Steve Joffe
@stevejoffe.bsky.social
Professor @ UPenn. Research ethics, pediatric ethics, cancer ethics, genomethics, science policy. Grateful immigrant, he/him. Speak only for myself. Reposts do not imply endorsement.
ORCID ID: 0000-0002-0667-7384
ORCID ID: 0000-0002-0667-7384
Reposted by Steve Joffe
Congratulations to CHIBE Associate Director Dr. Harsha Thirumurthy on being elected a Fellow of the Academy of Behavioral Medicine Research! @hthirumurthy.bsky.social
December 19, 2025 at 3:29 PM
Congratulations to CHIBE Associate Director Dr. Harsha Thirumurthy on being elected a Fellow of the Academy of Behavioral Medicine Research! @hthirumurthy.bsky.social
Not sure this is such a great idea. medicalfuturist.com/is-it-time-t...
Is It Time To Equip Our Toilets With Health Sensors? - The Medical Futurist
medicalfuturist.com
December 18, 2025 at 10:06 PM
Not sure this is such a great idea. medicalfuturist.com/is-it-time-t...
Reposted by Steve Joffe
The frontier of AI is still very messy. Hilarious column.
"Profits collapsed. Newsroom morale soared."
Amazing piece from @joannastern.bsky.social
www.wsj.com/tech/ai/anth...
Amazing piece from @joannastern.bsky.social
www.wsj.com/tech/ai/anth...
We Let AI Run Our Office Vending Machine. It Lost Hundreds of Dollars.
An AI agent ran a snack operation in the WSJ newsroom. It gave away a free PlayStation, ordered a live fish—and taught us lessons about the future of AI.
www.wsj.com
December 18, 2025 at 5:19 PM
The frontier of AI is still very messy. Hilarious column.
Reposted by Steve Joffe
I'm told that HHS has just terminated all funding agreements with the American Academy of Pediatrics.
Here's a letter HHS sent canceling one of the grants, relating to work on birth defects. Canceled because the project "emphasizes equity, diversity, and inclusion as key foundational components"
Here's a letter HHS sent canceling one of the grants, relating to work on birth defects. Canceled because the project "emphasizes equity, diversity, and inclusion as key foundational components"
December 17, 2025 at 6:00 PM
I'm told that HHS has just terminated all funding agreements with the American Academy of Pediatrics.
Here's a letter HHS sent canceling one of the grants, relating to work on birth defects. Canceled because the project "emphasizes equity, diversity, and inclusion as key foundational components"
Here's a letter HHS sent canceling one of the grants, relating to work on birth defects. Canceled because the project "emphasizes equity, diversity, and inclusion as key foundational components"
Reposted by Steve Joffe
Did you know that from tomorrow, Qualtrics is offering synthetic panels (AI-generated participants)?
Follow me down a rabbit hole I'm calling "doing science is tough and I'm so busy, can't we just make up participants?"
Follow me down a rabbit hole I'm calling "doing science is tough and I'm so busy, can't we just make up participants?"
December 16, 2025 at 5:38 PM
Did you know that from tomorrow, Qualtrics is offering synthetic panels (AI-generated participants)?
Follow me down a rabbit hole I'm calling "doing science is tough and I'm so busy, can't we just make up participants?"
Follow me down a rabbit hole I'm calling "doing science is tough and I'm so busy, can't we just make up participants?"
Reposted by Steve Joffe
Do you know an amazing post-doc interested in FDA policy and maybe even with some Delphi experience? Send them our way - we're looking to hire on our new project ASAP!
postdocs.yale.edu/posts/2025-1...
postdocs.yale.edu/posts/2025-1...
December 10, 2025 at 8:30 PM
Do you know an amazing post-doc interested in FDA policy and maybe even with some Delphi experience? Send them our way - we're looking to hire on our new project ASAP!
postdocs.yale.edu/posts/2025-1...
postdocs.yale.edu/posts/2025-1...
