Yara Sanchez
@ysanchez.bsky.social
Computational Research Fellow @UCLchildhealth @GGM_ICH Interested in understanding the molecular basis of human development and disease using -omics& images&AI
🚨 New preprint out!
“Spatially resolved fetal and maternal cell contributions to severe preeclampsia”
Years of work using single-cell + spatial transcriptomics to study the fetal-maternal interface.
Proud to share: www.biorxiv.org/content/10.1...
🧬🤰🧪@uclpophealthsci.bsky.social
“Spatially resolved fetal and maternal cell contributions to severe preeclampsia”
Years of work using single-cell + spatial transcriptomics to study the fetal-maternal interface.
Proud to share: www.biorxiv.org/content/10.1...
🧬🤰🧪@uclpophealthsci.bsky.social
Spatially resolved fetal and maternal cell contributions to severe Preeclampsia
The molecular and cellular pathophysiology of the fetal-maternal interface in preeclamsia remains poorly understood, but it is increasingly clear that both fetus and mother make independent contributi...
www.biorxiv.org
July 23, 2025 at 9:33 AM
🚨 New preprint out!
“Spatially resolved fetal and maternal cell contributions to severe preeclampsia”
Years of work using single-cell + spatial transcriptomics to study the fetal-maternal interface.
Proud to share: www.biorxiv.org/content/10.1...
🧬🤰🧪@uclpophealthsci.bsky.social
“Spatially resolved fetal and maternal cell contributions to severe preeclampsia”
Years of work using single-cell + spatial transcriptomics to study the fetal-maternal interface.
Proud to share: www.biorxiv.org/content/10.1...
🧬🤰🧪@uclpophealthsci.bsky.social
Reposted by Yara Sanchez
👶🏼 Many #vaccines are not effective in newborns. So how do we protect them from infectious disease?
🤰🏽 By vaccination in #pregnancy!
Here we review…
💉 Established campaigns vs whooping cough, flu, COVID
💡 New approaches to RSV, GBS
🌈 Future challenges, opportunities
#ReproSky #ImmunoSky #IDSky
🤰🏽 By vaccination in #pregnancy!
Here we review…
💉 Established campaigns vs whooping cough, flu, COVID
💡 New approaches to RSV, GBS
🌈 Future challenges, opportunities
#ReproSky #ImmunoSky #IDSky
Vaccination in pregnancy to protect the newborn - Nature Reviews Immunology
In this Review, Male and Jones provide an overview of the current vaccines that are offered during pregnancy and to newborns, explaining the rationale behind the different vaccination programmes and t...
www.nature.com
April 24, 2025 at 6:21 AM
👶🏼 Many #vaccines are not effective in newborns. So how do we protect them from infectious disease?
🤰🏽 By vaccination in #pregnancy!
Here we review…
💉 Established campaigns vs whooping cough, flu, COVID
💡 New approaches to RSV, GBS
🌈 Future challenges, opportunities
#ReproSky #ImmunoSky #IDSky
🤰🏽 By vaccination in #pregnancy!
Here we review…
💉 Established campaigns vs whooping cough, flu, COVID
💡 New approaches to RSV, GBS
🌈 Future challenges, opportunities
#ReproSky #ImmunoSky #IDSky
Reposted by Yara Sanchez
Ever wondered how organs take shape? Join us to find out!
The Organ Mechanobiology Lab @ncbsbangalore.bsky.social is recruiting Graduate Trainees. Perfect for final-year students curious about tissue mechanics, development & cell biology.
Check out the ad below 👇 Please RT! Thanks🙏
The Organ Mechanobiology Lab @ncbsbangalore.bsky.social is recruiting Graduate Trainees. Perfect for final-year students curious about tissue mechanics, development & cell biology.
Check out the ad below 👇 Please RT! Thanks🙏
April 10, 2025 at 9:59 AM
Ever wondered how organs take shape? Join us to find out!
The Organ Mechanobiology Lab @ncbsbangalore.bsky.social is recruiting Graduate Trainees. Perfect for final-year students curious about tissue mechanics, development & cell biology.
