Statistical Physics of Cells and Genomes
@spcggroup.bsky.social
BlueSky account of the scientific group Statistical Physics of Cells and Genomes (SPCG), IFOM and U Milan. Principal Investigator (PI) Marco Cosentino Lagomarsino (MCL).
http://spcg.unimi.it/
http://spcg.unimi.it/
Reposted by Statistical Physics of Cells and Genomes
Saddened to learn of the passing of Moselio "Elio" Schaechter—Distinguished Professor at Tufts, SDSU and UCSD—humanist and visionary leader in the fields of microbiology and scientific communication—mentor, friend, and inspiration to me and so many others
Small Things Considered
Big Things Achieved
Small Things Considered
Big Things Achieved
August 15, 2025 at 3:12 PM
Saddened to learn of the passing of Moselio "Elio" Schaechter—Distinguished Professor at Tufts, SDSU and UCSD—humanist and visionary leader in the fields of microbiology and scientific communication—mentor, friend, and inspiration to me and so many others
Small Things Considered
Big Things Achieved
Small Things Considered
Big Things Achieved
Our group has a SEMM PhD opening in single-cell dynamics and cancer persistence:
www.semm.it/sites/defaul...
We seek outstanding candidates with cell biology expertise and practical experience in microscopy; physics&engineering backgrounds welcome.
Apply here
www.semm.it/education/ap...
www.semm.it/sites/defaul...
We seek outstanding candidates with cell biology expertise and practical experience in microscopy; physics&engineering backgrounds welcome.
Apply here
www.semm.it/education/ap...
August 1, 2025 at 6:02 AM
Our group has a SEMM PhD opening in single-cell dynamics and cancer persistence:
www.semm.it/sites/defaul...
We seek outstanding candidates with cell biology expertise and practical experience in microscopy; physics&engineering backgrounds welcome.
Apply here
www.semm.it/education/ap...
www.semm.it/sites/defaul...
We seek outstanding candidates with cell biology expertise and practical experience in microscopy; physics&engineering backgrounds welcome.
Apply here
www.semm.it/education/ap...
Our "Growth Laws Theory Cookbook" preprint is out! 👨🍳👩🏼🍳🧑🍳
arxiv.org/abs/2507.19194
*Learn our hands-on recipes and create your own!*
With Ciandrini and Micali labs
@micalilab.bsky.social
Thanks to Rossana Droghetti for coordinating the heavy lift.
arxiv.org/abs/2507.19194
*Learn our hands-on recipes and create your own!*
With Ciandrini and Micali labs
@micalilab.bsky.social
Thanks to Rossana Droghetti for coordinating the heavy lift.
The Hands-On Growth Laws Theory Cookbook
This tutorial covers the emerging field of coarse-grained cellular growth modeling, and aims to bridge the gap between theoretical foundations and practical application. By adopting an original "cookb...
arxiv.org
July 28, 2025 at 7:10 AM
Our "Growth Laws Theory Cookbook" preprint is out! 👨🍳👩🏼🍳🧑🍳
arxiv.org/abs/2507.19194
*Learn our hands-on recipes and create your own!*
With Ciandrini and Micali labs
@micalilab.bsky.social
Thanks to Rossana Droghetti for coordinating the heavy lift.
arxiv.org/abs/2507.19194
*Learn our hands-on recipes and create your own!*
With Ciandrini and Micali labs
@micalilab.bsky.social
Thanks to Rossana Droghetti for coordinating the heavy lift.
Our work on optimal treatment in presence of cancer persisters is out today in @prxlife.bsky.social 🎉
Alternated drug-release periods may be an advantage due to dose-dependent transition rates and slow death of persisters
journals.aps.org/prxlife/abst...
Alternated drug-release periods may be an advantage due to dose-dependent transition rates and slow death of persisters
journals.aps.org/prxlife/abst...
Optimal Treatment for Drug-Induced Cancer Persisters Involves Release Periods and Intermediate Drug Doses
Extending persistence modeling to drug-induced, dose-dependent cancer persistence reveals that strategic drug holidays and reduced doses can improve long-term treatment outcomes.
journals.aps.org
June 26, 2025 at 5:57 PM
Our work on optimal treatment in presence of cancer persisters is out today in @prxlife.bsky.social 🎉
Alternated drug-release periods may be an advantage due to dose-dependent transition rates and slow death of persisters
journals.aps.org/prxlife/abst...
Alternated drug-release periods may be an advantage due to dose-dependent transition rates and slow death of persisters
journals.aps.org/prxlife/abst...
Reposted by Statistical Physics of Cells and Genomes
🚨 We're hiring! 🚨
A 2-year postdoc position is now open in our lab to explore the fascinating world of yeast polyploid genomes, their structure, stability, and adaptive potential.
🔗 More info here:
docs.google.com/document/d/1...
Please repost!
#Postdoc #Genomics #Yeast #Polyploidy #Evolution
A 2-year postdoc position is now open in our lab to explore the fascinating world of yeast polyploid genomes, their structure, stability, and adaptive potential.
🔗 More info here:
docs.google.com/document/d/1...
Please repost!
