimatter atoms than ever before
Studying trapped antimatter could help to explain why our world is so full of matter.
go.nature.com
November 28, 2025 at 10:33 AM
Studying trapped antimatter could help to explain why our world is so full of matter
go.nature.com/4pAySqA
go.nature.com/4pAySqA
Reposted by Anabel Chang
Wang, Kim, Ding et al. of the Qing Deng lab demonstrate that inward-rectifying potassium channels maintain the resting membrane potential and are required for directional sensing during #neutrophil chemotaxis. rupress.org/jcb/article/...
November 19, 2025 at 6:15 PM
Wang, Kim, Ding et al. of the Qing Deng lab demonstrate that inward-rectifying potassium channels maintain the resting membrane potential and are required for directional sensing during #neutrophil chemotaxis. rupress.org/jcb/article/...
Reposted by Anabel Chang
Direct measurements of luminal Ca²⁺ with endo-lysosomal GFP-aequorin reveal functional IP3 receptors. New study from Belén Calvo, Sandip Patel, Teresa Alonso @uva-es.bsky.social and colleagues: rupress.org/jcb/article/...
#Technology #Physiology #CellSignaling #Organelles #Lysosomes #Endosomes
#Technology #Physiology #CellSignaling #Organelles #Lysosomes #Endosomes
November 14, 2025 at 2:45 PM
Direct measurements of luminal Ca²⁺ with endo-lysosomal GFP-aequorin reveal functional IP3 receptors. New study from Belén Calvo, Sandip Patel, Teresa Alonso @uva-es.bsky.social and colleagues: rupress.org/jcb/article/...
#Technology #Physiology #CellSignaling #Organelles #Lysosomes #Endosomes
#Technology #Physiology #CellSignaling #Organelles #Lysosomes #Endosomes
Reposted by Anabel Chang
Watson – who won the Nobel Prize for his role in divining the structure of DNA; was instrumental in initiating and propelling the Human Genome Project; and who became notorious for his history of racist and sexist comments – has died at 97
Read the full story: go.nature.com/47NJ6wy
Read the full story: go.nature.com/47NJ6wy
November 8, 2025 at 10:24 AM
Watson – who won the Nobel Prize for his role in divining the structure of DNA; was instrumental in initiating and propelling the Human Genome Project; and who became notorious for his history of racist and sexist comments – has died at 97
Read the full story: go.nature.com/47NJ6wy
Read the full story: go.nature.com/47NJ6wy
Reposted by Anabel Chang
Lysosomal permeabilization by Group A Streptococcus releases proteins into the macrophage cytosol https://www.biorxiv.org/content/10.1101/2025.10.25.684498v1
October 26, 2025 at 1:16 AM
Lysosomal permeabilization by Group A Streptococcus releases proteins into the macrophage cytosol https://www.biorxiv.org/content/10.1101/2025.10.25.684498v1
Reposted by Anabel Chang
LLMs can mirror expert judgment but often rely on word patterns rather than reasoning. A new study introduces epistemia, the illusion of knowledge that occurs when surface plausibility replaces verification. In PNAS: https://ow.ly/ry7S50Xcv9b
October 16, 2025 at 7:00 PM
LLMs can mirror expert judgment but often rely on word patterns rather than reasoning. A new study introduces epistemia, the illusion of knowledge that occurs when surface plausibility replaces verification. In PNAS: https://ow.ly/ry7S50Xcv9b
Reposted by Anabel Chang
Analysis of native Ist1 dynamics reveals multiple pools of ESCRT-III on #endosomes. New work from Kevin Swift, Iryna Pustova, Anjon Audhya and colleagues @uwmadison.bsky.social: rupress.org/jcb/article/...
#membrane #lipid
#membrane #lipid
October 15, 2025 at 2:15 PM
Analysis of native Ist1 dynamics reveals multiple pools of ESCRT-III on #endosomes. New work from Kevin Swift, Iryna Pustova, Anjon Audhya and colleagues @uwmadison.bsky.social: rupress.org/jcb/article/...
#membrane #lipid
#membrane #lipid
Reposted by Anabel Chang
New study from Swift, Pustova, Audhya et al. @uwmadison.bsky.social defines the native dynamics of the ESCRT-III component Ist1 in mammalian cells, highlighting the existence of multiple, unique pools at #endosomes. rupress.org/jcb/article/...
#membrane #lipid
#membrane #lipid
October 8, 2025 at 4:01 PM
New study from Swift, Pustova, Audhya et al. @uwmadison.bsky.social defines the native dynamics of the ESCRT-III component Ist1 in mammalian cells, highlighting the existence of multiple, unique pools at #endosomes. rupress.org/jcb/article/...