Check out the ad below 👇 Please RT! Thanks🙏
The Organ Mechanobiology Lab @ncbsbangalore.bsky.social is recruiting Graduate Trainees. Perfect for final-year students curious about tissue mechanics, development & cell biology.
Check out the ad below 👇 Please RT! Thanks🙏
Reposted by Yara Sanchez
Short read sequencing
April 3, 2025 at 6:08 PM
Short read sequencing
Reposted by Yara Sanchez
Excited to share our new study revealing the intricate dynamics of pregnancy & postpartum physiology! We analyzed 40M lab tests from 300K pregnancies and 160K women (cross-sectional) and mapped week-by-week changes starting from preconception to months-long postpartum recovery.
March 27, 2025 at 12:44 PM
Excited to share our new study revealing the intricate dynamics of pregnancy & postpartum physiology! We analyzed 40M lab tests from 300K pregnancies and 160K women (cross-sectional) and mapped week-by-week changes starting from preconception to months-long postpartum recovery.
Reposted by Yara Sanchez
1) I am delighted to share a manuscript long in the making (7 years), elucidating the forces that shape metastatic adaptation PDAC using scRNA-seq across multiple organs from a rapid autopsy combined with a powerful new clonal phylogeny inference algorithm www.biorxiv.org/content/10.1...
Transcriptomic plasticity is a hallmark of metastatic pancreatic cancer
Metastasis is the leading cause of cancer deaths; nonetheless, how tumor cells adapt to vastly different organ contexts is largely unknown. To investigate this question, we generated a transcriptomic ...
www.biorxiv.org
March 7, 2025 at 11:26 AM
1) I am delighted to share a manuscript long in the making (7 years), elucidating the forces that shape metastatic adaptation PDAC using scRNA-seq across multiple organs from a rapid autopsy combined with a powerful new clonal phylogeny inference algorithm www.biorxiv.org/content/10.1...
Reposted by Yara Sanchez
Have you received a Travelling Fellowship from @biologists.bsky.social to visit another lab?
We're collecting stories from you, our community, about your experience and how this has impacted your career. #biologists100
Share your story by sending us a digital 'message in a bottle'✍️
We're collecting stories from you, our community, about your experience and how this has impacted your career. #biologists100
Share your story by sending us a digital 'message in a bottle'✍️
Are you the recipient of a Travelling Fellowship? Tell us your story - the Node
Did you know that The Company of Biologists’ journals - Development, Journal of Cell Science, Journal of Experimental Biology and
thenode.biologists.com
February 28, 2025 at 2:33 PM
Have you received a Travelling Fellowship from @biologists.bsky.social to visit another lab?
We're collecting stories from you, our community, about your experience and how this has impacted your career. #biologists100
Share your story by sending us a digital 'message in a bottle'✍️
We're collecting stories from you, our community, about your experience and how this has impacted your career. #biologists100
Share your story by sending us a digital 'message in a bottle'✍️
Reposted by Yara Sanchez
I’m disappointed by @cziscience.bsky.social’s decision to discontinue the Science Diversity Leadership Award
chanzuckerberg.com/rfa/science-... no longer exists. But we exist & science needs us❤️🔥
👀 previous info at web.archive.org/web/20250130...
I’m among those who had written a Letter of Intent
chanzuckerberg.com/rfa/science-... no longer exists. But we exist & science needs us❤️🔥
👀 previous info at web.archive.org/web/20250130...
I’m among those who had written a Letter of Intent
Supporting Scientific Research to Cure All Diseases
We’re investing in new technology and collaborative research to cure all disease by 2100
chanzuckerberg.com
February 19, 2025 at 3:23 AM
I’m disappointed by @cziscience.bsky.social’s decision to discontinue the Science Diversity Leadership Award
chanzuckerberg.com/rfa/science-... no longer exists. But we exist & science needs us❤️🔥
👀 previous info at web.archive.org/web/20250130...
I’m among those who had written a Letter of Intent
chanzuckerberg.com/rfa/science-... no longer exists. But we exist & science needs us❤️🔥
👀 previous info at web.archive.org/web/20250130...
I’m among those who had written a Letter of Intent
Reposted by Yara Sanchez
Disease diagnostics using machine learning of B cell and T cell receptor sequences
www.science.org/doi/10.1126/...
