Alex Gyftopoulos
@agyftomd.bsky.social
Chief Cardiology Fellow @UMMC, interested in preventive cardiology, lipidology, and medical education
Reposted by Alex Gyftopoulos
How should ApoB and Lp(a) be used as core measures to assess cardiovascular risk?
Join experts Allan Sniderman, George Thanassoulis and Michael Pencina as they unpack the power of these biomarkers – and what they mean for prevention strategies.
Listen now👉 bit.ly/3LjJWcC
#ApoB #LipoproteinA
Join experts Allan Sniderman, George Thanassoulis and Michael Pencina as they unpack the power of these biomarkers – and what they mean for prevention strategies.
Listen now👉 bit.ly/3LjJWcC
#ApoB #LipoproteinA
October 22, 2025 at 9:52 AM
How should ApoB and Lp(a) be used as core measures to assess cardiovascular risk?
Join experts Allan Sniderman, George Thanassoulis and Michael Pencina as they unpack the power of these biomarkers – and what they mean for prevention strategies.
Listen now👉 bit.ly/3LjJWcC
#ApoB #LipoproteinA
Join experts Allan Sniderman, George Thanassoulis and Michael Pencina as they unpack the power of these biomarkers – and what they mean for prevention strategies.
Listen now👉 bit.ly/3LjJWcC
#ApoB #LipoproteinA
Reposted by Alex Gyftopoulos
An inclisiran-based treatment strategy for patients with hypercholesterolemia at high risk for #CVD events helped achieve individual LDL-C goals compared with placebo, based on findings from VICTORION-Difference presented at #ESCCongress. Details: https://bit.ly/463MS43
August 30, 2025 at 8:14 PM
An inclisiran-based treatment strategy for patients with hypercholesterolemia at high risk for #CVD events helped achieve individual LDL-C goals compared with placebo, based on findings from VICTORION-Difference presented at #ESCCongress. Details: https://bit.ly/463MS43
Reposted by Alex Gyftopoulos
Treatment with olezarsen significantly reduced triglyceride levels at 6 months compared to placebo in pts w/ moderate hypertriglyceridemia & elevated CV risk, according to results of the Essence-TIMI 73b study presented during #ESCCongress. 🔗 More: https://bit.ly/4g4r50H
August 30, 2025 at 5:31 PM
Treatment with olezarsen significantly reduced triglyceride levels at 6 months compared to placebo in pts w/ moderate hypertriglyceridemia & elevated CV risk, according to results of the Essence-TIMI 73b study presented during #ESCCongress. 🔗 More: https://bit.ly/4g4r50H
Reposted by Alex Gyftopoulos
For Very High Risk Women - Use of Statins in Pregnancy - cardiovascularbusiness.com/topics/clinical/pharmaceutics/statin-therapy-safe-pregnant-women?utm_source=newsletter&utm_medium=cvb_video @nationallipid.bsky.social @escardio.bsky.social @aspcardio.bsky.social @familyheartfdn.bsky.social
Is statin therapy safe for pregnant women?
Laxmi Mehta, MD, explained that the use of statins when treating pregnant women is no longer forbidden. However, she added, cardiologists should always discuss it first with their patients.
cardiovascularbusiness.com
April 13, 2025 at 3:33 PM
For Very High Risk Women - Use of Statins in Pregnancy - cardiovascularbusiness.com/topics/clinical/pharmaceutics/statin-therapy-safe-pregnant-women?utm_source=newsletter&utm_medium=cvb_video @nationallipid.bsky.social @escardio.bsky.social @aspcardio.bsky.social @familyheartfdn.bsky.social
Reposted by Alex Gyftopoulos
Best publication in Preventive Cardiology I have ever read just out in Nature Reviews Cardiology by Ference, Braunwald, and Catapano. Most statin trials only last 4 years, but now it's clear that being on a statin for decades is key to preventing heart attack & stroke. www.nature.com/articles/s41...
