Adriaan
@adriaan-vd-graaf.bsky.social
Post-doc in statistical genetics at the University of Lausanne.
Working on developing new techniques for observational causality and validation datasets on which to test our inferences
Working on developing new techniques for observational causality and validation datasets on which to test our inferences
Pinned
Adriaan
@adriaan-vd-graaf.bsky.social
· Jul 4
Our paper, MR-link-2 has just been published! Offering pleiotropy robust Mendelian randomization from a single region! www.nature.com/articles/s41...
EMGM 2026 will be in beautiful Davos this year!
emgm2026.sciencesconf.org?lang=en
Registration abstract submission and travel grant applications are open!
Hope to see you there!
emgm2026.sciencesconf.org?lang=en
Registration abstract submission and travel grant applications are open!
Hope to see you there!
54th European Mathematical Genetics Meeting - Sciencesconf.org
54th European Mathematical Genetics Meeting
emgm2026.sciencesconf.org
November 4, 2025 at 9:48 AM
EMGM 2026 will be in beautiful Davos this year!
emgm2026.sciencesconf.org?lang=en
Registration abstract submission and travel grant applications are open!
Hope to see you there!
emgm2026.sciencesconf.org?lang=en
Registration abstract submission and travel grant applications are open!
Hope to see you there!
Hi #ASHG2025, the Lausanne team made it to Boston ! Excited to present our latest discoveries — come say hi and learn more about our research! @samuelmoix.bsky.social @rjhfmstr.bsky.social
October 14, 2025 at 11:18 AM
Hi #ASHG2025, the Lausanne team made it to Boston ! Excited to present our latest discoveries — come say hi and learn more about our research! @samuelmoix.bsky.social @rjhfmstr.bsky.social
Reposted by Adriaan
Tip for presentations: avoid saying "I don't think this audience needs an introduction to X". Try instead giving a v brief introduction tailored to the key points you will reference in the rest of the talk.
So often people assume I have knowledge I don't, and this hurts my ability to follow.
So often people assume I have knowledge I don't, and this hurts my ability to follow.
August 4, 2025 at 1:08 PM
Tip for presentations: avoid saying "I don't think this audience needs an introduction to X". Try instead giving a v brief introduction tailored to the key points you will reference in the rest of the talk.
So often people assume I have knowledge I don't, and this hurts my ability to follow.
So often people assume I have knowledge I don't, and this hurts my ability to follow.
Using google gemini with grounding for later reference? Make sure you download your links before they expire... :(
August 18, 2025 at 11:03 AM
Using google gemini with grounding for later reference? Make sure you download your links before they expire... :(
Reposted by Adriaan
🚨 Our parent-of-origin study is out in Nature! 🧬
Maternal and paternal alleles can have distinct — even opposite — effects on human traits, revealing a hidden layer of genetic architecture that standard GWAS miss.
🔗 www.nature.com/articles/s41...
Highlights below!
Maternal and paternal alleles can have distinct — even opposite — effects on human traits, revealing a hidden layer of genetic architecture that standard GWAS miss.
🔗 www.nature.com/articles/s41...
Highlights below!
August 6, 2025 at 6:27 PM
🚨 Our parent-of-origin study is out in Nature! 🧬
Maternal and paternal alleles can have distinct — even opposite — effects on human traits, revealing a hidden layer of genetic architecture that standard GWAS miss.
🔗 www.nature.com/articles/s41...
Highlights below!
Maternal and paternal alleles can have distinct — even opposite — effects on human traits, revealing a hidden layer of genetic architecture that standard GWAS miss.
🔗 www.nature.com/articles/s41...
Highlights below!
Wild ride.
Someone just sent me this study, and all I can say is that I don't understand why anyone would bother investigating this question. 1/n
August 6, 2025 at 6:31 AM
Wild ride.
