The Lancet Diabetes & Endocrinology
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Your leading source of international, cutting-edge research, review, and opinion in clinical #diabetes and #endocrinology. IF=41¡8.
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The Lancet is a weekly peer-reviewed general medical journal, founded in England in 1823. It is one of the world's highest-impact academic journals and also one of the oldest medical journals still in publication. .. more
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Read our December Issue, featuring familial hypercholesterolaemia, chronic kidney disease, type 2 diabetes, cyclic Cushingâs syndrome, primary aldosteronism, type 1 diabetes, menopause, obesity, iodine deficiency, & much more tinyurl.com/mwfu4c6m
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#MedSky #EndoSky #RenalSky #CardioSky
Severe #glucocorticoid-induced #osteoporosis requires a long-term sequential treatment approach consisting of a bone-anabolic agent followed by an antiresorptive drug www.thelancet.com/journals/lan...
#OpenAccess
#MedSky #EndoSky #RheumSky
#OpenAccess
#MedSky #EndoSky #RheumSky
Recent advances in research and care of familial hypercholesterolaemia
Heterozygous familial hypercholesterolaemia is a common, autosomal semi-dominant condition
characterised by elevation of LDL cholesterol from birth and early onset of atherosclerotic
cardiovascular di...
www.thelancet.com
Although #heterozygous #familial #hypercholesterolaemia was traditionally thought to affect approximately one in 500 individuals in the general population, multiple contemporary epidemiological studies have revealed that this condition is much more common www.thelancet.com/journals/lan...
#ASCVD
#ASCVD
Cardiovascular mortality trends among people with and without diabetes
Cardiovascular disease (CVD), a composite of coronary heart disease (CHD), cerebrovascular
disease, and heart failure, remains the leading cause of morbidity and mortality worldwide.
Although mortalit...
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Linked Comment by Ranjit Mohan Anjana:
#Cardiovascular mortality trends among people with and without #diabetes thelancet.com/journals/lan...
#T2D #ASCVD #heartfailure
#MedSky #EndoSky #CardioSky
#Cardiovascular mortality trends among people with and without #diabetes thelancet.com/journals/lan...
#T2D #ASCVD #heartfailure
#MedSky #EndoSky #CardioSky
Time trends in mortality from heart failure and atherosclerotic cardiovascular disease in people with and without diabetes: a multi-national population-based study
Declines in heart failure mortality in both people with and without diabetes were
less marked than were declines in CHD and cerebrovascular disease mortality in most
jurisdictions. Heart failure morta...
thelancet.com
Effective approaches to reducing #heartfailure mortality in people with & without #diabetes might be required; this could include appropriate targeting of existing cardioprotective therapies towards those at high risk of heart failure death thelancet.com/journals/lan...
#ASCVD
#EndoSky #CardioSky
#ASCVD
#EndoSky #CardioSky
Michael Roden comments on:
The long and winding road to precision diabetology thelancet.com/journals/lan... thelancet.com/journals/lan...
#diabetes #subgroups #PrecisionMedicine
#MedSky #EndoSky
The long and winding road to precision diabetology thelancet.com/journals/lan... thelancet.com/journals/lan...
#diabetes #subgroups #PrecisionMedicine
#MedSky #EndoSky
Comorbidities and mortality in subgroups of adults with diabetes with up to 14 years follow-up: a prospective cohort study in Sweden
Diabetes subgroups could inform on outcomes, as well as guide treatment and follow-up
needed for newly diagnosed individuals with diabetes. SIRD stands out as a high-risk
subgroup that is not identifi...
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NewâComorbidities and mortality in subgroups of adults with diabetes with up to 14 years follow-up: a prospective cohort study in Sweden thelancet.com/journals/lan...
#diabetes #subgroups #PrecisionMedicine
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#diabetes #subgroups #PrecisionMedicine
#MedSky #EndoSky
Reposted by The Lancet Diabetes Endocrinology
The Lancet
@thelancet.com
¡ 22h
Early-onset type 2 diabetes remains under-researched and undertreated.
A recent Series synthesises emerging evidence, highlighting urgent research gaps, and calls for population-level prevention & tailored care.
