Dr. Utkarsh Bhardwaj
@utkarshbh.bsky.social
Ex-PhD @DrSunitKSingh lab (Molecular Virologist) @bhupro | #Zika #virus #microRNA #vascularbiology
https://scholar.google.com/citations?user=VZqH690AAAAJ&hl=en
https://scholar.google.com/citations?user=VZqH690AAAAJ&hl=en
Reposted by Dr. Utkarsh Bhardwaj
The brain neurovascular epigenome and its association with dementia. #cerebrovascular #epigenetics
The brain neurovascular epigenome and its association with dementia
Ziegler et al. reveal distinct genetic and epigenetic mechanisms underlying Alzheimer’s
disease and cerebral small vessel disease within neurovascular cells, identifying
immune-related AD risk and bro...
www.cell.com
November 12, 2025 at 10:42 AM
The brain neurovascular epigenome and its association with dementia. #cerebrovascular #epigenetics
Reposted by Dr. Utkarsh Bhardwaj
#Autophagy #Mechanobiology
Interesting evidence on opposite effects of ⏫matrix stiffness on Autophagy of #EndothelialCell⏬ vs #SmoothMuscleCell⏫
280~480 kPa, crosslinked poly(L-lysine)-hyaluronic acid film on coverglass
#BioactiveMat 2021
www.sciencedirect.com/science/arti...
Interesting evidence on opposite effects of ⏫matrix stiffness on Autophagy of #EndothelialCell⏬ vs #SmoothMuscleCell⏫
280~480 kPa, crosslinked poly(L-lysine)-hyaluronic acid film on coverglass
#BioactiveMat 2021
www.sciencedirect.com/science/arti...
November 12, 2025 at 7:59 PM
#Autophagy #Mechanobiology
Interesting evidence on opposite effects of ⏫matrix stiffness on Autophagy of #EndothelialCell⏬ vs #SmoothMuscleCell⏫
280~480 kPa, crosslinked poly(L-lysine)-hyaluronic acid film on coverglass
#BioactiveMat 2021
www.sciencedirect.com/science/arti...
Interesting evidence on opposite effects of ⏫matrix stiffness on Autophagy of #EndothelialCell⏬ vs #SmoothMuscleCell⏫
280~480 kPa, crosslinked poly(L-lysine)-hyaluronic acid film on coverglass
#BioactiveMat 2021
www.sciencedirect.com/science/arti...
Reposted by Dr. Utkarsh Bhardwaj
Perturbing MEK–ERK–c-Myc bioenergetic axis in tumor #EndothelialCell suppress primary tumor growth
Evidence from an engineered tumor cell type-selective #AnthraxToxin system allowing
MEK cleavage/inactivation in selective #TumorMicroEnvironmental cell types
#PNAS 2025
www.pnas.org/doi/10.1073/...
Evidence from an engineered tumor cell type-selective #AnthraxToxin system allowing
MEK cleavage/inactivation in selective #TumorMicroEnvironmental cell types
#PNAS 2025
www.pnas.org/doi/10.1073/...
November 9, 2025 at 8:29 PM
Perturbing MEK–ERK–c-Myc bioenergetic axis in tumor #EndothelialCell suppress primary tumor growth
Evidence from an engineered tumor cell type-selective #AnthraxToxin system allowing
MEK cleavage/inactivation in selective #TumorMicroEnvironmental cell types
#PNAS 2025
www.pnas.org/doi/10.1073/...
Evidence from an engineered tumor cell type-selective #AnthraxToxin system allowing
MEK cleavage/inactivation in selective #TumorMicroEnvironmental cell types
#PNAS 2025
www.pnas.org/doi/10.1073/...
Reposted by Dr. Utkarsh Bhardwaj
In Science, researchers report the observation of dendritic nanotubes in brain tissue from mice and humans. The discovery suggests that the current understanding of the brain’s organization may be incomplete, overlooking a hidden layer of connectivity. #SciencePerspective https://scim.ag/470Cdr4
Hidden networks in the brain
Dendritic nanotubes extend brain connectivity beyond synapses
scim.ag
October 13, 2025 at 3:20 PM
In Science, researchers report the observation of dendritic nanotubes in brain tissue from mice and humans. The discovery suggests that the current understanding of the brain’s organization may be incomplete, overlooking a hidden layer of connectivity. #SciencePerspective https://scim.ag/470Cdr4
Reposted by Dr. Utkarsh Bhardwaj
A rundown on the big advances we’re seeing on the brain-immune axis
erictopol.substack.com/p/our-braini...
erictopol.substack.com/p/our-braini...
Our Brain—Immune Axis Gets A Jolt
Facts, data and analytics about biomedical matters
erictopol.substack.com
August 3, 2025 at 6:33 PM
A rundown on the big advances we’re seeing on the brain-immune axis
erictopol.substack.com/p/our-braini...
erictopol.substack.com/p/our-braini...
Reposted by Dr. Utkarsh Bhardwaj
Great new work by Brian MacVicar's team, showing that pericytes and perivascular fibroblasts are distinct subpopulations of stromal progenitor cells in the adult brain that coordinate revascularization and scar formation after injury. #cerebrovascular #stroke #pericytes
Brain pericytes and perivascular fibroblasts are stromal progenitors with dual functions in cerebrovascular regeneration after stroke - Nature Neuroscience
Bernier, Hefendehl et al. describe a stromal progenitor cell population consisting of pericytes, venular smooth muscle cells and perivascular fibroblasts in the adult brain that modify their function ...
doi.org
February 18, 2025 at 1:39 AM
Great new work by Brian MacVicar's team, showing that pericytes and perivascular fibroblasts are distinct subpopulations of stromal progenitor cells in the adult brain that coordinate revascularization and scar formation after injury. #cerebrovascular #stroke #pericytes
Reposted by Dr. Utkarsh Bhardwaj
#WeekendRead! #LiveForever! Ji &co show @cp-cellmetabolism.bsky.social that stem cell derived exomes contain a miRA capable of block cell cycle inhibitors, allowing the proliferation of senescent cells & rejuvenating mice extending life span & physical performances! www.cell.com/cell-metabol...
