sho
@shoyip.bsky.social
physics of complex systems. biophys, biochem, biomol. florence / rome / paris.
Reposted by sho
This isn’t about left versus right.
It’s about science versus pseudoscience.
- Dr. Jessica Knurick
It’s about science versus pseudoscience.
- Dr. Jessica Knurick
September 23, 2025 at 10:24 PM
This isn’t about left versus right.
It’s about science versus pseudoscience.
- Dr. Jessica Knurick
It’s about science versus pseudoscience.
- Dr. Jessica Knurick
Reposted by sho
Medical science: Ahaha we have invented tens of thousands of life improving and saving medications ahaha we are unstoppable
Grapefruit:
Grapefruit:
August 31, 2025 at 3:06 PM
Medical science: Ahaha we have invented tens of thousands of life improving and saving medications ahaha we are unstoppable
Grapefruit:
Grapefruit:
Reposted by sho
*looks across campus*
Yup…still producing plutocrats
Yup…still producing plutocrats
August 31, 2025 at 3:32 PM
*looks across campus*
Yup…still producing plutocrats
Yup…still producing plutocrats
Back from two weeks of Summer School in #Cargèse, great venue and discussions!
Bringing back many memories and a whole lot of new ideas to try 🧬
#biomolecules #evolution
Bringing back many memories and a whole lot of new ideas to try 🧬
#biomolecules #evolution
August 30, 2025 at 9:42 PM
Back from two weeks of Summer School in #Cargèse, great venue and discussions!
Bringing back many memories and a whole lot of new ideas to try 🧬
#biomolecules #evolution
Bringing back many memories and a whole lot of new ideas to try 🧬
#biomolecules #evolution
Reposted by sho
De novo once meant no BLAST hit but later sensitive methods revealed that many designs had hits. Now TMscore is used, but it’s easy to game by adding helices or rewiring secondary structures due to its scores length normalization. I wish new functions eg. unknown enzymatic reactions would be de-novo
July 31, 2025 at 5:59 PM
De novo once meant no BLAST hit but later sensitive methods revealed that many designs had hits. Now TMscore is used, but it’s easy to game by adding helices or rewiring secondary structures due to its scores length normalization. I wish new functions eg. unknown enzymatic reactions would be de-novo
Reposted by sho
Marron
Assainissement et Pluvial.
Violet
Chauffage et climatisation.
Vert
Télécommunications ; Feux tricolores et Signalisation routière TBT.
Blanc
Zone de travaux.
Rose
Zone d’emprise multi-réseaux.
Assainissement et Pluvial.
Violet
Chauffage et climatisation.
Vert
Télécommunications ; Feux tricolores et Signalisation routière TBT.
Blanc
Zone de travaux.
Rose
Zone d’emprise multi-réseaux.
July 3, 2025 at 10:15 PM
Marron
Assainissement et Pluvial.
Violet
Chauffage et climatisation.
Vert
Télécommunications ; Feux tricolores et Signalisation routière TBT.
Blanc
Zone de travaux.
Rose
Zone d’emprise multi-réseaux.
Assainissement et Pluvial.
Violet
Chauffage et climatisation.
Vert
Télécommunications ; Feux tricolores et Signalisation routière TBT.
Blanc
Zone de travaux.
Rose
Zone d’emprise multi-réseaux.
Reposted by sho
Norme NF P 98-332 :
Rouge
Electricité BT, HTA ou HTB, éclairage ; Feux tricolores et Signalisation routière.
Jaune
Gaz combustible (transport ou distribution) et Hydrocarbures.
Orange
Produits chimiques.
Bleu
Eau potable.
Rouge
Electricité BT, HTA ou HTB, éclairage ; Feux tricolores et Signalisation routière.
Jaune
Gaz combustible (transport ou distribution) et Hydrocarbures.
Orange
Produits chimiques.
Bleu
Eau potable.
July 3, 2025 at 10:15 PM
Norme NF P 98-332 :
Rouge
Electricité BT, HTA ou HTB, éclairage ; Feux tricolores et Signalisation routière.
Jaune
Gaz combustible (transport ou distribution) et Hydrocarbures.
Orange
Produits chimiques.
Bleu
Eau potable.
Rouge
Electricité BT, HTA ou HTB, éclairage ; Feux tricolores et Signalisation routière.
Jaune
Gaz combustible (transport ou distribution) et Hydrocarbures.
Orange
Produits chimiques.
Bleu
Eau potable.
Reposted by sho
For many of those who were asking on BLOW5 vs POD5 for nanopore signal data, here is a finally detailed benchmark we did:
biorxiv.org/content/10.1...