Reposted by Steve Joffe
🚨Research ethics job🚨
The Morgridge Institute for Research at UW–Madison is hiring at the assistant/associate level. I'm on the search committee. AMA!
uwmadison.box.com/s/5jvm5qidyk...
cc: @douglasmackay.bsky.social @hollylynchez.bsky.social @stevejoffe.bsky.social
The Morgridge Institute for Research at UW–Madison is hiring at the assistant/associate level. I'm on the search committee. AMA!
uwmadison.box.com/s/5jvm5qidyk...
cc: @douglasmackay.bsky.social @hollylynchez.bsky.social @stevejoffe.bsky.social
December 9, 2025 at 5:32 PM
🚨Research ethics job🚨
The Morgridge Institute for Research at UW–Madison is hiring at the assistant/associate level. I'm on the search committee. AMA!
uwmadison.box.com/s/5jvm5qidyk...
cc: @douglasmackay.bsky.social @hollylynchez.bsky.social @stevejoffe.bsky.social
The Morgridge Institute for Research at UW–Madison is hiring at the assistant/associate level. I'm on the search committee. AMA!
uwmadison.box.com/s/5jvm5qidyk...
cc: @douglasmackay.bsky.social @hollylynchez.bsky.social @stevejoffe.bsky.social
Reposted by Steve Joffe
TT #PhilJobs in Philosophy Dept joint w/ Bouvé College of Health in Ethics & Health @ Northeastern University, Boston. Ph.D. in #Philosophy, #HPS #STS, #Bioethics
To apply northeastern.wd1.myworkdayjobs.com/careers/job/...
Review of applications begins December 15 til position is filled.
To apply northeastern.wd1.myworkdayjobs.com/careers/job/...
Review of applications begins December 15 til position is filled.
Assistant Professor/ Associate Professor/ Full Professor
About the Opportunity The College of Social Sciences and Humanities and its ten tenure units are the home of the Experiential Liberal Arts. Through its research, teaching, and engagement missions, the...
northeastern.wd1.myworkdayjobs.com
December 3, 2025 at 7:40 PM
TT #PhilJobs in Philosophy Dept joint w/ Bouvé College of Health in Ethics & Health @ Northeastern University, Boston. Ph.D. in #Philosophy, #HPS #STS, #Bioethics
To apply northeastern.wd1.myworkdayjobs.com/careers/job/...
Review of applications begins December 15 til position is filled.
To apply northeastern.wd1.myworkdayjobs.com/careers/job/...
Review of applications begins December 15 til position is filled.
This is a great story, but adjuvant systemic chemotherapy for breast cancer was tested as early as the '50s. The National Cancer Institute funded a cooperative group, the National Surgical Adjuvant Breast and Bowel Project (NSABP) specifically for this purpose. www.ncbi.nlm.nih.gov/books/NBK130...
December 3, 2025 at 1:05 PM
This is a great story, but adjuvant systemic chemotherapy for breast cancer was tested as early as the '50s. The National Cancer Institute funded a cooperative group, the National Surgical Adjuvant Breast and Bowel Project (NSABP) specifically for this purpose. www.ncbi.nlm.nih.gov/books/NBK130...
Smack between a Scaramucci and a head of lettuce.
BREAKING scoop: Top drug regulator Rick Pazdur filed papers to retire from the FDA at the end of this month, according to agency sources. He alerted leaders at the drug center this morning. He could still withdraw the papers. www.statnews.com/2025/12/02/r...
Top drug regulator Richard Pazdur set to leave FDA
Top drug regulator Richard Pazdur filed papers to retire from the Food and Drug Administration at the end of this month, but could withdraw them.
www.statnews.com
December 2, 2025 at 6:53 PM
Smack between a Scaramucci and a head of lettuce.
Reposted by Steve Joffe
W/o showing his work, Prasad blames at least 10 pediatric deaths on the COVID vax.
Meanwhile, a "2023 JAMA paper said that during the 12 months ending in July 2022, 821 people aged 19 and under died of Covid." The authors also indicated that was an underestimate.
www.statnews.com/2025/11/29/c...
Meanwhile, a "2023 JAMA paper said that during the 12 months ending in July 2022, 821 people aged 19 and under died of Covid." The authors also indicated that was an underestimate.
www.statnews.com/2025/11/29/c...
