Suel-Kee Kim
@suelkeekim.bsky.social
Neuroscientist, Sestan Lab @yaleneuro.bsky.social, Brain Development and Evolution, Human-Specific Features, #Cerebellum, Pluripotent Stem Cells, #iPSC, Individual Variation
Pinned
Suel-Kee Kim
@suelkeekim.bsky.social
· Sep 9
Human-specific features of the cerebellum and ZP2-regulated synapse development
Understanding the unique features of the human brain compared to non-human primates has long intrigued humankind. The cerebellum refines motor coordination and cognitive functions, contributing to the...
www.biorxiv.org
Excited to share our recent study on human-specific features of the cerebellum and the unexpected, novel role of zona pellucida protein 2 (ZP2) in synapse development. Grateful to the Sestan lab and all our collaborators for their outstanding contributions. www.biorxiv.org/content/10.1...
Reposted by Suel-Kee Kim
How have concerted and mosaic evolutionary mechanisms shaped the expansion of the human cerebellum?
Our review with @tyamadat.bsky.social and @ioansarr.bsky.social available free till March 29:
authors.elsevier.com/a/1ma2wFzn7a...
Our review with @tyamadat.bsky.social and @ioansarr.bsky.social available free till March 29:
authors.elsevier.com/a/1ma2wFzn7a...
February 12, 2026 at 10:38 AM
How have concerted and mosaic evolutionary mechanisms shaped the expansion of the human cerebellum?
Our review with @tyamadat.bsky.social and @ioansarr.bsky.social available free till March 29:
authors.elsevier.com/a/1ma2wFzn7a...
Our review with @tyamadat.bsky.social and @ioansarr.bsky.social available free till March 29:
authors.elsevier.com/a/1ma2wFzn7a...
Reposted by Suel-Kee Kim
NEXT TUE: DDD seminar, Feb. 17, 2026 @ 1PM Eastern US: Dr. Annerieke Sierksma (in Dr. Bart De Strooper's group at KU Leuven) will share her recent work on "Polygenic risk for Alzheimer’s disease shapes microglial inflammatory and antigen-presentation programs in vivo". carlocolantuoni.org/seminar
SeminarPage | Carlo Colantuoni
carlocolantuoni.org
February 11, 2026 at 4:35 AM
NEXT TUE: DDD seminar, Feb. 17, 2026 @ 1PM Eastern US: Dr. Annerieke Sierksma (in Dr. Bart De Strooper's group at KU Leuven) will share her recent work on "Polygenic risk for Alzheimer’s disease shapes microglial inflammatory and antigen-presentation programs in vivo". carlocolantuoni.org/seminar
Reposted by Suel-Kee Kim
NEXT TUE: DDD seminar, Jan. 27, 2025 @ 1PM Eastern US: Nadezhda Azbukina @nazbukina.bsky.social (from Dr. Barbara Treutlein's group) will speak on "A systematic study of morphogen patterning and its reproducibility in human neural organoids". carlocolantuoni.org/seminar
SeminarPage | Carlo Colantuoni
carlocolantuoni.org
January 23, 2026 at 9:47 PM
NEXT TUE: DDD seminar, Jan. 27, 2025 @ 1PM Eastern US: Nadezhda Azbukina @nazbukina.bsky.social (from Dr. Barbara Treutlein's group) will speak on "A systematic study of morphogen patterning and its reproducibility in human neural organoids". carlocolantuoni.org/seminar
Reposted by Suel-Kee Kim
NEXT TUE: DDD seminar, Dec. 16, 2025 @ 1PM Eastern US:
Dr. Tommy Vierbuchen @tvierbuchen.bsky.social will share his recent work on on cell villages using outbred mice: "A pluripotent stem cell platform for in vitro systems genetics studies of mouse brain development". carlocolantuoni.org/seminar
Dr. Tommy Vierbuchen @tvierbuchen.bsky.social will share his recent work on on cell villages using outbred mice: "A pluripotent stem cell platform for in vitro systems genetics studies of mouse brain development". carlocolantuoni.org/seminar
SeminarPage | Carlo Colantuoni
carlocolantuoni.org
December 9, 2025 at 4:21 PM
NEXT TUE: DDD seminar, Dec. 16, 2025 @ 1PM Eastern US:
Dr. Tommy Vierbuchen @tvierbuchen.bsky.social will share his recent work on on cell villages using outbred mice: "A pluripotent stem cell platform for in vitro systems genetics studies of mouse brain development". carlocolantuoni.org/seminar