The LDL cumulative exposure hypothesis: evidence and practical applications - Nature Reviews Cardiology
In this Review, Catapano and colleagues discuss the evidence supporting the LDL cumulative exposure hypothesis and how measuring cumulative LDL exposure can be used to estimate risk and contribute to ...
www.nature.com
February 9, 2025 at 2:11 AM
Best publication in Preventive Cardiology I have ever read just out in Nature Reviews Cardiology by Ference, Braunwald, and Catapano. Most statin trials only last 4 years, but now it's clear that being on a statin for decades is key to preventing heart attack & stroke. www.nature.com/articles/s41...
Reposted by Alex Gyftopoulos
📢NEW NLA & AGS expert clinical consensus on managing #hypercholesterolemia in adults older than 75 years without a history of #ASCVD.
Read the article now: sciencedirect.com/science/arti...
#Cardiosky
Read the article now: sciencedirect.com/science/arti...
#Cardiosky
April 10, 2025 at 6:55 PM
📢NEW NLA & AGS expert clinical consensus on managing #hypercholesterolemia in adults older than 75 years without a history of #ASCVD.
Read the article now: sciencedirect.com/science/arti...
#Cardiosky
Read the article now: sciencedirect.com/science/arti...
#Cardiosky
Reposted by Alex Gyftopoulos
ICYMI at #ACC25: #JACCAsia EiC Dr. Jian’an Wang & colleagues presented the results of a phase 2 study demonstrating that SHR-1918, a monoclonal antibody against ANGPTL-3, achieved dose-dependent reductions of LDL
📄: www.jacc.org/doi/10.1016/... #JACC #ASCVD #CardioSky
📄: www.jacc.org/doi/10.1016/... #JACC #ASCVD #CardioSky
Angiopoietin-Like 3 Antibody Therapy in Patients With Suboptimally Controlled Hyperlipidemia: A Phase 2 Study
www.jacc.org
April 10, 2025 at 1:41 PM
ICYMI at #ACC25: #JACCAsia EiC Dr. Jian’an Wang & colleagues presented the results of a phase 2 study demonstrating that SHR-1918, a monoclonal antibody against ANGPTL-3, achieved dose-dependent reductions of LDL
📄: www.jacc.org/doi/10.1016/... #JACC #ASCVD #CardioSky
📄: www.jacc.org/doi/10.1016/... #JACC #ASCVD #CardioSky
More data supporting that lower LDL is better. This time in the context of dementia. jnnp.bmj.com/content/earl...
Low-density lipoprotein cholesterol levels and risk of incident dementia: a distributed network analysis using common data models
Background The link between low-density lipoprotein cholesterol (LDL-C) levels and dementia risk is poorly understood, with conflicting evidence on the role of LDL-C and the impact of statin therapy o...
jnnp.bmj.com
April 6, 2025 at 1:41 PM
More data supporting that lower LDL is better. This time in the context of dementia. jnnp.bmj.com/content/earl...
Reposted by Alex Gyftopoulos
Some Lp(a) (LPA) genetics - Get tested and if abnormal get adult family members tested and get competent advice. If any clinician, including a cardiologist tells you Lp(a) is not important, is experimental or its risk cannot be treated -- run fast out of that office
March 15, 2025 at 7:53 PM
Some Lp(a) (LPA) genetics - Get tested and if abnormal get adult family members tested and get competent advice. If any clinician, including a cardiologist tells you Lp(a) is not important, is experimental or its risk cannot be treated -- run fast out of that office
A fantastic conference with plenty of informative and insightful presentations!
Missed the 2024 ASPC Congress or want to revisit the highlights? 🩺✨ Discover the enduring content from the event and stay ahead in the field!
📚 Access it all here: www.aspconline.org/aspc-2024-en...
#CardioSky #MedSky #ASPC2024 #MedicalEducation #LifelongLearning
📚 Access it all here: www.aspconline.org/aspc-2024-en...
#CardioSky #MedSky #ASPC2024 #MedicalEducation #LifelongLearning
ASPC 2024 Enduring Content - American Society for Preventive Cardiology
www.aspconline.org
January 18, 2025 at 2:15 AM
A fantastic conference with plenty of informative and insightful presentations!
