Sjoerd van Wijk
@sjoerdvanwijk.bsky.social
Group leader at the Institute of Experimental Paediatric Haematology and Oncology at the Goethe University Frankfurt, Germany. Ubiquitin, autophagy, cell death, inflammation. Immigrant. (all views my own).
Reposted by Sjoerd van Wijk
Opening a "Decision on your Manuscript" email
August 29, 2025 at 8:22 AM
Opening a "Decision on your Manuscript" email
Join us at the 28th Meeting on Signal Transduction - CellCommSummit 2025 from November 3 - 5 2025 in Weimar, Germany, with a great line-up of speakers!!! 🔥 🔥 🔥
Apply for short talks, science prizes and travel stipends!!!
Great for networking, from Master students to groupleaders!!!
Apply for short talks, science prizes and travel stipends!!!
Great for networking, from Master students to groupleaders!!!
August 6, 2025 at 11:57 AM
Join us at the 28th Meeting on Signal Transduction - CellCommSummit 2025 from November 3 - 5 2025 in Weimar, Germany, with a great line-up of speakers!!! 🔥 🔥 🔥
Apply for short talks, science prizes and travel stipends!!!
Great for networking, from Master students to groupleaders!!!
Apply for short talks, science prizes and travel stipends!!!
Great for networking, from Master students to groupleaders!!!
Reposted by Sjoerd van Wijk
Das ist Trumpisch, um es politisch zu sagen. Das ist Wissenschaftsfeindlichkeit im dünnen moralisierenden Mäntelchen. Und, das ist toxische Weiblichkeit im Amt: Andere Frauen schmähen, sie als nicht hinreichend hart schmähen, sich selber damit andienen an phantasmatische "Männlichkeit"....
July 16, 2025 at 5:40 AM
Das ist Trumpisch, um es politisch zu sagen. Das ist Wissenschaftsfeindlichkeit im dünnen moralisierenden Mäntelchen. Und, das ist toxische Weiblichkeit im Amt: Andere Frauen schmähen, sie als nicht hinreichend hart schmähen, sich selber damit andienen an phantasmatische "Männlichkeit"....
Reposted by Sjoerd van Wijk
sowie die Wissenschaft selbst hiervon abzugrenzen, davor zu schützen und solchen politischen Dreck in die Schranken zu weisen. Das ist enorm beunruhigend, was D. Bär hier abzieht. In aller Öffentlichkeit und ganz bestimmt in Abstimmung mit Merz et al. ...
July 16, 2025 at 5:40 AM
sowie die Wissenschaft selbst hiervon abzugrenzen, davor zu schützen und solchen politischen Dreck in die Schranken zu weisen. Das ist enorm beunruhigend, was D. Bär hier abzieht. In aller Öffentlichkeit und ganz bestimmt in Abstimmung mit Merz et al. ...
Reposted by Sjoerd van Wijk
unsinnigen Behauptungen operiert hat, nicht zuletzt mit den raunenden Andeutungen eines selbst verurteilten & dubiosen 'Plagiatsjäger'. Das kann man alles politisch machen, meinetwegen. Aber als Wissenschaftsministerin hat man die verdammte Pflicht, Wissenschaftlerinnen und Wissenschaftler ...
July 16, 2025 at 5:39 AM
unsinnigen Behauptungen operiert hat, nicht zuletzt mit den raunenden Andeutungen eines selbst verurteilten & dubiosen 'Plagiatsjäger'. Das kann man alles politisch machen, meinetwegen. Aber als Wissenschaftsministerin hat man die verdammte Pflicht, Wissenschaftlerinnen und Wissenschaftler ...
Reposted by Sjoerd van Wijk
Bär hätte qua Amt die Integrität und (Teil-)Autonomie der Wissenschaft sowie der Rechtsprofessorin Brosius-Gersdorf zu betonen sowie zu schützen. Es ist inzwischen hinlänglich dokumentiert, dass die Kampagne massiv mit fake news, irren Verzerrungen...
July 16, 2025 at 5:39 AM
Bär hätte qua Amt die Integrität und (Teil-)Autonomie der Wissenschaft sowie der Rechtsprofessorin Brosius-Gersdorf zu betonen sowie zu schützen. Es ist inzwischen hinlänglich dokumentiert, dass die Kampagne massiv mit fake news, irren Verzerrungen...
