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smtevidence.com
SMT Evidence
@smtevidence.com
18 followers 71 following 16 posts
Helping industry and academic partners generate the evidence they need to successfully bring their new drugs and technologies to market www.smtevidence.com
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smtevidence.com
Very excited to be off to the @nihr-io.bsky.social Futures, Foresight & Horizon Scanning conference on 19th-20th November!

Looking forward to lots of great talks - the lightning sessions especially sound fantastic ⚡️⚡️⚡️

Please do shout if you are going along - would be great to say hello 👋

#FFHSC25
November 7, 2025 at 12:47 PM
smtevidence.com
A new #systematicreview and #networkmetaanalysis shows that antidepressants differ markedly in their physiological effects, with substantial differences in parameters such as weight, cholesterol, heart rate, blood pressure

www.thelancet.com/journals/lan...

@thelancet.com

#OA #depression #NMA
October 28, 2025 at 10:59 AM
smtevidence.com
Happy Ada Lovelace Day! Enjoy this annual international celebration of the achievements of women in science, technology, engineering and maths (STEM).

findingada.com
Ada Lovelace Day – Celebrating the achievements of women in science, technology, engineering and maths
findingada.com
October 14, 2025 at 4:58 PM
smtevidence.com
“The most important thing about #AI isn't its technical capabilities or limitations. The most important thing is the investor story and the ensuing mania that has teed up an economical catastrophe that will harm hundreds of millions or even billions of people.”

pluralistic.net/2025/09/27/e...
Pluralistic: The real (economic) AI apocalypse is nigh (27 Sep 2025) – Pluralistic: Daily links from Cory Doctorow
pluralistic.net
October 10, 2025 at 9:23 AM
smtevidence.com
A microsimulation model to estimate the impact of care disruption during the COVID-19 pandemic on breast cancer mortality using an administrative database.

www.jclinepi.com/article/S089...

Via @jclinepi.bsky.social
A microsimulation model based on healthcare pathways to estimate the impact of COVID-19 pandemic–induced delays on breast cancer mortality
This study aimed to develop a microsimulation model to estimate the impact of a care disruption during the COVID-19 pandemic on breast cancer mortality using an administrative database.
www.jclinepi.com
October 8, 2025 at 3:42 PM
Reposted by SMT Evidence
acog.org
ACOG reaffirms that acetaminophen is safe for managing pain and fever during pregnancy. No reputable studies support suggestions like those in HHS’s recent announcement linking acetaminophen use in pregnancy to autism; in fact, high-quality studies show no such risk. https://bit.ly/47Wxc59
September 22, 2025 at 9:24 PM
Reposted by SMT Evidence
nihr-io.bsky.social
🚨Emerging Point-of-Care Testing in Genomics

Exploring the development pipeline of genomic POCTs designed to identify variations in the genome & epigenome, supporting diagnosis, prognosis & treatment decisions across clinical areas👉 ow.ly/UB2R50WQcvo @newcastleuni.bsky.social @nihr.bsky.social
September 3, 2025 at 9:21 AM
smtevidence.com
The contribution of conference abstracts in #systematicreviews - "Their inclusion changed the effect estimate in 55.6% and imprecision in 16% of cases when using MIDs. In a few instances, CAs also influenced RoB and inconsistency assessments."

www.jclinepi.com/article/S089...

@jclinepi.bsky.social
Including conference abstracts rarely changed systematic review conclusions: a case study from a living network meta-analysis of COVID-19 treatments
Including conference abstracts (CAs) in systematic reviews (SRs) helps reduce publication bias but raises concerns about reporting quality and reliability. While discrepancies with full publications a...
www.jclinepi.com
September 14, 2025 at 11:21 AM
Reposted by SMT Evidence
swiftsciencewriting.co.uk
Most Americans still don’t know that #alcohol can cause #cancer — and the alcohol industry and Trump are working hard to make sure it stays that way by discrediting and burying a new report that offers new evidence of the link between drinking alcohol and dying www.vox.com/health/46008... @vox.com
Exclusive: RFK Jr. and the White House buried a major study on alcohol and cancer. Here’s what it shows.
Kennedy wants to “Make America Healthy Again” — but doesn’t want you to see a report that could do just that.
www.vox.com
September 4, 2025 at 2:43 PM
Reposted by SMT Evidence
science.org
In a new #ScienceExpertVoices article, Seth Berkley unravels the arc of vaccine progress. https://scim.ag/3VrCDBx
Quote by Seth Berkley on a black background, stating: "…one of humanity's most dramatic successes has been the application of science to understand and then decisively intervene to improve...harrowing conditions."
September 2, 2025 at 5:10 PM
Reposted by SMT Evidence
us.theconversation.com
Most air cleaning devices have not been tested on people, and little is known about their potential harms. Professors of medicine and public health explain:
Most air cleaning devices have not been tested on people − and little is known about their potential harms, new study finds
Manufacturers often make bold claims about how well these technologies work. Better testing would allow consumers and institutions to pick the most effective ones.
buff.ly
August 20, 2025 at 10:03 PM
smtevidence.com
New #research that could help clinical trials avoid early termination.

Identifying predictors of early trial termination: a meta-epidemiological study utilising elements of the research ethics committee evaluation.

www.jclinepi.com/article/S089...

