New paper out: "Apico-basal intercalations enable the integrity of curved epithelia"

(aka Scutoids rock 😎)

@i2sysbio.bsky.social
@lmescu.bsky.social
@epimechfc.bsky.social

www.csbj.org/article/S200...

Can you spot the difference? 🔬
SiR-actin labeling can be cytotoxic and affects actin dynamics - while the new XActin probes do not! Developed by @veselin-nasufovic.bsky.social and perfect for time-resolved and STED imaging without the need for genetic manipulation.
www.biorxiv.org/content/10.1...

Finally had a bit of time to play with multi-GPU deconvolution. Using @truenorth-ia.bsky.social and @haesleinhuepf.bsky.social previous work.

Here it is in action in #BigDataViewer using async and lazy processing. Look at the two poor laptop GPUs going as fast as they can:

I am super excited to share our article addressing a longstanding question in neurobiology: how Ca²⁺ signaling cascades initiated at dendritic spines operate at a distance. Check it out here: authors.elsevier.com/sd/article/S... @cp-cell.bsky.social.

Look at this fold,
what mysteries does it hold?

What is this cellular ravine,
Is it perhaps something you’ve already seen?

🧪#ACloserLook 🔎

(🏆= honourable mention for the right answer + importantly, for the best wrong one!)

Could stochasticity play a role in ensuring robustness during development?

Read this 'Behind the paper' story from Bernat Corominas-Murtra about his work with Dimitri Fabreges, @virginieuhlmann.bsky.social, @ehannezo.bsky.social, Takashi Hiiragi @hubrechtinstitute.bsky.social & co:

#DevBio

An actin bracket-induced elastoplastic transition determines epithelial folding irreversibility

doi.org/10.1038/s414...

Excited to share our latest work published in Nature Communications!

We reported an elastoplastic property of epithelia that determines the irreversibility of folding and is regulated in a mechanosensitive manner.
#Mechanobiology #Biophysics #Developmentalbiology

www.nature.com/articles/s41...

Ever wonder how cells in our epithelia fight for space? 🤔

Let's dive into the fascinating world of mechanical cell competition! #EpithelialMechanics

Hello, I am @akshar21.bsky.social and I'll be your guide through this thread on mechanical #CellCompetition

Today we report in 𝘾𝙚𝙡𝙡 𝙎𝙩𝙚𝙢 𝘾𝙚𝙡𝙡 a systematic approach to generate neural #organoids resembling various domains of the neural axis
Neal Amin & @kevinkelley.bsky.social developed a multiplexed morphogen screen to generate #organoids that mapped to almost 2/3 of the clusters in the 1st trimester CNS

New review: together with PhD student Ciarán Butler-Hallissey, we provide a comprehensive overview on how super-resolution microscopy can dissect the neuronal cytoskeleton, and the exciting perspectives ahead. Shock full of beautiful images, published or from our lab! www.nature.com/articles/s44...

Featured Resource: Gene Expression Database (GXD)

Here, Connie Smith and Martin Ringwald introduce the data and functionalities available at GXD @mousegenome.bsky.social and talk about future directions of the database:
https://thenode.biologists.com/featured-resource-gene-expression-database-gxd/

🎈New preprint! We study how single cells move up, down and about fibronectin gradients. Experiments by @icfortunato.bsky.social, theory by David Bruckner. Collaboration with @raimonsunyer.bsky.social and @ehannezo.bsky.social 👇https://biorxiv.org/cgi/content/short/2024.12.02.626413v1

The Living Materials & Tissue Engineering community continues to grow on Bluesky. So great to see more colleagues over here AND to met new/rising stars in our community.

Lets keep growing & sharing our work.

And let me know others to add including self-nominations!

go.bsky.app/AeG8FWr

Excited to share a new review on Magnets for Mechanobiology - teamed up w/ fellow 🧲 enthusiasts from Boston/Madrid/Zurich/Singapore to share how we manipulate cellular microenvironments w/ magnetic fields! Thanks to @danielgmadrid11.bsky.social for bringing us together!

doi.org/10.1002/aisy...

While our bodies seem static, our cells are constantly changing shape or on the move during tissue homeostasis or wound repair & even more dramatically during embryonic development, during events like gastrulation. Defining how cellular machines mediate these events is a key task for our field 1/n