Amanda M. Buch, Ph.D.
@amandambuch.bsky.social
Neuroscientist, AI/ML Engineer & Classical Visual Artist | Comp. Psychiatry & Neurodev. 🧠✨🎨
SFARI Fellows-to-Faculty | Burroughs Wellcome Fund | Leading Edge Fellow | NASEM/Ford Fellow
Weill Cornell Medicine & Columbia University
www.amandabuch.com
SFARI Fellows-to-Faculty | Burroughs Wellcome Fund | Leading Edge Fellow | NASEM/Ford Fellow
Weill Cornell Medicine & Columbia University
www.amandabuch.com
Reposted by Amanda M. Buch, Ph.D.
Missed that must-see lecture?
The #SfN25 Virtual Component has you covered with on-demand access to livestreamed sessions.
Plus explore virtual posters and join ongoing discussions.
Don’t let scheduling conflicts limit your learning.
🔗 vist.ly/4f3m3
#neurosky #neuroskyence
The #SfN25 Virtual Component has you covered with on-demand access to livestreamed sessions.
Plus explore virtual posters and join ongoing discussions.
Don’t let scheduling conflicts limit your learning.
🔗 vist.ly/4f3m3
#neurosky #neuroskyence
November 18, 2025 at 10:59 PM
Missed that must-see lecture?
The #SfN25 Virtual Component has you covered with on-demand access to livestreamed sessions.
Plus explore virtual posters and join ongoing discussions.
Don’t let scheduling conflicts limit your learning.
🔗 vist.ly/4f3m3
#neurosky #neuroskyence
The #SfN25 Virtual Component has you covered with on-demand access to livestreamed sessions.
Plus explore virtual posters and join ongoing discussions.
Don’t let scheduling conflicts limit your learning.
🔗 vist.ly/4f3m3
#neurosky #neuroskyence
Reposted by Amanda M. Buch, Ph.D.
👀
Morphogenesis and morphometry of brain folding patterns across species | bioRxiv www.biorxiv.org/content/10.1...
Morphogenesis and morphometry of brain folding patterns across species | bioRxiv www.biorxiv.org/content/10.1...
November 11, 2025 at 1:17 AM
👀
Morphogenesis and morphometry of brain folding patterns across species | bioRxiv www.biorxiv.org/content/10.1...
Morphogenesis and morphometry of brain folding patterns across species | bioRxiv www.biorxiv.org/content/10.1...
Reposted by Amanda M. Buch, Ph.D.
Delighted to see this finally out: rdcu.be/eO9oW
We tested whether brief striatal dopamine release events influence the vigor of skilled movements. Despite popular belief, we did not find any evidence linking rapid dopamine dynamics to motor vigor on a moment-by-moment basis.
We tested whether brief striatal dopamine release events influence the vigor of skilled movements. Despite popular belief, we did not find any evidence linking rapid dopamine dynamics to motor vigor on a moment-by-moment basis.
Subsecond dopamine fluctuations do not specify the vigor of ongoing actions
Nature Neuroscience - Liu and colleagues show that the vigor (that is, speed and amplitude) of dexterous movements is not controlled by ongoing fluctuations in extracellular dopamine within the...
rdcu.be
November 10, 2025 at 3:43 PM
Delighted to see this finally out: rdcu.be/eO9oW
We tested whether brief striatal dopamine release events influence the vigor of skilled movements. Despite popular belief, we did not find any evidence linking rapid dopamine dynamics to motor vigor on a moment-by-moment basis.
We tested whether brief striatal dopamine release events influence the vigor of skilled movements. Despite popular belief, we did not find any evidence linking rapid dopamine dynamics to motor vigor on a moment-by-moment basis.
Reposted by Amanda M. Buch, Ph.D.
Research in primate brains has been essential for the development of brain-computer interfaces and artificial neural networks. New funding and policy changes put future such advances at risk, write Cory Miller, @movshon.bsky.social and Doris Tsao.
