ZahadyV.bsky.social
@zahadyv.bsky.social
Host-parasite interaction. Passionate about exploring how Toxoplasma and Neospora induce host cell genome instability. #JLUgiessen.
Pinned
ZahadyV.bsky.social
@zahadyv.bsky.social
· Jun 18
Could the answer to the male fertility crisis be lurking in your cat’s litter tray?
Discovery that the world’s most successful parasite can ‘decapitate’ sperm offers a new path to understanding rising infertility among men
www.telegraph.co.uk
Excited to see our collaborative research featured in the Telegraph! Grateful for the amazing team effort behind it and hopeful it helps raise awareness about toxoplasmosis in men. Thanks @arthurscottgeddes.bsky.social for highlighting our research! www.telegraph.co.uk/global-healt... #Toxoplasmosis
Reposted by ZahadyV.bsky.social
Our paper has finally graduated from pre-print to peer-reviewed, pretty much unscathed, and is out now! www.cell.com/cell/fulltex...
The essential host genome for Cryptosporidium survival exposes metabolic dependencies that can be leveraged for treatment
An arrayed microscopy-based CRISPR screen revealed host genes affecting multiple infection
phenotypes of the intracellular parasite Cryptosporidium. Hits in the host cholesterol
biosynthesis pathway a...
www.cell.com
July 24, 2025 at 2:08 PM
Our paper has finally graduated from pre-print to peer-reviewed, pretty much unscathed, and is out now! www.cell.com/cell/fulltex...
Reposted by ZahadyV.bsky.social
Such a fascinating, albeit terrifying study! In case you didn't see it, the study was also covered in @theconversation.com
theconversation.com/a-common-par...
theconversation.com/a-common-par...
A common parasite can decapitate human sperm − with implications for male fertility
If you’ve handled cat litter or eaten raw meat or unwashed produce, there’s a chance you might have a permanent toxoplasmosis infection spread throughout your body.
theconversation.com
June 19, 2025 at 3:47 PM
Such a fascinating, albeit terrifying study! In case you didn't see it, the study was also covered in @theconversation.com
theconversation.com/a-common-par...
theconversation.com/a-common-par...
Reposted by ZahadyV.bsky.social
Could the answer to the male fertility crisis be lurking in your cat’s litter tray?
Discovery that the world’s most successful parasite can ‘decapitate’ sperm offers a new path to understanding rising infertility among men
✍️ @arthurscottgeddes.bsky.social
www.telegraph.co.uk/global-healt...
Discovery that the world’s most successful parasite can ‘decapitate’ sperm offers a new path to understanding rising infertility among men
✍️ @arthurscottgeddes.bsky.social
www.telegraph.co.uk/global-healt...
Could the answer to the male fertility crisis be lurking in your cat’s litter tray?
Discovery that the world’s most successful parasite can ‘decapitate’ sperm offers a new path to understanding rising infertility among men
www.telegraph.co.uk
June 19, 2025 at 7:06 AM
Could the answer to the male fertility crisis be lurking in your cat’s litter tray?
Discovery that the world’s most successful parasite can ‘decapitate’ sperm offers a new path to understanding rising infertility among men
✍️ @arthurscottgeddes.bsky.social
www.telegraph.co.uk/global-healt...
Discovery that the world’s most successful parasite can ‘decapitate’ sperm offers a new path to understanding rising infertility among men
✍️ @arthurscottgeddes.bsky.social
www.telegraph.co.uk/global-healt...
Excited to see our collaborative research featured in the Telegraph! Grateful for the amazing team effort behind it and hopeful it helps raise awareness about toxoplasmosis in men. Thanks @arthurscottgeddes.bsky.social for highlighting our research! www.telegraph.co.uk/global-healt... #Toxoplasmosis
Could the answer to the male fertility crisis be lurking in your cat’s litter tray?
Discovery that the world’s most successful parasite can ‘decapitate’ sperm offers a new path to understanding rising infertility among men
www.telegraph.co.uk
June 18, 2025 at 11:42 AM
Excited to see our collaborative research featured in the Telegraph! Grateful for the amazing team effort behind it and hopeful it helps raise awareness about toxoplasmosis in men. Thanks @arthurscottgeddes.bsky.social for highlighting our research! www.telegraph.co.uk/global-healt... #Toxoplasmosis
Reposted by ZahadyV.bsky.social
It turns out the world’s most successful parasite can ‘decapitate’ sperm. For @telglobalhealth.bsky.social I wrote about the implications of this discovery for our understanding of the male infertility crisis. With thanks to @zahadyv.bsky.social and Bill Sullivan
www.telegraph.co.uk/global-healt...
www.telegraph.co.uk/global-healt...