Reposted by Sjoerd van Wijk
Wissenschaftsministerin ein massiver fail. Ideologisch, dumm, und in der Sache so falsch wie im Amt unprofessionell. Anstatt sachlich nüchtern die Professorin vor Diffamierungen & gegen 1 Kampagne zu schützen, wirft sie diese erneut dem geifernden Polit-Mob zum Fraß hin.
www.zeit.de/politik/deut...
www.zeit.de/politik/deut...
Wahl der Verfassungsrichter: Brosius-Gersdorf berichtet von Drohungen nach gescheiterter Wahl
Aufgrund von Drohungen hat Frauke Brosius-Gersdorf ihre Mitarbeiter gebeten, nicht am Lehrstuhl zu arbeiten. Einen Verzicht auf ihre Kandidatur schließt sie nicht aus.
www.zeit.de
July 16, 2025 at 5:38 AM
Wissenschaftsministerin ein massiver fail. Ideologisch, dumm, und in der Sache so falsch wie im Amt unprofessionell. Anstatt sachlich nüchtern die Professorin vor Diffamierungen & gegen 1 Kampagne zu schützen, wirft sie diese erneut dem geifernden Polit-Mob zum Fraß hin.
www.zeit.de/politik/deut...
www.zeit.de/politik/deut...
Reposted by Sjoerd van Wijk
Also, so langsam wäre man dann ja schon bereit für eine kompetente Leitung des Bundesforschungsministeriums …
July 16, 2025 at 8:20 AM
Also, so langsam wäre man dann ja schon bereit für eine kompetente Leitung des Bundesforschungsministeriums …
Reposted by Sjoerd van Wijk
Eigentlich sollte eine Wissenschaftsministerin Stimme der Wissenschaft im politischen System sein.
Bär will hingegen was anderes sein und fordert von Wissenschaftlerinnen "Kritikfähigkeit" ein, wenn sie diffamiert werden.
www.zeit.de/politik/deut...
Bär will hingegen was anderes sein und fordert von Wissenschaftlerinnen "Kritikfähigkeit" ein, wenn sie diffamiert werden.
www.zeit.de/politik/deut...
Wahl der Verfassungsrichter: Brosius-Gersdorf berichtet von Drohungen nach gescheiterter Wahl
Aufgrund von Drohungen hat Frauke Brosius-Gersdorf ihre Mitarbeiter gebeten, nicht am Lehrstuhl zu arbeiten. Einen Verzicht auf ihre Kandidatur schließt sie nicht aus.
www.zeit.de
July 16, 2025 at 8:20 AM
Eigentlich sollte eine Wissenschaftsministerin Stimme der Wissenschaft im politischen System sein.
Bär will hingegen was anderes sein und fordert von Wissenschaftlerinnen "Kritikfähigkeit" ein, wenn sie diffamiert werden.
www.zeit.de/politik/deut...
Bär will hingegen was anderes sein und fordert von Wissenschaftlerinnen "Kritikfähigkeit" ein, wenn sie diffamiert werden.
www.zeit.de/politik/deut...
Reposted by Sjoerd van Wijk
Our latest work:
The immunoproteasome disturbs neuronal metabolism and drives neurodegeneration in multiple sclerosis: Cell www.cell.com/cell/fulltex...
The immunoproteasome disturbs neuronal metabolism and drives neurodegeneration in multiple sclerosis: Cell www.cell.com/cell/fulltex...
The immunoproteasome disturbs neuronal metabolism and drives neurodegeneration in multiple sclerosis
Neuronal proteasomal dysfunction is a hallmark of neuroinflammatory and neurodegenerative
diseases. This study reveals that the interferon-induced immunoproteasome drastically
decreases proteasomal ac...
www.cell.com
June 17, 2025 at 7:18 PM
Our latest work:
The immunoproteasome disturbs neuronal metabolism and drives neurodegeneration in multiple sclerosis: Cell www.cell.com/cell/fulltex...
The immunoproteasome disturbs neuronal metabolism and drives neurodegeneration in multiple sclerosis: Cell www.cell.com/cell/fulltex...
Reposted by Sjoerd van Wijk
I was today years old when I first heard this gorgeous quote at #EMBOclimateResilience: “The way in which our universities have divided up our sciences does not reflect the way in which nature has divided up its problems” (Kurt Salzinger) - thank you @luciastrader.bsky.social!