#neuroskyence
bit.ly/47MXYLH
#neuroskyence
bit.ly/47MXYLH
Without monkeys, neuroscience has no future
Research in primate brains has been essential for the development of BCIs, ANNs. New funding and policy changes put future such advances at risk.
bit.ly
November 10, 2025 at 2:56 PM
Research in primate brains has been essential for the development of brain-computer interfaces and artificial neural networks. New funding and policy changes put future such advances at risk, write Cory Miller, @movshon.bsky.social and Doris Tsao.
#neuroskyence
bit.ly/47MXYLH
#neuroskyence
bit.ly/47MXYLH
Reposted by Amanda M. Buch, Ph.D.
Connectome datasets alone are generally not sufficient to predict neural activity. However, pairing connectivity information with neural recordings can produce accurate predictions of activity in unrecorded neurons
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Prediction of neural activity in connectome-constrained recurrent networks - Nature Neuroscience
The authors show that connectome datasets alone are generally not sufficient to predict neural activity. However, pairing connectivity information with neural recordings can produce accurate predictio...
www.nature.com
November 10, 2025 at 10:12 PM
Connectome datasets alone are generally not sufficient to predict neural activity. However, pairing connectivity information with neural recordings can produce accurate predictions of activity in unrecorded neurons
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Amanda M. Buch, Ph.D.
Reposted by Amanda M. Buch, Ph.D.
A team involving @uclqsion.bsky.social scientists has, for the first time, directly visualised and quantified the protein clusters believed to trigger Parkinson’s disease.
Parkinson’s breakthrough could unlock treatments for devastating disease
Scientists have developed a groundbreaking new technique to visualise the brain clusters that may trigger Parkinson’s
www.the-independent.com
November 9, 2025 at 11:08 AM
A team involving @uclqsion.bsky.social scientists has, for the first time, directly visualised and quantified the protein clusters believed to trigger Parkinson’s disease.
Reposted by Amanda M. Buch, Ph.D.
I appreciate the work of these authors to show that this problem not only is still here but has grown:
www.nbcnews.com/tech/tech-ne...
But it is also quite frustrating 🧵>>
www.nbcnews.com/tech/tech-ne...
But it is also quite frustrating 🧵>>
AI's capabilities may be exaggerated by flawed tests, according to new study
A study from the Oxford Internet Institute analyzed 445 tests used to evaluate AI models.
www.nbcnews.com
November 9, 2025 at 2:59 PM
I appreciate the work of these authors to show that this problem not only is still here but has grown:
www.nbcnews.com/tech/tech-ne...
But it is also quite frustrating 🧵>>
www.nbcnews.com/tech/tech-ne...
But it is also quite frustrating 🧵>>
Reposted by Amanda M. Buch, Ph.D.
Hidden Markov Models
Speaking of HMMs, really enjoyed this paper on dynamics underlying resting state and other conditions. The idea of a baseline state from which excursions lead to more integrated states is really interesting.
doi.org/10.7554/eLif...
#neuroskyence
Speaking of HMMs, really enjoyed this paper on dynamics underlying resting state and other conditions. The idea of a baseline state from which excursions lead to more integrated states is really interesting.
doi.org/10.7554/eLif...
#neuroskyence
November 9, 2025 at 3:03 PM
Hidden Markov Models
Speaking of HMMs, really enjoyed this paper on dynamics underlying resting state and other conditions. The idea of a baseline state from which excursions lead to more integrated states is really interesting.
doi.org/10.7554/eLif...
#neuroskyence
Speaking of HMMs, really enjoyed this paper on dynamics underlying resting state and other conditions. The idea of a baseline state from which excursions lead to more integrated states is really interesting.
doi.org/10.7554/eLif...
#neuroskyence
Reposted by Amanda M. Buch, Ph.D.
