Matteo Gravino
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matteogravino.bsky.social
Matteo Gravino
@matteogravino.bsky.social
35 followers 37 following 9 posts
Scientist at the John Innes Centre. Interested in plant-aphid interactions.
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matteogravino.bsky.social
Matteo Gravino @matteogravino.bsky.social · Aug 1
🎉Thrilled to share our latest work, now published in @newphyt.bsky.social!

🧑‍🔬 @matteogravino.bsky.social, @samtmugford.bsky.social, @saskiahogenhout.bsky.social et al., @johninnescentre.bsky.social

#️⃣ #PlantScience #PlantImmunity

📄 Read the full paper👇
nph.onlinelibrary.wiley.com/share/8QSRJ9...
Model: Activation and suppression of defences in plant–aphid interactions. Upper left panel: aphid stylet penetration of the cell wall releases oligogalacturonides (OGs), which induce PAMP/DAMP-triggered immunity (PTI/DTI) in a process dependent on BRASSINOSTEROID INSENSITIVE 1-ASSOCIATED RECEPTOR KINASE 1 (BAK1), ENHANCED DISEASE SUSCEPTIBILITY 1 (EDS1), and CPK5/6/11 (data herein). The stabilisation of pattern recognition receptors (PRRs) and coreceptors at the plasma membrane may rely on the deubiquitination (DUB) activity of ASSOCIATED MOLECULE WITH THE SH3 DOMAIN OF STAM (AMSHs; Gravino et al., 2024). Upper right panel: the Mp10 effector, introduced by aphids into the cell cytoplasm (Mugford et al., 2016), suppresses OG-induced reactive oxygen species (ROS) (data herein) and flg22-induced PTI (Bos et al., 2010). Mp10 targeting of plant AMSHs is implicated in these processes (Gravino et al., 2024). EDS1 is essential for Mp10-mediated ROS suppression and PRR destabilisation (data herein), acting through an unidentified mechanism (denoted by the double-sided arrow with an asterisk). Lower left panel: effector-triggered immunity (ETI) is activated through EDS1, either directly or indirectly, upon recognition of Mp10 and/or its activities by a TNL (Gravino et al., 2024; Rao et al., 2024). Salicylic acid glucosyltransferase 1 (SGT1) is also required for TNL/ETI activation (Bos et al., 2010). Lower right panel: aphids secrete additional effectors, such as cathepsin B proteins (e.g. CathB6), which target EDS1 to suppress ETI (Liu et al., 2025). Solid arrows, increased activation; solid blunt-ended arrows, increased suppression; Dashed arrows, reduced activation; Dashed -blunt-ended arrows, reduced suppression.
Reposted by Matteo Gravino
samtmugford.bsky.social
Now published in @newphyt.bsky.social , congrats @matteogravino.bsky.social @saskiahogenhout.bsky.social et al @johninnescentre.bsky.social nph.onlinelibrary.wiley.com/doi/10.1111/...
July 31, 2025 at 10:20 AM
matteogravino.bsky.social
🎉Thrilled to share our latest work, now published in @newphyt.bsky.social!

🧑‍🔬 @matteogravino.bsky.social, @samtmugford.bsky.social, @saskiahogenhout.bsky.social et al., @johninnescentre.bsky.social

