Prof Amanda J Farrin
@amandafarrin.bsky.social
Director of Edinburgh Clinical Trials Unit | NIHR Senior Investigator | innovative trials methods | robust development & evaluation of complex interventions | data science for trials
Reposted by Prof Amanda J Farrin
I'm doing a webinar in two weeks (15 Oct 1-2pm BST), part of NIHR Research Support Service's Methods Academy series, on the age-old question: should I do a stepped wedge trial?
Free registration, details here: tinyurl.com/z6cjvce3
@nihr-rss.bsky.social @wiphcem.bsky.social @qmul-wiph.bsky.social
Free registration, details here: tinyurl.com/z6cjvce3
@nihr-rss.bsky.social @wiphcem.bsky.social @qmul-wiph.bsky.social
October 1, 2025 at 8:32 AM
I'm doing a webinar in two weeks (15 Oct 1-2pm BST), part of NIHR Research Support Service's Methods Academy series, on the age-old question: should I do a stepped wedge trial?
Free registration, details here: tinyurl.com/z6cjvce3
@nihr-rss.bsky.social @wiphcem.bsky.social @qmul-wiph.bsky.social
Free registration, details here: tinyurl.com/z6cjvce3
@nihr-rss.bsky.social @wiphcem.bsky.social @qmul-wiph.bsky.social
Reposted by Prof Amanda J Farrin
Great to have so many engaged people in the room!
More workshops are planned for 2026.
Follow us here and on LinkedIn find out about future training opportunities.
www.linkedin.com/company/ukcrc-registered-ctu-network/
#UKCTUNetwork #HTBAGCI #ClinicalTrials
More workshops are planned for 2026.
Follow us here and on LinkedIn find out about future training opportunities.
www.linkedin.com/company/ukcrc-registered-ctu-network/
#UKCTUNetwork #HTBAGCI #ClinicalTrials
October 10, 2025 at 9:56 AM
Great to have so many engaged people in the room!
More workshops are planned for 2026.
Follow us here and on LinkedIn find out about future training opportunities.
www.linkedin.com/company/ukcrc-registered-ctu-network/
#UKCTUNetwork #HTBAGCI #ClinicalTrials
More workshops are planned for 2026.
Follow us here and on LinkedIn find out about future training opportunities.
www.linkedin.com/company/ukcrc-registered-ctu-network/
#UKCTUNetwork #HTBAGCI #ClinicalTrials
Reposted by Prof Amanda J Farrin
Fern Harvey’s fab poster presentation of her systematic review on process evaluations for complex intervention trials. Better reporting of context, mechanisms of action and fidelity would enable greater learning about successful interventions #ImpSci #EIE2025 @au-primarycareuol.bsky.social
June 6, 2025 at 4:37 PM
Fern Harvey’s fab poster presentation of her systematic review on process evaluations for complex intervention trials. Better reporting of context, mechanisms of action and fidelity would enable greater learning about successful interventions #ImpSci #EIE2025 @au-primarycareuol.bsky.social
Reposted by Prof Amanda J Farrin
A cluster randomised crossover design incorporates the principles of both cluster trials (where groups of individuals eg wards, schools etc are randomly assigned) and crossover trials where, in this case, the clusters cross over to different treatment/s for set time periods 2/7
June 2, 2025 at 6:38 AM
A cluster randomised crossover design incorporates the principles of both cluster trials (where groups of individuals eg wards, schools etc are randomly assigned) and crossover trials where, in this case, the clusters cross over to different treatment/s for set time periods 2/7
Reposted by Prof Amanda J Farrin
At #CCR25, we saw some trials use a #CompositeOutcome (an endpoint that combines more than one outcome into a single measure) & also saw some of the problems these can throw up. I have discussed these before but thought it would be useful to revisit 1/9
#MethodologyMonday #120
#MethodologyMonday #120
June 16, 2025 at 5:56 AM
At #CCR25, we saw some trials use a #CompositeOutcome (an endpoint that combines more than one outcome into a single measure) & also saw some of the problems these can throw up. I have discussed these before but thought it would be useful to revisit 1/9
#MethodologyMonday #120
#MethodologyMonday #120
Reposted by Prof Amanda J Farrin
🚀 Exciting News! 🚀
Interested in or leading a clinical trial?
Want to be the best Chief Investigator you can be?
This updated course is for you!
tinyurl.com/HTBAGCI
#ClinicalTrials #CITraining
@leedsctru.bsky.social @amandafarrin.bsky.social
Interested in or leading a clinical trial?
Want to be the best Chief Investigator you can be?
