Matthew Witney
@virotuned.bsky.social
#postdoc at the Purcell Lab, #monashuni, #BDI
#antigenpresentation, #MHC, #immunopeptidomics, #Tcells and a smattering of #classicalmusic
#antigenpresentation, #MHC, #immunopeptidomics, #Tcells and a smattering of #classicalmusic
Reposted by Matthew Witney
My student's diversity F31 has been pulled from study section even though it's the SAME APPLICATION as regular F31s, normally reviewed together in the same panel. Throwing out all the applications from URMs while the ones from white/privileged students get to be reviewed is blatant discrimination.
The CSR comm I'm on just pulled all Diversity F grants from the current review cycle. These apps are reviewed alongside (and by the same criteria) as all other F grants. So, instead of helping these trainees, they will actually be punished by having their grant reviews delayed at least 1 cycle !?!?
February 7, 2025 at 3:31 AM
My student's diversity F31 has been pulled from study section even though it's the SAME APPLICATION as regular F31s, normally reviewed together in the same panel. Throwing out all the applications from URMs while the ones from white/privileged students get to be reviewed is blatant discrimination.
Nice to see this work presented recently at BDI ! Congratulations!
The first major body of work from my PhD is now up on BioRxiv!
We used AI-designed binders to block the uptake of heme from hemoglobin through ChuA, a heme transporter found in pathogenic E. coli. 🦠🩸🔬
I’m very grateful for my supervisors and all coauthors for their support!
We used AI-designed binders to block the uptake of heme from hemoglobin through ChuA, a heme transporter found in pathogenic E. coli. 🦠🩸🔬
I’m very grateful for my supervisors and all coauthors for their support!
Excited to share our first foray in ML-guided protein design. With the @gavinjknott lab we designed protein binders as that block heme piracy by pathogenic E. coli and potently inhibit CRISPR-Cas13. www.biorxiv.org/content/10.1..., www.biorxiv.org/content/10.1...
December 9, 2024 at 4:28 AM
Nice to see this work presented recently at BDI ! Congratulations!
Reposted by Matthew Witney
Excited to share our first foray in ML-guided protein design. With the @gavinjknott lab we designed protein binders as that block heme piracy by pathogenic E. coli and potently inhibit CRISPR-Cas13. www.biorxiv.org/content/10.1..., www.biorxiv.org/content/10.1...
December 8, 2024 at 10:42 PM
Excited to share our first foray in ML-guided protein design. With the @gavinjknott lab we designed protein binders as that block heme piracy by pathogenic E. coli and potently inhibit CRISPR-Cas13. www.biorxiv.org/content/10.1..., www.biorxiv.org/content/10.1...
Reposted by Matthew Witney
The latest greenhouse gas emissions figures show Australia emits more gas now than when the government was elected.
But the govt wants us to believe we are "on target" to achieve 43% cuts below 2005 levels by 2030.
Enough with the spin: we need to stop approving new coal & gas mines *now*.
But the govt wants us to believe we are "on target" to achieve 43% cuts below 2005 levels by 2030.
Enough with the spin: we need to stop approving new coal & gas mines *now*.
November 28, 2024 at 10:22 PM
The latest greenhouse gas emissions figures show Australia emits more gas now than when the government was elected.
But the govt wants us to believe we are "on target" to achieve 43% cuts below 2005 levels by 2030.
Enough with the spin: we need to stop approving new coal & gas mines *now*.
But the govt wants us to believe we are "on target" to achieve 43% cuts below 2005 levels by 2030.
Enough with the spin: we need to stop approving new coal & gas mines *now*.
Reposted by Matthew Witney
ALSO! We are hiring for the last open position (Bioinformatics Research Scientist) in the TIRTL group! Love coding, math, robotics, and uncovering the immune system's secrets? You know you do, so join us! (stjude.wd1.myworkdayjobs.com/stjude/job/M...).
Bioinformatics Research Scientist (TIRTL Bluesky)
The Bioinformatics Research Scientist is responsible for designing, developing, improving, modifying, and operating data analysis pipelines. Manages projects and coordinates other efforts related to a...
stjude.wd1.myworkdayjobs.com
November 26, 2024 at 7:42 PM
ALSO! We are hiring for the last open position (Bioinformatics Research Scientist) in the TIRTL group! Love coding, math, robotics, and uncovering the immune system's secrets? You know you do, so join us! (stjude.wd1.myworkdayjobs.com/stjude/job/M...).
