Saskia Hogenhout
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saskiahogenhout.bsky.social
Saskia Hogenhout
@saskiahogenhout.bsky.social
1.8K followers 1.4K following 5 posts
Scientist at the John Innes Centre. Molecular Plant-Microbe-Insect Interactions. Loves travelling, reading and hiking. Location : Norwich, UK. Website: https://www.jic.ac.uk/people/saskia-hogenhout/
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saskiahogenhout.bsky.social
Saskia Hogenhout @saskiahogenhout.bsky.social · Jul 16
www.science.org/doi/10.1126/...
Aphid effectors suppress plant immunity via recruiting defense proteins to processing bodies
Aphids hijack plant immunity via p-bodies, but plants fight back with a heat shock protein in an unexpected twist on defense.
www.science.org
saskiahogenhout.bsky.social
Guillaume de Nourriche! #Norwich 🇬🇧
November 1, 2025 at 2:04 PM
Reposted by Saskia Hogenhout
matteogravino.bsky.social
🎉Thrilled to share our latest work, now published in @newphyt.bsky.social!

🧑‍🔬 @matteogravino.bsky.social, @samtmugford.bsky.social, @saskiahogenhout.bsky.social et al., @johninnescentre.bsky.social

#️⃣ #PlantScience #PlantImmunity

📄 Read the full paper👇
nph.onlinelibrary.wiley.com/share/8QSRJ9...
Model: Activation and suppression of defences in plant–aphid interactions. Upper left panel: aphid stylet penetration of the cell wall releases oligogalacturonides (OGs), which induce PAMP/DAMP-triggered immunity (PTI/DTI) in a process dependent on BRASSINOSTEROID INSENSITIVE 1-ASSOCIATED RECEPTOR KINASE 1 (BAK1), ENHANCED DISEASE SUSCEPTIBILITY 1 (EDS1), and CPK5/6/11 (data herein). The stabilisation of pattern recognition receptors (PRRs) and coreceptors at the plasma membrane may rely on the deubiquitination (DUB) activity of ASSOCIATED MOLECULE WITH THE SH3 DOMAIN OF STAM (AMSHs; Gravino et al., 2024). Upper right panel: the Mp10 effector, introduced by aphids into the cell cytoplasm (Mugford et al., 2016), suppresses OG-induced reactive oxygen species (ROS) (data herein) and flg22-induced PTI (Bos et al., 2010). Mp10 targeting of plant AMSHs is implicated in these processes (Gravino et al., 2024). EDS1 is essential for Mp10-mediated ROS suppression and PRR destabilisation (data herein), acting through an unidentified mechanism (denoted by the double-sided arrow with an asterisk). Lower left panel: effector-triggered immunity (ETI) is activated through EDS1, either directly or indirectly, upon recognition of Mp10 and/or its activities by a TNL (Gravino et al., 2024; Rao et al., 2024). Salicylic acid glucosyltransferase 1 (SGT1) is also required for TNL/ETI activation (Bos et al., 2010). Lower right panel: aphids secrete additional effectors, such as cathepsin B proteins (e.g. CathB6), which target EDS1 to suppress ETI (Liu et al., 2025). Solid arrows, increased activation; solid blunt-ended arrows, increased suppression; Dashed arrows, reduced activation; Dashed -blunt-ended arrows, reduced suppression.
August 1, 2025 at 12:40 PM
Reposted by Saskia Hogenhout
qunliu07.bsky.social
Our paper is now online in Science Advances! Congrats @saskiahogenhout.bsky.social @johninnescentre.bsky.social and all coauthors!
www.science.org/doi/10.1126/...
Aphid effectors suppress plant immunity via recruiting defense proteins to processing bodies
Aphids hijack plant immunity via p-bodies, but plants fight back with a heat shock protein in an unexpected twist on defense.
www.science.org
July 17, 2025 at 1:37 AM
Reposted by Saskia Hogenhout
samtmugford.bsky.social
Aphid Saliva fans, happy news, this amazing story is now out in Science Advances www.science.org/doi/10.1126/... congrats @qunliu07.bsky.social @saskiahogenhout.bsky.social et al @johninnescentre.bsky.social 24h after a triumphant presentation at #ismpmi2025
July 16, 2025 at 6:35 PM
saskiahogenhout.bsky.social
www.science.org/doi/10.1126/...
Aphid effectors suppress plant immunity via recruiting defense proteins to processing bodies
Aphids hijack plant immunity via p-bodies, but plants fight back with a heat shock protein in an unexpected twist on defense.
www.science.org
July 16, 2025 at 9:19 PM
saskiahogenhout.bsky.social
www.biorxiv.org/content/10.1...
Effector Innovation in Genome-Reduced Phytoplasmas and Other Host-Dependent Mollicutes
Obligate host-associated bacteria with reduced genomes, such as phytoplasmas, face strong evolutionary constraints, including metabolic dependence on hosts, limited horizontal gene transfer (HGT), and...
www.biorxiv.org
July 16, 2025 at 6:44 AM
Reposted by Saskia Hogenhout
kamounlab.bsky.social
I just published: Postcard from Sardinia: a fragile migrant