Brain Dynamics and Flexible Behaviors
@lucinauddin.bsky.social presenting at the University of Maryland
@lucinauddin.bsky.social presenting at the University of Maryland
October 31, 2025 at 2:24 PM
Brain Dynamics and Flexible Behaviors
@lucinauddin.bsky.social presenting at the University of Maryland
@lucinauddin.bsky.social presenting at the University of Maryland
Reposted by Amanda M. Buch, Ph.D.
Just out! ✨ Using a novel machine learning approach, we identify a developmental pathway by which the early life gut microbiome may shape mental health at school age via effects on functional brain development. This work can help identify microbial biomarkers of later health issues. 👉 rdcu.be/eNsUK
Childhood gut microbiome is linked to internalizing symptoms at school age via the functional connectome
Nature Communications - Here, the authors find that relative abundances of stress-sensitive gastrointestinal microbes at age 2 years predicts internalizing symptoms in middle childhood through...
rdcu.be
October 31, 2025 at 7:03 PM
Just out! ✨ Using a novel machine learning approach, we identify a developmental pathway by which the early life gut microbiome may shape mental health at school age via effects on functional brain development. This work can help identify microbial biomarkers of later health issues. 👉 rdcu.be/eNsUK
Reposted by Amanda M. Buch, Ph.D.
Thank you @jhuartssciences.bsky.social magazine for featuring this work! This project — the largest ever study of inattentional blindness — was led by Makaela Nartker, in collaboration with Howard Egeth and (senior author) @ianbphillips.bsky.social
We tend to assume that we will see things right in front of us. "But if there is some big object casting light into our eyes, and we wouldn't see it because our attention is elsewhere—that's really fascinating!" says @chazfirestone.bsky.social. hub.jhu.edu/magazine/202...
Seeing the bigger picture
Experts at Johns Hopkins shed new light on inattentional blindness, the tendency among us to miss noticing something obvious when our minds are caught up in other things
hub.jhu.edu
October 30, 2025 at 9:52 PM
Thank you @jhuartssciences.bsky.social magazine for featuring this work! This project — the largest ever study of inattentional blindness — was led by Makaela Nartker, in collaboration with Howard Egeth and (senior author) @ianbphillips.bsky.social
Reposted by Amanda M. Buch, Ph.D.
Reposted by Amanda M. Buch, Ph.D.
🧠✨ Genetic Tools Atlas 3.0 is here!
The GTA now has an additional 750 datasets, including 80+ mouse whole-brain light sheet microscopy images as well as the first macaque datasets.
🔗 https://portal.brain-map.org/genetic-tools/genetic-tools-atlas
#neuroskyence
The GTA now has an additional 750 datasets, including 80+ mouse whole-brain light sheet microscopy images as well as the first macaque datasets.
🔗 https://portal.brain-map.org/genetic-tools/genetic-tools-atlas
#neuroskyence
November 2, 2025 at 3:46 PM
🧠✨ Genetic Tools Atlas 3.0 is here!
The GTA now has an additional 750 datasets, including 80+ mouse whole-brain light sheet microscopy images as well as the first macaque datasets.
🔗 https://portal.brain-map.org/genetic-tools/genetic-tools-atlas
#neuroskyence
The GTA now has an additional 750 datasets, including 80+ mouse whole-brain light sheet microscopy images as well as the first macaque datasets.
🔗 https://portal.brain-map.org/genetic-tools/genetic-tools-atlas
#neuroskyence
Reposted by Amanda M. Buch, Ph.D.
Nature research paper: Mechanism of conductance control and neurosteroid binding in NMDA receptors
go.nature.com/48QfMYq
go.nature.com/48QfMYq
Mechanism of conductance control and neurosteroid binding in NMDA receptors - Nature
Ion-channel conductance levels are controlled by the bending patterns of pore-forming transmembrane helices in the heterotetrameric neuronal channel GluN1a-2B N-methyl-D-aspartate receptor.
go.nature.com
November 2, 2025 at 5:28 PM
Nature research paper: Mechanism of conductance control and neurosteroid binding in NMDA receptors
go.nature.com/48QfMYq
go.nature.com/48QfMYq
Reposted by Amanda M. Buch, Ph.D.