Reposted by Matthew Witney
Anyone knows a good set of validated T-cell epitopes? Meaning epitopes that definitely showed a good T-cell response.
I've used IEDB in the past but maybe there are other valuable resources?
#Immunosky
I've used IEDB in the past but maybe there are other valuable resources?
#Immunosky
November 26, 2024 at 11:13 AM
Anyone knows a good set of validated T-cell epitopes? Meaning epitopes that definitely showed a good T-cell response.
I've used IEDB in the past but maybe there are other valuable resources?
#Immunosky
I've used IEDB in the past but maybe there are other valuable resources?
#Immunosky
Reposted by Matthew Witney
With Bluesky getting popular and the brands coming here, it’s time to prepare. So I launched @brandblock.online to label corporate accounts.
Let’s keep social media social.
Let’s keep social media social.
November 20, 2024 at 3:15 PM
With Bluesky getting popular and the brands coming here, it’s time to prepare. So I launched @brandblock.online to label corporate accounts.
Let’s keep social media social.
Let’s keep social media social.
Reposted by Matthew Witney
Our new work!
We show that T cell cross-reactivity can be reduced without modifying the TCR itself (by dramatically enhancing antigen discrimination).
Generation of T cells with reduced off-target cross-reactivities by engineering co-signalling receptors
www.biorxiv.org/content/10.1...
We show that T cell cross-reactivity can be reduced without modifying the TCR itself (by dramatically enhancing antigen discrimination).
Generation of T cells with reduced off-target cross-reactivities by engineering co-signalling receptors
www.biorxiv.org/content/10.1...
November 20, 2024 at 9:55 AM
Our new work!
We show that T cell cross-reactivity can be reduced without modifying the TCR itself (by dramatically enhancing antigen discrimination).
Generation of T cells with reduced off-target cross-reactivities by engineering co-signalling receptors
www.biorxiv.org/content/10.1...
We show that T cell cross-reactivity can be reduced without modifying the TCR itself (by dramatically enhancing antigen discrimination).
Generation of T cells with reduced off-target cross-reactivities by engineering co-signalling receptors
www.biorxiv.org/content/10.1...
Finally out! Our contribution to a better understanding of quantitative features of virus p:MHC epitopes. We compared 45 vaccinia epitopes and their source antigens across multiple cell lines, over time, and from the spleen on infected mice against T cell responses in mice.
A quantitative approach to poxvirus infection reveals general correlates of antigen presentation and immunogenicity for viral CD8+ T cell epitopes https://www.biorxiv.org/content/10.1101/2024.11.18.624047v1
A quantitative approach to poxvirus infection reveals general correlates of antigen presentation and immunogenicity for viral CD8+ T cell epitopes https://www.biorxiv.org/content/10.1101/2024.11.18.624047v1
CD8+ T cells are essential effectors in antiviral immunity that kill infected cells displaying viral
www.biorxiv.org
November 19, 2024 at 2:58 AM
Finally out! Our contribution to a better understanding of quantitative features of virus p:MHC epitopes. We compared 45 vaccinia epitopes and their source antigens across multiple cell lines, over time, and from the spleen on infected mice against T cell responses in mice.
Reposted by Matthew Witney
A quantitative approach to poxvirus infection reveals general correlates of antigen presentation and immunogenicity for viral CD8+ T cell epitopes https://www.biorxiv.org/content/10.1101/2024.11.18.624047v1
A quantitative approach to poxvirus infection reveals general correlates of antigen presentation and immunogenicity for viral CD8+ T cell epitopes https://www.biorxiv.org/content/10.1101/2024.11.18.624047v1
CD8+ T cells are essential effectors in antiviral immunity that kill infected cells displaying viral
www.biorxiv.org
November 19, 2024 at 2:16 AM
A quantitative approach to poxvirus infection reveals general correlates of antigen presentation and immunogenicity for viral CD8+ T cell epitopes https://www.biorxiv.org/content/10.1101/2024.11.18.624047v1
I need the PTV app (public transport Victoria) on Bluesky so I know when my train will start start running again. Deadline is a concert… so stress levels slowly increasing .
November 16, 2024 at 12:52 AM
I need the PTV app (public transport Victoria) on Bluesky so I know when my train will start start running again. Deadline is a concert… so stress levels slowly increasing .