SchurichLab
@schurichlab.bsky.social
Research group interested in T cell immunometabolism and advanced therapies
Reposted by SchurichLab
Genetic delivery of designed protein nanoparticles displaying the SARS-CoV-2 RBD elicits potent neutralizing antibody and CD8 T cell responses
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
October 15, 2025 at 7:25 PM
Genetic delivery of designed protein nanoparticles displaying the SARS-CoV-2 RBD elicits potent neutralizing antibody and CD8 T cell responses
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by SchurichLab
To celebrate #BiologyWeek, let's talk about how vaccines work!
See our “How do vaccines work?” infographic below 👇 and learn more in the Vaccines & Therapeutics section of our BiteSized #Immunology resource: https://bit.ly/482sVND
See our “How do vaccines work?” infographic below 👇 and learn more in the Vaccines & Therapeutics section of our BiteSized #Immunology resource: https://bit.ly/482sVND
October 16, 2025 at 8:45 AM
To celebrate #BiologyWeek, let's talk about how vaccines work!
See our “How do vaccines work?” infographic below 👇 and learn more in the Vaccines & Therapeutics section of our BiteSized #Immunology resource: https://bit.ly/482sVND
See our “How do vaccines work?” infographic below 👇 and learn more in the Vaccines & Therapeutics section of our BiteSized #Immunology resource: https://bit.ly/482sVND
Reposted by SchurichLab
In case you missed it….great study from @lindavsinclair.bsky.social and Doreen Cantrell.
Autophagy and how it shapes CD8 T cell responses
-Differentially pruning naive and effector T cell proteomes
-Dynamically repressed by antigen receptors and inflammatory cytokines
rdcu.be/eJBFA
Autophagy and how it shapes CD8 T cell responses
-Differentially pruning naive and effector T cell proteomes
-Dynamically repressed by antigen receptors and inflammatory cytokines
rdcu.be/eJBFA
Autophagy repression by antigen and cytokines shapes mitochondrial, migration and effector machinery in CD8 T cells
Nature Immunology - Sinclair et al. combine quantitative proteomics and an autophagy flux reporter to map autophagy substrates and triggers during CD8 T cell differentiation. Proteins...
rdcu.be
October 5, 2025 at 9:54 PM
In case you missed it….great study from @lindavsinclair.bsky.social and Doreen Cantrell.
Autophagy and how it shapes CD8 T cell responses
-Differentially pruning naive and effector T cell proteomes
-Dynamically repressed by antigen receptors and inflammatory cytokines
rdcu.be/eJBFA
Autophagy and how it shapes CD8 T cell responses
-Differentially pruning naive and effector T cell proteomes
-Dynamically repressed by antigen receptors and inflammatory cytokines
rdcu.be/eJBFA
Very excited to share our new study comparing the metabolic profile of patient-derived CAR-T cells ex vivo.
CAR-T cells containing CD28 versus 4-1BB co-stimulatory domains show distinct metabolic profiles in patients: Cell Reports www.cell.com/cell-reports...
CAR-T cells containing CD28 versus 4-1BB co-stimulatory domains show distinct metabolic profiles in patients: Cell Reports www.cell.com/cell-reports...
CAR-T cells containing CD28 versus 4-1BB co-stimulatory domains show distinct metabolic profiles in patients
Cook et al. investigate the metabolic profile of DLBCL patient-derived CAR-T cells
ex vivo. Comparing Axi-cel (CD28-co-stimulated) and Tisa-cel (4-1BB-co-stimulated)
products, they find divergent meta...
www.cell.com
July 17, 2025 at 4:31 PM
Very excited to share our new study comparing the metabolic profile of patient-derived CAR-T cells ex vivo.
CAR-T cells containing CD28 versus 4-1BB co-stimulatory domains show distinct metabolic profiles in patients: Cell Reports www.cell.com/cell-reports...
CAR-T cells containing CD28 versus 4-1BB co-stimulatory domains show distinct metabolic profiles in patients: Cell Reports www.cell.com/cell-reports...
