Alex Shcheglovitov 🇺🇦
@alexshch.bsky.social
Associate Professor of Neurobiology at the University of Utah studying brain development and disorders using human brain organoids
Pinned
Generating and characterizing human telencephalic brain organoids from stem cell-derived single neural rosettes - Nature Protocols
Generating and characterizing human telencephalic brain organoids from stem cell-derived single neural rosettes for studying the specification and organization of different neural cells, as well as mo...
doi.org
Our lab generates brain 🧠 organoids from isolated single neural rosettes - and now it's all in a new Nature Protocols paper 📄 !
Step-by-step details to try it yourself👇
doi.org/10.1038/s415... #Organoids #Neuroscience #StemCells
Step-by-step details to try it yourself👇
doi.org/10.1038/s415... #Organoids #Neuroscience #StemCells
Our lab generates brain 🧠 organoids from isolated single neural rosettes - and now it's all in a new Nature Protocols paper 📄 !
Step-by-step details to try it yourself👇
doi.org/10.1038/s415... #Organoids #Neuroscience #StemCells
Step-by-step details to try it yourself👇
doi.org/10.1038/s415... #Organoids #Neuroscience #StemCells
Generating and characterizing human telencephalic brain organoids from stem cell-derived single neural rosettes - Nature Protocols
Generating and characterizing human telencephalic brain organoids from stem cell-derived single neural rosettes for studying the specification and organization of different neural cells, as well as mo...
doi.org
June 28, 2025 at 3:32 PM
Our lab generates brain 🧠 organoids from isolated single neural rosettes - and now it's all in a new Nature Protocols paper 📄 !
Step-by-step details to try it yourself👇
doi.org/10.1038/s415... #Organoids #Neuroscience #StemCells
Step-by-step details to try it yourself👇
doi.org/10.1038/s415... #Organoids #Neuroscience #StemCells
Enjoying tremendously all aspects of Neurogenomics GRC in Ventura CA!!
April 9, 2025 at 5:40 AM
Enjoying tremendously all aspects of Neurogenomics GRC in Ventura CA!!
Reposted by Alex Shcheglovitov 🇺🇦
A funding setback led Rafael Yuste to the Hydra, and a new way to study neural networks.
By @shaena.bsky.social, Brady Huggett
#neuroskyence
www.thetransmitter.org/neural-netwo...
By @shaena.bsky.social, Brady Huggett
#neuroskyence
www.thetransmitter.org/neural-netwo...
Releasing the Hydra with Rafael Yuste
Losing HHMI Investigator status caused Yuste to study neural networks in a new way.
www.thetransmitter.org
April 4, 2025 at 1:57 PM
A funding setback led Rafael Yuste to the Hydra, and a new way to study neural networks.
By @shaena.bsky.social, Brady Huggett
#neuroskyence
www.thetransmitter.org/neural-netwo...
By @shaena.bsky.social, Brady Huggett
#neuroskyence
www.thetransmitter.org/neural-netwo...
Reposted by Alex Shcheglovitov 🇺🇦
Our NIH funded work @utah.edu @uuhsresearch.bsky.social is revealing new mechanisms of complex neurological disorders. Modern medicine wouldn't be where it is today without the NIH and the discoveries made by scientists at universities. utah-health.shorthandstories.com/ptf-unveilin...
Pioneering the Future: Unveiling Tomorrow's Medicine
For many difficult health problems, efforts to improve the lives of patients begin in the lab, where researchers can explore the most intricate origins of disease. University of Utah Health scientists...
utah-health.shorthandstories.com
March 21, 2025 at 7:31 PM
Our NIH funded work @utah.edu @uuhsresearch.bsky.social is revealing new mechanisms of complex neurological disorders. Modern medicine wouldn't be where it is today without the NIH and the discoveries made by scientists at universities. utah-health.shorthandstories.com/ptf-unveilin...