Dr. Tommy Vierbuchen @tvierbuchen.bsky.social will share his recent work on on cell villages using outbred mice: "A pluripotent stem cell platform for in vitro systems genetics studies of mouse brain development". carlocolantuoni.org/seminar
Reposted by Suel-Kee Kim
Remarkable energy at the inaugural @cshlnews.bsky.social conference on Assembloids and complex cell–cell interactions across tissues and systems
A wonderful series of talks so far highlighting advances & discoveries being made with these self-organizing systems and a few common themes are emerging
A wonderful series of talks so far highlighting advances & discoveries being made with these self-organizing systems and a few common themes are emerging
December 10, 2025 at 8:50 PM
Remarkable energy at the inaugural @cshlnews.bsky.social conference on Assembloids and complex cell–cell interactions across tissues and systems
A wonderful series of talks so far highlighting advances & discoveries being made with these self-organizing systems and a few common themes are emerging
A wonderful series of talks so far highlighting advances & discoveries being made with these self-organizing systems and a few common themes are emerging
Reposted by Suel-Kee Kim
NEXT TUE: DDD seminar, Nov. 18, 2025 @ 1PM Eastern US: Continuing our focus on approaches to the study of many pluripotent stem cell lines, Dr. Michael Wells @mfwells.bsky.social will share his recent work on "cell villages". seminar info: carlocolantuoni.org/seminar [repost to spread the word]
SeminarPage | Carlo Colantuoni
carlocolantuoni.org
November 11, 2025 at 6:10 PM
NEXT TUE: DDD seminar, Nov. 18, 2025 @ 1PM Eastern US: Continuing our focus on approaches to the study of many pluripotent stem cell lines, Dr. Michael Wells @mfwells.bsky.social will share his recent work on "cell villages". seminar info: carlocolantuoni.org/seminar [repost to spread the word]
Reposted by Suel-Kee Kim
NEXT TUE: DDD seminar, Oct. 14, 2025 @ 1PM Eastern US: Continuing our focus on variation in early fate decisions and CNS regionalization, Dr. Alex Pollen will share his recent work on cross-species midbrain dopaminergic organoids. seminar info: carlocolantuoni.org/seminar -repost to spread the word
SeminarPage | Carlo Colantuoni
carlocolantuoni.org
October 8, 2025 at 5:54 PM
NEXT TUE: DDD seminar, Oct. 14, 2025 @ 1PM Eastern US: Continuing our focus on variation in early fate decisions and CNS regionalization, Dr. Alex Pollen will share his recent work on cross-species midbrain dopaminergic organoids. seminar info: carlocolantuoni.org/seminar -repost to spread the word
Reposted by Suel-Kee Kim
In a new @natcomms.nature.com study, @yaleneuro.bsky.social's Nicola Micali from the Rakic lab, alongside a team of researchers @prbb.org, found that many genes 🧬 linked to mental illness 🧠 are turned ON in neural stem cells as early as the first trimester.👶
Origins of mental illness, fast gas for a black hole
Yale researchers discover a gas guzzling black hole, learn that mental illness may start to develop earlier than once thought, and explore why some brain seizures cause a loss of consciousness.
news.yale.edu
September 23, 2025 at 4:45 PM
In a new @natcomms.nature.com study, @yaleneuro.bsky.social's Nicola Micali from the Rakic lab, alongside a team of researchers @prbb.org, found that many genes 🧬 linked to mental illness 🧠 are turned ON in neural stem cells as early as the first trimester.👶
Reposted by Suel-Kee Kim
#aECM (apical extracellular matrix) is a subset of #ECMatrix that is distinct from stromal matrices or basement membranes. Anybody out there studying #mucins #ZPproteins #cuticle #glycocalyx #surfactant or the like? We need to find each other and start talking!
November 16, 2024 at 2:06 PM
#aECM (apical extracellular matrix) is a subset of #ECMatrix that is distinct from stromal matrices or basement membranes. Anybody out there studying #mucins #ZPproteins #cuticle #glycocalyx #surfactant or the like? We need to find each other and start talking!
