The Pratt Group
@theprattgroup.bsky.social
Organic chemistry / chemical biology research group at the University of Ottawa. We love to study radicals and cell death.
Thanks for highlighting our work!!! We’ve been a bit slow to post group news since moving to Bluesky! Indeed, we still have a surprising amount to learn about lipid peroxidation. Congratulations to Ali Dehdari for his careful work in revealing this important aspect.
pubs.acs.org/doi/abs/10.1...
Congrats @theprattgroup.bsky.social for this thought provocative study. Still some unexpected observations in the autoxidation of lpids 👀
Congrats @theprattgroup.bsky.social for this thought provocative study. Still some unexpected observations in the autoxidation of lpids 👀
Intramolecular Hydrogen Atom Transfer Enables Hydroperoxyl Radical Formation during the Peroxidation of Unsaturated Lipids
Lipid peroxidation (autoxidation) is among the most well-studied free radical chain reactions and drives a cell death modality (ferroptosis) implicated in neurodegeneration and the damage resulting fr...
pubs.acs.org
November 7, 2025 at 12:22 PM
Thanks for highlighting our work!!! We’ve been a bit slow to post group news since moving to Bluesky! Indeed, we still have a surprising amount to learn about lipid peroxidation. Congratulations to Ali Dehdari for his careful work in revealing this important aspect.
Congratulations, Andreas and team - and welcome to BlueSky!
Happy to start at Bluesky with a post on our recent manuscript at @nature.com:
www.nature.com/articles/s41...
Great collaboration with cool scientists such as @theprattgroup.bsky.social, @fedorovalab.bsky.social and many who do not (yet) have a Bluesky account.
www.nature.com/articles/s41...
Great collaboration with cool scientists such as @theprattgroup.bsky.social, @fedorovalab.bsky.social and many who do not (yet) have a Bluesky account.
Multiple oestradiol functions inhibit ferroptosis and acute kidney injury - Nature
17β-oestradiol establishes an anti-ferroptotic state in female kidney tubules.
www.nature.com
August 19, 2025 at 11:40 AM
Congratulations, Andreas and team - and welcome to BlueSky!
Reposted by The Pratt Group
The first FASEB Ferroptosis conference! ✔️ Thank you to my co-organizer Scott Dixon, our sponsors, and the whole #Ferroptosis community for showing up and making this such a wonderful meeting! 🤩 ❤️
August 1, 2025 at 6:07 PM
The first FASEB Ferroptosis conference! ✔️ Thank you to my co-organizer Scott Dixon, our sponsors, and the whole #Ferroptosis community for showing up and making this such a wonderful meeting! 🤩 ❤️
Reposted by The Pratt Group
FYI - We've extended abstract submission deadline to June 8. Submit soon to be considered for a short talk. Come join us at the first FASEB #Ferroptosis meeting! It's going to be awwwwesome! 🤩
events.faseb.org/event/11797f...
events.faseb.org/event/11797f...
Home - Ferroptosis, Oxidative Stress, and Lipid Metabolism
events.faseb.org
June 3, 2025 at 4:24 PM
FYI - We've extended abstract submission deadline to June 8. Submit soon to be considered for a short talk. Come join us at the first FASEB #Ferroptosis meeting! It's going to be awwwwesome! 🤩
events.faseb.org/event/11797f...
events.faseb.org/event/11797f...
Reposted by The Pratt Group
and the News & Views www.nature.com/articles/d41...
Lipid-degrading small molecule kills cancer cells by ferroptosis
A molecule designed to activate iron locked up in organelles called lysosomes and thereby induce cell death might offer a way to tackle treatment-resistant cancer.
www.nature.com
May 7, 2025 at 3:48 PM
and the News & Views www.nature.com/articles/d41...
Reposted by The Pratt Group
new out in Nature, very cool story www.nature.com/articles/s41...
Activation of lysosomal iron triggers ferroptosis in cancer - Nature
Some cancer cells exhibit high loads of reactive iron in lysosomes, and this feature is exploited by using fentomycin-1, a newly developed small molecule, to induce ferroptosis.
www.nature.com
May 7, 2025 at 3:48 PM
new out in Nature, very cool story www.nature.com/articles/s41...
