Gabriel Santpere
@santperelab.bsky.social
We’re excited to share our new preprint on the mechanisms underlying DNA binding by bHLH transcription factors and how they achieve distinct DNA binding specificities. The study has been spearheaded by Xabier de Martín.
@grib-barcelona.bsky.social
Take a look! 👇
www.biorxiv.org/content/10.6...
@grib-barcelona.bsky.social
Take a look! 👇
www.biorxiv.org/content/10.6...
www.biorxiv.org
February 11, 2026 at 9:30 AM
We’re excited to share our new preprint on the mechanisms underlying DNA binding by bHLH transcription factors and how they achieve distinct DNA binding specificities. The study has been spearheaded by Xabier de Martín.
@grib-barcelona.bsky.social
Take a look! 👇
www.biorxiv.org/content/10.6...
@grib-barcelona.bsky.social
Take a look! 👇
www.biorxiv.org/content/10.6...
Sofia Ognibene presented a poster at the XIII Bioinformatics and Genomics Conference on a pipeline to analyze Epstein–Barr virus genomes in the context of the #EBVMS project 🧬🚀
Great work!
Great work!
December 20, 2025 at 8:23 AM
Sofia Ognibene presented a poster at the XIII Bioinformatics and Genomics Conference on a pipeline to analyze Epstein–Barr virus genomes in the context of the #EBVMS project 🧬🚀
Great work!
Great work!
Great days in Bergen for the EBV-MS consortium meeting. Inspiring discussions, outstanding science, and a truly collaborative spirit. Excited to be part of such a stimulating international effort to unravel the role of EBV in MS. #EBVMS #MultipleSclerosis
@researchmar.bsky.social
@researchmar.bsky.social
November 19, 2025 at 4:23 PM
Great days in Bergen for the EBV-MS consortium meeting. Inspiring discussions, outstanding science, and a truly collaborative spirit. Excited to be part of such a stimulating international effort to unravel the role of EBV in MS. #EBVMS #MultipleSclerosis
@researchmar.bsky.social
@researchmar.bsky.social
Reposted by Gabriel Santpere
Excited to share our recent study on human-specific features of the cerebellum and the unexpected, novel role of zona pellucida protein 2 (ZP2) in synapse development. Grateful to the Sestan lab and all our collaborators for their outstanding contributions. www.biorxiv.org/content/10.1...
Human-specific features of the cerebellum and ZP2-regulated synapse development
Understanding the unique features of the human brain compared to non-human primates has long intrigued humankind. The cerebellum refines motor coordination and cognitive functions, contributing to the...
www.biorxiv.org
September 9, 2025 at 4:49 PM
Excited to share our recent study on human-specific features of the cerebellum and the unexpected, novel role of zona pellucida protein 2 (ZP2) in synapse development. Grateful to the Sestan lab and all our collaborators for their outstanding contributions. www.biorxiv.org/content/10.1...
Reposted by Gabriel Santpere
Reposted by Gabriel Santpere
Linking alterations in precursor cells of brain 🧠 formation with the origin of #neuropsychiatricdiseases
#bioinformàtica #neuropsiquiatria #salutmental #autisme #Alzheimer #TalentMAR @santperelab.bsky.social @yaleneuro.bsky.social @hospitaldelmar.bsky.social
www.researchmar.net/news/742/lin...
#bioinformàtica #neuropsiquiatria #salutmental #autisme #Alzheimer #TalentMAR @santperelab.bsky.social @yaleneuro.bsky.social @hospitaldelmar.bsky.social
www.researchmar.net/news/742/lin...
July 25, 2025 at 7:09 AM
Linking alterations in precursor cells of brain 🧠 formation with the origin of #neuropsychiatricdiseases
#bioinformàtica #neuropsiquiatria #salutmental #autisme #Alzheimer #TalentMAR @santperelab.bsky.social @yaleneuro.bsky.social @hospitaldelmar.bsky.social
www.researchmar.net/news/742/lin...