If Your North Star Is Lost, New Techniques Can Point You South
www.nytimes.com
October 22, 2025 at 12:30 PM
Reposted by Amanda M. Buch, Ph.D.
New preprint ↙️
Using 2 independent 7T fMRI datasets (HCP & our PNI dataset 🧲 💅 ), we found that intersubject synchronization 👯 during movies aligns closely with cortical gradients 🌈, especially along the visual-to-transmodal axis
by Meaghan Smith & a terrific team ↙️
doi.org/10.1101/2025...
Using 2 independent 7T fMRI datasets (HCP & our PNI dataset 🧲 💅 ), we found that intersubject synchronization 👯 during movies aligns closely with cortical gradients 🌈, especially along the visual-to-transmodal axis
by Meaghan Smith & a terrific team ↙️
doi.org/10.1101/2025...
October 22, 2025 at 2:43 PM
New preprint ↙️
Using 2 independent 7T fMRI datasets (HCP & our PNI dataset 🧲 💅 ), we found that intersubject synchronization 👯 during movies aligns closely with cortical gradients 🌈, especially along the visual-to-transmodal axis
by Meaghan Smith & a terrific team ↙️
doi.org/10.1101/2025...
Using 2 independent 7T fMRI datasets (HCP & our PNI dataset 🧲 💅 ), we found that intersubject synchronization 👯 during movies aligns closely with cortical gradients 🌈, especially along the visual-to-transmodal axis
by Meaghan Smith & a terrific team ↙️
doi.org/10.1101/2025...
Reposted by Amanda M. Buch, Ph.D.
Great review on The Genetics of Human Handedness: Microtubules and Beyond www.cell.com/trends/genet... - handedness is such an interesting phenotype!
Genetics of human handedness: microtubules and beyond
Handedness (i.e., the preference to use either the left or the right hand for fine
motor tasks) is a widely investigated trait. Handedness heritability is consistently
estimated to be 25%. After decad...
www.cell.com
October 16, 2025 at 6:12 PM
Great review on The Genetics of Human Handedness: Microtubules and Beyond www.cell.com/trends/genet... - handedness is such an interesting phenotype!
Reposted by Amanda M. Buch, Ph.D.
"human deep sleep has a unique way of facilitating CSF dynamics that are distinctive from arousal mechanisms." www.pnas.org/doi/10.1073/...
Human deep sleep facilitates cerebrospinal fluid dynamics linked to spontaneous brain oscillations and neural events | PNAS
How sleep maintains our healthy brain function has remained one of the biggest mysteries
in neuroscience, medical settings, and daily lives. While ...
www.pnas.org
October 19, 2025 at 10:30 AM
"human deep sleep has a unique way of facilitating CSF dynamics that are distinctive from arousal mechanisms." www.pnas.org/doi/10.1073/...
Reposted by Amanda M. Buch, Ph.D.
🧠 Excited to share the full program of our #NeuroAI workshop at the @fieldsinstitute.bsky.social (next Monday & Tuesday)
📍 Toronto + Online: fields.utoronto.ca/activities/2...
🎙️ Talks by VanRullen, @neurograce.bsky.social, Eliasmith, Pitkow, Kanai, Thompson & more.
📍 Toronto + Online: fields.utoronto.ca/activities/2...
🎙️ Talks by VanRullen, @neurograce.bsky.social, Eliasmith, Pitkow, Kanai, Thompson & more.
Mini-Symposium on Cognition and Computation: Bidirectional Insights Between Cognitive Neuroscience and AI
Details forthcoming.
fields.utoronto.ca
October 19, 2025 at 12:07 PM
🧠 Excited to share the full program of our #NeuroAI workshop at the @fieldsinstitute.bsky.social (next Monday & Tuesday)
📍 Toronto + Online: fields.utoronto.ca/activities/2...
🎙️ Talks by VanRullen, @neurograce.bsky.social, Eliasmith, Pitkow, Kanai, Thompson & more.
