Gabriel Santpere
@santperelab.bsky.social
Reposted by Gabriel Santpere
Excited to share our recent study on human-specific features of the cerebellum and the unexpected, novel role of zona pellucida protein 2 (ZP2) in synapse development. Grateful to the Sestan lab and all our collaborators for their outstanding contributions. www.biorxiv.org/content/10.1...
Human-specific features of the cerebellum and ZP2-regulated synapse development
Understanding the unique features of the human brain compared to non-human primates has long intrigued humankind. The cerebellum refines motor coordination and cognitive functions, contributing to the...
www.biorxiv.org
September 9, 2025 at 4:49 PM
Excited to share our recent study on human-specific features of the cerebellum and the unexpected, novel role of zona pellucida protein 2 (ZP2) in synapse development. Grateful to the Sestan lab and all our collaborators for their outstanding contributions. www.biorxiv.org/content/10.1...
Reposted by Gabriel Santpere
Reposted by Gabriel Santpere
Linking alterations in precursor cells of brain 🧠 formation with the origin of #neuropsychiatricdiseases
#bioinformàtica #neuropsiquiatria #salutmental #autisme #Alzheimer #TalentMAR @santperelab.bsky.social @yaleneuro.bsky.social @hospitaldelmar.bsky.social
www.researchmar.net/news/742/lin...
#bioinformàtica #neuropsiquiatria #salutmental #autisme #Alzheimer #TalentMAR @santperelab.bsky.social @yaleneuro.bsky.social @hospitaldelmar.bsky.social
www.researchmar.net/news/742/lin...
July 25, 2025 at 7:09 AM
Linking alterations in precursor cells of brain 🧠 formation with the origin of #neuropsychiatricdiseases
#bioinformàtica #neuropsiquiatria #salutmental #autisme #Alzheimer #TalentMAR @santperelab.bsky.social @yaleneuro.bsky.social @hospitaldelmar.bsky.social
www.researchmar.net/news/742/lin...
#bioinformàtica #neuropsiquiatria #salutmental #autisme #Alzheimer #TalentMAR @santperelab.bsky.social @yaleneuro.bsky.social @hospitaldelmar.bsky.social
www.researchmar.net/news/742/lin...
Excited to share our latest work, spearheaded by my brilliant student Xoel Mato and co-led by Nicola Micali. After years of sweat, intense weekly meetings, and meticulous discussion of every panel, we learned a lot from each other. Grateful for the journey!
@researchmar.bsky.social
rdcu.be/evCaU
@researchmar.bsky.social
rdcu.be/evCaU
Early developmental origins of cortical disorders modeled in human neural stem cells
Nature Communications - The implications of early telencephalic development in cortical disorders remain elusive. Here, the authors define risk gene dynamics and perturbation effects in neural stem...
rdcu.be
July 10, 2025 at 6:24 AM
Excited to share our latest work, spearheaded by my brilliant student Xoel Mato and co-led by Nicola Micali. After years of sweat, intense weekly meetings, and meticulous discussion of every panel, we learned a lot from each other. Grateful for the journey!
@researchmar.bsky.social
rdcu.be/evCaU
@researchmar.bsky.social
rdcu.be/evCaU
Reposted by Gabriel Santpere
Excited to showcase as a co-first author our latest work "Adaptive Evolution of Gene Regulatory Networks in Mammalian Neocortical Neurons "https://www.biorxiv.org/content/10.1101/2025.05.20.652233v1
May 22, 2025 at 5:43 PM
Excited to showcase as a co-first author our latest work "Adaptive Evolution of Gene Regulatory Networks in Mammalian Neocortical Neurons "https://www.biorxiv.org/content/10.1101/2025.05.20.652233v1
Mice grow bigger brains when given this stretch of human DNA www.nature.com/articles/d41...
Mice grow bigger brains when given this stretch of human DNA
Finding adds to the bigger picture of how humans developed such large brains.
www.nature.com
May 14, 2025 at 6:37 PM
Mice grow bigger brains when given this stretch of human DNA www.nature.com/articles/d41...
Last week we attended the #ECCN2025 meeting in Alacant. It was an impressive succession of mind-blowing talks—exhilarating and exhausting. You couldn’t let your guard down for a second!
Here are Paula Mayo and Josema Ruiz presenting their posters.
@grib-barcelona.bsky.social
Here are Paula Mayo and Josema Ruiz presenting their posters.
@grib-barcelona.bsky.social
May 14, 2025 at 8:04 AM
Last week we attended the #ECCN2025 meeting in Alacant. It was an impressive succession of mind-blowing talks—exhilarating and exhausting. You couldn’t let your guard down for a second!
Here are Paula Mayo and Josema Ruiz presenting their posters.
@grib-barcelona.bsky.social
Here are Paula Mayo and Josema Ruiz presenting their posters.
@grib-barcelona.bsky.social
Reposted by Gabriel Santpere
🦠Although infection by the #EpsteinBarrVirus is necessary to develop #MultipleSclerosis, only 0.3% of those infected develop it. A new European project with the participation of 3 PRBB centres aims to understand why and the underlying mechanism.
