Samuele Laudani
@samuelelaud.bsky.social
Postdoctoral researcher passionate about neuroscience and the study of the gut microbiota in health and disease
Reposted by Samuele Laudani
Annual ISD Research Retreat 🎆 Great talks, project presentations, poster session, games, guest talks and an amazing LLM workshop by Rainer Malik 🙏
July 10, 2025 at 9:05 AM
Annual ISD Research Retreat 🎆 Great talks, project presentations, poster session, games, guest talks and an amazing LLM workshop by Rainer Malik 🙏
Metabolic modelling reveals the aging-associated decline of host–microbiome metabolic interactions in mice rdcu.be/efio5
Metabolic modelling reveals the aging-associated decline of host–microbiome metabolic interactions in mice
Nature Microbiology - A multi-omics approach reveals host–microbiome interactions in aging in mice.
rdcu.be
March 27, 2025 at 8:48 AM
Metabolic modelling reveals the aging-associated decline of host–microbiome metabolic interactions in mice rdcu.be/efio5
Reposted by Samuele Laudani
New paper: We show that especially female mice benefit from moderate early life adversity under stressful situations in adulthood. This pro-resilient effect requires the psychiatric risk factor FKBP51, which turns out to be also required for adaptive stress responses. www.nature.com/articles/s41...
FKBP51 in glutamatergic forebrain neurons promotes early life stress inoculation in female mice - Nature Communications
Early life stress can induce lasting changes in brain function and behavior. Here, authors show that glutamatergic FKBP51 specifically in females mediates adaptive stress effects on anxiety and cognit...
www.nature.com
March 14, 2025 at 4:24 PM
New paper: We show that especially female mice benefit from moderate early life adversity under stressful situations in adulthood. This pro-resilient effect requires the psychiatric risk factor FKBP51, which turns out to be also required for adaptive stress responses. www.nature.com/articles/s41...
Sweetener aspartame aggravates atherosclerosis through insulin-triggered inflammation: Cell Metabolism www.cell.com/cell-metabol...
Sweetener aspartame aggravates atherosclerosis through insulin-triggered inflammation
Wu et al. provide new insights into how aspartame consumption exacerbates atherosclerosis
through an insulin-dependent mechanism. Aspartame-triggered high insulin levels upregulate
the endothelial mem...
www.cell.com
February 20, 2025 at 5:46 PM
Sweetener aspartame aggravates atherosclerosis through insulin-triggered inflammation: Cell Metabolism www.cell.com/cell-metabol...
"The neuroimmune connectome in health and disease"
rdcu.be/d9Qmc
rdcu.be/d9Qmc
The neuroimmune connectome in health and disease
Nature - A review of studies on communication between the nervous and immune systems redefines the neuroimmune connectome with a focus on health and disease, and discusses how the latest techniques...
rdcu.be
February 14, 2025 at 9:01 AM
"The neuroimmune connectome in health and disease"
rdcu.be/d9Qmc
rdcu.be/d9Qmc
Chronic intermittent fasting impairs β cell maturation and function in adolescent mice: Cell Reports www.cell.com/cell-reports...
Chronic intermittent fasting impairs β cell maturation and function in adolescent mice
Intermittent fasting (IF) is generally associated with improved metabolism, but whether
there are age-dependent limitations of IF needs to be explored. Matta et al. now demonstrate
that while IF impro...
www.cell.com
February 13, 2025 at 2:29 PM
Chronic intermittent fasting impairs β cell maturation and function in adolescent mice: Cell Reports www.cell.com/cell-reports...
Interplay between gut microbial communities and metabolites modulates pan-cancer immunotherapy responses: Cell Metabolism www.cell.com/cell-metabol...
Interplay between gut microbial communities and metabolites modulates pan-cancer immunotherapy responses
Zhu et al. employed multi-omics analysis to reveal critical links among the gut microbiome,
the gut metabolome, and anti-PD-1/PD-L1 therapy response. Five distinct enterotypes
with unique metabolic pr...
www.cell.com
February 5, 2025 at 1:40 PM
Interplay between gut microbial communities and metabolites modulates pan-cancer immunotherapy responses: Cell Metabolism www.cell.com/cell-metabol...
Reposted by Samuele Laudani
Temperature-related deaths in European cities could increase by up to 50% by the end of the century in the absence of climate change-mitigation policies, totalling up to 2.3 million additional deaths, suggests a paper published in Nature Medicine. https://go.nature.com/4glnYzU 🧪
January 27, 2025 at 10:21 PM
Temperature-related deaths in European cities could increase by up to 50% by the end of the century in the absence of climate change-mitigation policies, totalling up to 2.3 million additional deaths, suggests a paper published in Nature Medicine. https://go.nature.com/4glnYzU 🧪
Reposted by Samuele Laudani
Super proud of this paper on infant gut microbiome age coming from my lab. The paper has just been published with @springernature.bsky.social in @naturecomms.bsky.social. Read about it here: rdcu.be/d6cCw.