#membrane #lipid
#membrane #lipid
Reposted by Anabel Chang
Here's a reminder on #InternationalCoffeeDay: It's OK to take a (coffee) break. ☕
"It’s ... helpful to have a venue to share the day-to-day ups and downs of life as a grad student," a #PhD student wrote in this 2019 #ScienceWorkingLife. https://scim.ag/4nvLTBb
"It’s ... helpful to have a venue to share the day-to-day ups and downs of life as a grad student," a #PhD student wrote in this 2019 #ScienceWorkingLife. https://scim.ag/4nvLTBb
October 1, 2025 at 4:24 PM
Here's a reminder on #InternationalCoffeeDay: It's OK to take a (coffee) break. ☕
"It’s ... helpful to have a venue to share the day-to-day ups and downs of life as a grad student," a #PhD student wrote in this 2019 #ScienceWorkingLife. https://scim.ag/4nvLTBb
"It’s ... helpful to have a venue to share the day-to-day ups and downs of life as a grad student," a #PhD student wrote in this 2019 #ScienceWorkingLife. https://scim.ag/4nvLTBb
Reposted by Anabel Chang
Duque et al @unm.edu show that a core membrane #atg8ylation & #autophagy factor ATG16L1 controls proton V-ATPase under homeostatic conditions, ensuring normo-acidification, preservation of cellular energy charge & function, & defense against #tuberculosis in murine models rupress.org/jcb/article/...
September 9, 2025 at 4:15 PM
Duque et al @unm.edu show that a core membrane #atg8ylation & #autophagy factor ATG16L1 controls proton V-ATPase under homeostatic conditions, ensuring normo-acidification, preservation of cellular energy charge & function, & defense against #tuberculosis in murine models rupress.org/jcb/article/...
Reposted by Anabel Chang
Virulence priming of Listeria monocytogenes inside replication-permissive endolysosomes https://www.biorxiv.org/content/10.1101/2025.09.02.673654v1
September 3, 2025 at 4:17 AM
Virulence priming of Listeria monocytogenes inside replication-permissive endolysosomes https://www.biorxiv.org/content/10.1101/2025.09.02.673654v1
Reposted by Anabel Chang
Event-triggered MINFLUX microscopy: smart microscopy to catch and follow rare events https://www.biorxiv.org/content/10.1101/2025.08.27.672674v1
September 1, 2025 at 7:48 PM
Event-triggered MINFLUX microscopy: smart microscopy to catch and follow rare events https://www.biorxiv.org/content/10.1101/2025.08.27.672674v1
Live U2OS cells: G3BP1-GFP + MitoTracker, treated with sodium arsenite. Imaged on Elyra 7. #SuperResolution #Microscopy #CellBiology #LiveCellImaging
August 30, 2025 at 12:46 PM
Live U2OS cells: G3BP1-GFP + MitoTracker, treated with sodium arsenite. Imaged on Elyra 7. #SuperResolution #Microscopy #CellBiology #LiveCellImaging
Reposted by Anabel Chang
Identification of organelle-specific #autophagy regulators from tandem #CRISPR screens. New study from Truc Losier, Karyn King, Maxime Rousseaux, and Ryan Russell (@russellbiolab.bsky.social) @uottawa.ca: rupress.org/jcb/article/...
#Biochemistry #CellSignaling
#Biochemistry #CellSignaling
August 28, 2025 at 1:45 PM
Identification of organelle-specific #autophagy regulators from tandem #CRISPR screens. New study from Truc Losier, Karyn King, Maxime Rousseaux, and Ryan Russell (@russellbiolab.bsky.social) @uottawa.ca: rupress.org/jcb/article/...
