Gokul Upadhyayula
@supgokul.bsky.social
Asst Prof of Molecular and Cell Biology, UC Berkeley
Scientific Director, Advanced Bioimaging Center
Scientific Director, Advanced Bioimaging Center
Reposted by Gokul Upadhyayula
🔬🔦Check out our ‘Imaging spotlight’ on Volumetric Imaging via Photochemical Sectioning (VIPS) from @ruixuan3.bsky.social, Srigokul Upadhyayula and colleagues.
VIPS helps researchers scale super resolution imaging to large whole-mount tissues.
focalplane.biologists.com/2025/12/02/i...
VIPS helps researchers scale super resolution imaging to large whole-mount tissues.
focalplane.biologists.com/2025/12/02/i...
Imaging spotlight: Volumetric Imaging via Photochemical Sectioning (VIPS) - FocalPlane
Imaging spotlight: Volumetric Imaging via Photochemical Sectioning (VIPS) - Tools
focalplane.biologists.com
December 2, 2025 at 2:39 PM
🔬🔦Check out our ‘Imaging spotlight’ on Volumetric Imaging via Photochemical Sectioning (VIPS) from @ruixuan3.bsky.social, Srigokul Upadhyayula and colleagues.
VIPS helps researchers scale super resolution imaging to large whole-mount tissues.
focalplane.biologists.com/2025/12/02/i...
VIPS helps researchers scale super resolution imaging to large whole-mount tissues.
focalplane.biologists.com/2025/12/02/i...
Reposted by Gokul Upadhyayula
(1/x) Excited to report VIPS (Volumetric imaging of biological specimens via photochemical sectioning) @science.org! VIPS uses light-based sample sectioning to eliminate the inherent imaging depth limit of high-resolution optical microscopes @supgokul.bsky.social: www.science.org/doi/10.1126/...
Mesoscale volumetric fluorescence imaging at nanoscale resolution by photochemical sectioning
Optical nanoscopy of intact biological specimens has been transformed by recent advancements in hydrogel-based tissue clearing and expansion, enabling the imaging of cellular and subcellular structure...
www.science.org
October 17, 2025 at 11:06 AM
(1/x) Excited to report VIPS (Volumetric imaging of biological specimens via photochemical sectioning) @science.org! VIPS uses light-based sample sectioning to eliminate the inherent imaging depth limit of high-resolution optical microscopes @supgokul.bsky.social: www.science.org/doi/10.1126/...
Thrilled to share our Science cover! VIPS (volumetric imaging via photochemical sectioning) eliminates working-distance limits for whole-mount, nanoscale imaging. LLSM + photodegradable hydrogel + petabyte-scale compute → mapped axons & myelin across two mouse olfactory bulbs (WT vs NPC1).
October 17, 2025 at 12:30 AM
Thrilled to share our Science cover! VIPS (volumetric imaging via photochemical sectioning) eliminates working-distance limits for whole-mount, nanoscale imaging. LLSM + photodegradable hydrogel + petabyte-scale compute → mapped axons & myelin across two mouse olfactory bulbs (WT vs NPC1).
Reposted by Gokul Upadhyayula
Adaptive optical vision Fourier transformer (AOViFT): a machine learning framework for inferring image aberrations and restoring diffraction-limited performance.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Fourier-based three-dimensional multistage transformer for aberration correction in multicellular specimens - Nature Methods
Adaptive optical vision Fourier transformer (AOViFT) is a machine learning-based framework for accurately inferring aberrations and restoring diffraction-limited performance in diverse biological specimens.
www.nature.com
October 2, 2025 at 3:09 PM
Adaptive optical vision Fourier transformer (AOViFT): a machine learning framework for inferring image aberrations and restoring diffraction-limited performance.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Finally here! Our preprint on the MOSAIC, a multimodal adaptive optical microscope enabling non‑invasive in‑vivo imaging from molecules to organisms, is out. MOSAIC captures everything from subcellular dynamics to neural activity in live mice.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
June 16, 2025 at 9:26 PM
Finally here! Our preprint on the MOSAIC, a multimodal adaptive optical microscope enabling non‑invasive in‑vivo imaging from molecules to organisms, is out. MOSAIC captures everything from subcellular dynamics to neural activity in live mice.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Gokul Upadhyayula
A Multimodal Adaptive Optical Microscope For In Vivo Imaging from Molecules to Organisms https://www.biorxiv.org/content/10.1101/2025.06.02.657494v1
June 16, 2025 at 8:30 AM
A Multimodal Adaptive Optical Microscope For In Vivo Imaging from Molecules to Organisms https://www.biorxiv.org/content/10.1101/2025.06.02.657494v1