TL;DR: BCRs ARE ALL YOU NEED!
(Well actually .... keep reading) 1/
www.science.org/doi/10.1126/...
TL;DR: BCRs ARE ALL YOU NEED!
(Well actually .... keep reading) 1/
Disease diagnostics using machine learning of B cell and T cell receptor sequences
Clinical diagnosis typically incorporates physical examination, patient history, various laboratory tests, and imaging studies but makes limited use of the human immune system’s own record of antigen ...
www.science.org
February 21, 2025 at 1:12 AM
Disease diagnostics using machine learning of B cell and T cell receptor sequences
www.science.org/doi/10.1126/...
TL;DR: BCRs ARE ALL YOU NEED!
(Well actually .... keep reading) 1/
www.science.org/doi/10.1126/...
TL;DR: BCRs ARE ALL YOU NEED!
(Well actually .... keep reading) 1/
Reposted by Yara Sanchez
"Genes are... the easy part" @philipcball.bsky.social argues biologists need to embrace complexity from the start, rather than beginning with oversimplified "one gene, one trait" models
+1
www.cell.com/cell-systems...
+1
www.cell.com/cell-systems...
Should biology put complexity first?
The dictum “Everything should be made as simple as possible, but no simpler” poses
a problem for biology. How simply can it be told without doing damage to its complex
nature? The answer might be foun...
www.cell.com
February 21, 2025 at 7:44 AM
"Genes are... the easy part" @philipcball.bsky.social argues biologists need to embrace complexity from the start, rather than beginning with oversimplified "one gene, one trait" models
+1
www.cell.com/cell-systems...
+1
www.cell.com/cell-systems...
Reposted by Yara Sanchez
I am absolutely gutted to be moving away from @dev-journal.bsky.social & its wonderful community. I'll still be focussing on Development for the next few months, & I'll still be very involved in the journal in my new job, but I'm really going to miss hanging out with you all at #devbio meetings!
Big news - I'm going to be moving to a new position at The Company of Biologists, working across all our journals. This means my job is up for grabs! If you're an experienced editor with a love of developmental biology and its community, this could be the role for you. Full details in the link.
www.biologists.com
February 13, 2025 at 1:52 PM
I am absolutely gutted to be moving away from @dev-journal.bsky.social & its wonderful community. I'll still be focussing on Development for the next few months, & I'll still be very involved in the journal in my new job, but I'm really going to miss hanging out with you all at #devbio meetings!
Reposted by Yara Sanchez
Attention Attention Attention
If anyone knows clinicians or patients who have knowledge of pediatric patients with the very rare cancer interdigitating dendritic cell sarcoma (IDCS) or other (non-LCH) dendritic or histiocytoc sarcomas please contact Sri
If anyone knows clinicians or patients who have knowledge of pediatric patients with the very rare cancer interdigitating dendritic cell sarcoma (IDCS) or other (non-LCH) dendritic or histiocytoc sarcomas please contact Sri
It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS or other (non-LCH) dendritic or histiocytic sarcomas cases.
February 9, 2025 at 2:29 AM
Attention Attention Attention
If anyone knows clinicians or patients who have knowledge of pediatric patients with the very rare cancer interdigitating dendritic cell sarcoma (IDCS) or other (non-LCH) dendritic or histiocytoc sarcomas please contact Sri
If anyone knows clinicians or patients who have knowledge of pediatric patients with the very rare cancer interdigitating dendritic cell sarcoma (IDCS) or other (non-LCH) dendritic or histiocytoc sarcomas please contact Sri
Reposted by Yara Sanchez
There’s a simple rule about giving a presentation: if you don’t practice it’s not going to be a good one. Students know this but many professors seem to have forgotten.
January 28, 2025 at 3:33 AM
There’s a simple rule about giving a presentation: if you don’t practice it’s not going to be a good one. Students know this but many professors seem to have forgotten.
Reposted by Yara Sanchez
How to do differential expression with scRNAseq data? State of the art is "pseudo-bulk" analysis with RNA-seq methods like edgeR or DESeq2, where "cell type" is encoded as discrete categories. Biologically, discrete categories are not always the most appropriate concept.(1/3)
doi.org/10.1038/s415...
doi.org/10.1038/s415...