Experts say top FDA official’s claim that Covid vaccines caused kids’ deaths requires more evidence
The FDA’s top vaccine regulator asserted in a staff email that the Covid vaccine caused at least 10 kids' deaths, but experts told STAT they are skeptical of the “extraordinary” claim because it was n...
www.statnews.com
November 30, 2025 at 12:13 PM
W/o showing his work, Prasad blames at least 10 pediatric deaths on the COVID vax.
Meanwhile, a "2023 JAMA paper said that during the 12 months ending in July 2022, 821 people aged 19 and under died of Covid." The authors also indicated that was an underestimate.
www.statnews.com/2025/11/29/c...
Meanwhile, a "2023 JAMA paper said that during the 12 months ending in July 2022, 821 people aged 19 and under died of Covid." The authors also indicated that was an underestimate.
www.statnews.com/2025/11/29/c...
Reposted by Steve Joffe
🚨New Paper🚨 US doctors are paid very different amounts for treating different patients—even when providing identical services.
How much less are physicians paid for treating non-White patients?
In @jamahealthforum.com, we offer the 1st national estimates. (1/7)
jamanetwork.com/journals/jam...
How much less are physicians paid for treating non-White patients?
In @jamahealthforum.com, we offer the 1st national estimates. (1/7)
jamanetwork.com/journals/jam...
Payments to Physician Practices and Incentives to Serve Different Racial and Ethnic Groups
This study measures disparities across patient racial and ethnic groups in per-visit payment to physician practices from health insurers and other sources, adjusted for visit content, geographic marke...
jamanetwork.com
November 26, 2025 at 4:21 PM
🚨New Paper🚨 US doctors are paid very different amounts for treating different patients—even when providing identical services.
How much less are physicians paid for treating non-White patients?
In @jamahealthforum.com, we offer the 1st national estimates. (1/7)
jamanetwork.com/journals/jam...
How much less are physicians paid for treating non-White patients?
In @jamahealthforum.com, we offer the 1st national estimates. (1/7)
jamanetwork.com/journals/jam...
Reposted by Steve Joffe
Amazing! Science is so cool.
Hunter syndrome: Boy with rare condition amazes doctors after world-first gene therapy share.google/POY4UXyNcBUL...
Hunter syndrome: Boy with rare condition amazes doctors after world-first gene therapy share.google/POY4UXyNcBUL...
Hunter syndrome: Boy with rare condition amazes doctors after world-first gene therapy
Oliver has an inherited condition called Hunter syndrome, which causes progressive damage to the body and brain.
share.google
November 24, 2025 at 7:01 PM
Amazing! Science is so cool.
Hunter syndrome: Boy with rare condition amazes doctors after world-first gene therapy share.google/POY4UXyNcBUL...
Hunter syndrome: Boy with rare condition amazes doctors after world-first gene therapy share.google/POY4UXyNcBUL...
Reposted by Steve Joffe
“You are taking the decision away from the reviewers, and you’re putting it in the hands of the political leaders of FDA,” Fernandez Lynch said.
It doesn't take an expert to understand how bad this is. More great reporting from @lizzylawrence.bsky.social
www.statnews.com/2025/11/21/t...
It doesn't take an expert to understand how bad this is. More great reporting from @lizzylawrence.bsky.social
www.statnews.com/2025/11/21/t...
FDA review staff was excluded from voting on whether to approve first priority voucher drug
Top officials like Vinay Prasad and George Tidmarsh voted on the drug, a major break from the FDA's typical practice.
www.statnews.com
November 24, 2025 at 4:31 PM
“You are taking the decision away from the reviewers, and you’re putting it in the hands of the political leaders of FDA,” Fernandez Lynch said.
It doesn't take an expert to understand how bad this is. More great reporting from @lizzylawrence.bsky.social
www.statnews.com/2025/11/21/t...
It doesn't take an expert to understand how bad this is. More great reporting from @lizzylawrence.bsky.social
www.statnews.com/2025/11/21/t...
Reposted by Steve Joffe
Working on a project about AI and trust in historically marginalized communities and need your voices. 🙏 If you’re open to sharing your views (and maybe a short video), please take this quick survey and share widely. Selected video contributors get a $25 gift card. 💳🗣️ Link: forms.gle/RFvedx2e2Lmd...