Could the answer to the male fertility crisis be lurking in your cat’s litter tray?
Discovery that the world’s most successful parasite can ‘decapitate’ sperm offers a new path to understanding rising infertility among men
www.telegraph.co.uk
June 18, 2025 at 9:58 AM
It turns out the world’s most successful parasite can ‘decapitate’ sperm. For @telglobalhealth.bsky.social I wrote about the implications of this discovery for our understanding of the male infertility crisis. With thanks to @zahadyv.bsky.social and Bill Sullivan
www.telegraph.co.uk/global-healt...
www.telegraph.co.uk/global-healt...
Reposted by ZahadyV.bsky.social
🧵 Ever wondered what Toxoplasma is doing in your brain years after that undercooked steak 🥩 or a sip of contaminated water? Turns out, it's been hiding in your brain 🧠and we finally have a way to spot it. New study just dropped in EMBO Molecular Medicine 👇
doi.org/10.1038/s443...
doi.org/10.1038/s443...
Uncovering biomarkers for chronic toxoplasmosis detection highlights alternative pathways shaping parasite dormancy | EMBO Molecular Medicine
imageimageDespite their clinical relevance, bradyzoite-filled cysts - the hallmark of chronic
toxoplasmosis - are largely overlooked in current diagnostics. This study highlights
bradyzoite serologica...
doi.org
May 19, 2025 at 10:31 AM
🧵 Ever wondered what Toxoplasma is doing in your brain years after that undercooked steak 🥩 or a sip of contaminated water? Turns out, it's been hiding in your brain 🧠and we finally have a way to spot it. New study just dropped in EMBO Molecular Medicine 👇
doi.org/10.1038/s443...
doi.org/10.1038/s443...
🚨New Research: Adverse impact of acute Toxoplasma gondii infection on human spermatozoa- The FEBS Journal - febs.onlinelibrary.wiley.com/doi/10.1111/.... Thanks to @mariaefrancia.bsky.social Lab and all wonderful people who collaborate to make this possible. Here below what we found :).
FEBS Press
Toxoplasma gondii tachyzoites injected intraperitoneally crossed the blood-testes barrier, appearing in testes/epididymis by day 6 post-infection. In vitro exposure caused increased sperm necrosis/ap...
febs.onlinelibrary.wiley.com
May 4, 2025 at 8:54 AM
🚨New Research: Adverse impact of acute Toxoplasma gondii infection on human spermatozoa- The FEBS Journal - febs.onlinelibrary.wiley.com/doi/10.1111/.... Thanks to @mariaefrancia.bsky.social Lab and all wonderful people who collaborate to make this possible. Here below what we found :).
Reposted by ZahadyV.bsky.social
🎉 Finally online 🎉 GRA12, the first identified common virulence factor across Toxoplasma strains and murine subspecies! Check this improved manuscript after reviewers’ helpful suggestions www.nature.com/articles/s41...
GRA12 is a common virulence factor across Toxoplasma gondii strains and mouse subspecies - Nature Communications
CRISPR screens reveal Toxoplasma’s GRA12 as a strain- and mouse species-transcendent virulence factor. GRA12 protects parasites from IFNγ-activated macrophage clearance and parasitophorous vacuole col...
www.nature.com
April 16, 2025 at 9:57 AM
🎉 Finally online 🎉 GRA12, the first identified common virulence factor across Toxoplasma strains and murine subspecies! Check this improved manuscript after reviewers’ helpful suggestions www.nature.com/articles/s41...
Reposted by ZahadyV.bsky.social
Delighted to share our study on a major Toxoplasma virulence factor that prevents lytic host cell death.
Many thanks to @parafrap.bsky.social for support, constructive reviews and all labs involved: Melissa Lodoen, Hiba El Hajj, @gissotlab.bsky.social, Karine Le Roch
Link : rdcu.be/d6m3G
Many thanks to @parafrap.bsky.social for support, constructive reviews and all labs involved: Melissa Lodoen, Hiba El Hajj, @gissotlab.bsky.social, Karine Le Roch
Link : rdcu.be/d6m3G
The Toxoplasma rhoptry protein ROP55 is a major virulence factor that prevents lytic host cell death
Nature Communications - Ruivo et al uncover a Toxoplasma survival mechanism conserved across different cell types and species. By repressing NF-kB activation and lytic host cell death pathways, the...
rdcu.be
January 16, 2025 at 1:35 PM
Delighted to share our study on a major Toxoplasma virulence factor that prevents lytic host cell death.