Analysis of multi-condition single-cell data with latent embedding multivariate regression - Nature Genetics
Latent embedding multivariate regression models multi-condition single-cell RNA-seq using a continuous latent space, enabling data integration, per-cell gene expression prediction and clustering-free ...
doi.org
January 3, 2025 at 7:18 PM
How to do differential expression with scRNAseq data? State of the art is "pseudo-bulk" analysis with RNA-seq methods like edgeR or DESeq2, where "cell type" is encoded as discrete categories. Biologically, discrete categories are not always the most appropriate concept.(1/3)
doi.org/10.1038/s415...
doi.org/10.1038/s415...
Reposted by Yara Sanchez
which one do you want to be?
There are two types of scientists. When I mention a new paper, the one type asks:
“What is it about?”
The other type asks:
“In which journal?”
#SciSky
“What is it about?”
The other type asks:
“In which journal?”
#SciSky
January 12, 2025 at 5:23 PM
which one do you want to be?
Reposted by Yara Sanchez
Something you don't see every day!
Digitizing the human proteome in >53,000 individuals with 15-year follow-up and, with machine learning, unraveling nearly 500 disease-causing proteins
www.cell.com/cell/fulltex...
open-access
Digitizing the human proteome in >53,000 individuals with 15-year follow-up and, with machine learning, unraveling nearly 500 disease-causing proteins
www.cell.com/cell/fulltex...
open-access
January 10, 2025 at 6:56 PM
Something you don't see every day!
Digitizing the human proteome in >53,000 individuals with 15-year follow-up and, with machine learning, unraveling nearly 500 disease-causing proteins
www.cell.com/cell/fulltex...
open-access
Digitizing the human proteome in >53,000 individuals with 15-year follow-up and, with machine learning, unraveling nearly 500 disease-causing proteins
www.cell.com/cell/fulltex...
open-access
Reposted by Yara Sanchez
very happy to share our latest preprint, led by Michaela Unger: www.biorxiv.org/content/10.1... We are using Deep Learning to improve the detection of biomarkers in cancer genomic data 👇 This is an emerging field, much more to come.
January 9, 2025 at 11:25 AM
very happy to share our latest preprint, led by Michaela Unger: www.biorxiv.org/content/10.1... We are using Deep Learning to improve the detection of biomarkers in cancer genomic data 👇 This is an emerging field, much more to come.
Reposted by Yara Sanchez
Exciting work! A mitochondrial perspective of scRNAseq datasets!
New year, new version of mitoXplorer 3.0 (mitoxplorer3.ibdm.univ-amu.fr) : mine your single-cell RNA-seq data from a mitochondrial perspective by creating cell-type specific pseudo-bulks or by looking at mitochondrial variability on single-cell level. Check it out at doi: doi.org/10.1101/2024...
mitoXplorer 3.0, a web tool for exploring mitochondrial dynamics in single-cell RNA-seq data
Mitochondria are important eukaryotic organelles, best known for their function in ATP production and in cellular metabolism and signalling. It is widely accepted that their structure, composition and...
doi.org
January 9, 2025 at 8:24 AM
Exciting work! A mitochondrial perspective of scRNAseq datasets!
Reposted by Yara Sanchez
Do you also think that #SpatialTranstriptomics and #AI will give rise to #DigitalPathology 2.0? We have an open PhD position for the HISTOMAP (Histology-based Molecular Analysis Platform) project to accelerate biomarker detection. Please apply here: www.bihealth.org/en/notices/b....
Spread the word!
Spread the word!
BIH PhD Program - Call for PhD candidates 2025 - News - BIH at Charité
The BIH PhD program aims to promote interdisciplinarity and support young translational talents. The program co-funds PhD positions for excellent translational projects that fit one of the four BIH re...
www.bihealth.org
January 8, 2025 at 8:29 AM
Do you also think that #SpatialTranstriptomics and #AI will give rise to #DigitalPathology 2.0? We have an open PhD position for the HISTOMAP (Histology-based Molecular Analysis Platform) project to accelerate biomarker detection. Please apply here: www.bihealth.org/en/notices/b....