April 14, 2025 at 10:43 AM
I was today years old when I first heard this gorgeous quote at #EMBOclimateResilience: “The way in which our universities have divided up our sciences does not reflect the way in which nature has divided up its problems” (Kurt Salzinger) - thank you @luciastrader.bsky.social!
It was great being in Cologne! Meeting many new people and seeing many known faces, thanks for the invitation Christina Ising @cecad.bsky.social
April 12, 2025 at 3:45 PM
It was great being in Cologne! Meeting many new people and seeing many known faces, thanks for the invitation Christina Ising @cecad.bsky.social
Reposted by Sjoerd van Wijk
Keukenhof, Netherlands 🇳🇱
#photography
#photography
April 11, 2025 at 12:20 PM
Keukenhof, Netherlands 🇳🇱
#photography
#photography
Reposted by Sjoerd van Wijk
How do cytosol-invading bacteria evade LPS ubiquitylation by the host's defence machinery?
@felixrandow.bsky.social's group determined that Shigella flexneri uses IpaH1.4 to degrade the LPS ligase RNF213, inhibiting the cell's ubiquitylation abilities.
Read more: tinyurl.com/3y4kv2bp
#LMBResearch🧪
@felixrandow.bsky.social's group determined that Shigella flexneri uses IpaH1.4 to degrade the LPS ligase RNF213, inhibiting the cell's ubiquitylation abilities.
Read more: tinyurl.com/3y4kv2bp
#LMBResearch🧪
April 9, 2025 at 9:09 AM
How do cytosol-invading bacteria evade LPS ubiquitylation by the host's defence machinery?
@felixrandow.bsky.social's group determined that Shigella flexneri uses IpaH1.4 to degrade the LPS ligase RNF213, inhibiting the cell's ubiquitylation abilities.
Read more: tinyurl.com/3y4kv2bp
#LMBResearch🧪
@felixrandow.bsky.social's group determined that Shigella flexneri uses IpaH1.4 to degrade the LPS ligase RNF213, inhibiting the cell's ubiquitylation abilities.
Read more: tinyurl.com/3y4kv2bp
#LMBResearch🧪
Reposted by Sjoerd van Wijk
We are delighted to announce 4 Early Career Research Awards for 2026! Firstly, congratulations to Georgia Atkin-Smith who is internationally recognised throughout the cell death community for high-calibre landmark discoveries in the field of cell death and biology @someblondesci.bsky.social
April 8, 2025 at 11:00 AM
We are delighted to announce 4 Early Career Research Awards for 2026! Firstly, congratulations to Georgia Atkin-Smith who is internationally recognised throughout the cell death community for high-calibre landmark discoveries in the field of cell death and biology @someblondesci.bsky.social
Reposted by Sjoerd van Wijk
🥳 Out now @embojournal.org!
Interferon induces a new class of p62 bodies, with #antiviral & #immunotherapy implications.
p62 is usually linked to #autophagy — but not here.
These are driven by PARP14-mediated ADP-ribosylation & rely on #ubiquitin #proteasome system. www.embopress.org/doi/full/10....
Interferon induces a new class of p62 bodies, with #antiviral & #immunotherapy implications.
p62 is usually linked to #autophagy — but not here.
These are driven by PARP14-mediated ADP-ribosylation & rely on #ubiquitin #proteasome system. www.embopress.org/doi/full/10....
Interferon-induced PARP14-mediated ADP-ribosylation in p62 bodies requires the ubiquitin-proteasome system | The EMBO Journal
imageimageInterferon induces the formation of ADP-ribosylation (ADPr)-enriched p62 bodies, requiring
PARP14 and p62. Unlike canonical p62 bodies, these ADPr-enriched structures are independent
of auto...
www.embopress.org
April 8, 2025 at 1:43 AM
🥳 Out now @embojournal.org!
Interferon induces a new class of p62 bodies, with #antiviral & #immunotherapy implications.
p62 is usually linked to #autophagy — but not here.
These are driven by PARP14-mediated ADP-ribosylation & rely on #ubiquitin #proteasome system. www.embopress.org/doi/full/10....
Interferon induces a new class of p62 bodies, with #antiviral & #immunotherapy implications.
p62 is usually linked to #autophagy — but not here.
These are driven by PARP14-mediated ADP-ribosylation & rely on #ubiquitin #proteasome system. www.embopress.org/doi/full/10....