Reposted by Suel-Kee Kim
There is so much cool #aECM work going on but most of the researchers don’t know or talk to each other; this is an attempt to change that! Link below
... a new virtual seminar series on apical extracellular matrix #aECM on different #organisms 🪱🪰🐁🌱🦠will start in Fall 2025, with short talks and discussions
If you are interested
👉https://forms.gle/Y6UjbnXPH1pDHAE97
@meera-sundaram.bsky.social @gotworms.bsky.social @heiman.bsky.social
If you are interested
👉https://forms.gle/Y6UjbnXPH1pDHAE97
@meera-sundaram.bsky.social @gotworms.bsky.social @heiman.bsky.social
July 17, 2025 at 12:14 PM
There is so much cool #aECM work going on but most of the researchers don’t know or talk to each other; this is an attempt to change that! Link below
Excited to share our recent study on human-specific features of the cerebellum and the unexpected, novel role of zona pellucida protein 2 (ZP2) in synapse development. Grateful to the Sestan lab and all our collaborators for their outstanding contributions. www.biorxiv.org/content/10.1...
Human-specific features of the cerebellum and ZP2-regulated synapse development
Understanding the unique features of the human brain compared to non-human primates has long intrigued humankind. The cerebellum refines motor coordination and cognitive functions, contributing to the...
www.biorxiv.org
September 9, 2025 at 4:49 PM
Excited to share our recent study on human-specific features of the cerebellum and the unexpected, novel role of zona pellucida protein 2 (ZP2) in synapse development. Grateful to the Sestan lab and all our collaborators for their outstanding contributions. www.biorxiv.org/content/10.1...
Reposted by Suel-Kee Kim
NEXT TUE: DDD seminar, Sept. 16, 2025 @ 1PM Eastern US:
Continuing our focus on early fate decisions and CNS regionalization, next Tuesday Sept. 16th at 1PM Eastern US time, Gaurav Rathore (from Angete Kirkeby's group) will share his recent work. seminar info: carlocolantuoni.org/seminar.
Continuing our focus on early fate decisions and CNS regionalization, next Tuesday Sept. 16th at 1PM Eastern US time, Gaurav Rathore (from Angete Kirkeby's group) will share his recent work. seminar info: carlocolantuoni.org/seminar.
SeminarPage | Carlo Colantuoni
carlocolantuoni.org
September 8, 2025 at 12:26 PM
NEXT TUE: DDD seminar, Sept. 16, 2025 @ 1PM Eastern US:
Continuing our focus on early fate decisions and CNS regionalization, next Tuesday Sept. 16th at 1PM Eastern US time, Gaurav Rathore (from Angete Kirkeby's group) will share his recent work. seminar info: carlocolantuoni.org/seminar.
Continuing our focus on early fate decisions and CNS regionalization, next Tuesday Sept. 16th at 1PM Eastern US time, Gaurav Rathore (from Angete Kirkeby's group) will share his recent work. seminar info: carlocolantuoni.org/seminar.
Reposted by Suel-Kee Kim
today's discussion of CNS regionalization and its modeling in vitro is now online at:
www.youtube.com/playlist?lis...
www.youtube.com/playlist?lis...
Developmental Diversity in a Dish Seminar Series - YouTube
A virtual seminar series focusing on stem cell models and functional variation across human iPSC lines. Monthly virtual seminar series, held on one Tuesday o...
www.youtube.com
August 19, 2025 at 8:43 PM
today's discussion of CNS regionalization and its modeling in vitro is now online at:
www.youtube.com/playlist?lis...
www.youtube.com/playlist?lis...
Reposted by Suel-Kee Kim
Linking alterations in precursor cells of brain 🧠 formation with the origin of #neuropsychiatricdiseases
#bioinformàtica #neuropsiquiatria #salutmental #autisme #Alzheimer #TalentMAR @santperelab.bsky.social @yaleneuro.bsky.social @hospitaldelmar.bsky.social
www.researchmar.net/news/742/lin...
#bioinformàtica #neuropsiquiatria #salutmental #autisme #Alzheimer #TalentMAR @santperelab.bsky.social @yaleneuro.bsky.social @hospitaldelmar.bsky.social
www.researchmar.net/news/742/lin...
July 25, 2025 at 7:09 AM
Linking alterations in precursor cells of brain 🧠 formation with the origin of #neuropsychiatricdiseases
#bioinformàtica #neuropsiquiatria #salutmental #autisme #Alzheimer #TalentMAR @santperelab.bsky.social @yaleneuro.bsky.social @hospitaldelmar.bsky.social
www.researchmar.net/news/742/lin...
#bioinformàtica #neuropsiquiatria #salutmental #autisme #Alzheimer #TalentMAR @santperelab.bsky.social @yaleneuro.bsky.social @hospitaldelmar.bsky.social
www.researchmar.net/news/742/lin...