Reposted by Alex Gyftopoulos
Missed the 2024 ASPC Congress or want to revisit the highlights? 🩺✨ Discover the enduring content from the event and stay ahead in the field!
📚 Access it all here: www.aspconline.org/aspc-2024-en...
#CardioSky #MedSky #ASPC2024 #MedicalEducation #LifelongLearning
📚 Access it all here: www.aspconline.org/aspc-2024-en...
#CardioSky #MedSky #ASPC2024 #MedicalEducation #LifelongLearning
ASPC 2024 Enduring Content - American Society for Preventive Cardiology
www.aspconline.org
January 17, 2025 at 6:04 PM
Missed the 2024 ASPC Congress or want to revisit the highlights? 🩺✨ Discover the enduring content from the event and stay ahead in the field!
📚 Access it all here: www.aspconline.org/aspc-2024-en...
#CardioSky #MedSky #ASPC2024 #MedicalEducation #LifelongLearning
📚 Access it all here: www.aspconline.org/aspc-2024-en...
#CardioSky #MedSky #ASPC2024 #MedicalEducation #LifelongLearning
Reposted by Alex Gyftopoulos
Redefining obesity. It is time.
📏BMI is NOT a direct measure of fat
📏BMI does NOT establish the distribution of fat
📏BMI cannot determine with excess fat is a health problem
@thelancet.bsky.social
Lancet Commission
📎 www.thelancet.com/commissions/...
📏BMI is NOT a direct measure of fat
📏BMI does NOT establish the distribution of fat
📏BMI cannot determine with excess fat is a health problem
@thelancet.bsky.social
Lancet Commission
📎 www.thelancet.com/commissions/...
January 15, 2025 at 5:47 AM
Redefining obesity. It is time.
📏BMI is NOT a direct measure of fat
📏BMI does NOT establish the distribution of fat
📏BMI cannot determine with excess fat is a health problem
@thelancet.bsky.social
Lancet Commission
📎 www.thelancet.com/commissions/...
📏BMI is NOT a direct measure of fat
📏BMI does NOT establish the distribution of fat
📏BMI cannot determine with excess fat is a health problem
@thelancet.bsky.social
Lancet Commission
📎 www.thelancet.com/commissions/...
Reposted by Alex Gyftopoulos
🆕 Global Commission proposes overhaul of obesity diagnosis – going beyond BMI to define when obesity is a disease.
Find out more: hubs.li/Q030v_j_0
Find out more: hubs.li/Q030v_j_0
January 15, 2025 at 7:53 AM
🆕 Global Commission proposes overhaul of obesity diagnosis – going beyond BMI to define when obesity is a disease.
Find out more: hubs.li/Q030v_j_0
Find out more: hubs.li/Q030v_j_0
Reposted by Alex Gyftopoulos
www.inova.org/our-services...
Please apply with CV, 3LOR and personal statement. We will select our next fellow in January 2025. #CardioOB #Prevention
Please apply with CV, 3LOR and personal statement. We will select our next fellow in January 2025. #CardioOB #Prevention
Women’s Cardiovascular Fellowship program (non-ACGME)
Learn about Inova's fellowship program for Women’s Cardiovascular health (non-ACGME)
www.inova.org
December 27, 2024 at 12:33 AM
www.inova.org/our-services...
Please apply with CV, 3LOR and personal statement. We will select our next fellow in January 2025. #CardioOB #Prevention
Please apply with CV, 3LOR and personal statement. We will select our next fellow in January 2025. #CardioOB #Prevention
Reposted by Alex Gyftopoulos
Ensuring every school is ready for a cardiac emergency is a huge step forward in protecting young hearts. We’re proud to support the #HEARTSact and continue our work with the Smart Heart Sports Coalition.
On December 26, 2024, President Biden signed the bipartisan #HEARTSact into law, ensuring schools nationwide are prepared for cardiac emergencies.
HRA & @heartrhythmsociety.bsky.social proudly supported this legislation as a member of the Smart Heart Sports Coalition.