More 👇
ellipse.prbb.org/ebv-ms-unvei...
More 👇
ellipse.prbb.org/ebv-ms-unvei...
EBV-MS: Unveiling the relationship between Epstein-Barr virus and multiple sclerosis - El·lipse
A 5-year Horizon Europe-funded project aims to uncover the role of the EBV virus in the onset and progression of the Multiple Sclerosis (MS) disease .
ellipse.prbb.org
April 25, 2025 at 11:13 AM
🦠Although infection by the #EpsteinBarrVirus is necessary to develop #MultipleSclerosis, only 0.3% of those infected develop it. A new European project with the participation of 3 PRBB centres aims to understand why and the underlying mechanism.
More 👇
ellipse.prbb.org/ebv-ms-unvei...
More 👇
ellipse.prbb.org/ebv-ms-unvei...
Our piece on the beautiful work by Cui et al. on the impact of human accelerated regions on neurons is out now!
@grib-barcelona.bsky.social
@researchmar.bsky.social
@cp-trendsgenetics.bsky.social
www.sciencedirect.com/science/arti...
@grib-barcelona.bsky.social
@researchmar.bsky.social
@cp-trendsgenetics.bsky.social
www.sciencedirect.com/science/arti...
The impact of human accelerated regions on neuronal development
Human accelerated regions (HARs) are the fastest-evolving sequences in the human genome since the divergence from chimpanzees. Some of these regions a…
www.sciencedirect.com
April 6, 2025 at 8:57 AM
Our piece on the beautiful work by Cui et al. on the impact of human accelerated regions on neurons is out now!
@grib-barcelona.bsky.social
@researchmar.bsky.social
@cp-trendsgenetics.bsky.social
www.sciencedirect.com/science/arti...
@grib-barcelona.bsky.social
@researchmar.bsky.social
@cp-trendsgenetics.bsky.social
www.sciencedirect.com/science/arti...
Reposted by Gabriel Santpere
Reposted by Gabriel Santpere
Great study from Nenad Sestan’s lab and collaborators (led by @babyamygdala.bsky.social) on the specification of claustro-amygdalar and ‘palaeocortical’ neurons and circuits — with a key role for TFAP2D dosage, now out in @nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Specification of claustro-amygdalar and palaeocortical neurons and circuits - Nature
A conserved gene regulatory network involving SOX4, SOX11 and TFAP2D shapes the development of excitatory neurons in ventrolateral pallium and their connectivity with the prefrontal cortex.
www.nature.com
January 15, 2025 at 6:06 PM
Great study from Nenad Sestan’s lab and collaborators (led by @babyamygdala.bsky.social) on the specification of claustro-amygdalar and ‘palaeocortical’ neurons and circuits — with a key role for TFAP2D dosage, now out in @nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Gabriel Santpere
Read the full paper from Dennis Joshy, Gabriel Santpere, & Soojin V. Yi of @ucsantabarbara.bsky.social & @researchmar.bsky.social in @pnas.org: www.pnas.org/doi/10.1073/... 4/8
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
www.pnas.org
January 6, 2025 at 2:30 PM
Read the full paper from Dennis Joshy, Gabriel Santpere, & Soojin V. Yi of @ucsantabarbara.bsky.social & @researchmar.bsky.social in @pnas.org: www.pnas.org/doi/10.1073/... 4/8
Reposted by Gabriel Santpere
🧬 Human Brain Evolution
New research reveals rapid, cell-type-specific regulatory evolution in human brains compared to primates, highlighting specialised changes in brain cells that shaped human cognition and behaviour.
🔗 www.pnas.org/doi/10.1073/...
#Neuroscience #Evolution #SciComm 🧪
New research reveals rapid, cell-type-specific regulatory evolution in human brains compared to primates, highlighting specialised changes in brain cells that shaped human cognition and behaviour.
🔗 www.pnas.org/doi/10.1073/...
#Neuroscience #Evolution #SciComm 🧪
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
www.pnas.org
January 5, 2025 at 11:36 AM
🧬 Human Brain Evolution
New research reveals rapid, cell-type-specific regulatory evolution in human brains compared to primates, highlighting specialised changes in brain cells that shaped human cognition and behaviour.
🔗 www.pnas.org/doi/10.1073/...
#Neuroscience #Evolution #SciComm 🧪
New research reveals rapid, cell-type-specific regulatory evolution in human brains compared to primates, highlighting specialised changes in brain cells that shaped human cognition and behaviour.
🔗 www.pnas.org/doi/10.1073/...
#Neuroscience #Evolution #SciComm 🧪
Reposted by Gabriel Santpere
Accelerated cell-type-specific regulatory evolution of the human brain | PNAS www.pnas.org/doi/full/10....
Accelerated cell-type-specific regulatory evolution of the human brain | PNAS
The molecular basis of human brain evolution is a key piece in understanding the evolution
of human-specific cognitive and behavioral traits. Compa...
www.pnas.org
December 18, 2024 at 10:09 AM
Accelerated cell-type-specific regulatory evolution of the human brain | PNAS www.pnas.org/doi/full/10....