Via @jclinepi.bsky.social
August 20, 2025 at 10:02 AM
smtevidence.com
A really thought-provoking article from @elife.bsky.social about manuscript publication, peer review and who acts as the gatekeepers of publishing: “why are indexers unable to see that peer review can be more than a thumbs up or a thumbs down?” sfdora.org/2025/07/30/s... H/T @hildabast.bsky.social
Why are indexers unable to see that peer review can be more than a thumbs up or a thumbs down? | DORA
Journals and peer review are unlikely to change for the better if the companies that operate scientific indexes and citation databases continue to stifle innovation. At eLife we believe that the conte...
sfdora.org
August 6, 2025 at 11:36 AM
Reposted by SMT Evidence
natureportfolio.nature.com
A Review in Nature Reviews Endocrinology assesses the role of ultra-processed foods in obesity, examining the epidemiological evidence, biological mechanisms and implications for policymakers. go.nature.com/44zGHoO 🍎📃 #medsky 🧪
This is figure 2, which shows physiological pathways underlying the association between ultra-processed dietary patterns and obesity.
July 25, 2025 at 1:46 AM
Reposted by SMT Evidence
newscientist.com
In human beings, egg cells need to survive for about five decades, much longer than most other cell types – and they may achieve this unusually long lifespan by slowing down their natural cell processes.
How human eggs stay fresh for decades
In human beings, egg cells need to survive for about five decades, much longer than most other cell types – and they may achieve this unusually long lifespan by slowing down their natural cell processes
www.newscientist.com
July 20, 2025 at 4:38 PM
Reposted by SMT Evidence
zbmed.bsky.social
#SupportOLSPub - every vote counts
The first giant steps have been taken, the OLSPub application has been submitted. For all those who, as researchers, information specialists or simply as people, would like to position themselves, everyone can leave a signature here.
blog.zbmed.de/olspub-support
OLSPub support – ZB MED-Blog
Support for the project OLSPub - Open Life Science Publications Database as individuals.
blog.zbmed.de
June 12, 2025 at 11:19 AM
Reposted by SMT Evidence
erictopol.bsky.social
The MAHA report critique, by @hiltzikm.bsky.social
www.latimes.com/business/sto...
And the Trojan horse, by @drjengunter.bsky.social
vajenda.substack.com/p/hijacking-...
June 4, 2025 at 3:19 PM
Reposted by SMT Evidence
erictopol.bsky.social
The remarkable benefit of exercise was just extended to improved survival after cancer in a randomized trial
@nejm.org
nejm.org/doi/full/10....
June 1, 2025 at 2:52 PM
smtevidence.com
In the wake of several countries legalising #marijuana, questions remain about the drug's long-term #health effects. A new study has found that people who smoke weed or use edibles do worse on measures of vascular health that predict cardiovascular risk.

jamanetwork.com/journals/jam...

@jama.com
Endothelial Dysfunction and Chronic Cannabis Use
This cross-sectional study aims to determine whether cannabis use is associated with vascular endothelial function.
jamanetwork.com
May 29, 2025 at 11:45 AM
smtevidence.com
A scoping review of carbon emissions associated with clinical trials finds that several trial activities, including travel and meetings, trial facilities, and sample & lab activities, are consistently carbon heavy.

www.jclinepi.com/article/S089...

@jclinepi.bsky.social

#scopingreview #openaccess
May 23, 2025 at 10:41 AM
smtevidence.com
Brand new SPIRIT and CONSORT #reporting #guidelines are out now!

🎯 CONSORT 2025 for reporting RCTs now has a 30-item checklist

🎯 SPIRIT 2025 for reporting trial protocols now has a 34-item checklist

www.jclinepi.com/article/S089...

@jclinepi.bsky.social

#SPIRIT #CONSORT #RCTs #protocols
May 18, 2025 at 10:14 AM
Reposted by SMT Evidence
jclinepi.bsky.social
What makes a good guideline? – A systematic review and analysis of 120 clinical practice guidelines using the AGREE II tool - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
What makes a good guideline? – A systematic review and analysis of 120 clinical practice guidelines using the AGREE II tool
Clinical practice guidelines (CPGs) translate evidence into actionable recommendations to enhance care quality, improve clinical outcomes, reduce treatment variations, and make healthcare delivery mor...
www.jclinepi.com
May 17, 2025 at 7:28 PM
smtevidence.com
A new reporting guideline has just been published for the involvement of patients and caregivers in identifying and designing healthcare interventions: the IDEAS framework www.jclinepi.com/article/S089... HT @jclinepi.bsky.social #OA #openaccess #IDEAS #coproduction #patients #partners #research
A diagram with seven blue circles describing the different items within a patient-researcher research cycle. The seven blue circles include: designing and managing, undertaking, disseminating, implementing, evaluating impact, prioritising and commissioning
May 11, 2025 at 2:12 PM
Reposted by SMT Evidence
thelancet.com
The RTS,S/AS01E malaria vaccine has been successfully administered to over 2 million children since 2019.

On #WorldMalariaDay, a paper in @lancetgh.bsky.social reports the results of a study evaluating RTS,S/AS01E safety and effectiveness in real-world settings: tinyurl.com/3jthn39h
Research in context panel for The Lancet Global Health article "Safety of RTS,S/AS01E malaria vaccine up to 1 year after the third dose in Ghana, Kenya, and Malawi (EPI-MAL-003): a phase 4 cohort event monitoring study". Copyright: 2025 GSK plc. Published by Elsevier Ltd. CC By 4.0.
April 25, 2025 at 8:58 AM
Reposted by SMT Evidence
healthfoundation.bsky.social
Electronic patient records (EPRs) can potentially transform health care delivery, improving quality, efficiency and patient safety. Most trusts in England now have EPRs but many are not yet using them to their full potential.

We explored the challenges in our recent analysis ⬇️
Electronic patient records: why the NHS urgently needs a strategy to reap the benefits
Our qualitative research with five acute NHS trusts and a US medical centre investigates the current state of EPR adoption and use, and what it takes to really see the benefits.
bit.ly
April 16, 2025 at 10:00 AM