Shih-Hsun Walter Hung
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walterhung.bsky.social
Shih-Hsun Walter Hung
@walterhung.bsky.social
40 followers 91 following 4 posts
Predoc @johninnescentre.bsky.social | Host-Microbe Interactions 🌿 #Phytoplasma #Endophyte #Symbiosis #Chloroplast #Evolution 🪸🤿 🌊

www.walterhung.com
Posts Replies Media Videos
Reposted by Shih-Hsun Walter Hung
igemhq.bsky.social
Engineering flowers as a means for public outreach and art!

Dr. @nickdesnoyer.bsky.social reimagines Arabidopsis with new colors and shapes, blending plant biology, synthetic biology and creative arts!

Hear him speak at SB 8.0 at the iGEM Grand Jamboree! jamboree.igem.org/2025/program...
September 26, 2025 at 2:29 PM
Reposted by Shih-Hsun Walter Hung
kamounlab.bsky.social
DO-DIFFERENT. @uniofeastanglia

Matt Dickinson #PPATH2025
September 10, 2025 at 8:48 AM
Reposted by Shih-Hsun Walter Hung
kamounlab.bsky.social
Coconut lethal-yellowing type phytoplasma — Matt Dickinson #PPATH2025
September 10, 2025 at 8:58 AM
Reposted by Shih-Hsun Walter Hung
kamounlab.bsky.social
Next up at #PPATH2025 is Erh-Min @erhminlai all the way from @IPMBSinica Taipei 🇹🇼 / optimising Agrobacterium for plant gene editing; cool use of a RUBY red readout assay

See the preprint doi.org/10.1101/2025...
September 10, 2025 at 2:26 PM
Reposted by Shih-Hsun Walter Hung
kamounlab.bsky.social
A Shakespearean title for Jan van Kan our next speaker #PPATH2025 @WageningenUR 🇳🇱 #Botrytis
September 11, 2025 at 12:06 PM
Reposted by Shih-Hsun Walter Hung
kamounlab.bsky.social
Now we have Chih-hang Wu @IPMBSinica Taiwan 🇹🇼 at #PPATH2025 — Fast and Furious: What happens after helper NLR immune receptors are activated to cause hypersensitive cell death.

See paper doi.org/10.1101/2025...
September 11, 2025 at 1:29 PM
Reposted by Shih-Hsun Walter Hung
kamounlab.bsky.social
My PhD student and my PhD supervisor showed up in matching outfits. Am I supposed to complete the set?
September 12, 2025 at 1:41 PM
Reposted by Shih-Hsun Walter Hung
kamounlab.bsky.social
My two favorite Ethiopians 😍
September 12, 2025 at 6:15 PM
Reposted by Shih-Hsun Walter Hung
kamounlab.bsky.social
The sequences of 91,366 NLR immune proteins from 230 superasterid genomes are now printed in 931 bound volumes #OpenScience #OpenPlantNLR
September 14, 2025 at 1:11 PM
Reposted by Shih-Hsun Walter Hung
amiralito.bsky.social
Also indexed on
@ZENODO_ORG
as an #OpenPlantNLR #NLRbiology dataset

zenodo.org/records/1472...
Deep-learning-based annotation of 230 superasterid genomes reveals a harmonized dataset of 91,366 NLRs (v250214_91366)
Abstract Plant nucleotide-binding leucine-rich repeat receptors (NLRs) are intracellular immune receptors crucial for pathogen recognition and immune responses. Despite their importance, NLRs are ofte...
zenodo.org
May 9, 2025 at 11:19 AM
walterhung.bsky.social
Dual-cycle CO2 fixation enhances growth and lipid synthesis in Arabidopsis thaliana | Science www.science.org/doi/10.1126/...
Dual-cycle CO2 fixation enhances growth and lipid synthesis in Arabidopsis thaliana
Carbon fixation through the Calvin-Benson-Bassham (CBB) cycle accounts for the majority of carbon dioxide (CO2) uptake from the atmosphere. The CBB cycle generates C3 carbohydrates but is inefficient ...
www.science.org
September 14, 2025 at 5:42 AM
Reposted by Shih-Hsun Walter Hung
mpimarinemicrobio.bsky.social
Atmende Endosymbionten ebnen den Weg in neue Lebensräume: Umweltmetagenome mitochondrien-ähnlicher #Endosymbionten können auch #Sauerstopff atmen und so den Wirten neue Lebenräume eröffnen.
@einzeller.bsky.social & Kolleginnen in #Biospektrum @springernature.com