On #WorldDiabetesDay, explore the Series đ spkl.io/63321AjMM9
A recent Series synthesises emerging evidence, highlighting urgent research gaps, and calls for population-level prevention & tailored care.
On #WorldDiabetesDay, explore the Series đ spkl.io/63321AjMM9
Dissection of type 2 diabetes: a genetic perspective
Diabetes is a leading cause of global mortality and disability, and its economic burden
is substantial. This Review focuses on type 2 diabetes, which makes up 90â95% of all
diabetes cases. Type 2 diab...
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Although obesity & a sedentary lifestyle are considerable contributors, research over the last 25 years has shown that type 2 #diabetes develops on a predisposing #genetic background, with family & twin studies indicating considerable heritability www.thelancet.com/journals/lan...
#WorldDiabetesDay
#WorldDiabetesDay
Realigning diabetes regimens in older adults: a 4S Pathway to guide simplification and deprescribing strategies
Treating older people with diabetes is challenging due to multiple medical comorbidities
that might interfere with patients' ability to perform self-care. Most diabetes guidelines
focus on improving g...
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Most #diabetes guidelines focus on improving glycaemia through addition of medications, but few address strategies to reduce medication burden for older adultsâa concept known as deprescribing www.thelancet.com/journals/lan... #T1D #T2D #olderadults
#WorldDiabetesDay
#MedSky #EndoSky
#WorldDiabetesDay
#MedSky #EndoSky
Re-evaluating the concept of remission in type 2 diabetes: a call for patient-centric approaches
Controlling weight and cardiovascular risk factors is paramount in type 2 diabetes
management; however, the definition and feasibility of remission warrant closer examination.
Type 2 diabetes remissio...
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Re-evaluating the concept of #remission in type 2 #diabetes: a call for patient-centric approaches www.thelancet.com/journals/lan... #T2D
#WorldDiabetesDay
#MedSky #EndoSky
#WorldDiabetesDay
#MedSky #EndoSky
Reposted by The Lancet Diabetes Endocrinology
The Lancet
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¡ 1d
People with diabetes can face many challenges in the workplace.
On #WorldDiabetesDay, an Editorial in @thelancetendo.bsky.social explores how employers and employees can foster supportive, health-promoting workplaces that empower people with diabetes: spkl.io/63322Aj3Xj
On #WorldDiabetesDay, an Editorial in @thelancetendo.bsky.social explores how employers and employees can foster supportive, health-promoting workplaces that empower people with diabetes: spkl.io/63322Aj3Xj
Diabetes support at work: an unmet need
According to the latest edition of the IDF Diabetes Atlas, 589 million people around
the world were living with diabetes in 2024, with 70% being of working age. People
with diabetes face many challeng...
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Today, World Diabetes Day 2025, is a wake-up call to both employers and employees to create workplaces that empower people with #diabetes to thrive and promote health as a key part of work and life www.thelancet.com/journals/lan...
#FREE to read
#WorldDiabetesDay #DiabetesAtWork
#MedSky #EndoSky
#FREE to read
#WorldDiabetesDay #DiabetesAtWork
#MedSky #EndoSky
Reposted by The Lancet Diabetes Endocrinology
The Lancet
@thelancet.com
¡ 2d
Preventing disease through early intervention is a compelling alternative to chronic disease management.
A recent study investigated the safety & efficacy of oral insulin immunotherapy in children genetically at risk for type 1 diabetes: spkl.io/63326AjJ6O
A recent study investigated the safety & efficacy of oral insulin immunotherapy in children genetically at risk for type 1 diabetes: spkl.io/63326AjJ6O
Reposted by The Lancet Diabetes Endocrinology
The Lancet
@thelancet.com
¡ 2d
Despite major strides in the treatment and management of type 1 diabetes, the disease burden remains high.
A Seminar reviews the field of type 1 diabetes, and highlights progress, challenges to clinical care, & future directions in research: spkl.io/63324Ab7f4 #WorldDiabetesDay
A Seminar reviews the field of type 1 diabetes, and highlights progress, challenges to clinical care, & future directions in research: spkl.io/63324Ab7f4 #WorldDiabetesDay
Primary aldosteronism and plasma renin targets
Over the past two decades there have been tremendous advancements in the understanding
of both the prevalence and the clinical significance of primary aldosteronism. Where
previously only the most ext...