Learn more ➡️ bit.ly/3VXTAEf
HRA & @heartrhythmsociety.bsky.social proudly supported this legislation as a member of the Smart Heart Sports Coalition.
Learn more ➡️ bit.ly/3VXTAEf
January 2, 2025 at 10:34 PM
Ensuring every school is ready for a cardiac emergency is a huge step forward in protecting young hearts. We’re proud to support the #HEARTSact and continue our work with the Smart Heart Sports Coalition.
Reposted by Alex Gyftopoulos
ICYMI: Top General Cardiology and Prevention News of 2024
Top General Cardiology and Prevention News of 2024
Top General Cardiology and Prevention News of 2024
sciprian@crf.org
Mon, 12/23/2024 - 15:21
Caitlin E. Cox
The year had a lot to offer, from advanced therapies aimed at Lp(a), GLP-1, and other targets, to support for simpler strategies.
www.tctmd.com
January 2, 2025 at 2:03 PM
ICYMI: Top General Cardiology and Prevention News of 2024
Reposted by Alex Gyftopoulos
Great news in this meta-analysis which showed no increase in cardiovascular events in women undergoing fertility treatments.
academic.oup.com/eurheartj/ad...
academic.oup.com/eurheartj/ad...
December 29, 2024 at 2:45 PM
Great news in this meta-analysis which showed no increase in cardiovascular events in women undergoing fertility treatments.
academic.oup.com/eurheartj/ad...
academic.oup.com/eurheartj/ad...
More evidence that we should he aggressive when treating risk factors like elevated atherogenic lipoproteins in our patients.
Discover the article: "Alirocumab and Chest Pain After Acute Coronary Syndrome: An Analysis of ODYSSEY OUTCOMES."
📖 Read it here: www.sciencedirect.com/science/arti...
#Cardiology #Alirocumab #HeartHealth #ACS #MedicalResearch #cardiosky #medsky
📖 Read it here: www.sciencedirect.com/science/arti...
#Cardiology #Alirocumab #HeartHealth #ACS #MedicalResearch #cardiosky #medsky
December 27, 2024 at 7:20 PM
More evidence that we should he aggressive when treating risk factors like elevated atherogenic lipoproteins in our patients.
Reposted by Alex Gyftopoulos
Congrats to Dr. Sharma & Inova. What a great honor & opportunity for this Ciccarone Center alumnus.
December 22, 2024 at 7:28 PM
Congrats to Dr. Sharma & Inova. What a great honor & opportunity for this Ciccarone Center alumnus.
Reposted by Alex Gyftopoulos
A bit delayed, but finally, here is a Skytorial (Bluetorial?) on our recent study of guideline recommended statin use in younger adults. #CardioSky #MedSky #CVPrev
www.sciencedirect.com/science/arti...
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www.sciencedirect.com/science/arti...
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Guideline recommended statin eligibility and use among U.S. adults ages 20 to 39 years
Guidelines for statin therapy emphasize treatment of adults ages 40–75 years, with less guidance for the treatment of younger adults, ages 20–39 years…
www.sciencedirect.com
December 17, 2024 at 6:01 PM
A bit delayed, but finally, here is a Skytorial (Bluetorial?) on our recent study of guideline recommended statin use in younger adults. #CardioSky #MedSky #CVPrev
www.sciencedirect.com/science/arti...
1/
www.sciencedirect.com/science/arti...
1/
Reposted by Alex Gyftopoulos
The times - they are a changing! The evolving definition of obesity by the FDA should revolutionize the way think and treat patients
The Definition of Obesity Is Changing And What It Means for You ⤵️
medium.com/@MichaelAlbe...
medium.com/@MichaelAlbe...
The Future Definition of Obesity: Rethinking an Outdated Paradigm
Generated by DALL-E
medium.com
December 21, 2024 at 3:45 PM
The times - they are a changing! The evolving definition of obesity by the FDA should revolutionize the way think and treat patients
Reposted by Alex Gyftopoulos
Shocking to see the @nytimes.com give any credibility to Mark Hyman. His strategy is get rich off off supplements that aren’t evidence based & blood tests that also aren’t evidence based.