Reposted by Adriaan
1
To predict the behaviour of a primate, would you rather base your guess on a closely related species or one with a similar brain shape? We looked at brains & behaviours of 70 species, you’ll be surprised!
🧵Thread on our new preprint with @r3rt0.bsky.social , doi.org/10.1101/2025...
To predict the behaviour of a primate, would you rather base your guess on a closely related species or one with a similar brain shape? We looked at brains & behaviours of 70 species, you’ll be surprised!
🧵Thread on our new preprint with @r3rt0.bsky.social , doi.org/10.1101/2025...
July 27, 2025 at 5:26 PM
1
To predict the behaviour of a primate, would you rather base your guess on a closely related species or one with a similar brain shape? We looked at brains & behaviours of 70 species, you’ll be surprised!
🧵Thread on our new preprint with @r3rt0.bsky.social , doi.org/10.1101/2025...
To predict the behaviour of a primate, would you rather base your guess on a closely related species or one with a similar brain shape? We looked at brains & behaviours of 70 species, you’ll be surprised!
🧵Thread on our new preprint with @r3rt0.bsky.social , doi.org/10.1101/2025...
Reposted by Adriaan
Super excited to see this out. What started as some math in a grant in 2020, to a student deciding to take this on in 2022, to published in 2025.
These things can take time and patience is key!
These things can take time and patience is key!
📢OUT TODAY @natgenet.nature.com
📰Improved multiancestry fine-mapping identifies cis-regulatory variants underlying molecular traits and disease risk.
By @zeyunlu.bsky.social, @nmancuso.bsky.social and colleagues.
⬇️
www.nature.com/articles/s41...
📰Improved multiancestry fine-mapping identifies cis-regulatory variants underlying molecular traits and disease risk.
By @zeyunlu.bsky.social, @nmancuso.bsky.social and colleagues.
⬇️
www.nature.com/articles/s41...
Improved multiancestry fine-mapping identifies cis-regulatory variants underlying molecular traits and disease risk - Nature Genetics
SuShiE is a multiancestry fine-mapping method for molecular quantitative trait loci that leverages linkage disequilibrium heterogeneity to improve resolution, infer cross-ancestry effect size correlat...
www.nature.com
July 21, 2025 at 6:54 PM
Super excited to see this out. What started as some math in a grant in 2020, to a student deciding to take this on in 2022, to published in 2025.
These things can take time and patience is key!
These things can take time and patience is key!
Reposted by Adriaan
I wrote a little bit about a cool recent paper looking at heritability estimates from very large registry data, and how we still really don't understand why outcomes track in families. A short 🧵:
We still do not understand family resemblance
...
theinfinitesimal.substack.com
July 12, 2025 at 2:25 AM
I wrote a little bit about a cool recent paper looking at heritability estimates from very large registry data, and how we still really don't understand why outcomes track in families. A short 🧵:
Reposted by Adriaan
🚨New preprint is out!
How do genetic effects on complex traits change with age? In this work, we compare different approaches to obtain age-varying genetic effects, and show how design and modeling choices can impact the conclusions we draw.
shorturl.at/17snd
A thread 🧵👇
How do genetic effects on complex traits change with age? In this work, we compare different approaches to obtain age-varying genetic effects, and show how design and modeling choices can impact the conclusions we draw.
shorturl.at/17snd
A thread 🧵👇
Design and model choices shape inference of age-varying genetic effects on complex traits
Understanding how genetic influences on complex traits change with age is a fundamental question in genetic epidemiology. Both cross-sectional (between-subject) and longitudinal (within-subject) appro...
shorturl.at
July 8, 2025 at 12:47 PM
🚨New preprint is out!
How do genetic effects on complex traits change with age? In this work, we compare different approaches to obtain age-varying genetic effects, and show how design and modeling choices can impact the conclusions we draw.
shorturl.at/17snd
A thread 🧵👇
How do genetic effects on complex traits change with age? In this work, we compare different approaches to obtain age-varying genetic effects, and show how design and modeling choices can impact the conclusions we draw.
shorturl.at/17snd
A thread 🧵👇
Our paper, MR-link-2 has just been published! Offering pleiotropy robust Mendelian randomization from a single region! www.nature.com/articles/s41...