#️⃣ #PlantScience #PlantImmunity

📄 Read the full paper👇
nph.onlinelibrary.wiley.com/share/8QSRJ9...
Model: Activation and suppression of defences in plant–aphid interactions. Upper left panel: aphid stylet penetration of the cell wall releases oligogalacturonides (OGs), which induce PAMP/DAMP-triggered immunity (PTI/DTI) in a process dependent on BRASSINOSTEROID INSENSITIVE 1-ASSOCIATED RECEPTOR KINASE 1 (BAK1), ENHANCED DISEASE SUSCEPTIBILITY 1 (EDS1), and CPK5/6/11 (data herein). The stabilisation of pattern recognition receptors (PRRs) and coreceptors at the plasma membrane may rely on the deubiquitination (DUB) activity of ASSOCIATED MOLECULE WITH THE SH3 DOMAIN OF STAM (AMSHs; Gravino et al., 2024). Upper right panel: the Mp10 effector, introduced by aphids into the cell cytoplasm (Mugford et al., 2016), suppresses OG-induced reactive oxygen species (ROS) (data herein) and flg22-induced PTI (Bos et al., 2010). Mp10 targeting of plant AMSHs is implicated in these processes (Gravino et al., 2024). EDS1 is essential for Mp10-mediated ROS suppression and PRR destabilisation (data herein), acting through an unidentified mechanism (denoted by the double-sided arrow with an asterisk). Lower left panel: effector-triggered immunity (ETI) is activated through EDS1, either directly or indirectly, upon recognition of Mp10 and/or its activities by a TNL (Gravino et al., 2024; Rao et al., 2024). Salicylic acid glucosyltransferase 1 (SGT1) is also required for TNL/ETI activation (Bos et al., 2010). Lower right panel: aphids secrete additional effectors, such as cathepsin B proteins (e.g. CathB6), which target EDS1 to suppress ETI (Liu et al., 2025). Solid arrows, increased activation; solid blunt-ended arrows, increased suppression; Dashed arrows, reduced activation; Dashed -blunt-ended arrows, reduced suppression.
August 1, 2025 at 12:40 PM
Reposted by Matteo Gravino
samtmugford.bsky.social
Aphid Saliva fans, happy news, this amazing story is now out in Science Advances www.science.org/doi/10.1126/... congrats @qunliu07.bsky.social @saskiahogenhout.bsky.social et al @johninnescentre.bsky.social 24h after a triumphant presentation at #ismpmi2025
July 16, 2025 at 6:35 PM
Reposted by Matteo Gravino
baptistebio.bsky.social
🔗 Preprint alert: www.biorxiv.org/content/10.1...

🧵 New insights into plant immunity: using ferns to understand evolution! 🌱✨🌿

Excited to share my first (but not last) published research at @lrsv-toulouse.bsky.social. A THREAD … [1/9]
Exploring fern pathosystems and immune receptors to bridge gaps in plant immunity
Land plants include angiosperms, bryophytes, lycophytes and ferns, each of which may deploy distinct strategies to resist pathogens. Here, we investigate fern-pathogen interactions by characterizing n...
www.biorxiv.org
March 20, 2025 at 10:35 AM
Reposted by Matteo Gravino
somssich.bsky.social
📜 Aphid effector Mp10 balances immune suppression and defence activation through EDS1-dependent modulation of plant DAMP responses

🧑‍🔬 @matteogravino.bsky.social, @saskiahogenhout.bsky.social, et al.

📔 @biorxiv-plants.bsky.social

🔗 www.biorxiv.org/content/10.1...

#️⃣ #PlantScience #PlantImmunity
www.biorxiv.org
March 3, 2025 at 6:07 AM
Reposted by Matteo Gravino
samtmugford.bsky.social
We are excited to share our latest preprint from the Hogenhout lab (@matteogravino.bsky.social @saskiahogenhout.bsky.social
, @johninnescentre.bsky.social
) on plant-aphid interactions, showing that the aphid effector Mp10 balances suppression of DAMP responses and activation of ETI via EDS1.
biorxiv-plants.bsky.social bioRxiv Plant Bio @biorxiv-plants.bsky.social · Feb 28
Aphid effector Mp10 balances immune suppression and defence activation through EDS1-dependent modulation of plant DAMP responses https://www.biorxiv.org/content/10.1101/2025.02.26.640334v1
March 1, 2025 at 10:08 AM
Reposted by Matteo Gravino
samtmugford.bsky.social
We’re delighted to share our latest preprint from the Hogenhout lab (@saskiahogenhout.bsky.social) on the molecular mechanisms on plant-aphid interactions. Here we show how the aphid Mp10 effector protein acts as a local anaesthetic to suppress the plant perception of aphid attack
November 18, 2024 at 9:58 AM