This updated course is for you!
tinyurl.com/HTBAGCI
#ClinicalTrials #CITraining
@leedsctru.bsky.social @amandafarrin.bsky.social
March 20, 2025 at 1:08 PM
🚀 Exciting News! 🚀
Interested in or leading a clinical trial?
Want to be the best Chief Investigator you can be?
This updated course is for you!
tinyurl.com/HTBAGCI
#ClinicalTrials #CITraining
@leedsctru.bsky.social @amandafarrin.bsky.social
Interested in or leading a clinical trial?
Want to be the best Chief Investigator you can be?
This updated course is for you!
tinyurl.com/HTBAGCI
#ClinicalTrials #CITraining
@leedsctru.bsky.social @amandafarrin.bsky.social
Phew: ResearchFish submitted again for another year ✅️
March 12, 2025 at 10:47 AM
Phew: ResearchFish submitted again for another year ✅️
Reposted by Prof Amanda J Farrin
A common issue in trials is how to accommodate multiple important outcomes. Approaches include composite outcomes or using the win ratio method (I have posted on these before). A newer method is the #DOOR (Desirability of Outcome Ranking) approach 1/7
#MethodologyMonday #113
#MethodologyMonday #113
March 10, 2025 at 7:27 AM
A common issue in trials is how to accommodate multiple important outcomes. Approaches include composite outcomes or using the win ratio method (I have posted on these before). A newer method is the #DOOR (Desirability of Outcome Ranking) approach 1/7
#MethodologyMonday #113
#MethodologyMonday #113
📢 Delighted our CHART trial is now OPEN to recruitment
Massive effort from our @complexleedsctru.bsky.social trial team, @drandyclegg.bsky.social @vickigphysio.bsky.social & many others to get this complex study ready to go 🎉
🙏 @nihr.bsky.social for funding
Massive effort from our @complexleedsctru.bsky.social trial team, @drandyclegg.bsky.social @vickigphysio.bsky.social & many others to get this complex study ready to go 🎉
🙏 @nihr.bsky.social for funding
PenARC & @arc-yharc.bsky.social researchers are working in partnership with older people with #heartfailure and #frailty to increase their independence.
> Learn more: tinyurl.com/4xt8f7en
@nihrarcs.bsky.social @exeter.ac.uk @universityofleeds.bsky.social @livunipress.bsky.social @nihr.bsky.social
> Learn more: tinyurl.com/4xt8f7en
@nihrarcs.bsky.social @exeter.ac.uk @universityofleeds.bsky.social @livunipress.bsky.social @nihr.bsky.social
February 13, 2025 at 12:55 PM
📢 Delighted our CHART trial is now OPEN to recruitment
Massive effort from our @complexleedsctru.bsky.social trial team, @drandyclegg.bsky.social @vickigphysio.bsky.social & many others to get this complex study ready to go 🎉
🙏 @nihr.bsky.social for funding
Massive effort from our @complexleedsctru.bsky.social trial team, @drandyclegg.bsky.social @vickigphysio.bsky.social & many others to get this complex study ready to go 🎉
🙏 @nihr.bsky.social for funding
Reposted by Prof Amanda J Farrin
Currently low response rates from CTU Directors (n=5), Programmers/Data Managers (n=0), & QA Managers (n=3) working in clinical trials. We need to know what these groups think the challenges are for greener trials.
forms.office.com/e/fkeLD8HbMA
Please complete &RT
@ukctunetwork.bsky.social
forms.office.com/e/fkeLD8HbMA
Please complete &RT
@ukctunetwork.bsky.social
February 12, 2025 at 8:59 AM
Currently low response rates from CTU Directors (n=5), Programmers/Data Managers (n=0), & QA Managers (n=3) working in clinical trials. We need to know what these groups think the challenges are for greener trials.
forms.office.com/e/fkeLD8HbMA
Please complete &RT
@ukctunetwork.bsky.social
forms.office.com/e/fkeLD8HbMA
Please complete &RT
@ukctunetwork.bsky.social
Reposted by Prof Amanda J Farrin
Consider what to report about your rehabilitation intervention? Here's a newly published TIDieR Rehab checklist
bmjopen.bmj.com/content/14/1...
bmjopen.bmj.com/content/14/1...
Enhancing the reporting quality of rehabilitation interventions through an extension of the Template for Intervention Description and Replication (TIDieR): the TIDieR-Rehab checklist and supplementary...