July 4, 2025 at 8:52 AM
Our paper, MR-link-2 has just been published! Offering pleiotropy robust Mendelian randomization from a single region! www.nature.com/articles/s41...
Reposted by Adriaan
Happy to share our new study on genetic & environmental contributors to age-related decline in ~100K UK Biobank participants!
Here, we used simulation work + longitudinal GWAS and downstream analyses to explore risks involved in cognitive/physical decline
(1/)🧵🧵
shorturl.at/99gqL
Here, we used simulation work + longitudinal GWAS and downstream analyses to explore risks involved in cognitive/physical decline
(1/)🧵🧵
shorturl.at/99gqL
Combining cross-sectional and longitudinal genomic approaches to identify determinants of cognitive and physical decline - Nature Communications
Large-scale genomic studies focusing on the genetic contribution to human aging have mostly relied on cross-sectional data. With the release of longitudinally curated aging phenotypes by the UK Bioban...
shorturl.at
May 19, 2025 at 12:29 PM
Happy to share our new study on genetic & environmental contributors to age-related decline in ~100K UK Biobank participants!
Here, we used simulation work + longitudinal GWAS and downstream analyses to explore risks involved in cognitive/physical decline
(1/)🧵🧵
shorturl.at/99gqL
Here, we used simulation work + longitudinal GWAS and downstream analyses to explore risks involved in cognitive/physical decline
(1/)🧵🧵
shorturl.at/99gqL
Reposted by Adriaan
Deaths from heart disease down 75%, that’s NIH.
Deaths from stroke down 75%, that’s NIH.
HIV/AIDS no longer a death sentence, that’s NIH.
99% of FDA approved drugs in the last decade, that’s NIH.
Please show this video to anyone who doesn’t understand why the NIH is so important.
Deaths from stroke down 75%, that’s NIH.
HIV/AIDS no longer a death sentence, that’s NIH.
99% of FDA approved drugs in the last decade, that’s NIH.
Please show this video to anyone who doesn’t understand why the NIH is so important.
April 28, 2025 at 5:20 PM
Deaths from heart disease down 75%, that’s NIH.
Deaths from stroke down 75%, that’s NIH.
HIV/AIDS no longer a death sentence, that’s NIH.
99% of FDA approved drugs in the last decade, that’s NIH.
Please show this video to anyone who doesn’t understand why the NIH is so important.
Deaths from stroke down 75%, that’s NIH.
HIV/AIDS no longer a death sentence, that’s NIH.
99% of FDA approved drugs in the last decade, that’s NIH.
Please show this video to anyone who doesn’t understand why the NIH is so important.
Reposted by Adriaan
We've just posted an updated version of our metabolic trait GWAS preprint. The GWAS summary statistics are still the same as in October, but we've included several new follow-up analyses and completely rewritten the manuscript! See thread below for some highlights.
www.medrxiv.org/content/10.1...
www.medrxiv.org/content/10.1...
April 13, 2025 at 7:48 AM
We've just posted an updated version of our metabolic trait GWAS preprint. The GWAS summary statistics are still the same as in October, but we've included several new follow-up analyses and completely rewritten the manuscript! See thread below for some highlights.
www.medrxiv.org/content/10.1...
www.medrxiv.org/content/10.1...
