Sina Neyazi
@sinaneyazi.bsky.social
Physician Scientist | @DanaFarber.bsky.social @Harvardmed.bsky.social | Postdoc in Neuro-Oncology Research @ Filbin Lab | Pediatrics Resident @UKEHamburg
Reposted by Sina Neyazi
1/ Thrilled to share our TWO back-to-back papers published in Nature Genetics today! www.nature.com/articles/s41... , www.nature.com/articles/s41...
The multilayered transcriptional architecture of glioblastoma ecosystems - Nature Genetics
Integrated single-cell transcriptomic and genetic characterization of 121 adult glioblastomas identifies heterogeneity at cell type, cell state and baseline expression program levels associated with s...
www.nature.com
May 9, 2025 at 10:14 AM
1/ Thrilled to share our TWO back-to-back papers published in Nature Genetics today! www.nature.com/articles/s41... , www.nature.com/articles/s41...
Exciting new work from our lab characterizing the immune cell landscape in pediatric high-grade glioma and ependymoma and revealing immune-suppressive changes following treatment! Biggest congratulations to Rebecca, Jenna and Mariella! 🥳
Online now: Dissecting the immune landscape in pediatric high-grade glioma reveals cell state changes under therapeutic pressure Online now:
Dissecting the immune landscape in pediatric high-grade glioma reveals cell state changes under therapeutic pressure
LaBelle et al. show immune microenvironment changes following chemo-/radiotherapy and immune checkpoint blockade therapy via single-cell RNA-seq of matched tumor, T cells, and myeloid cells in pediatric high-grade gliomas (pHGGs). This study might help to explain the limited response of pHGGs to conventional therapies.
dlvr.it
May 2, 2025 at 10:54 AM
Exciting new work from our lab characterizing the immune cell landscape in pediatric high-grade glioma and ependymoma and revealing immune-suppressive changes following treatment! Biggest congratulations to Rebecca, Jenna and Mariella! 🥳
Thrilled to share our work with Mariella Filbin, Johannes Gojo and Carl Koschmann, now published in @cp-cancercell.bsky.social We present a translational approach identifying the PDGFRA inhibitor avapritinib as a novel targeted treatment for pHGG with PDGFRA alterations www.cell.com/cancer-cell/...
Effective targeting of PDGFRA-altered high-grade glioma with avapritinib
PDGFRA is commonly altered in pediatric HGG. Mayr et al. report that the PDGFRA/KIT
inhibitor avapritinib demonstrates on-target activity, brain penetrance, and survival
benefit in pre-clinical H3K27M...
www.cell.com
March 13, 2025 at 3:30 PM
Thrilled to share our work with Mariella Filbin, Johannes Gojo and Carl Koschmann, now published in @cp-cancercell.bsky.social We present a translational approach identifying the PDGFRA inhibitor avapritinib as a novel targeted treatment for pHGG with PDGFRA alterations www.cell.com/cancer-cell/...
Very impressive, rapid intraoperative methylation classification for brain tumors in under 1 hour
🧵(1/3) Several cool new #braincancer and brain #metastases studies in #NatureMedicine this week! First up, presenting MethyLYZR, a new, super rapid (15 min!) epigenetic sequencing classifier for brain tumors. #NeuroSky #OncSky #MedSky www.nature.com/articles/s41...
Rapid brain tumor classification from sparse epigenomic data - Nature Medicine
MethyLYZR, an epigenetic classifier of brain tumors, provides clinically relevant cancer classification results within 15 min of sequencing, with potential applications for neurosurgical intraoperativ...
www.nature.com
March 1, 2025 at 4:46 AM
Very impressive, rapid intraoperative methylation classification for brain tumors in under 1 hour
Reposted by Sina Neyazi
Happy to share your latest collaboration with
@sahm_lab
leveraging spatial transcriptomics
@10xGenomics
for neuropathology diagnosis #DeepLearning
! 107 patients across 15 CNS tumors!
www.nature.com/articles/s43...