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Linked Comment by Kevin S Fay & Debbie L Cohen:
Primary #aldosteronism and plasma #renin targets www.thelancet.com/journals/lan...
#MedSky #EndoSky #CardioSky
Primary #aldosteronism and plasma #renin targets www.thelancet.com/journals/lan...
#MedSky #EndoSky #CardioSky
The association between unsuppressed #renin following medical therapy for primary #aldosteronism and reduced risk of cardiovascular events and all-cause mortality suggests that renin normalisation might serve as a therapeutic target www.thelancet.com/journals/lan...
#primary #aldosteronism
#EndoSky
#primary #aldosteronism
#EndoSky
Empagliflozin in chronic kidney disease: evidence for early, inclusive, and confident use
The scenario of chronic kidney disease (CKD) management has been transformed by the
advent of sodium glucose co-transporter-2 (SGLT2) inhibitors, a class of drugs with
benefits extending well beyond g...
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Also read the Linked Comment;
#Empagliflozin in chronic #kidney disease: evidence for early, inclusive, and confident use www.thelancet.com/journals/lan...
#CKD #T2D
#FREE to read with registration (also FREE)
#MedSky #endoSky #RenalSky
#Empagliflozin in chronic #kidney disease: evidence for early, inclusive, and confident use www.thelancet.com/journals/lan...
#CKD #T2D
#FREE to read with registration (also FREE)
#MedSky #endoSky #RenalSky
Effects of empagliflozin on conventional and exploratory acute and chronic kidney outcomes: an individual participant-level meta-analysis
SGLT2 inhibition reduces risk of acute and chronic kidney outcomes irrespective of
the size of the acute dip in eGFR. Kidney benefits are evident irrespective of diabetes
status, heart failure status,...
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#SGLT2 inhibition reduces risk of acute and chronic kidney outcomes irrespective of the size of the acute dip in eGFR www.thelancet.com/journals/lan...
#CKD #T2D
#OpenAccess
#MedSky #EndoSky #RenalSky
#CKD #T2D
#OpenAccess
#MedSky #EndoSky #RenalSky
Reposted by The Lancet Diabetes Endocrinology
The Lancet
@thelancet.com
¡ 3d
đŁ Big news! Weâre excited to announce the Advisory Board for The #LancetSummit: shaping the future of #diabetes prevention. Welcome Amanda Adler, Kamlesh Khunti, Dianna Magliano, Chantal Mathieu and Didac Mauricio Puente. Find out more and submit your abstract to join the Summit: hubs.li/Q03MV20T0
Life stage transitions for people with type 1 diabetes
Type 1 diabetes affects individuals of all ages, with different clinical priorities
and support needs at different stages of life. In this Personal View, we define the
two major transitions that occur...
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New in the December issue:
Life stage transitions for people with type 1 #diabetes www.thelancet.com/journals/lan...
#T1D
#MedSky #EndoSky
Life stage transitions for people with type 1 #diabetes www.thelancet.com/journals/lan...
#T1D
#MedSky #EndoSky
Diabetes support at work: an unmet need
According to the latest edition of the IDF Diabetes Atlas, 589 million people around
the world were living with diabetes in 2024, with 70% being of working age. People
with diabetes face many challeng...
thelancet.com
Ahead of World Diabetes Day, read our new December issue Editorial:
Diabetes support at work: an unmet need thelancet.com/journals/lan...
#FREE to read
#WorldDiabetesDay #DiabetesAtWork
#MedSky #EndoSky
Diabetes support at work: an unmet need thelancet.com/journals/lan...
#FREE to read
#WorldDiabetesDay #DiabetesAtWork
#MedSky #EndoSky
Hyperprolactinaemia can result from dopamine antagonist drug effects and reduced prolactin clearance with liver or kidney disease with loss of feedback regulation www.thelancet.com/journals/lan...
#hyperprolactinaemia #prolactinomas #pituitary
#MedSky #EndoSky
#hyperprolactinaemia #prolactinomas #pituitary
#MedSky #EndoSky
The road towards standardisation in cyclic Cushing's syndrome
Endogenous Cushing's syndrome is a severe, potentially lethal, endocrine condition.