Reposted by Adriaan
EMGM2025 abstract deadline extended – 09/02 (final). Conference 8-9 April, Brest, France. Everything statistical and population genetics, genetic epidemiology, bioinformatics… Invited speakers: Céline Bon, Beatriz Cuyabano, Garrett Hellenthal. emgm2025.sciencesconf.org
53rd European Mathematical Genetics Meeting - Sciencesconf.org
emgm2025.sciencesconf.org
February 2, 2025 at 3:40 PM
EMGM2025 abstract deadline extended – 09/02 (final). Conference 8-9 April, Brest, France. Everything statistical and population genetics, genetic epidemiology, bioinformatics… Invited speakers: Céline Bon, Beatriz Cuyabano, Garrett Hellenthal. emgm2025.sciencesconf.org
Reposted by Adriaan
🚨 Our preprint on parent-of-origin effects (POEs) is out!
With our novel method, we inferred the parental origin of alleles for >220,000 individuals, uncovering novel insights into genetics, evolution, and health.
👉 Read here: www.medrxiv.org/content/10.1...
👇 Highlights below!
With our novel method, we inferred the parental origin of alleles for >220,000 individuals, uncovering novel insights into genetics, evolution, and health.
👉 Read here: www.medrxiv.org/content/10.1...
👇 Highlights below!
Parent-of-Origin inference and its role in the genetic architecture of complex traits: evidence from ~220,000 individuals
Parent-of-origin effects (POEs) occur when the impact of a genetic variant depends on its parental origin. Traditionally linked to genomic imprinting, these effects are believed to have evolved from p...
www.medrxiv.org
December 6, 2024 at 12:12 PM
🚨 Our preprint on parent-of-origin effects (POEs) is out!
With our novel method, we inferred the parental origin of alleles for >220,000 individuals, uncovering novel insights into genetics, evolution, and health.
👉 Read here: www.medrxiv.org/content/10.1...
👇 Highlights below!
With our novel method, we inferred the parental origin of alleles for >220,000 individuals, uncovering novel insights into genetics, evolution, and health.
👉 Read here: www.medrxiv.org/content/10.1...
👇 Highlights below!
Reposted by Adriaan
So many awesome tools for complex trait genetics! 🧬
Great idea @michelnivard.bsky.social to create a repository listing them. I am learning about new ones every day at the moment, as people add to the repo
Add yours! 🤩
github.com/MichelNivard...
Great idea @michelnivard.bsky.social to create a repository listing them. I am learning about new ones every day at the moment, as people add to the repo
Add yours! 🤩
github.com/MichelNivard...
GitHub - MichelNivard/awesome-complex-trait-genetics: A list of awesome tools for complex trait genetics.
A list of awesome tools for complex trait genetics. - MichelNivard/awesome-complex-trait-genetics
github.com
December 3, 2024 at 11:23 AM
So many awesome tools for complex trait genetics! 🧬
Great idea @michelnivard.bsky.social to create a repository listing them. I am learning about new ones every day at the moment, as people add to the repo
Add yours! 🤩
github.com/MichelNivard...
Great idea @michelnivard.bsky.social to create a repository listing them. I am learning about new ones every day at the moment, as people add to the repo
Add yours! 🤩
github.com/MichelNivard...
Reposted by Adriaan
Visit the table of all #GWAS with #Metabolomics to read more about the latest #mQTL discoveries (updated 23 April 2024) wp.me/p6NCOp-2y
A Table of all published GWAS with metabolomics
Here you find references to all published mGWAS in humans, ordered by publication date. If a study is missing from this list, please let me know. Please note that I do not apply a strict inclusion …
wp.me
December 2, 2024 at 1:39 PM
Visit the table of all #GWAS with #Metabolomics to read more about the latest #mQTL discoveries (updated 23 April 2024) wp.me/p6NCOp-2y
Reposted by Adriaan
Hey, a question for the genetics community. Does genetic fine-mapping work well? How often does it miss?
We usually find that most fine-mapped variants do not fall within coding or regulatory regions. Is it a limitation of epigenomics or a limitation of fine-mapping? Please share your thoughts!
We usually find that most fine-mapped variants do not fall within coding or regulatory regions. Is it a limitation of epigenomics or a limitation of fine-mapping? Please share your thoughts!
