Alexander Ehrenberg
@ajehrenberg.bsky.social
Translational neuroscientist interested in mechanisms of vulnerability in neurodegenerative diseases and stress disorders | UCSF Memory and Aging Center & Doudna Lab, Innovative Genomics Institute
www.ajehrenberg.com
www.ajehrenberg.com
Please submit! We will be extending the deadline to November 30 as well
Call For Papers! Alzheimer's & Dementia Special Issue: Neuromodulatory Subcortical Systems in Alzheimer's Disease
Research on the intersection of the Neuromodulatory Subcortical Systems and AD are welcome! #AlzResearch
⏰Deadline: Aug. 30, 2025
alz-journals.onlinelibrary.wiley.com/hub/journal/...
Research on the intersection of the Neuromodulatory Subcortical Systems and AD are welcome! #AlzResearch
⏰Deadline: Aug. 30, 2025
alz-journals.onlinelibrary.wiley.com/hub/journal/...
Alzheimer's & Dementia
alz-journals.onlinelibrary.wiley.com
August 26, 2025 at 4:31 PM
Please submit! We will be extending the deadline to November 30 as well
Reposted by Alexander Ehrenberg
My paper reviewing how different neurodegenerative diseases affect autonomic function was just published.
Autonomic dysfunction in neurodegenerative disease — a Review by Mara Mather
www.nature.com/articles/s41...
@maramather.bsky.social
#neuroscience
www.nature.com/articles/s41...
@maramather.bsky.social
#neuroscience
Autonomic dysfunction in neurodegenerative disease - Nature Reviews Neuroscience
Neurodegenerative disorders are commonly associated with autonomic dysfunction as well as the more well-known cognitive and motor effects. In this Review, Mather describes how properties of neurons in...
www.nature.com
April 10, 2025 at 12:54 AM
My paper reviewing how different neurodegenerative diseases affect autonomic function was just published.
Reposted by Alexander Ehrenberg
New paper out! What kinds of things should therapies be addressing to prevent neurons from dying in Alzheimer’s?
alz-journals.onlinelibrary.wiley.com/share/UZTGYE...
@innovativegenomics.bsky.social @ucsfmac.bsky.social
alz-journals.onlinelibrary.wiley.com/share/UZTGYE...
@innovativegenomics.bsky.social @ucsfmac.bsky.social
Pathways underlying selective neuronal vulnerability in Alzheimer's disease: Contrasting the vulnerable locus coeruleus to the resilient substantia nigra
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alz-journals.onlinelibrary.wiley.com
March 26, 2025 at 5:06 PM
New paper out! What kinds of things should therapies be addressing to prevent neurons from dying in Alzheimer’s?
alz-journals.onlinelibrary.wiley.com/share/UZTGYE...
@innovativegenomics.bsky.social @ucsfmac.bsky.social
alz-journals.onlinelibrary.wiley.com/share/UZTGYE...
@innovativegenomics.bsky.social @ucsfmac.bsky.social
Have an upcoming paper focused on neuromodulatory subcortical nuclei in neurodegenerative diseases? Please consider submitting to a special issue in @alzdemjournals.bsky.social. I'll be the guest editor along with representatives from the @istaart.bsky.social neuromodulatory subcortical systems PIA.
February 12, 2025 at 8:09 PM
Have an upcoming paper focused on neuromodulatory subcortical nuclei in neurodegenerative diseases? Please consider submitting to a special issue in @alzdemjournals.bsky.social. I'll be the guest editor along with representatives from the @istaart.bsky.social neuromodulatory subcortical systems PIA.
Reposted by Alexander Ehrenberg
Check out our review highlighting the importance of monoamines towards understanding Alzheimer's disease. We describe promising neuroimaging and daily life sampling approaches to better elucidate the neurobiological mechanisms underlying AD.
'Examining resilience to Alzheimer’s disease through the lens of monoaminergic neuromodulator systems'
Trends in Neurosciences Review by Jennifer Crawford & Anne Berry @anneberry.bsky.social
www.cell.com/trends/neuro...
Trends in Neurosciences Review by Jennifer Crawford & Anne Berry @anneberry.bsky.social
www.cell.com/trends/neuro...
Examining resilience to Alzheimer’s disease through the lens of monoaminergic neuromodulator systems
The monoaminergic nuclei are thought to be some of the earliest sites of Alzheimer’s
disease (AD) pathology in the brain, with tau-containing pretangles appearing in these
nuclei decades before the on...
www.cell.com
January 29, 2025 at 8:44 PM
Check out our review highlighting the importance of monoamines towards understanding Alzheimer's disease. We describe promising neuroimaging and daily life sampling approaches to better elucidate the neurobiological mechanisms underlying AD.
Great new paper from Dan Silverman and the Dan lab on the relationships between LC activation and sleep-wake patterns. Wonderful experimental appraisal of the sleep pressure model of sleep-wake!
www.science.org/doi/epdf/10....
www.science.org/doi/epdf/10....
Activation of locus coeruleus noradrenergic neurons rapidly drives homeostatic sleep pressure
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www.science.org
January 18, 2025 at 1:34 AM
Great new paper from Dan Silverman and the Dan lab on the relationships between LC activation and sleep-wake patterns. Wonderful experimental appraisal of the sleep pressure model of sleep-wake!
www.science.org/doi/epdf/10....
www.science.org/doi/epdf/10....
Reposted by Alexander Ehrenberg
@tdowns.bsky.social 's latest is up!! www.biorxiv.org/content/10.1...