#Postdoc #Genomics #Yeast #Polyploidy #Evolution
Postdoc_Evol_Genomics_Sorbonne.docx
Postdoctoral position in Yeast Evolutionary Genomics Hosting unit Laboratory of Computational, Quantitative, and Synthetic Biology (CQSB). The CQSB is an interdisciplinary research unit within the ...
docs.google.com
May 19, 2025 at 3:41 PM
🚨 We're hiring! 🚨
A 2-year postdoc position is now open in our lab to explore the fascinating world of yeast polyploid genomes, their structure, stability, and adaptive potential.
🔗 More info here:
docs.google.com/document/d/1...
Please repost!
#Postdoc #Genomics #Yeast #Polyploidy #Evolution
A 2-year postdoc position is now open in our lab to explore the fascinating world of yeast polyploid genomes, their structure, stability, and adaptive potential.
🔗 More info here:
docs.google.com/document/d/1...
Please repost!
#Postdoc #Genomics #Yeast #Polyploidy #Evolution
Reposted by Statistical Physics of Cells and Genomes
Excellent opportunity for Palestinian 🇵🇸 students looking to pursue Bachelor/Master degrees
- 97 full scholarships across 37 Italian universities
- Covers fees, housing, meals, health insurance
- €12,000/year average scholarship
Inquiry deadline is May 23
Links below, please circulate widely!
- 97 full scholarships across 37 Italian universities
- Covers fees, housing, meals, health insurance
- €12,000/year average scholarship
Inquiry deadline is May 23
Links below, please circulate widely!
May 19, 2025 at 12:21 PM
Excellent opportunity for Palestinian 🇵🇸 students looking to pursue Bachelor/Master degrees
- 97 full scholarships across 37 Italian universities
- Covers fees, housing, meals, health insurance
- €12,000/year average scholarship
Inquiry deadline is May 23
Links below, please circulate widely!
- 97 full scholarships across 37 Italian universities
- Covers fees, housing, meals, health insurance
- €12,000/year average scholarship
Inquiry deadline is May 23
Links below, please circulate widely!
Great fun and great science at QMPE 2025 in Shenzhen! www.qmpe.net
May 18, 2025 at 12:20 PM
Great fun and great science at QMPE 2025 in Shenzhen! www.qmpe.net
Just out on bioRxiv - spcg collab with Piel lab: growing mammalian cells use two independent systems — one controlling volume, one driving protein synthesis — to control macromolecular density.
Together, they restore dry mass density homeostasis.
www.biorxiv.org/content/10.1...
Together, they restore dry mass density homeostasis.
www.biorxiv.org/content/10.1...
April 25, 2025 at 3:10 PM
Just out on bioRxiv - spcg collab with Piel lab: growing mammalian cells use two independent systems — one controlling volume, one driving protein synthesis — to control macromolecular density.
Together, they restore dry mass density homeostasis.
www.biorxiv.org/content/10.1...
Together, they restore dry mass density homeostasis.
www.biorxiv.org/content/10.1...
Spcg preprint with Bertotti lab and @litinice.bsky.social. It took >5y but proud to say it works—and we know why and how. μSeq infers mutation rates from deep sequencing of single clonal expansions, >10x faster than MALs. Validated in cancer organoids and in yeast.
tinyurl.com/4jmk3tkh
tinyurl.com/4jmk3tkh
April 23, 2025 at 9:19 AM
Spcg preprint with Bertotti lab and @litinice.bsky.social. It took >5y but proud to say it works—and we know why and how. μSeq infers mutation rates from deep sequencing of single clonal expansions, >10x faster than MALs. Validated in cancer organoids and in yeast.
tinyurl.com/4jmk3tkh
tinyurl.com/4jmk3tkh
New spcg preprint with Bokinsky lab (Milan Lacassin), by Andrea Ripamonti. We model the competition for transcriptional resources, and explain new data on E. coli’s second messengers ppGpp & cAMP reshaping gene expression globally.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
April 21, 2025 at 8:48 AM
New spcg preprint with Bokinsky lab (Milan Lacassin), by Andrea Ripamonti. We model the competition for transcriptional resources, and explain new data on E. coli’s second messengers ppGpp & cAMP reshaping gene expression globally.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
New spcg&collabs paper, by Rossana Droghetti: Model for E. coli dynamical balance of amino acid pools, ppGpp signaling, and ribosome allocation to regulate growth, explaining observed damped oscillatory feedback in response to nutrient shifts 🧫 #GrowthLaws
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Incoherent feedback from coupled amino acids and ribosome pools generates damped oscillations in growing E. coli - Nature Communications
Current theories of bacterial growth physiology often lack mechanistic detail. Here, Droghetti et al. present a theoretical framework that includes sensing and regulation of protein synthesis at the m...
www.nature.com
April 21, 2025 at 8:33 AM
New spcg&collabs paper, by Rossana Droghetti: Model for E. coli dynamical balance of amino acid pools, ppGpp signaling, and ribosome allocation to regulate growth, explaining observed damped oscillatory feedback in response to nutrient shifts 🧫 #GrowthLaws
www.nature.com/articles/s41...
www.nature.com/articles/s41...
We just landed from X... almost ready to post about a lot of our recent news!
See here for our old posts x.com/SPCGgroup
See here for our old posts x.com/SPCGgroup
x.com
April 18, 2025 at 5:53 PM
We just landed from X... almost ready to post about a lot of our recent news!
See here for our old posts x.com/SPCGgroup
See here for our old posts x.com/SPCGgroup