Reposted by SchurichLab
Vote for your facourite topic for our 2026 LIG meeting
1️⃣ <a href="https://poll.blue/p/SJu7An/1" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky">Immunology across the lifecourse
2️⃣ <a href="https://poll.blue/p/SJu7An/2" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky">Immunology in a changing world
3️⃣ <a href="https://poll.blue/p/SJu7An/3" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky">Signals & senses: external influences on imm.cells
4️⃣ <a href="https://poll.blue/p/SJu7An/4" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky">Bench to bedside Immunology
📊 Show results
1️⃣ <a href="https://poll.blue/p/SJu7An/1" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky">Immunology across the lifecourse
2️⃣ <a href="https://poll.blue/p/SJu7An/2" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky">Immunology in a changing world
3️⃣ <a href="https://poll.blue/p/SJu7An/3" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky">Signals & senses: external influences on imm.cells
4️⃣ <a href="https://poll.blue/p/SJu7An/4" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky">Bench to bedside Immunology
📊 Show results
July 11, 2025 at 3:34 PM
Vote for your facourite topic for our 2026 LIG meeting
1️⃣ <a href="https://poll.blue/p/SJu7An/1" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky">Immunology across the lifecourse
2️⃣ <a href="https://poll.blue/p/SJu7An/2" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky">Immunology in a changing world
3️⃣ <a href="https://poll.blue/p/SJu7An/3" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky">Signals & senses: external influences on imm.cells
4️⃣ <a href="https://poll.blue/p/SJu7An/4" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky">Bench to bedside Immunology
📊 Show results
1️⃣ <a href="https://poll.blue/p/SJu7An/1" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky">Immunology across the lifecourse
2️⃣ <a href="https://poll.blue/p/SJu7An/2" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky">Immunology in a changing world
3️⃣ <a href="https://poll.blue/p/SJu7An/3" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky">Signals & senses: external influences on imm.cells
4️⃣ <a href="https://poll.blue/p/SJu7An/4" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky">Bench to bedside Immunology
📊 Show results
Reposted by SchurichLab
Running a genetic stop sign accelerates oxygen metabolism and energy production in horses | Science www.science.org/doi/10.1126/...
Running a genetic stop sign accelerates oxygen metabolism and energy production in horses
Horses are among nature’s greatest athletes, yet the ancestral molecular adaptations fueling their energy demands are poorly understood. Within a clinically important pathway regulating redox and meta...
www.science.org
March 30, 2025 at 6:04 AM
Running a genetic stop sign accelerates oxygen metabolism and energy production in horses | Science www.science.org/doi/10.1126/...
Reposted by SchurichLab
15 American scientists working in climate, health & astrophysics to be brought to the University of Aix-Marseille , under a 3-year "Safe Place for Science".
Europe positions itself to reverse the decades-long transatlantic brain drain.
🧪
www.theguardian.com/commentisfre...
Europe positions itself to reverse the decades-long transatlantic brain drain.
🧪
www.theguardian.com/commentisfre...
A French university is offering ‘scientific asylum’ for US talent. The brain drain has started | Alexander Hurst
The Trump administration is cutting funding, while specifically targeting institutions like Columbia. No wonder academics want out, says Guardian Europe columnist Alexander Hurst
www.theguardian.com
March 24, 2025 at 6:30 AM
15 American scientists working in climate, health & astrophysics to be brought to the University of Aix-Marseille , under a 3-year "Safe Place for Science".
Europe positions itself to reverse the decades-long transatlantic brain drain.
🧪
www.theguardian.com/commentisfre...
Europe positions itself to reverse the decades-long transatlantic brain drain.
🧪
www.theguardian.com/commentisfre...
Reposted by SchurichLab
Fossil fuel companies should be forced to pay the public trillions in damages for the costs of their planetary arson. Instead they are trying to shut down one of the most important and storied environmental groups in the world. It's shameless - and it's not over. www.theguardian.com/us-news/2025...
Greenpeace must pay hundreds of millions over Dakota pipeline protests, says jury
Non-profit said in statement lawsuits like this aimed at ‘destroying the right to peaceful protest’
www.theguardian.com
March 19, 2025 at 9:10 PM
Fossil fuel companies should be forced to pay the public trillions in damages for the costs of their planetary arson. Instead they are trying to shut down one of the most important and storied environmental groups in the world. It's shameless - and it's not over. www.theguardian.com/us-news/2025...