Background Rehabilitation is a complex biopsychosocial process in which multidisciplinary professionals work in collaboration with a person and their family, with the shared objective of enhancing the...
bmjopen.bmj.com
January 31, 2025 at 1:06 PM
Consider what to report about your rehabilitation intervention? Here's a newly published TIDieR Rehab checklist
bmjopen.bmj.com/content/14/1...
bmjopen.bmj.com/content/14/1...
Follow @freshstart-uk.bsky.social for all updates from our @leedsctru.bsky.social @nihr.bsky.social programme grant. We've just moved over to this platform 🙂
FReSH START is a research project aiming to develop a therapy intervention for adults who self-harm. We are now running a clinical trial to see if the therapy we developed is effective and if it improves people's quality of life. #introduction #mentalhealthresearch #selfharm #NIHR
February 3, 2025 at 4:49 PM
Follow @freshstart-uk.bsky.social for all updates from our @leedsctru.bsky.social @nihr.bsky.social programme grant. We've just moved over to this platform 🙂
Reposted by Prof Amanda J Farrin
Another link to survey as initial link problematic for some - forms.office.com/e/fkeLD8HbMA
Microsoft Forms
forms.office.com
January 21, 2025 at 10:58 AM
Another link to survey as initial link problematic for some - forms.office.com/e/fkeLD8HbMA
Reposted by Prof Amanda J Farrin
Do you work on clinical trials?
We need your help to understand the challenges to designing & delivering greener trials. Only 30 responses so far but we can all have a say on this topic. Please take 10 minutes to tell us what you think tinyurl.com/GreenTrials
Please share across your networks
We need your help to understand the challenges to designing & delivering greener trials. Only 30 responses so far but we can all have a say on this topic. Please take 10 minutes to tell us what you think tinyurl.com/GreenTrials
Please share across your networks
Microsoft Forms
tinyurl.com
January 21, 2025 at 8:40 AM
Do you work on clinical trials?
We need your help to understand the challenges to designing & delivering greener trials. Only 30 responses so far but we can all have a say on this topic. Please take 10 minutes to tell us what you think tinyurl.com/GreenTrials
Please share across your networks
We need your help to understand the challenges to designing & delivering greener trials. Only 30 responses so far but we can all have a say on this topic. Please take 10 minutes to tell us what you think tinyurl.com/GreenTrials
Please share across your networks
Reposted by Prof Amanda J Farrin
Interesting historical principles of clinical trial conduct … Rule 5 “the medical statistician has to be competent” … sure hope we’ve got that one sorted!
#OTD 28 Jan 1809 Louis-Dominique-Jules Gavarret b (d 30 Aug 1890) An early proponent of the 'statistical method' in medicine, his 1840 book 'Principes de Statistique Médicale' was among the first to describe statistical principles for rigorous clinical trial conduct. /10 🧵
January 28, 2025 at 12:26 PM
Interesting historical principles of clinical trial conduct … Rule 5 “the medical statistician has to be competent” … sure hope we’ve got that one sorted!
Reposted by Prof Amanda J Farrin
An issue that often comes up is how to set a “non-inferiority margin” in a non-inferiority trial and how to ensure it is appropriate 1/8
#MethodologyMonday #109
#MethodologyMonday #109
January 27, 2025 at 7:32 AM
An issue that often comes up is how to set a “non-inferiority margin” in a non-inferiority trial and how to ensure it is appropriate 1/8
#MethodologyMonday #109
#MethodologyMonday #109
Welcome to bluesky @complexleedsctru.bsky.social 🎉
Please do follow our Complex Interventions Division account for our news of our training opportunities, trial progress and results, as well as signposting to relevant resources for Complex Intervention trialists 👇
Please do follow our Complex Interventions Division account for our news of our training opportunities, trial progress and results, as well as signposting to relevant resources for Complex Intervention trialists 👇
There's only 2 days left to sign up for our Masterclass in the Design and Conduct of Complex Intervention Evaluations!
Limited spaces are left! Register here - t.co/V6Q7p51feu
Limited spaces are left! Register here - t.co/V6Q7p51feu
We're running our annual online Masterclass in Complex Interventions Evaluations over 3 days in January and February.
Come and learn from our expert team of complex interventions trialists at @leedsctru.bsky.social
Register now to reserve your place. Deadline 24 Jan.
Link below 👇
Come and learn from our expert team of complex interventions trialists at @leedsctru.bsky.social
Register now to reserve your place. Deadline 24 Jan.