It’s one thing to be skeptical of research but this is not that.
#CardioSky
www.nytimes.com/2024/12/18/h...
It’s one thing to be skeptical of research but this is not that.
#CardioSky
www.nytimes.com/2024/12/18/h...
How RFK Jr’s Longtime Friend Mark Hyman Built a Wellness Empire
Dr. Mark Hyman, a “functional medicine” proponent and longtime friend of Robert F. Kennedy Jr., is finding powerful allies in his bid to treat disease with blood tests and supplements.
www.nytimes.com
December 19, 2024 at 12:53 PM
Shocking to see the @nytimes.com give any credibility to Mark Hyman. His strategy is get rich off off supplements that aren’t evidence based & blood tests that also aren’t evidence based.
It’s one thing to be skeptical of research but this is not that.
#CardioSky
www.nytimes.com/2024/12/18/h...
It’s one thing to be skeptical of research but this is not that.
#CardioSky
www.nytimes.com/2024/12/18/h...
Reposted by Alex Gyftopoulos
In this case study of a large medical system, an increased cardiopulmonary disease burden for residents of Maryland that was likely associated with contemporaneous wildfire smoke–based infiltration of polluted or toxic air originating from Western Canada up to 2100 miles remotely was identified
Polluted Air from Canadian Wildfires and Cardiopulmonary Disease in the Eastern US
This case-control study compares rates of clinical encounters for cardiopulmonary disease in the Eastern US following wildfires in Western Canada with previous periods of high air pollution within the...
jamanetwork.com
December 15, 2024 at 4:22 PM
In this case study of a large medical system, an increased cardiopulmonary disease burden for residents of Maryland that was likely associated with contemporaneous wildfire smoke–based infiltration of polluted or toxic air originating from Western Canada up to 2100 miles remotely was identified
Reposted by Alex Gyftopoulos
What’s the relation between CAC and osteoporosis? Dr. Matt Budoff now speaking at #WCIRDC25
♥️⤴️ CAC associated with⤵️ bone denisity: osteoporosis =CV risk
♥️ Disease process:osteoclast 🆚 osteoblasts
♥️ Osteopontin may promote atherosclerosis
♥️ therapies for osteoporosis need to be considered
#CardioSky
♥️⤴️ CAC associated with⤵️ bone denisity: osteoporosis =CV risk
♥️ Disease process:osteoclast 🆚 osteoblasts
♥️ Osteopontin may promote atherosclerosis
♥️ therapies for osteoporosis need to be considered
#CardioSky
December 14, 2024 at 8:57 PM
What’s the relation between CAC and osteoporosis? Dr. Matt Budoff now speaking at #WCIRDC25
♥️⤴️ CAC associated with⤵️ bone denisity: osteoporosis =CV risk
♥️ Disease process:osteoclast 🆚 osteoblasts
♥️ Osteopontin may promote atherosclerosis
♥️ therapies for osteoporosis need to be considered
#CardioSky
♥️⤴️ CAC associated with⤵️ bone denisity: osteoporosis =CV risk
♥️ Disease process:osteoclast 🆚 osteoblasts
♥️ Osteopontin may promote atherosclerosis
♥️ therapies for osteoporosis need to be considered
#CardioSky
Reposted by Alex Gyftopoulos
🎉 The HEARTS Act has passed the Senate & heads to President Biden's desk! HRS, a proud Smart Heart Sports Coalition member, led a grassroots effort urging legislators to act. Soon, schools nationwide will have AEDs, CPR training, & emergency plans—lifesaving tools for every kid ❤️smartheartsports.com
December 12, 2024 at 2:12 PM
🎉 The HEARTS Act has passed the Senate & heads to President Biden's desk! HRS, a proud Smart Heart Sports Coalition member, led a grassroots effort urging legislators to act. Soon, schools nationwide will have AEDs, CPR training, & emergency plans—lifesaving tools for every kid ❤️smartheartsports.com