Loss of excitatory inputs and decreased tonic and evoked activity of locus coeruleus neurons in aged P301S mice
Tau pathology in the locus coeruleus (LC) is associated with several neurodegenerative conditions including Alzheimers disease and frontotemporal dementia. Phosphorylated tau accumulates in the LC and...
www.biorxiv.org
January 17, 2025 at 11:12 PM
@tdowns.bsky.social 's latest is up!! www.biorxiv.org/content/10.1...
Reposted by Alexander Ehrenberg
Our latest paper, led by Emmy Li, is out on Neuron today:
CRISPRi-based screens in iAssembloids to elucidate neuron-glia interactions
www.cell.com/neuron/fullt...
CRISPRi-based screens in iAssembloids to elucidate neuron-glia interactions
www.cell.com/neuron/fullt...
CRISPRi-based screens in iAssembloids to elucidate neuron-glia interactions
Using a 3D co-culture system of iPSC-derived neurons and glia, termed iAssembloids,
combined with CRISPRi-based screening, Li et al. investigate the effect of glial cells
on neuronal activity and surv...
www.cell.com
January 14, 2025 at 6:27 PM
Our latest paper, led by Emmy Li, is out on Neuron today:
CRISPRi-based screens in iAssembloids to elucidate neuron-glia interactions
www.cell.com/neuron/fullt...
CRISPRi-based screens in iAssembloids to elucidate neuron-glia interactions
www.cell.com/neuron/fullt...
Reposted by Alexander Ehrenberg
🔵 #LocusCoeruleus alert!
Holy cow... I'm supposed to do something else, but this paper looks amazing! I mean the concept, the implications... wow.
www.cell.com/cell/fulltex...
Holy cow... I'm supposed to do something else, but this paper looks amazing! I mean the concept, the implications... wow.
www.cell.com/cell/fulltex...
Norepinephrine-mediated slow vasomotion drives glymphatic clearance during sleep
Norepinephrine oscillations during NREM sleep drive synchronized changes in cerebral blood volume and cerebrospinal fluid, promoting glymphatic clearance. Optogenetic and pharmacological manipulations confirm that vasomotion, regulated by norepinephrine, acts as a pump for brain fluid transport.
www.cell.com
January 9, 2025 at 1:06 PM
🔵 #LocusCoeruleus alert!
Holy cow... I'm supposed to do something else, but this paper looks amazing! I mean the concept, the implications... wow.
www.cell.com/cell/fulltex...
Holy cow... I'm supposed to do something else, but this paper looks amazing! I mean the concept, the implications... wow.
www.cell.com/cell/fulltex...
Reposted by Alexander Ehrenberg
Hello BlueSky. One of our cofounders, Linde Jacobs, is profiled in The New York Times today. It’s a moving snapshot of what an FTD family goes through. Help us fight for therapies that can cure dementia for under 60s. #ftd #aftd #dementia #tau #alzheimers #mapt
www.nytimes.com/2024/12/22/h...
A Woman With a Rare Gene Mutation Fights to Avoid Her Mother’s Fate (Gift Article)
A mutant gene is coming to steal Linde Jacobs’s mind. Can she find a way to stop it?
www.nytimes.com
December 22, 2024 at 2:57 PM
Hello BlueSky. One of our cofounders, Linde Jacobs, is profiled in The New York Times today. It’s a moving snapshot of what an FTD family goes through. Help us fight for therapies that can cure dementia for under 60s. #ftd #aftd #dementia #tau #alzheimers #mapt
www.nytimes.com/2024/12/22/h...
Reposted by Alexander Ehrenberg
🧪
Fantastic genetics resource coming your way from
@billingsleykj.bsky.social, Cornelis Blauwendraat, and their CARD colleagues. 351 long-read, whole-genome sequences (at ~40x coverage!) with paired brain expression and methylation data. Strong work. #Alzheimer's
www.biorxiv.org/content/10.1...
Fantastic genetics resource coming your way from
@billingsleykj.bsky.social, Cornelis Blauwendraat, and their CARD colleagues. 351 long-read, whole-genome sequences (at ~40x coverage!) with paired brain expression and methylation data. Strong work. #Alzheimer's
www.biorxiv.org/content/10.1...
Long-read sequencing of hundreds of diverse brains provides insight into the impact of structural variation on gene expression and DNA methylation
Structural variants (SVs) drive gene expression in the human brain and are causative of many neurological conditions. However, most existing genetic studies have been based on short-read sequencing me...
www.biorxiv.org
December 22, 2024 at 12:04 AM
🧪
Fantastic genetics resource coming your way from
@billingsleykj.bsky.social, Cornelis Blauwendraat, and their CARD colleagues. 351 long-read, whole-genome sequences (at ~40x coverage!) with paired brain expression and methylation data. Strong work. #Alzheimer's
www.biorxiv.org/content/10.1...
Fantastic genetics resource coming your way from
@billingsleykj.bsky.social, Cornelis Blauwendraat, and their CARD colleagues. 351 long-read, whole-genome sequences (at ~40x coverage!) with paired brain expression and methylation data. Strong work. #Alzheimer's
www.biorxiv.org/content/10.1...
I couldn’t find one so I made it! If you do neuropathology focused on neurodegenerative diseases and I didn’t include you here, please comment so I can add you!
go.bsky.app/77qD71g
go.bsky.app/77qD71g
December 5, 2024 at 3:53 PM
I couldn’t find one so I made it! If you do neuropathology focused on neurodegenerative diseases and I didn’t include you here, please comment so I can add you!
go.bsky.app/77qD71g
go.bsky.app/77qD71g