Reposted by Adrián Candelas
Thanks for the support of @caixaresearch.bsky.social to continue our efforts to use tissue engineering to study cerebral malaria. We will develop stem-cell derived immunocompetent BBB models with microglia to study malaria, in a side by side comparison with spatial transcriptomics in patients.
1/ Cerebral malaria is a severe form of malaria that causes damage to the blood vessels in the brain.
With a #HealthResearch grant, @mariabernabeu.bsky.social uses analytical techniques and human 3D models of blood vessels to ⬆️ our understanding and test new therapies.
https://tinyurl.com/2vtjnwn6
With a #HealthResearch grant, @mariabernabeu.bsky.social uses analytical techniques and human 3D models of blood vessels to ⬆️ our understanding and test new therapies.
https://tinyurl.com/2vtjnwn6
November 20, 2025 at 3:50 PM
Thanks for the support of @caixaresearch.bsky.social to continue our efforts to use tissue engineering to study cerebral malaria. We will develop stem-cell derived immunocompetent BBB models with microglia to study malaria, in a side by side comparison with spatial transcriptomics in patients.
Reposted by Adrián Candelas
What a crazy cool paper! First author @pierreucla.bsky.social with a large crew knocked it out of the park. (GIF below from @the.3i.social LLS) Quantifying cell traction forces at the single-fiber scale in 3D: An approach based on deformable photopolymerized fiber arrays www.pnas.org/doi/10.1073/...
November 13, 2025 at 6:21 PM
What a crazy cool paper! First author @pierreucla.bsky.social with a large crew knocked it out of the park. (GIF below from @the.3i.social LLS) Quantifying cell traction forces at the single-fiber scale in 3D: An approach based on deformable photopolymerized fiber arrays www.pnas.org/doi/10.1073/...
Reposted by Adrián Candelas
🔬 In JCB's November issue: image shows a #macrophage nibbling a #cancer cell. The bone marrow–derived mouse macrophage is expressing a Chimeric Antigen Receptor (green) that activates the Fc Receptor signaling pathway in response to Her2. From Rollins et al. rupress.org/jcb/issue/22...
November 10, 2025 at 3:03 PM
🔬 In JCB's November issue: image shows a #macrophage nibbling a #cancer cell. The bone marrow–derived mouse macrophage is expressing a Chimeric Antigen Receptor (green) that activates the Fc Receptor signaling pathway in response to Her2. From Rollins et al. rupress.org/jcb/issue/22...
Reposted by Adrián Candelas
Huge thanks to @mariabernabeu.bsky.social and to everyone else who contributed and made this project possible 🎉
Pre-print alert 🚨
We answer a longstanding question in the field. Do immune cells cause cerebral malaria?
The answer is YES!!!! And independently of P. falciparum accumulation in the brain.
www.biorxiv.org/cgi/content/...
We answer a longstanding question in the field. Do immune cells cause cerebral malaria?
The answer is YES!!!! And independently of P. falciparum accumulation in the brain.
www.biorxiv.org/cgi/content/...
Innate immune responses to Plasmodium falciparum disrupt the blood-brain barrier
Plasmodium falciparum accumulation at the blood-brain barrier (BBB) is a hallmark of cerebral malaria, a life-threatening complication. Conversely, the contribution of the immune response to vascular ...
www.biorxiv.org
October 21, 2025 at 7:42 PM
Huge thanks to @mariabernabeu.bsky.social and to everyone else who contributed and made this project possible 🎉
Reposted by Adrián Candelas
Pre-print alert 🚨
We answer a longstanding question in the field. Do immune cells cause cerebral malaria?
The answer is YES!!!! And independently of P. falciparum accumulation in the brain.
www.biorxiv.org/cgi/content/...
We answer a longstanding question in the field. Do immune cells cause cerebral malaria?
The answer is YES!!!! And independently of P. falciparum accumulation in the brain.
www.biorxiv.org/cgi/content/...
Innate immune responses to Plasmodium falciparum disrupt the blood-brain barrier
Plasmodium falciparum accumulation at the blood-brain barrier (BBB) is a hallmark of cerebral malaria, a life-threatening complication. Conversely, the contribution of the immune response to vascular ...
www.biorxiv.org
October 21, 2025 at 11:06 AM
Pre-print alert 🚨
We answer a longstanding question in the field. Do immune cells cause cerebral malaria?