Reposted by Sjoerd van Wijk
Super excited to share our latest work on deciphering the #Ubiquitin Code
“𝗨𝗯𝗶𝗥𝗘𝗔𝗗 𝗱𝗲𝗰𝗶𝗽𝗵𝗲𝗿𝘀 𝗽𝗿𝗼𝘁𝗲𝗮𝘀𝗼𝗺𝗮𝗹 𝗱𝗲𝗴𝗿𝗮𝗱𝗮𝘁𝗶𝗼𝗻 𝗰𝗼𝗱𝗲 𝗼𝗳 𝗵𝗼𝗺𝗼𝘁𝘆𝗽𝗶𝗰 𝗮𝗻𝗱 𝗯𝗿𝗮𝗻𝗰𝗵𝗲𝗱 𝗞48 𝗮𝗻𝗱 𝗞63 𝘂𝗯𝗶𝗾𝘂𝗶𝘁𝗶𝗻 𝗰𝗵𝗮𝗶𝗻𝘀”
@cp-molcell.bsky.social
1/8
www.cell.com/molecular-ce...
“𝗨𝗯𝗶𝗥𝗘𝗔𝗗 𝗱𝗲𝗰𝗶𝗽𝗵𝗲𝗿𝘀 𝗽𝗿𝗼𝘁𝗲𝗮𝘀𝗼𝗺𝗮𝗹 𝗱𝗲𝗴𝗿𝗮𝗱𝗮𝘁𝗶𝗼𝗻 𝗰𝗼𝗱𝗲 𝗼𝗳 𝗵𝗼𝗺𝗼𝘁𝘆𝗽𝗶𝗰 𝗮𝗻𝗱 𝗯𝗿𝗮𝗻𝗰𝗵𝗲𝗱 𝗞48 𝗮𝗻𝗱 𝗞63 𝘂𝗯𝗶𝗾𝘂𝗶𝘁𝗶𝗻 𝗰𝗵𝗮𝗶𝗻𝘀”
@cp-molcell.bsky.social
1/8
www.cell.com/molecular-ce...
UbiREAD deciphers proteasomal degradation code of homotypic and branched K48 and K63 ubiquitin chains
Ubiquitin chains determine the fates of their modified proteins, including proteasomal
degradation. Kiss et al. present UbiREAD, a technology to monitor cellular degradation
and deubiquitination at hi...
www.cell.com
March 24, 2025 at 2:54 PM
Super excited to share our latest work on deciphering the #Ubiquitin Code
“𝗨𝗯𝗶𝗥𝗘𝗔𝗗 𝗱𝗲𝗰𝗶𝗽𝗵𝗲𝗿𝘀 𝗽𝗿𝗼𝘁𝗲𝗮𝘀𝗼𝗺𝗮𝗹 𝗱𝗲𝗴𝗿𝗮𝗱𝗮𝘁𝗶𝗼𝗻 𝗰𝗼𝗱𝗲 𝗼𝗳 𝗵𝗼𝗺𝗼𝘁𝘆𝗽𝗶𝗰 𝗮𝗻𝗱 𝗯𝗿𝗮𝗻𝗰𝗵𝗲𝗱 𝗞48 𝗮𝗻𝗱 𝗞63 𝘂𝗯𝗶𝗾𝘂𝗶𝘁𝗶𝗻 𝗰𝗵𝗮𝗶𝗻𝘀”
@cp-molcell.bsky.social
1/8
www.cell.com/molecular-ce...
“𝗨𝗯𝗶𝗥𝗘𝗔𝗗 𝗱𝗲𝗰𝗶𝗽𝗵𝗲𝗿𝘀 𝗽𝗿𝗼𝘁𝗲𝗮𝘀𝗼𝗺𝗮𝗹 𝗱𝗲𝗴𝗿𝗮𝗱𝗮𝘁𝗶𝗼𝗻 𝗰𝗼𝗱𝗲 𝗼𝗳 𝗵𝗼𝗺𝗼𝘁𝘆𝗽𝗶𝗰 𝗮𝗻𝗱 𝗯𝗿𝗮𝗻𝗰𝗵𝗲𝗱 𝗞48 𝗮𝗻𝗱 𝗞63 𝘂𝗯𝗶𝗾𝘂𝗶𝘁𝗶𝗻 𝗰𝗵𝗮𝗶𝗻𝘀”
@cp-molcell.bsky.social
1/8
www.cell.com/molecular-ce...