Reposted by The Pratt Group
Important walkthrough for newcomers in the field
rdcu.be/eg58p
rdcu.be/eg58p
Recommendations for robust and reproducible research on ferroptosis
Nature Reviews Molecular Cell Biology - Ferroptosis is a non-apoptotic type of cell death that is induced by uncontrolled iron-dependent phospholipid peroxidation and has important roles in...
rdcu.be
April 9, 2025 at 8:21 PM
Important walkthrough for newcomers in the field
rdcu.be/eg58p
rdcu.be/eg58p
Reposted by The Pratt Group
This is literally what you get when you look for alcohol on the LCBO website. For those unfamiliar, the liquor control board of ontario is the LARGEST single purchaser of alcohol IN THE WORLD. Why? Because they buy for all of ontario.
March 4, 2025 at 8:49 PM
This is literally what you get when you look for alcohol on the LCBO website. For those unfamiliar, the liquor control board of ontario is the LARGEST single purchaser of alcohol IN THE WORLD. Why? Because they buy for all of ontario.
Reposted by The Pratt Group
Deadline for #CSC2025 abstracts is approaching. “Chemistry Sings the Blues” is a symposium in celebration of the life and contributions of Dr. Willie Leigh. It is in the INORG division (ORG doesn’t allow symposia in honour of) but is open to all areas of chemistry. www.xcdsystem.com/cic/abstract...
The Chemical Institute of Canada
www.xcdsystem.com
January 28, 2025 at 2:21 PM
Deadline for #CSC2025 abstracts is approaching. “Chemistry Sings the Blues” is a symposium in celebration of the life and contributions of Dr. Willie Leigh. It is in the INORG division (ORG doesn’t allow symposia in honour of) but is open to all areas of chemistry. www.xcdsystem.com/cic/abstract...
Congrats Kamyar and team! We are happy to have helped out. Very useful to have approved drugs to accelerate validation of ferroptosis inhibition as a therapeutic strategy!
Very pleased to see our latest study published at CDDpress. We show that #Seratrodast, an approved drug, is a suppressor of #ferroptosis by inihibiting lipid peroxidation.
Thanks to Jule, Wulf, and the rest of the team!
www.nature.com/articles/s41...
Thanks to Jule, Wulf, and the rest of the team!
www.nature.com/articles/s41...
November 22, 2024 at 10:06 PM
Congrats Kamyar and team! We are happy to have helped out. Very useful to have approved drugs to accelerate validation of ferroptosis inhibition as a therapeutic strategy!
No derivatization required! Thiol oxidation products (RSOH, RSCl, etc) can be observed and characterized directly using Dmitry’s water-soluble triptycene scaffold. Check it and some cool applications out now in ChemSci! pubs.rsc.org/en/content/a... @roysocchem.bsky.social
Monitoring electrophilic intermediates in reactions of thiols in aqueous solution directly with 19 F NMR - Chemical Science (RSC Publishing) DOI:10.1039/D4SC04871G
pubs.rsc.org
November 21, 2024 at 1:20 PM
No derivatization required! Thiol oxidation products (RSOH, RSCl, etc) can be observed and characterized directly using Dmitry’s water-soluble triptycene scaffold. Check it and some cool applications out now in ChemSci! pubs.rsc.org/en/content/a... @roysocchem.bsky.social
First post on the new (to us) platform! Now out with page numbers: Mike and Aditya inhibit #ferroptosis with platinum complexes!? You read that right… platinum is not just for killing cells! Check it out in JACS: pubs.acs.org/doi/abs/10.1...
Ligand-Based Radical Reactivity of Metal Thiosemicarbazones Prompts the Identification of Platinum(II)-Based Cytoprotectants
CuATSM, a copper(II) complex of a bis(thiosemicarbazone) of diacetyl, prevents oxidative cell death and acts as a neuroprotectant in vivo, prompting its evaluation to treat amyotrophic lateral scleros...
pubs.acs.org
November 19, 2024 at 10:34 PM
First post on the new (to us) platform! Now out with page numbers: Mike and Aditya inhibit #ferroptosis with platinum complexes!? You read that right… platinum is not just for killing cells! Check it out in JACS: pubs.acs.org/doi/abs/10.1...