In an age of growing tension between north and south, one ordinary orange butterfly flutters freely across continents, unbothered by border checkpoints. This is the story of the painted lady.

kamounlab.medium.com/postcard-fro...
Postcard from Sardinia: a fragile migrant
In an age of growing tension between north and south, one ordinary orange butterfly flutters freely across continents, unbothered by border…
kamounlab.medium.com
June 30, 2025 at 12:19 PM
Reposted by Saskia Hogenhout
genomebiolevol.bsky.social
Follow authors on Bluesky: @caterpillar-coevo.bsky.social
@tom-mathers.bsky.social
@samtmugford.bsky.social
@saskiahogenhout.bsky.social
@fionabugsnbees.bsky.social
@tcheaven.bsky.social
June 30, 2025 at 7:55 AM
Reposted by Saskia Hogenhout
samtmugford.bsky.social
Me on the radio this morning talking about UK preparedness for #xylella, froghoppers and the BRIGIT project in the @saskiahogenhout.bsky.social lab @johninnescentre.bsky.social

www.bbc.co.uk/sounds/play/...
Farming Today - 18/03/25 - Hare coursing, xylella and soil microplastics - BBC Sounds
Farmers fear the rise in violent encounters with illegal hare coursers.
www.bbc.co.uk
March 18, 2025 at 6:52 PM
Reposted by Saskia Hogenhout
samtmugford.bsky.social
Congrats Dr @reubenpjames.bsky.social! latest PhD from @saskiahogenhout.bsky.social lab @johninnescentre.bsky.social
March 7, 2025 at 2:44 PM
Reposted by Saskia Hogenhout
drrebeccajhall.bsky.social
I'm super excited to spend some time in Tracey Chapman's lab (UEA) learning all aspects of insect handling and infection. I'll then be working with @saskiahogenhout.bsky.social (JIC) on a bioinf project characterising bacterial symbionts in one of her really cool insect collections.
December 16, 2024 at 3:44 PM
Reposted by Saskia Hogenhout
tcheaven.bsky.social
@tom-mathers.bsky.social @samtmugford.bsky.social @fionabugsnbees.bsky.social @caterpillar-coevo.bsky.social
December 6, 2024 at 9:15 PM
Reposted by Saskia Hogenhout
tcheaven.bsky.social
Our preprint is now live! We have sequenced the genomes of three psyllid species. These insects pests transmit devastating plant diseases like 'zebra chip' in potatoes and 'carrot yellows' in carrots. 🥕

#MolecularEntomology #MPMI #PlantPathology #psyllids #liberibacter
December 6, 2024 at 9:15 PM
Reposted by Saskia Hogenhout
elisabethbik.bsky.social
Anyway, it's quite an accomplishment for this Dutch microbiologist to live rent-free in the head of "the greatest microbiologist of all times" (or however he thinks of himself).
He now even writes papers about me!
December 2, 2024 at 6:03 AM
Reposted by Saskia Hogenhout
johannajoyce.bsky.social
Women are under-represented at senior levels in #academia globally, & across all #science 🧪 disciplines, as shown by these "scissor-shaped curves" ✂️

So how can we ever achieve #gender #equality?