Already some time ago, but happy to share our contribution to BIOspektrum!!!
rdcu.be/eeEtZ
link.springer.com/article/10.1...
rdcu.be/eeEtZ
link.springer.com/article/10.1...
Signaling to survive: linear ubiquitination in health and disease
rdcu.be
March 22, 2025 at 6:44 PM
Already some time ago, but happy to share our contribution to BIOspektrum!!!
rdcu.be/eeEtZ
link.springer.com/article/10.1...
rdcu.be/eeEtZ
link.springer.com/article/10.1...
Reposted by Sjoerd van Wijk
Die uralte Frage 🧠🤝❤️
February 14, 2025 at 9:05 AM
Die uralte Frage 🧠🤝❤️
Reposted by Sjoerd van Wijk
Today in @nature.com we share our back-to-back stories with Ning Zheng’s lab revealing chemical-genetic convergence between a molecular glue degrader & E3 ligase cancer mutations. 1/5
February 12, 2025 at 4:20 PM
Today in @nature.com we share our back-to-back stories with Ning Zheng’s lab revealing chemical-genetic convergence between a molecular glue degrader & E3 ligase cancer mutations. 1/5
Reposted by Sjoerd van Wijk
🎉Super excited to share our story on how the substrate receptor FBXO31 functions as a quality control factor by recognizing amides. This has been an amazing collaboration between Bode lab and @jcornlab.bsky.social. Special shutout goes to @matthiasmuhar.bsky.social www.nature.com/articles/s41...
C-terminal amides mark proteins for degradation via SCF–FBXO31 - Nature
SCF–FBXO31 scans proteins for C-terminal amidation and marks them for subsequent proteasomal degradation.
www.nature.com
January 29, 2025 at 4:29 PM
🎉Super excited to share our story on how the substrate receptor FBXO31 functions as a quality control factor by recognizing amides. This has been an amazing collaboration between Bode lab and @jcornlab.bsky.social. Special shutout goes to @matthiasmuhar.bsky.social www.nature.com/articles/s41...
Reposted by Sjoerd van Wijk
🚨Our new preprint! IFITM3 KO mice accelerated SARS-CoV-2 Beta & Omicron adaptation, preserving human-relevant traits & enabling comparative pathology/transcriptomics in mice. 🫁🦠🧬🥼 With @parkerjdenz.bsky.social, @adforu.bsky.social & team. 🔗 www.biorxiv.org/content/10.1...
January 29, 2025 at 3:17 PM
🚨Our new preprint! IFITM3 KO mice accelerated SARS-CoV-2 Beta & Omicron adaptation, preserving human-relevant traits & enabling comparative pathology/transcriptomics in mice. 🫁🦠🧬🥼 With @parkerjdenz.bsky.social, @adforu.bsky.social & team. 🔗 www.biorxiv.org/content/10.1...
Reposted by Sjoerd van Wijk
Should I be proud or worried? This is the first time that one of my tweet makes it into the news.
www.researchprofessionalnews.com/rr-news-usa-...
www.researchprofessionalnews.com/rr-news-usa-...
Trump’s freeze on NIH causes alarm - Research Professional News
World’s largest public biomedical funder “cancels grant meetings”, while WHO pauses recruitment after US withdraws
www.researchprofessionalnews.com
January 24, 2025 at 7:58 PM
Should I be proud or worried? This is the first time that one of my tweet makes it into the news.
www.researchprofessionalnews.com/rr-news-usa-...
www.researchprofessionalnews.com/rr-news-usa-...
Reposted by Sjoerd van Wijk
Every once in a while we publish a paper that moves a whole field forward. I think that's the case for this one from the Bugaj lab, where they describe proteins for THERMOGENETIC control of cellular behavior. www.nature.com/articles/s41...
A temperature-inducible protein module for control of mammalian cell fate - Nature Methods
The Melt (Membrane localization using temperature) protein translocates to the plasma membrane upon temperature shift. Melt variants with a range of switching temperatures enable straightforward therm...
www.nature.com
January 23, 2025 at 6:34 PM
Every once in a while we publish a paper that moves a whole field forward. I think that's the case for this one from the Bugaj lab, where they describe proteins for THERMOGENETIC control of cellular behavior. www.nature.com/articles/s41...