Exosomal miR-302b rejuvenates aging mice by reversing the proliferative arrest of senescent cells
Bi et al. propose the Senoreverse anti-aging strategy, which aims to reverse the proliferative
arrest of senescent cells. Exosomal miR-302b is identified as a Senoreverse candidate
that targets the ce...
www.cell.com
January 18, 2025 at 5:17 PM
#WeekendRead! #LiveForever! Ji &co show @cp-cellmetabolism.bsky.social that stem cell derived exomes contain a miRA capable of block cell cycle inhibitors, allowing the proliferation of senescent cells & rejuvenating mice extending life span & physical performances! www.cell.com/cell-metabol...
Reposted by Dr. Utkarsh Bhardwaj
🚨 Timely and interesting review on brain endothelial cells doi.org/10.1038/s415... #cerebrovascular
Endothelial cells as key players in cerebral small vessel disease - Nature Reviews Neuroscience
Cerebral small vessel disease is a common cause of dementia and stroke. In this Perspective, Wardlaw and co-workers describe evidence from human brain imaging and preclinical models that points to dys...
doi.org
January 18, 2025 at 7:39 PM
🚨 Timely and interesting review on brain endothelial cells doi.org/10.1038/s415... #cerebrovascular
Reposted by Dr. Utkarsh Bhardwaj
#MustRead for #Neutrophils & #TumorImmunology lovers! @cp-immunity.bsky.social by @MelissaNg @DanielaCerezo-Wallis @LaiGuanNg & @andreshidalgo.bsky.social! www.sciencedirect.com/science/arti...
Adaptations of neutrophils in cancer
There is a renewed interest in neutrophil biology, largely instigated by their prominence in cancer. From an immunologist’s perspective, a conceptual …
www.sciencedirect.com
January 14, 2025 at 6:54 PM
#MustRead for #Neutrophils & #TumorImmunology lovers! @cp-immunity.bsky.social by @MelissaNg @DanielaCerezo-Wallis @LaiGuanNg & @andreshidalgo.bsky.social! www.sciencedirect.com/science/arti...
Reposted by Dr. Utkarsh Bhardwaj
ER stress in cells (cell-autonomous) can be transmitted to neighbouring unstressed cells to generate a broader systemic ER stress response (cell non-autonomous ER stress) and hence have a wider impact in an organism where the stress was initially induced. Its significance to virus infections! 👇🏽
Transmission of unfolded protein response—a regulator of disease progression, severity, and spread in virus infections | mBio
The unfolded protein response (UPR) is a cellular stress response pathway activated
by the accumulation of misfolded or unfolded proteins in the endoplasmic reticulum
(ER) (1). The UPR aims to restore...
journals.asm.org
January 8, 2025 at 9:21 PM
ER stress in cells (cell-autonomous) can be transmitted to neighbouring unstressed cells to generate a broader systemic ER stress response (cell non-autonomous ER stress) and hence have a wider impact in an organism where the stress was initially induced. Its significance to virus infections! 👇🏽
Reposted by Dr. Utkarsh Bhardwaj
Reposted by Dr. Utkarsh Bhardwaj
#AMentorIsForever 💎🔬🧪🧬🧫
You cannot underestimate all the positive and long-term benefits of having a supportive #mentor
One could argue this is at least as important as the research topic 🧪
Do choose wisely..
#MentoringMonth
One could argue this is at least as important as the research topic 🧪
Do choose wisely..
#MentoringMonth
January 8, 2025 at 1:54 PM
#AMentorIsForever 💎🔬🧪🧬🧫
Reposted by Dr. Utkarsh Bhardwaj
#EveryCellIsAnImmuneCell!💥Thrilled for the final version of our paper @cp-cell.bsky.social! We show that type III #interferons control ZBP1 activation driving gasdermin C cleavage & delaying gut repair by inducing #pyroptosis in intestinal epithelial cells! 1/n www.cell.com/cell/abstrac...
Type III interferons induce pyroptosis in gut epithelial cells and impair mucosal repair
Intestinal damage following colitis or irradiation induces type III interferons (IFNs), which delay the healing of the intestinal epithelium. IFN-λ directs the sensing of Z-form nucleic acids generated during gut injury and repair, triggering cell death and altering healthy epithelial regeneration.
www.cell.com
December 26, 2024 at 5:24 PM
#EveryCellIsAnImmuneCell!💥Thrilled for the final version of our paper @cp-cell.bsky.social! We show that type III #interferons control ZBP1 activation driving gasdermin C cleavage & delaying gut repair by inducing #pyroptosis in intestinal epithelial cells! 1/n www.cell.com/cell/abstrac...
Reposted by Dr. Utkarsh Bhardwaj
Another paper from a great collaboration in the OneHealthPACT consortium link.springer.com/article/10.1...
Overwintering of Usutu virus in mosquitoes, The Netherlands - Parasites & Vectors
Analyses of mosquito-borne virus outbreaks have revealed the presence of similar virus strains over several years. However, it remains unclear how mosquito-borne viruses can persist over winter, when ...
link.springer.com
December 23, 2024 at 8:34 PM
Another paper from a great collaboration in the OneHealthPACT consortium link.springer.com/article/10.1...