#bioinformàtica #neuropsiquiatria #salutmental #autisme #Alzheimer #TalentMAR @santperelab.bsky.social @yaleneuro.bsky.social @hospitaldelmar.bsky.social
www.researchmar.net/news/742/lin...
Excited to share our latest work, spearheaded by my brilliant student Xoel Mato and co-led by Nicola Micali. After years of sweat, intense weekly meetings, and meticulous discussion of every panel, we learned a lot from each other. Grateful for the journey!
@researchmar.bsky.social
rdcu.be/evCaU
@researchmar.bsky.social
rdcu.be/evCaU
Early developmental origins of cortical disorders modeled in human neural stem cells
Nature Communications - The implications of early telencephalic development in cortical disorders remain elusive. Here, the authors define risk gene dynamics and perturbation effects in neural stem...
rdcu.be
July 10, 2025 at 6:24 AM
Excited to share our latest work, spearheaded by my brilliant student Xoel Mato and co-led by Nicola Micali. After years of sweat, intense weekly meetings, and meticulous discussion of every panel, we learned a lot from each other. Grateful for the journey!
@researchmar.bsky.social
rdcu.be/evCaU
@researchmar.bsky.social
rdcu.be/evCaU
Reposted by Gabriel Santpere
Excited to showcase as a co-first author our latest work "Adaptive Evolution of Gene Regulatory Networks in Mammalian Neocortical Neurons "https://www.biorxiv.org/content/10.1101/2025.05.20.652233v1
May 22, 2025 at 5:43 PM
Excited to showcase as a co-first author our latest work "Adaptive Evolution of Gene Regulatory Networks in Mammalian Neocortical Neurons "https://www.biorxiv.org/content/10.1101/2025.05.20.652233v1
Mice grow bigger brains when given this stretch of human DNA www.nature.com/articles/d41...
Mice grow bigger brains when given this stretch of human DNA
Finding adds to the bigger picture of how humans developed such large brains.
www.nature.com
May 14, 2025 at 6:37 PM
Mice grow bigger brains when given this stretch of human DNA www.nature.com/articles/d41...
Last week we attended the #ECCN2025 meeting in Alacant. It was an impressive succession of mind-blowing talks—exhilarating and exhausting. You couldn’t let your guard down for a second!
Here are Paula Mayo and Josema Ruiz presenting their posters.
@grib-barcelona.bsky.social
Here are Paula Mayo and Josema Ruiz presenting their posters.
@grib-barcelona.bsky.social
May 14, 2025 at 8:04 AM
Last week we attended the #ECCN2025 meeting in Alacant. It was an impressive succession of mind-blowing talks—exhilarating and exhausting. You couldn’t let your guard down for a second!
Here are Paula Mayo and Josema Ruiz presenting their posters.
@grib-barcelona.bsky.social
Here are Paula Mayo and Josema Ruiz presenting their posters.
@grib-barcelona.bsky.social
Reposted by Gabriel Santpere
🦠Although infection by the #EpsteinBarrVirus is necessary to develop #MultipleSclerosis, only 0.3% of those infected develop it. A new European project with the participation of 3 PRBB centres aims to understand why and the underlying mechanism.
More 👇
ellipse.prbb.org/ebv-ms-unvei...
More 👇
ellipse.prbb.org/ebv-ms-unvei...
EBV-MS: Unveiling the relationship between Epstein-Barr virus and multiple sclerosis - El·lipse
A 5-year Horizon Europe-funded project aims to uncover the role of the EBV virus in the onset and progression of the Multiple Sclerosis (MS) disease .
ellipse.prbb.org
April 25, 2025 at 11:13 AM
🦠Although infection by the #EpsteinBarrVirus is necessary to develop #MultipleSclerosis, only 0.3% of those infected develop it. A new European project with the participation of 3 PRBB centres aims to understand why and the underlying mechanism.
More 👇
ellipse.prbb.org/ebv-ms-unvei...
More 👇
ellipse.prbb.org/ebv-ms-unvei...
Our piece on the beautiful work by Cui et al. on the impact of human accelerated regions on neurons is out now!
@grib-barcelona.bsky.social
@researchmar.bsky.social
@cp-trendsgenetics.bsky.social
www.sciencedirect.com/science/arti...