We discuss various strategies in this #Cell Commentary

#WomeninSTEM

www.cell.com/cell/fulltex...
🧵 1/
November 25, 2024 at 12:38 PM
Reposted by Saskia Hogenhout
schwessinger.bsky.social
Our latest contribution to understanding plant pathogenic fungi better led by UQ. Intragenomic variants of a putative effector drive early-stage infection in a broad host-range rust fungus www.biorxiv.org/content/10.1...
Intragenomic variants of a putative effector drive early-stage infection in a broad host-range rust fungus
Rust fungi are pathogens that impact plants of environmental, agricultural, cultural, and economic importance. Their mechanisms of pathogenicity are not well-understood but are likely governed by effe...
www.biorxiv.org
December 1, 2024 at 2:17 AM
Reposted by Saskia Hogenhout
getgenome.bsky.social
GetGenome Newsletter November 2024 getgenome.net/network
November 27, 2024 at 7:38 PM
Reposted by Saskia Hogenhout
tatsuyanobori.bsky.social
Excited to co-organize the session 'Resolving heterogeneity in plants with imaging and omics' with @ignaciorubiosomoza.bsky.social at ICAR2025! Looking forward to having a wide range of speakers from abstracts. Stay tuned for more details!

📅 June 16-20 Ghent 🇧🇪
web.cvent.com/event/448810...
Concurrent Sessions. - International Conference on Arabidopsis Research: ICAR2025
web.cvent.com
November 27, 2024 at 12:00 AM
Reposted by Saskia Hogenhout
beverleycubg.bsky.social
My first post here! We’re looking for an enthusiastic plant developmentalist to join our team as a postdoc working on how this wonderful plant builds sexually deceptive flowers. Link here: www.jobs.cam.ac.uk/job/49334/
November 26, 2024 at 6:40 PM
Reposted by Saskia Hogenhout
nickdesnoyer.bsky.social
Mutations in da1, eod1, and erecta
November 22, 2024 at 9:58 PM
Reposted by Saskia Hogenhout
samtmugford.bsky.social
The @saskiahogenhout.bsky.social lab are knocking it out of the park this week, another preprint about the mechanisms of an aphid effector protein
qunliu07.bsky.social Qun Liu @qunliu07.bsky.social · Nov 21
We're happy to present a pre-print from the Hogenhout lab (@saskiahogenhout.bsky.social), describing how a family of proteases in aphid oral secretions suppress plant immunity.
biorxiv-plants.bsky.social bioRxiv Plant Bio @biorxiv-plants.bsky.social · Nov 21
Aphid effectors suppress plant immunity via recruiting defence proteins to processing bodies https://www.biorxiv.org/content/10.1101/2024.11.20.624400v1
November 21, 2024 at 10:46 AM
Reposted by Saskia Hogenhout
qunliu07.bsky.social
Thanks to everyone involved in this work
@qunliu07.bsky.social, Anna Neefjes, Roksolana Kobylinska, @samtmugford.bsky.social, @mmarzo.bsky.social, James Canham (@thesainsburylab.bsky.social), @marischuster.bsky.social, Renier van der Hoorn,
Yazhou Chen, @saskiahogenhout.bsky.social
November 21, 2024 at 10:45 AM
Reposted by Saskia Hogenhout
qunliu07.bsky.social
We're happy to present a pre-print from the Hogenhout lab (@saskiahogenhout.bsky.social), describing how a family of proteases in aphid oral secretions suppress plant immunity.
November 21, 2024 at 10:45 AM
Reposted by Saskia Hogenhout
caterpillar-coevo.bsky.social
I'm currently a postdoc with @saskiahogenhout.bsky.social but will be starting as a Presidential Postdoctoral Fellow at Arizona State University next year with @kstsosie.bsky.social
November 19, 2024 at 11:26 AM