Summary: performance of BLOW5 is >= POD5 (from ~= to 100X, see below), with benefit of having ~3 dependencies instead of >50.
biorxiv.org/content/10.1...
Summary: performance of BLOW5 is >= POD5 (from ~= to 100X, see below), with benefit of having ~3 dependencies instead of >50.
July 5, 2025 at 4:26 AM
For many of those who were asking on BLOW5 vs POD5 for nanopore signal data, here is a finally detailed benchmark we did:
biorxiv.org/content/10.1...
Summary: performance of BLOW5 is >= POD5 (from ~= to 100X, see below), with benefit of having ~3 dependencies instead of >50.
biorxiv.org/content/10.1...
Summary: performance of BLOW5 is >= POD5 (from ~= to 100X, see below), with benefit of having ~3 dependencies instead of >50.
I discovered to my great dismay that teabags don't float on milk
July 4, 2025 at 8:45 AM
I discovered to my great dismay that teabags don't float on milk
Reposted by sho
Great news! I’m hiring a PhD student in structural #Bioinformatics to work on modeling protein conformations and interactions at @i2bcparissaclay.bsky.social
as part of the ANR SPPICES project! 🚀
📅 Start: 1 Sept 2025
⏳ Deadline: 23 June 2025
👉Apply now: emploi.cnrs.fr/Offres/Docto...
as part of the ANR SPPICES project! 🚀
📅 Start: 1 Sept 2025
⏳ Deadline: 23 June 2025
👉Apply now: emploi.cnrs.fr/Offres/Docto...
Portail Emploi CNRS - Offre d'emploi - Doctorant en bioinformatique structurale et évolution des protéines (H/F)
emploi.cnrs.fr
June 12, 2025 at 9:33 AM
Great news! I’m hiring a PhD student in structural #Bioinformatics to work on modeling protein conformations and interactions at @i2bcparissaclay.bsky.social
as part of the ANR SPPICES project! 🚀
📅 Start: 1 Sept 2025
⏳ Deadline: 23 June 2025
👉Apply now: emploi.cnrs.fr/Offres/Docto...
as part of the ANR SPPICES project! 🚀
📅 Start: 1 Sept 2025
⏳ Deadline: 23 June 2025
👉Apply now: emploi.cnrs.fr/Offres/Docto...
Reposted by sho
I worry that escalating war with Iran will be used to whip up more fear and hate for non-white immigrants, particularly those of Arab descent, and be used for unjust deportations.
June 22, 2025 at 3:33 AM
I worry that escalating war with Iran will be used to whip up more fear and hate for non-white immigrants, particularly those of Arab descent, and be used for unjust deportations.
Reposted by sho
Oggi Parigi è una palla di fuoco
June 21, 2025 at 4:10 PM
Oggi Parigi è una palla di fuoco
Reposted by sho
“Where is it? Where is the warrant?”
Watch NYC comptroller and mayoral candidate Brad Lander detained at an immigration court⬇️
Watch NYC comptroller and mayoral candidate Brad Lander detained at an immigration court⬇️
June 17, 2025 at 7:54 PM
“Where is it? Where is the warrant?”
Watch NYC comptroller and mayoral candidate Brad Lander detained at an immigration court⬇️
Watch NYC comptroller and mayoral candidate Brad Lander detained at an immigration court⬇️
Ribaltiamo le cattedre e rompiamo gli schemi!
Dieci giorni di orditure, disfacimenti, esplosioni e rammendature per co-progettare la città di Bari su tre sfide urbane 💬🌱🤝 per migliorare la qualità di vita dell3 cittadin3.
Curiosə? Hai tempo fino al 16 Giugno per iscriverti 🔥
baricittaperta.xyz/it
Dieci giorni di orditure, disfacimenti, esplosioni e rammendature per co-progettare la città di Bari su tre sfide urbane 💬🌱🤝 per migliorare la qualità di vita dell3 cittadin3.
Curiosə? Hai tempo fino al 16 Giugno per iscriverti 🔥
baricittaperta.xyz/it
June 15, 2025 at 8:48 AM
Ribaltiamo le cattedre e rompiamo gli schemi!
Dieci giorni di orditure, disfacimenti, esplosioni e rammendature per co-progettare la città di Bari su tre sfide urbane 💬🌱🤝 per migliorare la qualità di vita dell3 cittadin3.