link.springer.com/epdf/10.1007...
September 5, 2025 at 1:02 PM
Reposted by Shih-Hsun Walter Hung
sangerinstitute.bsky.social
We are excited that the Earth BioGenome Project, a global network of scientists including those from the Sanger Institute, has mapped the second phase of its ambitious plan to sequence all 1.67 million known species on Earth by 2035. 👏

www.sanger.ac.uk/news_item/bi...
September 5, 2025 at 8:34 AM
Reposted by Shih-Hsun Walter Hung
thesainsburylab.bsky.social
Another Preprint Pizza Party has come and passed!

Students, postdocs and RAs from TSL and @johninnescentre.bsky.social gathered to discuss and review recent @biorxivpreprint.bsky.social articles 📝
Pizza kept the spirits high during this challenging task 🍕

#PreprintCommentClub #PreprintPizzaParty
About twenty people are gathered around five tables, discussing about biorxiv preprints Six people with their laptops are sitting around a table and discussing.
September 5, 2025 at 3:27 PM
walterhung.bsky.social
Super-resolution live-cell mapping of protein-protein interactions using chemogenetic split reporters and STED microscopy
Stephanie Board, Arnaud Gautier
bioRxiv 2025.08.05.668682; doi: doi.org/10.1101/2025...
Super-resolution live-cell mapping of protein-protein interactions using chemogenetic split reporters and STED microscopy
The ability to map protein-protein interactions (PPI) within living cells at high spatial resolution is essential for unravelling their roles in cellular biology. Although several super-resolution mic...
doi.org
September 6, 2025 at 9:46 AM
walterhung.bsky.social
Engineering non-exponential proliferation in Escherichia coli using functionalized protein aggregates
Ronald Van Eyken, Sam Jordens, Dries Oome, Kevin Broux, Abram Aertsen
bioRxiv 2025.08.23.671898; doi: doi.org/10.1101/2025...
Engineering non-exponential proliferation in Escherichia coli using functionalized protein aggregates
Uncurbed exponential proliferation might not always be required for genetically modified microorganisms, and might even cause unpredictable liabilities in their behavior and impact. We therefore const...
doi.org
September 6, 2025 at 9:42 AM
Reposted by Shih-Hsun Walter Hung
miangoar.bsky.social
1/13 🧵 Today, Bindcraft was published in
@nature.com , one of the most famous AIs in biology for designing protein–protein interactions (PPI). In my opinion. Bindcraft represents one of the most important advances in the post–AlphaFold2 era.
August 27, 2025 at 7:54 PM
Reposted by Shih-Hsun Walter Hung
miangoar.bsky.social
This is a breakthrough for protein science🔥AFAIK this is the largest protein DB, with >100B seqs (3B clustered at 50%). New biology will come from LOGAN: new folds, topologies, etc. You can also improve your AlphaFold models by building better MSAs. Future AI models will also use LOGAN for training
September 5, 2025 at 4:51 PM
Reposted by Shih-Hsun Walter Hung
alexdallaire.bsky.social
I’m super happy to present the first discoveries of the RIKEN-Cambridge Joint Crop Symbiosis Research Team, based in Japan 🇯🇵

doi.org/10.1101/2025...

A thread 👇
Reductive evolution of the DNA replication machinery in endosymbiotic fungi
The molecular machinery for replicating and repairing DNA accurately is critically important for life and highly conserved across the Tree of Life. Here we show that two major lineages of fungi, Glome...
doi.org
September 3, 2025 at 3:21 PM
Reposted by Shih-Hsun Walter Hung
philcarella.bsky.social
Conserved effectors underpin the virulence of liverwort-isolated Pseudomonas in divergent plants

Very happy to share the published version of our work on natural Marchantia-Pseudomonas interactions.