Many thanks to @parafrap.bsky.social for support, constructive reviews and all labs involved: Melissa Lodoen, Hiba El Hajj, @gissotlab.bsky.social, Karine Le Roch
Link : rdcu.be/d6m3G
Many thanks to @parafrap.bsky.social for support, constructive reviews and all labs involved: Melissa Lodoen, Hiba El Hajj, @gissotlab.bsky.social, Karine Le Roch
Link : rdcu.be/d6m3G
📣New Study Alert!
Toxoplasma gondii arrests host cell cycle early p.i. in a MYR1-dependent manner, inducing DNA damage and genome instability. This work unveils new insights into host-parasite interactions and the mechanisms driving cell cycle modulation.
rdcu.be/d3IxO #Toxoplasma #CellCycle
Toxoplasma gondii arrests host cell cycle early p.i. in a MYR1-dependent manner, inducing DNA damage and genome instability. This work unveils new insights into host-parasite interactions and the mechanisms driving cell cycle modulation.
rdcu.be/d3IxO #Toxoplasma #CellCycle
Toxoplasma gondii infection induces early host cell cycle arrest and DNA damage in primary human host cells by a MYR1-dependent mechanism
Communications Biology - Early T. gondii infection induces host S-phase arrest and DNA breaks, with binucleation and micronuclei formation observed by 3 h p.i., indicating genomic...
rdcu.be
December 16, 2024 at 2:02 PM
📣New Study Alert!
Toxoplasma gondii arrests host cell cycle early p.i. in a MYR1-dependent manner, inducing DNA damage and genome instability. This work unveils new insights into host-parasite interactions and the mechanisms driving cell cycle modulation.
rdcu.be/d3IxO #Toxoplasma #CellCycle
Toxoplasma gondii arrests host cell cycle early p.i. in a MYR1-dependent manner, inducing DNA damage and genome instability. This work unveils new insights into host-parasite interactions and the mechanisms driving cell cycle modulation.
rdcu.be/d3IxO #Toxoplasma #CellCycle
Reposted by ZahadyV.bsky.social
Have you ever wondered how knocking out every single gene in the human genome, one by one, might affect your intracellular pathogen of interest? We did, & boy was it a wild ride! Happy to share our preprint discovering the essential host genome for Cryptosporidium -
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
December 6, 2024 at 1:15 PM
Have you ever wondered how knocking out every single gene in the human genome, one by one, might affect your intracellular pathogen of interest? We did, & boy was it a wild ride! Happy to share our preprint discovering the essential host genome for Cryptosporidium -
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by ZahadyV.bsky.social
Cryptosporidium is an important public health threat, and it deserves better genetic tools to study it! Here we’ve developed a targeted in vivo CRISPR genetic screen to identify parasite genes required for survival and virulence…
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
November 23, 2024 at 1:29 PM
Cryptosporidium is an important public health threat, and it deserves better genetic tools to study it! Here we’ve developed a targeted in vivo CRISPR genetic screen to identify parasite genes required for survival and virulence…
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by ZahadyV.bsky.social
📣📣📣
Come join us and set up your team in the I2BC Cell Bio Dept!
You will find great science, diverse topics and models, spacious labs, supportive environment, and fun colleagues. We are a short (train) ride south of Paris.
Please DM me with any questions and help us spread the word 🙏
Come join us and set up your team in the I2BC Cell Bio Dept!
You will find great science, diverse topics and models, spacious labs, supportive environment, and fun colleagues. We are a short (train) ride south of Paris.
Please DM me with any questions and help us spread the word 🙏
November 25, 2024 at 11:05 AM
📣📣📣
Come join us and set up your team in the I2BC Cell Bio Dept!
You will find great science, diverse topics and models, spacious labs, supportive environment, and fun colleagues. We are a short (train) ride south of Paris.
Please DM me with any questions and help us spread the word 🙏
Come join us and set up your team in the I2BC Cell Bio Dept!
You will find great science, diverse topics and models, spacious labs, supportive environment, and fun colleagues. We are a short (train) ride south of Paris.
Please DM me with any questions and help us spread the word 🙏
Reposted by ZahadyV.bsky.social
Excited for my first bluesky post announcing TWO openings for tenure track positions in virology! I am chair of the search committee and with a new department head Mike Gale we are in an exciting building phase.
Please share with anyone who might be interested: hr.myu.umn.edu/jobs/ext/365...
Please share with anyone who might be interested: hr.myu.umn.edu/jobs/ext/365...
hr.myu.umn.edu
November 22, 2024 at 6:54 PM
Excited for my first bluesky post announcing TWO openings for tenure track positions in virology! I am chair of the search committee and with a new department head Mike Gale we are in an exciting building phase.