📍 Toronto + Online: fields.utoronto.ca/activities/2...
🎙️ Talks by VanRullen, @neurograce.bsky.social, Eliasmith, Pitkow, Kanai, Thompson & more.
Reposted by Amanda M. Buch, Ph.D.
It’s not the thought that counts: Allostasis at the core of brain function: Neuron www.cell.com/neuron/fullt...
This looks super cool; by @jtheriault.bsky.social
By the way congrats really!
This looks super cool; by @jtheriault.bsky.social
By the way congrats really!
It’s not the thought that counts: Allostasis at the core of brain function
The authors review evidence that the primary function of the brain, supported by distributed
neural systems, is the predictive regulation of physiology (i.e., allostasis). An
example from Alzheimer’s ...
www.cell.com
October 19, 2025 at 3:59 PM
It’s not the thought that counts: Allostasis at the core of brain function: Neuron www.cell.com/neuron/fullt...
This looks super cool; by @jtheriault.bsky.social
By the way congrats really!
This looks super cool; by @jtheriault.bsky.social
By the way congrats really!
Reposted by Amanda M. Buch, Ph.D.
Review of Dynamic Resting-State Methods in Neuroimaging: Applications to Depression and Rumination
Human Brain Mapping | Neuroimaging Journal | Wiley Online Library onlinelibrary.wiley.com/doi/full/10....
Human Brain Mapping | Neuroimaging Journal | Wiley Online Library onlinelibrary.wiley.com/doi/full/10....
Review of Dynamic Resting‐State Methods in Neuroimaging: Applications to Depression and Rumination
This timely review delves into dynamic functional connectivity approaches that could deepen our understanding of maladaptive neurocognitive processes underlying depression. Dynamic approaches may be ....
onlinelibrary.wiley.com
October 19, 2025 at 8:38 PM
Review of Dynamic Resting-State Methods in Neuroimaging: Applications to Depression and Rumination
Human Brain Mapping | Neuroimaging Journal | Wiley Online Library onlinelibrary.wiley.com/doi/full/10....
Human Brain Mapping | Neuroimaging Journal | Wiley Online Library onlinelibrary.wiley.com/doi/full/10....
Reposted by Amanda M. Buch, Ph.D.
These cells could be a fresh target for treating Alzheimer's disease and memory conditions associated with PTSD
go.nature.com/47uTJFq
go.nature.com/47uTJFq
How emotional memories are engraved on the brain, with surprising helper cells
Nature - Astrocytes have a more active role in stabilizing memories than once thought.
go.nature.com
October 19, 2025 at 10:15 AM
These cells could be a fresh target for treating Alzheimer's disease and memory conditions associated with PTSD
go.nature.com/47uTJFq
go.nature.com/47uTJFq
Reposted by Amanda M. Buch, Ph.D.
The number of infections for this time of year is unusual and could seed outbreaks in countries that are heading into winter
go.nature.com/4n8V616
go.nature.com/4n8V616
Japan declares a flu epidemic — what this means for other nations
Nature - Researchers say that the number of infections for this time of year is unusual.
go.nature.com
October 19, 2025 at 12:40 PM
The number of infections for this time of year is unusual and could seed outbreaks in countries that are heading into winter
go.nature.com/4n8V616
go.nature.com/4n8V616
Reposted by Amanda M. Buch, Ph.D.
For me, relating my drawings to scientific theories of drawing happens after drawing, not during ("what did I do?"), but it has really enriched my drawing practice and also inspired nearly all of my published research in the past 5 years.
psyarxiv.com/pq8nb
psyarxiv.com/pq8nb
October 15, 2025 at 2:17 PM
For me, relating my drawings to scientific theories of drawing happens after drawing, not during ("what did I do?"), but it has really enriched my drawing practice and also inspired nearly all of my published research in the past 5 years.
psyarxiv.com/pq8nb
psyarxiv.com/pq8nb