Reposted by Suel-Kee Kim
Excited to share our latest work, spearheaded by my brilliant student Xoel Mato and co-led by Nicola Micali. After years of sweat, intense weekly meetings, and meticulous discussion of every panel, we learned a lot from each other. Grateful for the journey!
@researchmar.bsky.social
rdcu.be/evCaU
@researchmar.bsky.social
rdcu.be/evCaU
Early developmental origins of cortical disorders modeled in human neural stem cells
Nature Communications - The implications of early telencephalic development in cortical disorders remain elusive. Here, the authors define risk gene dynamics and perturbation effects in neural stem...
rdcu.be
July 10, 2025 at 6:24 AM
Excited to share our latest work, spearheaded by my brilliant student Xoel Mato and co-led by Nicola Micali. After years of sweat, intense weekly meetings, and meticulous discussion of every panel, we learned a lot from each other. Grateful for the journey!
@researchmar.bsky.social
rdcu.be/evCaU
@researchmar.bsky.social
rdcu.be/evCaU
Excited to share our latest work, Mato-Blanco et al., nature.com/articles/s41.... Thanks to the incredible collaboration with Nicola Micali, Rakic lab, Sestan lab, Vaccarino lab
@yaleneuro.bsky.social @santperelab.bsky.social @carlocolantuoni.bsky.social
@yaleneuro.bsky.social @santperelab.bsky.social @carlocolantuoni.bsky.social
Early developmental origins of cortical disorders modeled in human neural stem cells - Nature Communications
The implications of early telencephalic development in cortical disorders remain elusive. Here, the authors define risk gene dynamics and perturbation effects in neural stem cells, revealing vulnerabi...
nature.com
July 9, 2025 at 11:11 PM
Excited to share our latest work, Mato-Blanco et al., nature.com/articles/s41.... Thanks to the incredible collaboration with Nicola Micali, Rakic lab, Sestan lab, Vaccarino lab
@yaleneuro.bsky.social @santperelab.bsky.social @carlocolantuoni.bsky.social
@yaleneuro.bsky.social @santperelab.bsky.social @carlocolantuoni.bsky.social
Reposted by Suel-Kee Kim
NEXT TUE: DDD seminar, July 8, 2025 @ 1PM Eastern US: Dr. Alessandro Vitriolo @alessandrovitriolo.bsky.social (Lab of Dr. Giuseppe Testa) “Regulatory logic of human cortex evolution by combinatorial perturbations”. seminar info: carlocolantuoni.org/seminar [repost to spread the word]
SeminarPage | Carlo Colantuoni
carlocolantuoni.org
July 1, 2025 at 9:39 PM
NEXT TUE: DDD seminar, July 8, 2025 @ 1PM Eastern US: Dr. Alessandro Vitriolo @alessandrovitriolo.bsky.social (Lab of Dr. Giuseppe Testa) “Regulatory logic of human cortex evolution by combinatorial perturbations”. seminar info: carlocolantuoni.org/seminar [repost to spread the word]
Reposted by Suel-Kee Kim
Thrilled to present MIND!
A model for how the sensorimotor–association axis of the neocortex develops.
Huge thanks to the incredible multidisciplinary team who made this happen.
www.biorxiv.org/content/10.1...
A model for how the sensorimotor–association axis of the neocortex develops.
Huge thanks to the incredible multidisciplinary team who made this happen.
www.biorxiv.org/content/10.1...
Competing Programs Shape Cortical Sensorimotor-Association Axis Development
The neocortex is organized along a dominant sensorimotor-to-association (S-A) axis, anchored by modality-specific primary sensorimotor areas at one end and transmodal association areas that form distr...
www.biorxiv.org
July 1, 2025 at 5:29 PM
Thrilled to present MIND!
A model for how the sensorimotor–association axis of the neocortex develops.
Huge thanks to the incredible multidisciplinary team who made this happen.
www.biorxiv.org/content/10.1...
A model for how the sensorimotor–association axis of the neocortex develops.
Huge thanks to the incredible multidisciplinary team who made this happen.
www.biorxiv.org/content/10.1...