Link below 👇
January 22, 2025 at 2:45 PM
Welcome to bluesky @complexleedsctru.bsky.social 🎉
Please do follow our Complex Interventions Division account for our news of our training opportunities, trial progress and results, as well as signposting to relevant resources for Complex Intervention trialists 👇
Please do follow our Complex Interventions Division account for our news of our training opportunities, trial progress and results, as well as signposting to relevant resources for Complex Intervention trialists 👇
Reposted by Prof Amanda J Farrin
We've frustratingly allowed "real world" to become a deceptive synonym for "observations we happened haphazardly to make". I'd say half the studies that come to me now, the majority of which are useful but modest clinical audits, will have "real world" in the proposal title. It's magic!
January 14, 2025 at 5:40 AM
We've frustratingly allowed "real world" to become a deceptive synonym for "observations we happened haphazardly to make". I'd say half the studies that come to me now, the majority of which are useful but modest clinical audits, will have "real world" in the proposal title. It's magic!
Reposted by Prof Amanda J Farrin
I am not that surprised that more women quit academic publishing than men- this chimes with data showing fewer women get their papers published, grants funded if they lead them and that more women get pushed into support roles. We do need to do more to support and mentor female staff. 🧪
Who’s quitting academia? Data reveal gender gaps in surprising fields
Even in scientific areas in which women are well represented, they are up to 40% more likely than men to leave research within 20 years.
www.nature.com
January 12, 2025 at 5:02 PM
I am not that surprised that more women quit academic publishing than men- this chimes with data showing fewer women get their papers published, grants funded if they lead them and that more women get pushed into support roles. We do need to do more to support and mentor female staff. 🧪
January 11, 2025 at 5:50 PM
Reposted by Prof Amanda J Farrin
Want to know how to report a cluster-crossover trial … the CONSORT extension reporting guidance is out 😊
www.bmj.com/content/388/...
www.bmj.com/content/388/...
Reporting of cluster randomised crossover trials: extension of the CONSORT 2010 statement with explanation and elaboration
This article presents the CONSORT (consolidated standards of reporting trials) extension for cluster randomised crossover trials. A cluster randomised crossover trial involves randomisation of groups ...
www.bmj.com
January 8, 2025 at 11:47 AM
Want to know how to report a cluster-crossover trial … the CONSORT extension reporting guidance is out 😊
www.bmj.com/content/388/...
www.bmj.com/content/388/...
We're running our annual online Masterclass in Complex Interventions Evaluations over 3 days in January and February.
Come and learn from our expert team of complex interventions trialists at @leedsctru.bsky.social
Register now to reserve your place. Deadline 24 Jan.
Link below 👇
Come and learn from our expert team of complex interventions trialists at @leedsctru.bsky.social
Register now to reserve your place. Deadline 24 Jan.
Link below 👇
January 9, 2025 at 10:17 AM
We're running our annual online Masterclass in Complex Interventions Evaluations over 3 days in January and February.
Come and learn from our expert team of complex interventions trialists at @leedsctru.bsky.social
Register now to reserve your place. Deadline 24 Jan.
Link below 👇
Come and learn from our expert team of complex interventions trialists at @leedsctru.bsky.social
Register now to reserve your place. Deadline 24 Jan.
Link below 👇
Just a wee bit of snow in Yorkshire 🥶❄️
January 5, 2025 at 3:00 PM
Just a wee bit of snow in Yorkshire 🥶❄️
Reposted by Prof Amanda J Farrin
🤢 horrifying piece of work, which we’ll see idiots quoting.
For goodness sake @jclinepi.bsky.social
For goodness sake @jclinepi.bsky.social
Treatment Effects in Pharmacological Clinical Randomized Controlled Trials are Mainly Due to Placebo - @jclinepi.bsky.social www.jclinepi.com/article/S089...
Treatment Effects in Pharmacological Clinical Randomized Controlled Trials are Mainly Due to Placebo
The placebo response in clinical trials has four components: regression to the mean (RTM), measurement artefacts, natural tendency (NT) of the disease, and the genuine placebo effect. Our objective is to determine what contributes to the size of the placebo-effect in clinical trials by meta-regressions of randomized placebo-controlled clinical trials.
www.jclinepi.com
January 3, 2025 at 1:39 PM
🤢 horrifying piece of work, which we’ll see idiots quoting.
For goodness sake @jclinepi.bsky.social
For goodness sake @jclinepi.bsky.social
Happy New Year!
May your 2025 be healthy, prosperous, and full of interesting research questions to explore!
May your 2025 be healthy, prosperous, and full of interesting research questions to explore!
January 2, 2025 at 1:04 PM
Happy New Year!
May your 2025 be healthy, prosperous, and full of interesting research questions to explore!
May your 2025 be healthy, prosperous, and full of interesting research questions to explore!