November 22, 2025 at 1:55 PM
Working on a project about AI and trust in historically marginalized communities and need your voices. 🙏 If you’re open to sharing your views (and maybe a short video), please take this quick survey and share widely. Selected video contributors get a $25 gift card. 💳🗣️ Link: forms.gle/RFvedx2e2Lmd...
Reposted by Steve Joffe
By @markhertling.bsky.social:
www.thebulwark.com/p/what-ameri... Clarifying duties (plural) of military personnel toward unlawful orders. "Officers are duty-bound to refuse an unlawful order. It is not optional. It is not situational. It is their job" Different oath for officers; I didn't know that
www.thebulwark.com/p/what-ameri... Clarifying duties (plural) of military personnel toward unlawful orders. "Officers are duty-bound to refuse an unlawful order. It is not optional. It is not situational. It is their job" Different oath for officers; I didn't know that
What Americans Should Understand About the Military Disobeying Illegal Orders
And why it matters there are two military oaths.
www.thebulwark.com
November 21, 2025 at 6:30 PM
By @markhertling.bsky.social:
www.thebulwark.com/p/what-ameri... Clarifying duties (plural) of military personnel toward unlawful orders. "Officers are duty-bound to refuse an unlawful order. It is not optional. It is not situational. It is their job" Different oath for officers; I didn't know that
www.thebulwark.com/p/what-ameri... Clarifying duties (plural) of military personnel toward unlawful orders. "Officers are duty-bound to refuse an unlawful order. It is not optional. It is not situational. It is their job" Different oath for officers; I didn't know that
This is one of the most internally contradictory lines I have ever seen in a supposedly authoritative piece. www.washingtonpost.com/opinions/202...
November 19, 2025 at 4:40 PM
This is one of the most internally contradictory lines I have ever seen in a supposedly authoritative piece. www.washingtonpost.com/opinions/202...
November 18, 2025 at 12:13 AM
November 16, 2025 at 3:00 PM
The key message. If tumor (somatic) testing reveals a variant in a cancer predisposition gene, our data suggests a 20% chance that it's present in the germline. Oncologists should test for it.
We demonstrated that testing was feasible and about 25% of recurrent tumors had variants in cancer predisposition genes of which 20% were germline. Rapid reflex germline testing of tumor results is warranted.
November 12, 2025 at 1:21 AM
The key message. If tumor (somatic) testing reveals a variant in a cancer predisposition gene, our data suggests a 20% chance that it's present in the germline. Oncologists should test for it.
Reposted by Steve Joffe
Happy to report that the results of germline testing as part of the National Cancer Institute/Children’s Oncology Group MATCH precision oncology trial was published. pubmed.ncbi.nlm.nih.gov/41166674/
Germline Cancer Predisposition Results From the National Cancer Institute-Children's Oncology Group Pediatric MATCH Trial - PubMed
Coordinated germline and tumor panel testing was feasible and revealed P/LP CPG variants in 6.3% of the Pediatric MATCH cohort. Tumor variant fraction, germline association of CPG with tumor type, and adult-oriented guidelines were not predictive of germline status, emphasizing the need for systemat …
pubmed.ncbi.nlm.nih.gov
November 11, 2025 at 9:11 PM
Happy to report that the results of germline testing as part of the National Cancer Institute/Children’s Oncology Group MATCH precision oncology trial was published. pubmed.ncbi.nlm.nih.gov/41166674/
If Whiskey can't have my wife, he'll make do with her shoe.
November 10, 2025 at 9:54 PM
If Whiskey can't have my wife, he'll make do with her shoe.
Reposted by Steve Joffe
Congrats to Dr. Harsha Thirumurthy on his latest running achievement! He ran the Tunnel Hill 50-mile race in Illinois. He finished in 5:38:27, setting a new American men’s record in his age group, and breaking the previous record which had stood for a quarter century! @hthirumurthy.bsky.social
November 10, 2025 at 5:27 PM
Congrats to Dr. Harsha Thirumurthy on his latest running achievement! He ran the Tunnel Hill 50-mile race in Illinois. He finished in 5:38:27, setting a new American men’s record in his age group, and breaking the previous record which had stood for a quarter century! @hthirumurthy.bsky.social
Administration Live Updates: Trump Appeals Ruling That Orders Fast and Full SNAP Payments
www.nytimes.com
November 7, 2025 at 3:40 PM