Please share with anyone who might be interested: hr.myu.umn.edu/jobs/ext/365...
Please share with anyone who might be interested: hr.myu.umn.edu/jobs/ext/365...
Reposted by ZahadyV.bsky.social
📣 We are hiring!
A 3-year postdoctoral position is available to work on 3D lymphoid organ models at the Pasteur Institute in Paris. The project aims to develop a lymphoid organ-on-chip model and to apply it to the testing of candidate mRNA vaccines.
@pasteur.fr #postdoc #microfluidics #immunology
A 3-year postdoctoral position is available to work on 3D lymphoid organ models at the Pasteur Institute in Paris. The project aims to develop a lymphoid organ-on-chip model and to apply it to the testing of candidate mRNA vaccines.
@pasteur.fr #postdoc #microfluidics #immunology
November 22, 2024 at 5:15 PM
📣 We are hiring!
A 3-year postdoctoral position is available to work on 3D lymphoid organ models at the Pasteur Institute in Paris. The project aims to develop a lymphoid organ-on-chip model and to apply it to the testing of candidate mRNA vaccines.
@pasteur.fr #postdoc #microfluidics #immunology
A 3-year postdoctoral position is available to work on 3D lymphoid organ models at the Pasteur Institute in Paris. The project aims to develop a lymphoid organ-on-chip model and to apply it to the testing of candidate mRNA vaccines.
@pasteur.fr #postdoc #microfluidics #immunology
Reposted by ZahadyV.bsky.social
Hiring! I'm looking for a postdoc in machine learning of spatial single-cell data. Exciting project to develop methods for modelling cellular circuits in disease and regeneration of heart, liver and bone marrow using Xenium data from our lab.
tinyurl.com/ymkvk7vn
tinyurl.com/ymkvk7vn
November 20, 2024 at 8:07 AM
Hiring! I'm looking for a postdoc in machine learning of spatial single-cell data. Exciting project to develop methods for modelling cellular circuits in disease and regeneration of heart, liver and bone marrow using Xenium data from our lab.
tinyurl.com/ymkvk7vn
tinyurl.com/ymkvk7vn
Reposted by ZahadyV.bsky.social
Interested in tissue immunity in infection, focusing on adipose tissue, brain and immunometabolism?
Then come join me & @juanquintana.bsky.social at
@lydiabeckeriii.bsky.social as a
research assistant
Email to arrange
an informal chat 🧪 #ImmunoSky #LGBTQSTEM www.jobs.manchester.ac.uk/Job/JobDetai...
Then come join me & @juanquintana.bsky.social at
@lydiabeckeriii.bsky.social as a
research assistant
Email to arrange
an informal chat 🧪 #ImmunoSky #LGBTQSTEM www.jobs.manchester.ac.uk/Job/JobDetai...
Research Assistant in Tissue Immunology:Oxford Road
www.jobs.manchester.ac.uk
November 20, 2024 at 7:38 PM
Interested in tissue immunity in infection, focusing on adipose tissue, brain and immunometabolism?
Then come join me & @juanquintana.bsky.social at
@lydiabeckeriii.bsky.social as a
research assistant
Email to arrange
an informal chat 🧪 #ImmunoSky #LGBTQSTEM www.jobs.manchester.ac.uk/Job/JobDetai...
Then come join me & @juanquintana.bsky.social at
@lydiabeckeriii.bsky.social as a
research assistant
Email to arrange
an informal chat 🧪 #ImmunoSky #LGBTQSTEM www.jobs.manchester.ac.uk/Job/JobDetai...
Reposted by ZahadyV.bsky.social
My goal is to understand the regulatory role of every nucleotide in the genome, and how this changes across every cell in the human body.
If you are interested in doing a Ph.D. with me at UMass Chan Medical (Genomics and Comp Bio Department), see the links below. Deadline is Dec 1st.
If you are interested in doing a Ph.D. with me at UMass Chan Medical (Genomics and Comp Bio Department), see the links below. Deadline is Dec 1st.
November 18, 2024 at 6:22 PM
My goal is to understand the regulatory role of every nucleotide in the genome, and how this changes across every cell in the human body.
If you are interested in doing a Ph.D. with me at UMass Chan Medical (Genomics and Comp Bio Department), see the links below. Deadline is Dec 1st.
If you are interested in doing a Ph.D. with me at UMass Chan Medical (Genomics and Comp Bio Department), see the links below. Deadline is Dec 1st.