Curiosə? Hai tempo fino al 16 Giugno per iscriverti 🔥
baricittaperta.xyz/it
Dieci giorni di orditure, disfacimenti, esplosioni e rammendature per co-progettare la città di Bari su tre sfide urbane 💬🌱🤝 per migliorare la qualità di vita dell3 cittadin3.
Curiosə? Hai tempo fino al 16 Giugno per iscriverti 🔥
baricittaperta.xyz/it
Novo Nordisk's Canadian Mistake
www.science.org
June 15, 2025 at 6:40 AM
Reposted by sho
“Tasted a little tear gas— tasted like fascism”
June 8, 2025 at 4:40 AM
“Tasted a little tear gas— tasted like fascism”
Internet connection down in #Jussieu campus @sorbonne-universite.fr 😥
June 3, 2025 at 8:22 AM
Internet connection down in #Jussieu campus @sorbonne-universite.fr 😥
Non stiamo messi molto meglio che oltreoceano
#Cnr alla deriva. Tutti i vertici scaduti, il governo non nomina i nuovi. Persi 3 milioni al giorno
La nave oceanografica del Cnr Gaia Blu ferma in porto.
Non si possono assumere precari né portare avanti progetti di ricerca. “Se ci fosse un’emergenza, nessuno avrebbe modo di intervenire”
La nave oceanografica del Cnr Gaia Blu ferma in porto.
Non si possono assumere precari né portare avanti progetti di ricerca. “Se ci fosse un’emergenza, nessuno avrebbe modo di intervenire”
Cnr alla deriva. Tutti i vertici scaduti, il governo non nomina i nuovi. Persi 3 milioni al giorno
Senza presidente né cda il più grande ente scientifico italiano non può spendere i suoi fondi, assumere precari né portare avanti progetti di ricerca. “Se ci f…
www.repubblica.it
June 1, 2025 at 10:07 AM
Non stiamo messi molto meglio che oltreoceano
Reposted by sho
Thank you @joshuasweitz.bsky.social for making this visually effective set of plots that puts into perspective the scale of the announced cuts to NIH, NSF and NASA
There are 2 previous historical cases of countries destroying their science and universities, crippling them for decades: Lysenkoism in the USSR and Nazi Germany. The Trump administration will be the 3rd.
It's not just budgets but research, institutions, expertise, and training the next generation.
It's not just budgets but research, institutions, expertise, and training the next generation.
May 31, 2025 at 12:49 PM
Thank you @joshuasweitz.bsky.social for making this visually effective set of plots that puts into perspective the scale of the announced cuts to NIH, NSF and NASA
😥
NIH funding supporting the HMMER and Infernal software projects has been terminated. NIH states that our work, as well as all other federally funded research at Harvard, is of no benefit to the US.
May 29, 2025 at 3:57 PM
😥
Reposted by sho
My father worked in a tire factory in Appalachia. Friends and family in the military. Used to vote Republican. Got into college on a diversity program for the underprivileged. Ended up a Harvard professor. And now my funding is terminated because we're trying to stick it to the elites.
May 28, 2025 at 3:07 PM
My father worked in a tire factory in Appalachia. Friends and family in the military. Used to vote Republican. Got into college on a diversity program for the underprivileged. Ended up a Harvard professor. And now my funding is terminated because we're trying to stick it to the elites.
this is very sad and worrisome
The war on science in the US is already having an effect on private sector research like AlphaFold. Bears repeating but the private sector builds on top of things created by academic research for the public good. This hurts everyone.
May 28, 2025 at 11:36 AM
this is very sad and worrisome
🧬 Great talk (and life lessons) by @ardemp.bskyverified.social at IBPS! Crazy how widespread are the medical conditions where Piezo mechanosensitive proteins are implied.
May 28, 2025 at 8:22 AM
🧬 Great talk (and life lessons) by @ardemp.bskyverified.social at IBPS! Crazy how widespread are the medical conditions where Piezo mechanosensitive proteins are implied.
Reposted by sho
Does anybody in #bioinformatics need a #Rust program to convert Stockholm format into FASTA? I'm using this to split multiple sequence alignments in an STK file into separate FASTA files. github.com/TravisWheele...
GitHub - TravisWheelerLab/stk2fasta: Split Stockholm file into FASTA files
Split Stockholm file into FASTA files. Contribute to TravisWheelerLab/stk2fasta development by creating an account on GitHub.
github.com
February 4, 2025 at 9:22 PM
Does anybody in #bioinformatics need a #Rust program to convert Stockholm format into FASTA? I'm using this to split multiple sequence alignments in an STK file into separate FASTA files. github.com/TravisWheele...