Reposted by Suel-Kee Kim
NEXT TUE: DDD seminar, June 10, 2025 @ 1PM Eastern US: Dr. Magdalena Sutcliffe (lab of Dr. M Lancaster @lancasterlab.bsky.social) “Epigenetic restoration of differentiation competency via reversal of epiblast regionalisation”. seminar info: carlocolantuoni.org/seminar [repost to spread the word]
SeminarPage | Carlo Colantuoni
carlocolantuoni.org
June 4, 2025 at 5:31 PM
NEXT TUE: DDD seminar, June 10, 2025 @ 1PM Eastern US: Dr. Magdalena Sutcliffe (lab of Dr. M Lancaster @lancasterlab.bsky.social) “Epigenetic restoration of differentiation competency via reversal of epiblast regionalisation”. seminar info: carlocolantuoni.org/seminar [repost to spread the word]
Reposted by Suel-Kee Kim
Excited to showcase as a co-first author our latest work "Adaptive Evolution of Gene Regulatory Networks in Mammalian Neocortical Neurons "https://www.biorxiv.org/content/10.1101/2025.05.20.652233v1
May 22, 2025 at 5:43 PM
Excited to showcase as a co-first author our latest work "Adaptive Evolution of Gene Regulatory Networks in Mammalian Neocortical Neurons "https://www.biorxiv.org/content/10.1101/2025.05.20.652233v1
Reposted by Suel-Kee Kim
The recording of today's DDD seminar by Dr. Ron McKay “Origin and consequences of genetically distinct behaviors in human neural stem cells” is now online at: www.youtube.com/playlist?lis...
Developmental Diversity in a Dish Seminar Series - YouTube
A virtual seminar series focusing on stem cell models and functional variation across human iPSC lines. Monthly virtual seminar series, held on one Tuesday o...
www.youtube.com
May 6, 2025 at 8:12 PM
The recording of today's DDD seminar by Dr. Ron McKay “Origin and consequences of genetically distinct behaviors in human neural stem cells” is now online at: www.youtube.com/playlist?lis...
Reposted by Suel-Kee Kim
Thrilled to share our latest study out in @natureportfolio.nature.com led by the fantastically talented Jing Liu. Our study provides insight into a long standing question in biology: What molecular features make us uniquely human and how do these function? www.nature.com/articles/s41...
A human-specific enhancer fine-tunes radial glia potency and corticogenesis - Nature
HARE5, a human accelerated region enhancer, modulates cortical development by influencing neural progenitor cell behaviour, leading to an enlarged neocortex with increased functional independence betw...
www.nature.com
May 14, 2025 at 4:09 PM
Thrilled to share our latest study out in @natureportfolio.nature.com led by the fantastically talented Jing Liu. Our study provides insight into a long standing question in biology: What molecular features make us uniquely human and how do these function? www.nature.com/articles/s41...
Reposted by Suel-Kee Kim
Today in @nature.com , we report a spatial single-cell atlas of human cortical development, revealing surprisingly early specification of human cortical layers and areas.
We built an interactive browser to explore the spatial data: walshlab.org/research/cor...
Paper link below 👇
We built an interactive browser to explore the spatial data: walshlab.org/research/cor...
Paper link below 👇
May 14, 2025 at 5:24 PM
Today in @nature.com , we report a spatial single-cell atlas of human cortical development, revealing surprisingly early specification of human cortical layers and areas.
We built an interactive browser to explore the spatial data: walshlab.org/research/cor...
Paper link below 👇
We built an interactive browser to explore the spatial data: walshlab.org/research/cor...
Paper link below 👇
Reposted by Suel-Kee Kim
NEXT TUE: DDD seminar, May 6, 2025 @ 1PM Eastern US: Dr. Ron McKay “Origin and consequences of genetically distinct behaviors in human neural stem cells”. seminar info: carlocolantuoni.org/seminar [repost to spread the word]
SeminarPage | Carlo Colantuoni
carlocolantuoni.org
April 29, 2025 at 10:38 PM
NEXT TUE: DDD seminar, May 6, 2025 @ 1PM Eastern US: Dr. Ron McKay “Origin and consequences of genetically distinct behaviors in human neural stem cells”. seminar info: carlocolantuoni.org/seminar [repost to spread the word]
Reposted by Suel-Kee Kim
NEXT TUE: DDD seminar, Apr. 1, 2025 @ 1PM Eastern US: Dr. Jason Stein steinlab.bsky.social “Modeling genetics altering human cortical structure”. seminar info: carlocolantuoni.org/seminar [repost to spread the word]
SeminarPage | Carlo Colantuoni
carlocolantuoni.org
March 26, 2025 at 8:56 PM
NEXT TUE: DDD seminar, Apr. 1, 2025 @ 1PM Eastern US: Dr. Jason Stein steinlab.bsky.social “Modeling genetics altering human cortical structure”. seminar info: carlocolantuoni.org/seminar [repost to spread the word]