November 19, 2024 at 7:56 PM
Hey, a question for the genetics community. Does genetic fine-mapping work well? How often does it miss?
We usually find that most fine-mapped variants do not fall within coding or regulatory regions. Is it a limitation of epigenomics or a limitation of fine-mapping? Please share your thoughts!
We usually find that most fine-mapped variants do not fall within coding or regulatory regions. Is it a limitation of epigenomics or a limitation of fine-mapping? Please share your thoughts!
Reposted by Adriaan
🚨NEW PREPRINT!
Interested in Mendelian randomization and proteomics? 🧬
We created a comprehensive multi-ancestry proteome-phenome-wide atlas of protein-disease associations in European, African, and East Asian ancestries!
Preprint: www.medrxiv.org/content/10.1...
Website: broad.io/protein_mr_a...
Interested in Mendelian randomization and proteomics? 🧬
We created a comprehensive multi-ancestry proteome-phenome-wide atlas of protein-disease associations in European, African, and East Asian ancestries!
Preprint: www.medrxiv.org/content/10.1...
Website: broad.io/protein_mr_a...
November 18, 2024 at 8:19 PM
🚨NEW PREPRINT!
Interested in Mendelian randomization and proteomics? 🧬
We created a comprehensive multi-ancestry proteome-phenome-wide atlas of protein-disease associations in European, African, and East Asian ancestries!
Preprint: www.medrxiv.org/content/10.1...
Website: broad.io/protein_mr_a...
Interested in Mendelian randomization and proteomics? 🧬
We created a comprehensive multi-ancestry proteome-phenome-wide atlas of protein-disease associations in European, African, and East Asian ancestries!
Preprint: www.medrxiv.org/content/10.1...
Website: broad.io/protein_mr_a...
Wanna do pleiotropy robust MR in a single region?
Introducing MR-link-2:
github.com/adriaan-vd-g...
Paper will be out soon, meanwhile some highlights:
1: MR-link-2 has superior AUC compared to MR and coloc methods
2: FPRs from 0.15 to 0.09
3: MR-link 2 results meaningfully deviate from other MR
Introducing MR-link-2:
github.com/adriaan-vd-g...
Paper will be out soon, meanwhile some highlights:
1: MR-link-2 has superior AUC compared to MR and coloc methods
2: FPRs from 0.15 to 0.09
3: MR-link 2 results meaningfully deviate from other MR
GitHub - adriaan-vd-graaf/mrlink2: MR-link 2 is a summary statistics _cis_ MR method that is pleiotr...
MR-link 2 is a summary statistics _cis_ MR method that is pleiotropy robust. - GitHub - adriaan-vd-graaf/mrlink2: MR-link 2 is a summary statistics _cis_ MR method that is pleiotropy robust.
github.com
December 21, 2023 at 10:08 AM
Wanna do pleiotropy robust MR in a single region?
Introducing MR-link-2:
github.com/adriaan-vd-g...
Paper will be out soon, meanwhile some highlights:
1: MR-link-2 has superior AUC compared to MR and coloc methods
2: FPRs from 0.15 to 0.09
3: MR-link 2 results meaningfully deviate from other MR
Introducing MR-link-2:
github.com/adriaan-vd-g...
Paper will be out soon, meanwhile some highlights:
1: MR-link-2 has superior AUC compared to MR and coloc methods
2: FPRs from 0.15 to 0.09
3: MR-link 2 results meaningfully deviate from other MR
In my work, I've been thinking about the genetic architecture of (all) human traits. Thinking of the following: Is there a way to prove that only one or two genetic variants are causal to a trait? So it's not 1000 or more snps in a region?
December 15, 2023 at 12:18 PM
In my work, I've been thinking about the genetic architecture of (all) human traits. Thinking of the following: Is there a way to prove that only one or two genetic variants are causal to a trait? So it's not 1000 or more snps in a region?