Reposted by Alex Shcheglovitov 🇺🇦
Rebecca Calisi Rodríguez writes in Nature that higher-education establishments in the US must not be bullied into abandoning their mission of diversity, equity and inclusion. “Higher education must not back down. But to win this fight, universities need a plan.” #Academicsky 🧪
‘Silence is complicity’ — universities must fight the anti-DEI crackdown
Higher-education establishments must not be bullied into abandoning their mission of diversity, equity and inclusion.
go.nature.com
March 7, 2025 at 2:21 PM
Rebecca Calisi Rodríguez writes in Nature that higher-education establishments in the US must not be bullied into abandoning their mission of diversity, equity and inclusion. “Higher education must not back down. But to win this fight, universities need a plan.” #Academicsky 🧪
Reposted by Alex Shcheglovitov 🇺🇦
🧪 Stand Up for Science. Science is for everyone. 🫶
Join us as we #marchforscience — for truth, discovery, and a future where research is valued and people matter. Science uplifts everyone, empowers communities, and drives real change. Stand up, Utah!
📍 Utah State Capitol
📅 March 7th 2025 at noon
Join us as we #marchforscience — for truth, discovery, and a future where research is valued and people matter. Science uplifts everyone, empowers communities, and drives real change. Stand up, Utah!
📍 Utah State Capitol
📅 March 7th 2025 at noon
March 1, 2025 at 12:36 AM
🧪 Stand Up for Science. Science is for everyone. 🫶
Join us as we #marchforscience — for truth, discovery, and a future where research is valued and people matter. Science uplifts everyone, empowers communities, and drives real change. Stand up, Utah!
📍 Utah State Capitol
📅 March 7th 2025 at noon
Join us as we #marchforscience — for truth, discovery, and a future where research is valued and people matter. Science uplifts everyone, empowers communities, and drives real change. Stand up, Utah!
📍 Utah State Capitol
📅 March 7th 2025 at noon
Reposted by Alex Shcheglovitov 🇺🇦
If you are interested in disease modelling using state of the art stem cell based approaches, consider joining us during the summer school. fellowships are available!
Deadline for FENS/IBRO-PERC stipends for our summer course extended to March 05, 2025‼️
EU students (outside Netherlands) can apply here for free course admission and 750 EUR travel funding 👉 loom.ly/yJqQ0rY
For regular registration 👉https://lnkd.in/gQ_zXCWH
EU students (outside Netherlands) can apply here for free course admission and 750 EUR travel funding 👉 loom.ly/yJqQ0rY
For regular registration 👉https://lnkd.in/gQ_zXCWH
February 27, 2025 at 11:16 PM
If you are interested in disease modelling using state of the art stem cell based approaches, consider joining us during the summer school. fellowships are available!
“Given the intensity with which modern neurophysiologists are prowling around the brain with multi-contact electrophysiology probes and wide-field optical imaging, I doubt that there are new, fundamental discoveries to be made with qualitative assessments of neural activity. But who knows?” 🤔
In the latest “This paper changed my life,” Bill Newsome shares how Goldberg and Wurtz’s classic papers from the 1970s showed him that ambitious mechanistic studies of higher brain functions were feasible.
www.thetransmitter.org/this-paper-c...
www.thetransmitter.org/this-paper-c...
This paper changed my Life: Bill Newsome reflects on a quadrilogy of classic visual perception studies
The 1970s papers from Goldberg and Wurtz made ambitious mechanistic studies of higher brain functions seem feasible.
www.thetransmitter.org
February 22, 2025 at 4:50 PM
“Given the intensity with which modern neurophysiologists are prowling around the brain with multi-contact electrophysiology probes and wide-field optical imaging, I doubt that there are new, fundamental discoveries to be made with qualitative assessments of neural activity. But who knows?” 🤔
Reposted by Alex Shcheglovitov 🇺🇦
"Scores of grant review panels were canceled this week, creating a gap in funding from the National Institutes of Health...the delays have deepened what scientists are calling a crisis in American biomedical research.." www.nytimes.com/2025/02/21/s...
Trump Administration Stalls Scientific Research Despite Court Ruling (Gift Article)
Using an arcane law, officials have effectively delayed funding from the National Institutes of Health, leaving medical studies in jeopardy.
www.nytimes.com
February 22, 2025 at 12:25 AM
"Scores of grant review panels were canceled this week, creating a gap in funding from the National Institutes of Health...the delays have deepened what scientists are calling a crisis in American biomedical research.." www.nytimes.com/2025/02/21/s...