#Biochemistry #CellSignaling
#Biochemistry #CellSignaling
Reposted by Anabel Chang
Refractive index mapping below the diffraction limit via single molecule localization microscopy https://www.biorxiv.org/content/10.1101/2025.08.20.670782v1
August 24, 2025 at 1:47 PM
Refractive index mapping below the diffraction limit via single molecule localization microscopy https://www.biorxiv.org/content/10.1101/2025.08.20.670782v1
Reposted by Anabel Chang
NRF2 inhibition of alveolar macrophage MHC II expression during Mycobacterium tuberculosis infection https://www.biorxiv.org/content/10.1101/2025.08.16.670319v1
August 18, 2025 at 4:15 AM
NRF2 inhibition of alveolar macrophage MHC II expression during Mycobacterium tuberculosis infection https://www.biorxiv.org/content/10.1101/2025.08.16.670319v1
Reposted by Anabel Chang
"Overcoming research bias: The untapped potential of biomedically important but understudied proteins" http://dlvr.it/TMXd85
@einsteinmededu.bsky.social Steven Grudman, Carlos Madrid-Aliste and Andras Fiser
@iScience_CP
@einsteinmededu.bsky.social Steven Grudman, Carlos Madrid-Aliste and Andras Fiser
@iScience_CP
Overcoming research bias: The untapped potential of biomedically important but understudied proteins
Biochemistry; Medical biochemistry; Omics; Proteomics
dlvr.it
August 17, 2025 at 10:02 PM
"Overcoming research bias: The untapped potential of biomedically important but understudied proteins" http://dlvr.it/TMXd85
@einsteinmededu.bsky.social Steven Grudman, Carlos Madrid-Aliste and Andras Fiser
@iScience_CP
@einsteinmededu.bsky.social Steven Grudman, Carlos Madrid-Aliste and Andras Fiser
@iScience_CP
Reposted by Anabel Chang
Yanzhe Zheng et al. reveal that during starvation, SOD1, linked to #ALS, is transported into #lysosomes through #autophagy and the receptor protein TP53INP1. Within lysosomes, SOD1 regulates ROS levels and safeguards lysosomal activity and integrity. rupress.org/jcb/article/...
August 7, 2025 at 5:00 PM
Yanzhe Zheng et al. reveal that during starvation, SOD1, linked to #ALS, is transported into #lysosomes through #autophagy and the receptor protein TP53INP1. Within lysosomes, SOD1 regulates ROS levels and safeguards lysosomal activity and integrity. rupress.org/jcb/article/...
Reposted by Anabel Chang
A Biotin-HaloTag ligand enables efficient affinity capture of protein variants from live cells. New tools developed by Anoop Kumar Yadav, Abhijeet Jadhav, Hana Polasek-Sedlackova @hanasedlackova.bsky.social and colleagues: rupress.org/jcb/article/...
#Technology #Chromatin #epigenetics #CellCycle
#Technology #Chromatin #epigenetics #CellCycle
July 23, 2025 at 1:59 PM
A Biotin-HaloTag ligand enables efficient affinity capture of protein variants from live cells. New tools developed by Anoop Kumar Yadav, Abhijeet Jadhav, Hana Polasek-Sedlackova @hanasedlackova.bsky.social and colleagues: rupress.org/jcb/article/...
#Technology #Chromatin #epigenetics #CellCycle
#Technology #Chromatin #epigenetics #CellCycle
Reposted by Anabel Chang
Exclusive: In response to White House concerns about allegedly risky research on viruses, bacteria, and other pathogens, the National Institutes of Health has begun a crackdown on dozens of studies it was funding, ScienceInsider has learned. scim.ag/44oJIbw
Exclusive: NIH suspends dozens of pathogen studies over ‘gain-of-function’ concerns
Trump executive order leads to pauses on U.S.-funded research into TB, influenza, COVID-19, and other diseases, dismaying some scientists
scim.ag
July 11, 2025 at 9:23 PM
Exclusive: In response to White House concerns about allegedly risky research on viruses, bacteria, and other pathogens, the National Institutes of Health has begun a crackdown on dozens of studies it was funding, ScienceInsider has learned. scim.ag/44oJIbw
Reposted by Anabel Chang
Bacteria leverage a secretion system to kill and scavenge nutrients from nearby competitors.
Learn more in a new #SciencePerspective: scim.ag/44y3iC6
Learn more in a new #SciencePerspective: scim.ag/44y3iC6
June 28, 2025 at 2:07 PM
Bacteria leverage a secretion system to kill and scavenge nutrients from nearby competitors.
Learn more in a new #SciencePerspective: scim.ag/44y3iC6
Learn more in a new #SciencePerspective: scim.ag/44y3iC6
Reposted by Anabel Chang
Nature research paper: Targeting de novo purine biosynthesis for tuberculosis treatment
https://go.nature.com/3SYNS3i
https://go.nature.com/3SYNS3i
Targeting de novo purine biosynthesis for tuberculosis treatment - Nature
The validation of inhibitors targeting PurF, a novel drug target for tuberculosis drug discovery, is described.
go.nature.com
June 24, 2025 at 12:40 PM
Nature research paper: Targeting de novo purine biosynthesis for tuberculosis treatment
https://go.nature.com/3SYNS3i
https://go.nature.com/3SYNS3i