Reposted by ZahadyV.bsky.social
🚨🪅 Registration is NOW OPEN for our Symposium on Ancient Pathogen Genomics! 🦠🧬 Join us on April 12-13 2025 in Juriquilla, Mexico. Featuring top speakers & great science in a beautiful venue! Plz RT !
liigh.unam.mx/apg/ 🪅🚨
liigh.unam.mx/apg/ 🪅🚨
Ancient Pathogens Genomics International Symposium
liigh.unam.mx
November 18, 2024 at 12:39 AM
🚨🪅 Registration is NOW OPEN for our Symposium on Ancient Pathogen Genomics! 🦠🧬 Join us on April 12-13 2025 in Juriquilla, Mexico. Featuring top speakers & great science in a beautiful venue! Plz RT !
liigh.unam.mx/apg/ 🪅🚨
liigh.unam.mx/apg/ 🪅🚨
Reposted by ZahadyV.bsky.social
Now that half of SciTwitter is here…
Come be my colleague!
The Dept of Cell Biology @EmoryUniversity is recruiting a developmental cell biologist.
🔬Do you study mechanisms of development using cell biological (and other) approaches? Join us!🔬
TY for RT!
jobs.sciencecareers.org/job/664684/t...
Come be my colleague!
The Dept of Cell Biology @EmoryUniversity is recruiting a developmental cell biologist.
🔬Do you study mechanisms of development using cell biological (and other) approaches? Join us!🔬
TY for RT!
jobs.sciencecareers.org/job/664684/t...
Tenure-track Faculty position in Cell and Developmental Biology - Atlanta, Georgia job with Emory University | 664684
This search is open to investigators conducting mechanistic studies of developmental cell biology using genetically tractable model organisms.
jobs.sciencecareers.org
November 12, 2024 at 6:37 PM
Now that half of SciTwitter is here…
Come be my colleague!
The Dept of Cell Biology @EmoryUniversity is recruiting a developmental cell biologist.
🔬Do you study mechanisms of development using cell biological (and other) approaches? Join us!🔬
TY for RT!
jobs.sciencecareers.org/job/664684/t...
Come be my colleague!
The Dept of Cell Biology @EmoryUniversity is recruiting a developmental cell biologist.
🔬Do you study mechanisms of development using cell biological (and other) approaches? Join us!🔬
TY for RT!
jobs.sciencecareers.org/job/664684/t...
Reposted by ZahadyV.bsky.social
Woohoo! The JCS Special Issue on Imaging Cell Architecture and Dynamics is complete, featuring our poster on ‘Imaging interorganelle contacts at a glance”!
Journal of Cell Science Special Issue on Imaging Cell Architecture and Dynamics is now complete.
You can explore our ToC here:
journals.biologists.com/jcs/issue/13...
‘Breaking symmetry’ from Antara Chakraborty was the winning image from the cover competition with JCS and FocalPlane.
You can explore our ToC here:
journals.biologists.com/jcs/issue/13...
‘Breaking symmetry’ from Antara Chakraborty was the winning image from the cover competition with JCS and FocalPlane.
November 15, 2024 at 3:24 PM
Woohoo! The JCS Special Issue on Imaging Cell Architecture and Dynamics is complete, featuring our poster on ‘Imaging interorganelle contacts at a glance”!
We are thrilled to share with you that different Toxoplasma gondii tachyzoites haplotypes infection induce DNA damage and micronuclei in host primary cells!. Thanks to our lab team for this beautiful work www.frontiersin.org/articles/10....
Toxoplasma gondii infection-induced host cellular DNA damage is strain-dependent and leads to the activation of the ATM-dependent homologous recombination pathway
Toxoplasma gondii is a globally occurring apicomplexan parasite that infects humans and animals. Globally, different typical and atypical haplotypes of T. gondii induce varying pathologies in hosts. A...
www.frontiersin.org
March 8, 2024 at 4:50 AM
We are thrilled to share with you that different Toxoplasma gondii tachyzoites haplotypes infection induce DNA damage and micronuclei in host primary cells!. Thanks to our lab team for this beautiful work www.frontiersin.org/articles/10....
Do you know that ME49 and NED #Toxoplasma tachyzoites arrest its host cell cycle and cytokinesis? Come and read it here: frontiersin.org/journals/micro…. Thanks to all authors and reviewers for their valuable comments!
February 28, 2024 at 5:50 PM
Do you know that ME49 and NED #Toxoplasma tachyzoites arrest its host cell cycle and cytokinesis? Come and read it here: frontiersin.org/journals/micro…. Thanks to all authors and reviewers for their valuable comments!