Reposted by Alex Shcheglovitov 🇺🇦
Our latest paper, led by Emmy Li, is out on Neuron today:
CRISPRi-based screens in iAssembloids to elucidate neuron-glia interactions
www.cell.com/neuron/fullt...
CRISPRi-based screens in iAssembloids to elucidate neuron-glia interactions
www.cell.com/neuron/fullt...
CRISPRi-based screens in iAssembloids to elucidate neuron-glia interactions
Using a 3D co-culture system of iPSC-derived neurons and glia, termed iAssembloids,
combined with CRISPRi-based screening, Li et al. investigate the effect of glial cells
on neuronal activity and surv...
www.cell.com
January 14, 2025 at 6:27 PM
Our latest paper, led by Emmy Li, is out on Neuron today:
CRISPRi-based screens in iAssembloids to elucidate neuron-glia interactions
www.cell.com/neuron/fullt...
CRISPRi-based screens in iAssembloids to elucidate neuron-glia interactions
www.cell.com/neuron/fullt...
Happy holidays from Snow Lake City!
December 27, 2024 at 12:27 AM
Happy holidays from Snow Lake City!
Reposted by Alex Shcheglovitov 🇺🇦
As part of The Transmitter’s first annual book, we asked some of our contributing editors what they think the field should focus on in the years to come. @nicolecrust.bsky.social, Anthony Zador, Joshua Sanes, @russpoldrack.bsky.social and Sheena Josselyn provided their responses.
bit.ly/4iObXp0
bit.ly/4iObXp0
Future watch: What should neuroscience prioritize during the next 10 to 20 years?
For The Transmitter’s first annual book, five contributing editors reflect on what subfields demand greater focus in the near future—from dynamical systems and computation to technologies for studying...
bit.ly
December 23, 2024 at 2:27 PM
As part of The Transmitter’s first annual book, we asked some of our contributing editors what they think the field should focus on in the years to come. @nicolecrust.bsky.social, Anthony Zador, Joshua Sanes, @russpoldrack.bsky.social and Sheena Josselyn provided their responses.
bit.ly/4iObXp0
bit.ly/4iObXp0
Reposted by Alex Shcheglovitov 🇺🇦
Amazing new work from the lab of @aliceyting.bsky.social @stanfordmedicine.bsky.social @stanfordbiosci.bsky.social, engineered GPCRs for ligand-activated cell responses
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Synthetic GPCRs for programmable sensing and control of cell behaviour - Nature
Modular synthetic G-protein-coupled receptors with nanobody-based ligand-recognition domains can be designed and used to programme transgene expression, real-time fluorescence or endogenous G-protein ...
www.nature.com
December 5, 2024 at 2:02 PM
Amazing new work from the lab of @aliceyting.bsky.social @stanfordmedicine.bsky.social @stanfordbiosci.bsky.social, engineered GPCRs for ligand-activated cell responses
www.nature.com/articles/s41...
www.nature.com/articles/s41...
so interesting!
After 60 years, scientists finally know why ginger, calico, and tortoiseshell #cats look the way they do. scim.ag/3BpxRxY
Gene behind orange fur in cats found at last
After 60 years, scientists know why gingers, calicos, and tortoiseshells look the way they do
scim.ag
December 5, 2024 at 3:47 PM
so interesting!
I recall an interview with Rusty Gage in Nat Neuroscience, where he mentioned that ChatGPT could help students choose research problems to study. Looks like this is shaping up now - BrainGPT to predict neuroscience findings! Fascinating… 🤔 www.nature.com/articles/s41...
Large language models surpass human experts in predicting neuroscience results - Nature Human Behaviour
Large language models (LLMs) can synthesize vast amounts of information. Luo et al. show that LLMs—especially BrainGPT, an LLM the authors tuned on the neuroscience literature—outperform experts in pr...
www.nature.com
November 28, 2024 at 1:58 AM
I recall an interview with Rusty Gage in Nat Neuroscience, where he mentioned that ChatGPT could help students choose research problems to study. Looks like this is shaping up now - BrainGPT to predict neuroscience findings! Fascinating… 🤔 www.nature.com/articles/s41...