It is well known for its pleomorphic clinical manifestations that often overlap with
those of frequent endocrine and...
thelancet.com
Dan Alexandru Niculescu comments on:
The road towards standardisation in cyclic Cushing's syndrome thelancet.com/journals/lan...
cyclic #Cushing's syndrome (#cCS)
#MedSky #EndoSky
The road towards standardisation in cyclic Cushing's syndrome thelancet.com/journals/lan...
cyclic #Cushing's syndrome (#cCS)
#MedSky #EndoSky
Cycle characterisation and clinical complications in patients with cyclic Cushing's syndrome: insights from an international retrospective cohort study
Even in specialised centres, cCS diagnosis and management remain challenging with
high rates of spontaneous adrenal insufficiency, inappropriate surgeries, and poor
outcomes. Ectopic cCS showed the mo...
thelancet.com
Cycle characterisation and clinical complications in patients with cyclic Cushing's syndrome: insights from an international retrospective cohort study thelancet.com/journals/lan...
cyclic #Cushing's syndrome (#cCS)
#MedSky #EndoSky
cyclic #Cushing's syndrome (#cCS)
#MedSky #EndoSky
Glucocorticoid-induced osteoporosis: novel concepts and clinical implications
Despite advances in targeted therapies, treatment with glucocorticoids remains a mainstay
in the management of various immune-mediated diseases. High cumulative doses of exogenous
glucocorticoids lead...
thelancet.com
Fragility #fractures remain a common & serious complication of long-term oral #glucocorticoid therapy that might affect all skeletal sites, although the spine is particularly prone to fractures owing to its high proportion of trabecular bone thelancet.com/journals/lan...
#OpenAccess
#MedSky #EndoSky
#OpenAccess
#MedSky #EndoSky
Current efforts to manage #diabetes appear to have narrowed the gap between people with and without diabetes in terms of
#atherosclerotic #cardiovascular disease mortality, but not in terms of heart failure mortality www.thelancet.com/journals/lan...
#T2D #heartfailure #ASCVD
#EndoSky #CardioSky
#atherosclerotic #cardiovascular disease mortality, but not in terms of heart failure mortality www.thelancet.com/journals/lan...
#T2D #heartfailure #ASCVD
#EndoSky #CardioSky
Recent advances in research and care of familial hypercholesterolaemia
Heterozygous familial hypercholesterolaemia is a common, autosomal semi-dominant condition
characterised by elevation of LDL cholesterol from birth and early onset of atherosclerotic
cardiovascular di...
www.thelancet.com
Heterozygous familial #hypercholesterolaemia is a common, autosomal semi-dominant condition characterised by elevation of #LDL #cholesterol from birth and early onset of #atherosclerotic #cardiovascular disease www.thelancet.com/journals/lan...
#HeFH #ASCVD
#MedSky #EndoSky #CardioSky
#HeFH #ASCVD
#MedSky #EndoSky #CardioSky
From reproduction to metabolism: FSH as a key modulator in menopause
Follicle-stimulating hormone (FSH), a glycoprotein secreted by gonadotroph cells of
the anterior pituitary, is classically known as a key regulator of reproduction in
both sexes, acting mainly on the ...
www.thelancet.com
Interventions targeting #FSH signalling could offer an integrated strategy to counteract #female #age-related metabolic changes, harmonising bone, adipose, and systemic energy regulation www.thelancet.com/journals/lan...
#follicle-stimulating hormone #menopause
#MedSky #EndoSky #WomensHealthSky
#follicle-stimulating hormone #menopause
#MedSky #EndoSky #WomensHealthSky
Redifferentiation therapy in unresectable or metastatic radioactive iodine refractory thyroid cancer: an International Thyroid Oncology Group statement
In patients with follicular cell-derived thyroid cancer that have distant metastases
and no iodine uptake, redifferentiationâie, the restoration of tumoural 131I uptake
with systemic therapyâis now po...
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In patients with follicular cell-derived #thyroid #cancer that have distant metastases and no iodine uptake, #redifferentiationâie, the restoration of tumoural 131I uptake with systemic therapyâis now possible www.thelancet.com/journals/lan...
#thyroidcancer
#OpenAccess
#MedSky #EndoSky #OncSky
#thyroidcancer
#OpenAccess
#MedSky #EndoSky #OncSky