The answer is YES!!!! And independently of P. falciparum accumulation in the brain.
www.biorxiv.org/cgi/content/...
We answer a longstanding question in the field. Do immune cells cause cerebral malaria?
The answer is YES!!!! And independently of P. falciparum accumulation in the brain.
www.biorxiv.org/cgi/content/...
Reposted by Adrián Candelas
Just hot out of the press! Rory developed a 3D microvessel model that recapitulates physiological pericyte coverage. We found that Plasmodium falciparum egress products disrupt the barrier and halt ang-1 secretion. The activator AKB-9778 could rescue barrier disruption! Congratulations, Rory!
Today my main PHD project in the lab of Dr. Maria Bernabeu was published!
Using a 3D brain microvessel model, we show:
1) an unappreciated role of brain pericytes in cerebral malaria pathogenesis
2) Tie-2 activation by AKB-9778 as a potential therapeutic avenue
www.embopress.org/doi/full/10....
Using a 3D brain microvessel model, we show:
1) an unappreciated role of brain pericytes in cerebral malaria pathogenesis
2) Tie-2 activation by AKB-9778 as a potential therapeutic avenue
www.embopress.org/doi/full/10....
October 18, 2025 at 12:42 PM
Just hot out of the press! Rory developed a 3D microvessel model that recapitulates physiological pericyte coverage. We found that Plasmodium falciparum egress products disrupt the barrier and halt ang-1 secretion. The activator AKB-9778 could rescue barrier disruption! Congratulations, Rory!
Reposted by Adrián Candelas
Just posted (bioRxiv): A novel #mechanobiology model revealing how #immune #Tcells combine a #nucleus as a #piston, an #uropod, and #microenvironment to power #amoeboid #cellmigration in #cellconfinement via a hydraulic cell engine. #CellBiophysics #ImmuneMigration
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
September 9, 2025 at 7:09 PM
Just posted (bioRxiv): A novel #mechanobiology model revealing how #immune #Tcells combine a #nucleus as a #piston, an #uropod, and #microenvironment to power #amoeboid #cellmigration in #cellconfinement via a hydraulic cell engine. #CellBiophysics #ImmuneMigration
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Adrián Candelas
We are happy to show one ourt first exciting papers. We have developed a blood-brain barrier model to study the disruptive effects caused by the malaria parasite, Plasmodium falciparum.
First, congratulations to the fearless @liviapiatti.bsky.social and @alinabatzi.bsky.social
rdcu.be/ezBl7
First, congratulations to the fearless @liviapiatti.bsky.social and @alinabatzi.bsky.social
rdcu.be/ezBl7
Plasmodium falciparum egress disrupts endothelial junctions and activates JAK-STAT signaling in a microvascular 3D blood-brain barrier model
Nature Communications - Here the authors show that Plasmodium falciparum egress products disrupt endothelial barrier and activate JAK-STAT and interferon type response in a 3D blood-brain barrier...
rdcu.be
August 7, 2025 at 7:27 AM
We are happy to show one ourt first exciting papers. We have developed a blood-brain barrier model to study the disruptive effects caused by the malaria parasite, Plasmodium falciparum.
First, congratulations to the fearless @liviapiatti.bsky.social and @alinabatzi.bsky.social
rdcu.be/ezBl7
First, congratulations to the fearless @liviapiatti.bsky.social and @alinabatzi.bsky.social
rdcu.be/ezBl7
Reposted by Adrián Candelas
With its scientific expeditions, EMBL is pioneering a new era of field-based molecular life sciences. 🚌🔬
Supported by the Klaus Tschira Stiftung & many partners, these ‘labs on wheels’ enable the study of life in context across Europe, with a view to global impact. 🌍🧬
www.embl.org/news/connect...
Supported by the Klaus Tschira Stiftung & many partners, these ‘labs on wheels’ enable the study of life in context across Europe, with a view to global impact. 🌍🧬
www.embl.org/news/connect...
August 11, 2025 at 8:10 AM
With its scientific expeditions, EMBL is pioneering a new era of field-based molecular life sciences. 🚌🔬
Supported by the Klaus Tschira Stiftung & many partners, these ‘labs on wheels’ enable the study of life in context across Europe, with a view to global impact. 🌍🧬
www.embl.org/news/connect...