@grib-barcelona.bsky.social
@researchmar.bsky.social
@cp-trendsgenetics.bsky.social
www.sciencedirect.com/science/arti...
The impact of human accelerated regions on neuronal development
Human accelerated regions (HARs) are the fastest-evolving sequences in the human genome since the divergence from chimpanzees. Some of these regions a…
www.sciencedirect.com
April 6, 2025 at 8:57 AM
Our piece on the beautiful work by Cui et al. on the impact of human accelerated regions on neurons is out now!
@grib-barcelona.bsky.social
@researchmar.bsky.social
@cp-trendsgenetics.bsky.social
www.sciencedirect.com/science/arti...
@grib-barcelona.bsky.social
@researchmar.bsky.social
@cp-trendsgenetics.bsky.social
www.sciencedirect.com/science/arti...
Reposted by Gabriel Santpere
Reposted by Gabriel Santpere
Great study from Nenad Sestan’s lab and collaborators (led by @babyamygdala.bsky.social) on the specification of claustro-amygdalar and ‘palaeocortical’ neurons and circuits — with a key role for TFAP2D dosage, now out in @nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Specification of claustro-amygdalar and palaeocortical neurons and circuits - Nature
A conserved gene regulatory network involving SOX4, SOX11 and TFAP2D shapes the development of excitatory neurons in ventrolateral pallium and their connectivity with the prefrontal cortex.
www.nature.com
January 15, 2025 at 6:06 PM
Great study from Nenad Sestan’s lab and collaborators (led by @babyamygdala.bsky.social) on the specification of claustro-amygdalar and ‘palaeocortical’ neurons and circuits — with a key role for TFAP2D dosage, now out in @nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Gabriel Santpere
Read the full paper from Dennis Joshy, Gabriel Santpere, & Soojin V. Yi of @ucsantabarbara.bsky.social & @researchmar.bsky.social in @pnas.org: www.pnas.org/doi/10.1073/... 4/8
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
www.pnas.org
January 6, 2025 at 2:30 PM
Read the full paper from Dennis Joshy, Gabriel Santpere, & Soojin V. Yi of @ucsantabarbara.bsky.social & @researchmar.bsky.social in @pnas.org: www.pnas.org/doi/10.1073/... 4/8
Reposted by Gabriel Santpere
🧬 Human Brain Evolution
New research reveals rapid, cell-type-specific regulatory evolution in human brains compared to primates, highlighting specialised changes in brain cells that shaped human cognition and behaviour.
🔗 www.pnas.org/doi/10.1073/...
#Neuroscience #Evolution #SciComm 🧪
New research reveals rapid, cell-type-specific regulatory evolution in human brains compared to primates, highlighting specialised changes in brain cells that shaped human cognition and behaviour.
🔗 www.pnas.org/doi/10.1073/...
#Neuroscience #Evolution #SciComm 🧪
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
www.pnas.org
January 5, 2025 at 11:36 AM
🧬 Human Brain Evolution
New research reveals rapid, cell-type-specific regulatory evolution in human brains compared to primates, highlighting specialised changes in brain cells that shaped human cognition and behaviour.
🔗 www.pnas.org/doi/10.1073/...
#Neuroscience #Evolution #SciComm 🧪
New research reveals rapid, cell-type-specific regulatory evolution in human brains compared to primates, highlighting specialised changes in brain cells that shaped human cognition and behaviour.
🔗 www.pnas.org/doi/10.1073/...
#Neuroscience #Evolution #SciComm 🧪
Reposted by Gabriel Santpere
Accelerated cell-type-specific regulatory evolution of the human brain | PNAS www.pnas.org/doi/full/10....
Accelerated cell-type-specific regulatory evolution of the human brain | PNAS
The molecular basis of human brain evolution is a key piece in understanding the evolution
of human-specific cognitive and behavioral traits. Compa...
www.pnas.org
December 18, 2024 at 10:09 AM
Accelerated cell-type-specific regulatory evolution of the human brain | PNAS www.pnas.org/doi/full/10....