@sahm_lab
leveraging spatial transcriptomics
@10xGenomics
for neuropathology diagnosis #DeepLearning
! 107 patients across 15 CNS tumors!
www.nature.com/articles/s43...
Spatially resolved transcriptomics and graph-based deep learning improve accuracy of routine CNS tumor diagnostics - Nature Cancer
Ritter et al. present a spatial transcriptomics and deep learning-based approach named NePSTA (neuropathology spatial transcriptomic analysis) and leverage it to improve neuropathological diagnostics ...
www.nature.com
January 30, 2025 at 3:28 PM
Happy to share your latest collaboration with
@sahm_lab
leveraging spatial transcriptomics
@10xGenomics
for neuropathology diagnosis #DeepLearning
! 107 patients across 15 CNS tumors!
www.nature.com/articles/s43...
@sahm_lab
leveraging spatial transcriptomics
@10xGenomics
for neuropathology diagnosis #DeepLearning
! 107 patients across 15 CNS tumors!
www.nature.com/articles/s43...
Reposted by Sina Neyazi
Out today in @naturegenet.bsky.social -- PERFF-seq! With @tsionabay.bsky.social , @ronanchaligne.bsky.social, Bob Stickels, Meril Takizawa, + Ansu Satpathy, we describe this new assay to study rare populations with programmable nucleic acid cytometry. 1/n
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Transcript-specific enrichment enables profiling of rare cell states via single-cell RNA sequencing - Nature Genetics
Programmable Enrichment via RNA FlowFISH by sequencing (PERFF-seq) isolates rare cells based on RNA marker transcripts for single-cell RNA sequencing profiling of complex tissues, with applicability t...
www.nature.com
January 8, 2025 at 1:30 PM
Out today in @naturegenet.bsky.social -- PERFF-seq! With @tsionabay.bsky.social , @ronanchaligne.bsky.social, Bob Stickels, Meril Takizawa, + Ansu Satpathy, we describe this new assay to study rare populations with programmable nucleic acid cytometry. 1/n
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Sina Neyazi
🌟 NEW in #NatureMedicine: Repeat infusions of B7-H3 #CARTcells were safe in children with diffuse intrinsic pontine glioma (#DIPG). Median OS = 19.8 months vs historical OS = 11 months. 3 patients alive 40 months post-diagnosis! @nickvitanza.bsky.social #OncSky www.nature.com/articles/s41...
Intracerebroventricular B7-H3-targeting CAR T cells for diffuse intrinsic pontine glioma: a phase 1 trial - Nature Medicine
In the final report of a phase 1 trial evaluating intracerebroventricular B7-H3-targeting CAR T cells in children and young adults with diffuse intrinsic pontine glioma, repeated intracranial infusion...
www.nature.com
January 7, 2025 at 1:24 PM
🌟 NEW in #NatureMedicine: Repeat infusions of B7-H3 #CARTcells were safe in children with diffuse intrinsic pontine glioma (#DIPG). Median OS = 19.8 months vs historical OS = 11 months. 3 patients alive 40 months post-diagnosis! @nickvitanza.bsky.social #OncSky www.nature.com/articles/s41...
Reposted by Sina Neyazi
new out in Nature www.nature.com/articles/s41...
Gliomagenesis mimics an injury response orchestrated by neural crest-like cells - Nature
A study using glioblastoma mouse models, serial magnetic resonance imaging and single-cell profiling details changes in the identity and balance of cellular states from initiation of tumorigenesis to ...
www.nature.com
January 4, 2025 at 1:32 PM
new out in Nature www.nature.com/articles/s41...
Reposted by Sina Neyazi
Great story; Gliomagenesis mimics an injury response orchestrated by neural crest-like cells www.nature.com/articles/s41...
Gliomagenesis mimics an injury response orchestrated by neural crest-like cells - Nature
A study using glioblastoma mouse models, serial magnetic resonance imaging and single-cell profiling details changes in the identity and balance of cellular states from initiation of tumorigenesis to ...
www.nature.com
January 3, 2025 at 4:28 AM
Great story; Gliomagenesis mimics an injury response orchestrated by neural crest-like cells www.nature.com/articles/s41...