Reposted by Alex Shcheglovitov 🇺🇦
We are hiring mid-to-senior-level faculty to expand brain health and trauma research at #UTSA
Individuals at the Associate/Full Professor level are encouraged to apply by December 1st
Please share this opportunity with others or reach out if you would like to learn more
Apply here: bit.ly/3zUK2lI
Individuals at the Associate/Full Professor level are encouraged to apply by December 1st
Please share this opportunity with others or reach out if you would like to learn more
Apply here: bit.ly/3zUK2lI
November 24, 2024 at 11:13 PM
We are hiring mid-to-senior-level faculty to expand brain health and trauma research at #UTSA
Individuals at the Associate/Full Professor level are encouraged to apply by December 1st
Please share this opportunity with others or reach out if you would like to learn more
Apply here: bit.ly/3zUK2lI
Individuals at the Associate/Full Professor level are encouraged to apply by December 1st
Please share this opportunity with others or reach out if you would like to learn more
Apply here: bit.ly/3zUK2lI
Great to know these online tools are available for making cartoons!
bioart.niaid.nih.gov
bioicons.com
scidraw.io
bioart.niaid.nih.gov
bioicons.com
scidraw.io
November 24, 2024 at 10:46 PM
Great to know these online tools are available for making cartoons!
bioart.niaid.nih.gov
bioicons.com
scidraw.io
bioart.niaid.nih.gov
bioicons.com
scidraw.io
Reposted by Alex Shcheglovitov 🇺🇦
How to write a grant?
1. The application is for the reviewer, not you, the applicant.
2. Communicate in stories.
3. Make your story cohesive—leave no puzzling gaps.
4. Make your story resonate to keep the reviewer reading.
5. Accept chance and noise in peer-review.
www.pnas.org/doi/epub/10....
November 24, 2024 at 3:38 PM
How to write a grant?
1. The application is for the reviewer, not you, the applicant.
2. Communicate in stories.
3. Make your story cohesive—leave no puzzling gaps.
4. Make your story resonate to keep the reviewer reading.
5. Accept chance and noise in peer-review.
www.pnas.org/doi/epub/10....
Reposted by Alex Shcheglovitov 🇺🇦
Still thinking about which neuroscience conferences to attend next year?
Explore our events page, featuring a curated list of top neuroscience meetings with topic-based filters. Plus, check out upcoming webinars compiled by @worldwideneuro.bsky.social.
thetransmitter.org/events
Explore our events page, featuring a curated list of top neuroscience meetings with topic-based filters. Plus, check out upcoming webinars compiled by @worldwideneuro.bsky.social.
thetransmitter.org/events
November 20, 2024 at 4:23 PM
Still thinking about which neuroscience conferences to attend next year?
Explore our events page, featuring a curated list of top neuroscience meetings with topic-based filters. Plus, check out upcoming webinars compiled by @worldwideneuro.bsky.social.
thetransmitter.org/events
Explore our events page, featuring a curated list of top neuroscience meetings with topic-based filters. Plus, check out upcoming webinars compiled by @worldwideneuro.bsky.social.
thetransmitter.org/events
Reposted by Alex Shcheglovitov 🇺🇦
Too often we spend only two weeks choosing a problem and then many years trying solving it, but this limits our potential impact.
A must read for PhD students: Problem choice and decision trees in science and engineering.
pubmed.ncbi.nlm.nih.gov/38608651/
A must read for PhD students: Problem choice and decision trees in science and engineering.
pubmed.ncbi.nlm.nih.gov/38608651/
November 17, 2024 at 5:35 PM
Too often we spend only two weeks choosing a problem and then many years trying solving it, but this limits our potential impact.
A must read for PhD students: Problem choice and decision trees in science and engineering.
pubmed.ncbi.nlm.nih.gov/38608651/
A must read for PhD students: Problem choice and decision trees in science and engineering.
pubmed.ncbi.nlm.nih.gov/38608651/
November 17, 2024 at 5:03 PM
Fun read putting forth interesting ideas regarding intersection of cell biology and AI: www.cell.com/cell/fulltex...
The cellular dogma
In this essay, I will put forth what I see as a major conceptual challenge for biology
in the next decade, one that is inspired by Crick’s Central Dogma: understanding information
flow in the cell in ...
www.cell.com
November 17, 2024 at 5:21 AM
Fun read putting forth interesting ideas regarding intersection of cell biology and AI: www.cell.com/cell/fulltex...