Reposted by SchurichLab
⏲️Only a few days to go until Vaccine Engagement Day 2025!
We'll be highlighting the vital role of vaccines in public health throughout the day 🌟
Want to get involved? Check out our vaccine engagement resources: www.immunology.org/news/bsi-lau...
#CelebrateVaccines
We'll be highlighting the vital role of vaccines in public health throughout the day 🌟
Want to get involved? Check out our vaccine engagement resources: www.immunology.org/news/bsi-lau...
#CelebrateVaccines
March 24, 2025 at 12:58 PM
⏲️Only a few days to go until Vaccine Engagement Day 2025!
We'll be highlighting the vital role of vaccines in public health throughout the day 🌟
Want to get involved? Check out our vaccine engagement resources: www.immunology.org/news/bsi-lau...
#CelebrateVaccines
We'll be highlighting the vital role of vaccines in public health throughout the day 🌟
Want to get involved? Check out our vaccine engagement resources: www.immunology.org/news/bsi-lau...
#CelebrateVaccines
Reposted by SchurichLab
Pyruvate metabolism enzyme DLAT promotes tumorigenesis by suppressing leucine catabolism: Cell Metabolism www.cell.com/cell-metabol...
Pyruvate metabolism enzyme DLAT promotes tumorigenesis by suppressing leucine catabolism
Wang et al. reveal that DLAT, a pyruvate metabolism enzyme, modulates leucine metabolism
by directly acetylating the leucine catabolism enzyme AUH at K109, leading to leucine
accumulation and sustaine...
www.cell.com
March 20, 2025 at 5:07 PM
Pyruvate metabolism enzyme DLAT promotes tumorigenesis by suppressing leucine catabolism: Cell Metabolism www.cell.com/cell-metabol...
Reposted by SchurichLab
👋Hello Bluesky! We foster collaboration between cancer researchers at @uclofficial.bsky.social, @kingscollegelondon.bsky.social, @qmbci.bsky.social and @crick.ac.uk.
Through our world-class facilities, events, training, and funding opportunities, we aim to support the discoveries that save lives.
Through our world-class facilities, events, training, and funding opportunities, we aim to support the discoveries that save lives.
December 17, 2024 at 3:51 PM
👋Hello Bluesky! We foster collaboration between cancer researchers at @uclofficial.bsky.social, @kingscollegelondon.bsky.social, @qmbci.bsky.social and @crick.ac.uk.
Through our world-class facilities, events, training, and funding opportunities, we aim to support the discoveries that save lives.
Through our world-class facilities, events, training, and funding opportunities, we aim to support the discoveries that save lives.
Reposted by SchurichLab
I reported on patient outreach in Wisconsin ~10 years ago(?) when the HPV vaccine was rolling out on a large scale and it's really amazing to see this work come to fruition. 🧪
A recent study found that cervical cancer deaths in young women have plummeted since the introduction of the human papillomavirus vaccine.
As Cervical Cancer Deaths Plummet, Experts Credit HPV Vaccine
HPV can cause a variety of cancers, including cervical. New mortality data for women under 25 point to the success of the HPV vaccine.
buff.ly
March 11, 2025 at 4:15 PM
I reported on patient outreach in Wisconsin ~10 years ago(?) when the HPV vaccine was rolling out on a large scale and it's really amazing to see this work come to fruition. 🧪
Reposted by SchurichLab
"Ignoring #climate change won’t make it go away. Like the Ministry of Truth in George Orwell’s classic #dystopian novel, 1984, Trump seems to believe “ignorance is strength”. He’s trying to erase facts about the climate crisis, perhaps to keep people ignorant and subdued." 👇
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Trump’s war on climate science is pushing us into a dystopian future
Withdrawing support for research and scrubbing climate data from US government websites has repercussions for Australia and the world. But there are ways around it.
theconversation.com
February 28, 2025 at 9:10 AM
"Ignoring #climate change won’t make it go away. Like the Ministry of Truth in George Orwell’s classic #dystopian novel, 1984, Trump seems to believe “ignorance is strength”. He’s trying to erase facts about the climate crisis, perhaps to keep people ignorant and subdued." 👇
⚒️ 🧪
⚒️ 🧪