Out now in Current Biology: www.cell.com/current-biol...
Conserved effectors underpin the virulence of liverwort-isolated Pseudomonas in divergent plants
Robinson et al. identify pathogenic Pseudomonas viridiflava in wild Marchantia polymorpha liverworts and interrogate the mechanisms enabling virulence in non-flowering and flowering plants. Their resu...
www.cell.com
April 1, 2025 at 7:12 PM
Reposted by Shih-Hsun Walter Hung
nickdesnoyer.bsky.social
First of the Friday Flower Concepts series coming tomorrow! 🌹✨

Can you guess the first flower?
August 21, 2025 at 6:36 PM
Reposted by Shih-Hsun Walter Hung
nickdesnoyer.bsky.social
"Little Flower"

A Cryo-SEM portrait of my micro-rose depicting the flower as a sculpture of cells, fractured and frozen in time. Full image is 10k x 10k pixels.
August 19, 2025 at 2:04 PM
Reposted by Shih-Hsun Walter Hung
nickdesnoyer.bsky.social
To promote the collection, I’ve launched a designer clothing line where synthetic biology meets aesthetics.

I will give out 100 free limited edition shirts to the first who retweet and order with their handle in the name! Available here → nickdesnoyer.com 🧵(6/7)
August 11, 2025 at 6:54 PM
Reposted by Shih-Hsun Walter Hung
tatsuyanobori.bsky.social
How can we better understand the plant immune system? In my new @cp-cellhostmicrobe.bsky.social piece, I propose “immune cell states” as a framework for uniting molecular and cellular perspectives.

www.cell.com/cell-host-mi...
August 13, 2025 at 3:12 PM
Reposted by Shih-Hsun Walter Hung
matteogravino.bsky.social
🎉Thrilled to share our latest work, now published in @newphyt.bsky.social!

🧑‍🔬 @matteogravino.bsky.social, @samtmugford.bsky.social, @saskiahogenhout.bsky.social et al., @johninnescentre.bsky.social

#️⃣ #PlantScience #PlantImmunity

📄 Read the full paper👇
nph.onlinelibrary.wiley.com/share/8QSRJ9...
Model: Activation and suppression of defences in plant–aphid interactions. Upper left panel: aphid stylet penetration of the cell wall releases oligogalacturonides (OGs), which induce PAMP/DAMP-triggered immunity (PTI/DTI) in a process dependent on BRASSINOSTEROID INSENSITIVE 1-ASSOCIATED RECEPTOR KINASE 1 (BAK1), ENHANCED DISEASE SUSCEPTIBILITY 1 (EDS1), and CPK5/6/11 (data herein). The stabilisation of pattern recognition receptors (PRRs) and coreceptors at the plasma membrane may rely on the deubiquitination (DUB) activity of ASSOCIATED MOLECULE WITH THE SH3 DOMAIN OF STAM (AMSHs; Gravino et al., 2024). Upper right panel: the Mp10 effector, introduced by aphids into the cell cytoplasm (Mugford et al., 2016), suppresses OG-induced reactive oxygen species (ROS) (data herein) and flg22-induced PTI (Bos et al., 2010). Mp10 targeting of plant AMSHs is implicated in these processes (Gravino et al., 2024). EDS1 is essential for Mp10-mediated ROS suppression and PRR destabilisation (data herein), acting through an unidentified mechanism (denoted by the double-sided arrow with an asterisk). Lower left panel: effector-triggered immunity (ETI) is activated through EDS1, either directly or indirectly, upon recognition of Mp10 and/or its activities by a TNL (Gravino et al., 2024; Rao et al., 2024). Salicylic acid glucosyltransferase 1 (SGT1) is also required for TNL/ETI activation (Bos et al., 2010). Lower right panel: aphids secrete additional effectors, such as cathepsin B proteins (e.g. CathB6), which target EDS1 to suppress ETI (Liu et al., 2025). Solid arrows, increased activation; solid blunt-ended arrows, increased suppression; Dashed arrows, reduced activation; Dashed -blunt-ended arrows, reduced suppression.
August 1, 2025 at 12:40 PM