Supported by the Klaus Tschira Stiftung & many partners, these ‘labs on wheels’ enable the study of life in context across Europe, with a view to global impact. 🌍🧬
www.embl.org/news/connect...
Reposted by Adrián Candelas
How innate immunity starts? Early embryos eliminate bacterial infections by epithelial phagocytosis, a conserved process from zebrafish to human embryos. Check our story:
www.cell.com/cell-host-mi...
www.cell.com/cell-host-mi...
June 18, 2025 at 5:11 PM
How innate immunity starts? Early embryos eliminate bacterial infections by epithelial phagocytosis, a conserved process from zebrafish to human embryos. Check our story:
www.cell.com/cell-host-mi...
www.cell.com/cell-host-mi...
Reposted by Adrián Candelas
That's dramatic (and cool): "archaea species can also form multicellular tissue–like structures when compressive forces are applied... ... These results establish multicellularity as a feature of all three domains of life" www.science.org/doi/10.1126/...
Tissue-like multicellular development triggered by mechanical compression in archaea
The advent of clonal multicellularity is a critical evolutionary milestone, seen often in eukaryotes, rarely in bacteria, and only once in archaea. We show that uniaxial compression induces clonal mul...
www.science.org
April 4, 2025 at 10:39 AM
That's dramatic (and cool): "archaea species can also form multicellular tissue–like structures when compressive forces are applied... ... These results establish multicellularity as a feature of all three domains of life" www.science.org/doi/10.1126/...
Reposted by Adrián Candelas
I am very happy to share that my work on active deformations of lipid vesicles is finally out in Nature Physics. A nicer thread+movies coming soon, in the meantime:
www.nature.com/articles/s41...
Thx to Andreas, Hammad, Dmitry, Gerhard @laynefrechette.bsky.social and everybody else who contributed!
www.nature.com/articles/s41...
Thx to Andreas, Hammad, Dmitry, Gerhard @laynefrechette.bsky.social and everybody else who contributed!
March 25, 2025 at 2:37 PM
I am very happy to share that my work on active deformations of lipid vesicles is finally out in Nature Physics. A nicer thread+movies coming soon, in the meantime:
www.nature.com/articles/s41...
Thx to Andreas, Hammad, Dmitry, Gerhard @laynefrechette.bsky.social and everybody else who contributed!
www.nature.com/articles/s41...
Thx to Andreas, Hammad, Dmitry, Gerhard @laynefrechette.bsky.social and everybody else who contributed!
Reposted by Adrián Candelas
Interested to read the ins and outs of our Fast & Fair peer review experiment? Read the preprint at bit.ly/424d9x3 #fastandfairpeerreview
Fast & Fair peer review: a pilot study demonstrating feasibility of rapid, high-quality peer review in a biology journal
Traditional peer review is slow, often delayed by the time-consuming process of identifying reviewers and lengthy review turnaround times. This study tests the feasibility of the Fast & Fair peer revi...
bit.ly
March 25, 2025 at 1:51 PM
Interested to read the ins and outs of our Fast & Fair peer review experiment? Read the preprint at bit.ly/424d9x3 #fastandfairpeerreview
Reposted by Adrián Candelas
Monod Conference "Origin of metazoans": fossils, genomes, cell biology, gene regulation, development, and more.
Join us in Roscoff for an exceptional speaker line-up and stunning venue!
🗓️Abstract deadline: March 4.
Register and share!
www.insb.cnrs.fr/fr/origin-me...
Join us in Roscoff for an exceptional speaker line-up and stunning venue!
🗓️Abstract deadline: March 4.
Register and share!
www.insb.cnrs.fr/fr/origin-me...
Origin of metazoans
Roscoff (Bretagne), France, June 16-20, 2025Deadline for application: March 4, 2025
www.insb.cnrs.fr
January 8, 2025 at 9:59 AM
Monod Conference "Origin of metazoans": fossils, genomes, cell biology, gene regulation, development, and more.
Join us in Roscoff for an exceptional speaker line-up and stunning venue!
🗓️Abstract deadline: March 4.
Register and share!
www.insb.cnrs.fr/fr/origin-me...
Join us in Roscoff for an exceptional speaker line-up and stunning venue!
🗓️Abstract deadline: March 4.
Register and share!
www.insb.cnrs.fr/fr/origin-me...