Spread the word!
Spread the word!
Reposted by Yara Sanchez
After 4y in the making, I am super excited that my main PhD project is published 🎉🥳🎉🎉🥳
www.nature.com/articles/s41...
LEMUR is a tool to analyze multi-condition single-cell data and model differential expression as a continuous function of the cell-state space.
Some highlights⬇️
www.nature.com/articles/s41...
LEMUR is a tool to analyze multi-condition single-cell data and model differential expression as a continuous function of the cell-state space.
Some highlights⬇️
January 3, 2025 at 7:25 PM
After 4y in the making, I am super excited that my main PhD project is published 🎉🥳🎉🎉🥳
www.nature.com/articles/s41...
LEMUR is a tool to analyze multi-condition single-cell data and model differential expression as a continuous function of the cell-state space.
Some highlights⬇️
www.nature.com/articles/s41...
LEMUR is a tool to analyze multi-condition single-cell data and model differential expression as a continuous function of the cell-state space.
Some highlights⬇️
Reposted by Yara Sanchez
December 31, 2024 at 11:55 AM
Reposted by Yara Sanchez
Continuing the peer review discussion: @katherine-brown.bsky.social on principles for effective peer review:
1) Be respectful to authors
2) Request reasonable revisions
3) Focus on whether data support the conclusions
4) Be transparent about expertise limits
thenode.biologists.com/peer-review-...
1) Be respectful to authors
2) Request reasonable revisions
3) Focus on whether data support the conclusions
4) Be transparent about expertise limits
thenode.biologists.com/peer-review-...
Peer review - why we need it and what we need - the Node
Hopefully some of you will have seen the recent editorial in Development on our approach to peer review. If you haven't read it yet, please do take a
thenode.biologists.com
December 17, 2024 at 7:16 AM
Continuing the peer review discussion: @katherine-brown.bsky.social on principles for effective peer review:
1) Be respectful to authors
2) Request reasonable revisions
3) Focus on whether data support the conclusions
4) Be transparent about expertise limits
thenode.biologists.com/peer-review-...
1) Be respectful to authors
2) Request reasonable revisions
3) Focus on whether data support the conclusions
4) Be transparent about expertise limits
thenode.biologists.com/peer-review-...
Reposted by Yara Sanchez
I could not be more thrilled to announce the Nature Methods @naturemethods.bsky.social Method of the Year is Spatial Proteomics! Please see our editorial as a roadmap to the fantastic content in this special issue! www.nature.com/articles/s41...
Method of the Year 2024: spatial proteomics - Nature Methods
Approaches for profiling the spatial proteome in tissues are the basis of atlas-scale projects that are delivering on their promise for understanding biological complexity in health and disease.
www.nature.com
December 6, 2024 at 8:52 PM
I could not be more thrilled to announce the Nature Methods @naturemethods.bsky.social Method of the Year is Spatial Proteomics! Please see our editorial as a roadmap to the fantastic content in this special issue! www.nature.com/articles/s41...
Next month, Adam Bryce (University of Glasgow) and I will give an introductory workshop on #Spatial #Transcriptomics as part of the Festival of Genomics & Biodata. #FOG2025
Click here to reserve your space: hubs.la/Q02TptWZ0
Click here to reserve your space: hubs.la/Q02TptWZ0
December 6, 2024 at 2:46 PM
Next month, Adam Bryce (University of Glasgow) and I will give an introductory workshop on #Spatial #Transcriptomics as part of the Festival of Genomics & Biodata. #FOG2025
Click here to reserve your space: hubs.la/Q02TptWZ0
Click here to reserve your space: hubs.la/Q02TptWZ0
Reposted by Yara Sanchez
Journals reward sexy stories, ignore rigor, there are easy to use tools, lack of knowledgeable analysts and reviewers. There is very low reward for deep investigation of noise in the data and statistical methods to fix it
December 5, 2024 at 8:16 PM
Journals reward sexy stories, ignore rigor, there are easy to use tools, lack of knowledgeable analysts and reviewers. There is very low reward for deep investigation of noise in the data and statistical methods to fix it