Reposted by Sina Neyazi
Presented at #ASH24:
The addition of blinatumomab after induction chemotherapy in children with standard-risk disease of average or high risk of relapse significantly improved disease-free survival.
Full AALL1731 trial results: nej.md/49CVkc1
#medsky
The addition of blinatumomab after induction chemotherapy in children with standard-risk disease of average or high risk of relapse significantly improved disease-free survival.
Full AALL1731 trial results: nej.md/49CVkc1
#medsky
December 7, 2024 at 3:34 PM
Presented at #ASH24:
The addition of blinatumomab after induction chemotherapy in children with standard-risk disease of average or high risk of relapse significantly improved disease-free survival.
Full AALL1731 trial results: nej.md/49CVkc1
#medsky
The addition of blinatumomab after induction chemotherapy in children with standard-risk disease of average or high risk of relapse significantly improved disease-free survival.
Full AALL1731 trial results: nej.md/49CVkc1
#medsky
Reposted by Sina Neyazi
🧵Just in time for
: New research from the Venkataramani lab @CellCellPress
maps how brain tumor cells create extensive neural networks in glioblastoma. Check out our paper here: authors.elsevier.com/sd/article/S...
@ekinreyhan.bsky.social
@svenjaktetzlaff.bsky.social
1/15
: New research from the Venkataramani lab @CellCellPress
maps how brain tumor cells create extensive neural networks in glioblastoma. Check out our paper here: authors.elsevier.com/sd/article/S...
@ekinreyhan.bsky.social
@svenjaktetzlaff.bsky.social
1/15
December 6, 2024 at 11:18 PM
🧵Just in time for
: New research from the Venkataramani lab @CellCellPress
maps how brain tumor cells create extensive neural networks in glioblastoma. Check out our paper here: authors.elsevier.com/sd/article/S...
@ekinreyhan.bsky.social
@svenjaktetzlaff.bsky.social
1/15
: New research from the Venkataramani lab @CellCellPress
maps how brain tumor cells create extensive neural networks in glioblastoma. Check out our paper here: authors.elsevier.com/sd/article/S...
@ekinreyhan.bsky.social
@svenjaktetzlaff.bsky.social
1/15
Reposted by Sina Neyazi
Happy to share with you our new publication 🥳👏
A long journey, many years of outstanding teamwork and very exciting insights💡🙌
Looking forward to continuing our scientific journey 🍀💪🏼😀
@hih-tuebingen.bsky.social @tueneurocampus.bsky.social
genomebiology.biomedcentral.com/articles/10....
A long journey, many years of outstanding teamwork and very exciting insights💡🙌
Looking forward to continuing our scientific journey 🍀💪🏼😀
@hih-tuebingen.bsky.social @tueneurocampus.bsky.social
genomebiology.biomedcentral.com/articles/10....
Functional screening reveals genetic dependencies and diverging cell cycle control in atypical teratoid rhabdoid tumors - Genome Biology
Background Atypical teratoid rhabdoid tumors (ATRT) are incurable high-grade pediatric brain tumors. Despite intensive research efforts, the prognosis for ATRT patients under currently established tre...
genomebiology.biomedcentral.com
December 4, 2024 at 2:29 PM
Happy to share with you our new publication 🥳👏
A long journey, many years of outstanding teamwork and very exciting insights💡🙌
Looking forward to continuing our scientific journey 🍀💪🏼😀
@hih-tuebingen.bsky.social @tueneurocampus.bsky.social
genomebiology.biomedcentral.com/articles/10....
A long journey, many years of outstanding teamwork and very exciting insights💡🙌
Looking forward to continuing our scientific journey 🍀💪🏼😀
@hih-tuebingen.bsky.social @tueneurocampus.bsky.social
genomebiology.biomedcentral.com/articles/10....