Reposted by Adrián Candelas
New preprint out 🔥🔥 on my postdoc work with @manuelthery.bsky.social and @lblanchoin.bsky.social about how we can create sustained dynamic steady states of actin network inside microscopic wells that contract "forever" without collapsing! A thread 🧵
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
February 26, 2025 at 9:13 AM
New preprint out 🔥🔥 on my postdoc work with @manuelthery.bsky.social and @lblanchoin.bsky.social about how we can create sustained dynamic steady states of actin network inside microscopic wells that contract "forever" without collapsing! A thread 🧵
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
🎉 I am honored to receive the 2024 PhD Thesis Prize from French Society of Cell Biology !🎉
Deeply grateful to the Society for recognizing our work on understanding how niche cells drive polarization and asymmetric division of human hematopoietic progenitors.
sbcf.fr/en/newslette...
Deeply grateful to the Society for recognizing our work on understanding how niche cells drive polarization and asymmetric division of human hematopoietic progenitors.
sbcf.fr/en/newslette...
January 14, 2025 at 1:36 PM
🎉 I am honored to receive the 2024 PhD Thesis Prize from French Society of Cell Biology !🎉
Deeply grateful to the Society for recognizing our work on understanding how niche cells drive polarization and asymmetric division of human hematopoietic progenitors.
sbcf.fr/en/newslette...
Deeply grateful to the Society for recognizing our work on understanding how niche cells drive polarization and asymmetric division of human hematopoietic progenitors.
sbcf.fr/en/newslette...
Reposted by Adrián Candelas
I am thrilled to finally share our work on persister cancer cells: we identify distinctive features and actionable #vulnerabilities ⚡️of persister cancer cells (#DTP), and provide mechanistic insight into their low #inflammatory activity:
aacrjournals.org/cancerres/ar...
aacrjournals.org/cancerres/ar...
H4K20me3-Mediated Repression of Inflammatory Genes Is a Characteristic and Targetable Vulnerability of Persister Cancer Cells
Cell persistence and senescence are distinct states of proliferative arrest induced by cancer therapy, with persister cells being characterized by the silencing of inflammatory genes through the heter...
aacrjournals.org
January 8, 2025 at 12:08 PM
I am thrilled to finally share our work on persister cancer cells: we identify distinctive features and actionable #vulnerabilities ⚡️of persister cancer cells (#DTP), and provide mechanistic insight into their low #inflammatory activity:
aacrjournals.org/cancerres/ar...
aacrjournals.org/cancerres/ar...
Reposted by Adrián Candelas
Our January cover shows a reconstructed synapse from a cryo-electron tomogram of cultured hippocampal neurons expressing a SNAP-25 mutant, using CryoVesNet developed by Amin Khosrozadeh, Benoît Zuber et al. (https://buff.ly/4h0DjGN).
JCB's January issue is here ✨ https://buff.ly/3ZZLqwE
JCB's January issue is here ✨ https://buff.ly/3ZZLqwE
January 6, 2025 at 3:02 PM
Our January cover shows a reconstructed synapse from a cryo-electron tomogram of cultured hippocampal neurons expressing a SNAP-25 mutant, using CryoVesNet developed by Amin Khosrozadeh, Benoît Zuber et al. (https://buff.ly/4h0DjGN).
JCB's January issue is here ✨ https://buff.ly/3ZZLqwE
JCB's January issue is here ✨ https://buff.ly/3ZZLqwE
Reposted by Adrián Candelas
New preprint from Alex Long, Tim Stearns, Jessica Feldman, Lillian Fritz-Laylin and colleagues! Chytrids are neat, understudied and ecologically important as frog pathogens. Shown here, they also remodel their centrioles during cilia disassembly prior to mitosis:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Dynamic remodeling of centrioles and the microtubule cytoskeleton in the lifecycle of chytrid fungi
Cells reorganize in space and time to move and divide - complex behaviors driven by their internal cytoskeleton. While we have substantial knowledge of the molecular parts and rules of cytoskeletal as...
www.biorxiv.org
January 6, 2025 at 12:20 AM
New preprint from Alex Long, Tim Stearns, Jessica Feldman, Lillian Fritz-Laylin and colleagues! Chytrids are neat, understudied and ecologically important as frog pathogens. Shown here, they also remodel their centrioles during cilia disassembly prior to mitosis:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...