Early life microbial succession in the gut follows common patterns in humans across the globe
Nature Communications - Here, the authors perform a global analysis of over 3000 infant gut samples revealing a universal pattern of microbial changes over the first 1.5 years, with declines in...
rdcu.be
January 14, 2025 at 3:42 PM
Super proud of this paper on infant gut microbiome age coming from my lab. The paper has just been published with @springernature.bsky.social in @naturecomms.bsky.social. Read about it here: rdcu.be/d6cCw.
Using clusterProfiler to characterize multiomics data www.nature.com/articles/s41...
Using clusterProfiler to characterize multiomics data - Nature Protocols
clusterProfiler is a tool for characterizing and visualizing omics data. The example procedures show integration of metabolomics and metagenomics analyses, characterization of transcription factors an...
www.nature.com
January 13, 2025 at 5:27 PM
Using clusterProfiler to characterize multiomics data www.nature.com/articles/s41...
Gut microbiome signatures of vegan, vegetarian and omnivore diets and associated health outcomes across 21,561 individuals
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Gut microbiome signatures of vegan, vegetarian and omnivore diets and associated health outcomes across 21,561 individuals - Nature Microbiology
Using 21,561 individuals, the authors present a cross-sectional study of how gut microbiome signatures are associated with dietary intake patterns and with host health outcomes.
www.nature.com
January 7, 2025 at 6:45 PM
Gut microbiome signatures of vegan, vegetarian and omnivore diets and associated health outcomes across 21,561 individuals
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Samuele Laudani
The host genotype actively shapes its microbiome across generations in laboratory mice.
microbiomejournal.biomedcentral.com/articles/10....
The host genotype actively shapes its microbiome across generations in laboratory mice - Microbiome
Background The microbiome greatly affects health and wellbeing. Evolutionarily, it is doubtful that a host would rely on chance alone to pass on microbial colonization to its offspring. However, the l...
microbiomejournal.biomedcentral.com
December 23, 2024 at 5:00 PM
The host genotype actively shapes its microbiome across generations in laboratory mice.
microbiomejournal.biomedcentral.com/articles/10....
Reposted by Samuele Laudani
Deconstructing the neural circuit underlying social hierarchy in mice www.cell.com/neuron/abstr... - how your brain tells you if you're winning or losing (if you're a mouse)
Deconstructing the neural circuit underlying social hierarchy in mice
Xin et al. find that in the dorsomedial prefrontal cortex (dmPFC), layer 2/3 neurons projecting to the anterior basolateral amygdala promote losing, whereas layer 5 neurons projecting to the dorsal raphe nucleus and periaqueductal gray promote winning. Moreover, the lose-related pathway inhibits the win-related pathways through local GABAergic interneurons.
www.cell.com
December 12, 2024 at 8:12 AM
Deconstructing the neural circuit underlying social hierarchy in mice www.cell.com/neuron/abstr... - how your brain tells you if you're winning or losing (if you're a mouse)
Reposted by Samuele Laudani
We've uncovered sex-specific effects of early-life stress (ELS) exposure on fear memory, HPA-axis regulation, and brain metabolism🧠. Unsupervised clustering shows that fear responses are more than only freezing.
@mathiasvschmidt.bsky.social
nature.com/articles/s42...
Highlights in thread👇
@mathiasvschmidt.bsky.social
nature.com/articles/s42...
Highlights in thread👇
Sex-specific fear acquisition following early life stress is linked to amygdala and hippocampal purine and glutamate metabolism - Communications Biology
This study models early life stress (ELS) to observe sex-specific effects on fear memory formation using innovative unsupervised classification together with cellular metabolism alterations in key str...
nature.com
December 20, 2024 at 3:09 PM
We've uncovered sex-specific effects of early-life stress (ELS) exposure on fear memory, HPA-axis regulation, and brain metabolism🧠. Unsupervised clustering shows that fear responses are more than only freezing.
@mathiasvschmidt.bsky.social
nature.com/articles/s42...
Highlights in thread👇
@mathiasvschmidt.bsky.social
nature.com/articles/s42...
Highlights in thread👇
Reposted by Samuele Laudani
Enhancer reprogramming underlies therapeutic utility of a SMARCA2 degrader in SMARCA4 mutant cancer by Sasikumar Kotagiri, Nicholas Blazanin, @yonathanlissanu, and colleagues at @MDAndersonNews http://dlvr.it/TGvsrj
December 20, 2024 at 2:01 PM
Enhancer reprogramming underlies therapeutic utility of a SMARCA2 degrader in SMARCA4 mutant cancer by Sasikumar Kotagiri, Nicholas Blazanin, @yonathanlissanu, and colleagues at @MDAndersonNews http://dlvr.it/TGvsrj
Reposted by Samuele Laudani
Sidharth Madhavan, et al show ketone body β-hydroxybutyrate alters solubility of misfolded proteins, facilitating their removal & reducing pathological aggregation @buckinstitute.bsky.social @ucsfgeriatrics.bsky.social @ithacacollege.bsky.social @cellchembiol.bsky.social www.cell.com/cell-chemica...
β-hydroxybutyrate is a metabolic regulator of proteostasis in the aged and Alzheimer disease brain
Madhavan et al. identify and characterize the selective regulation of protein solubility
by the ketone body β-hydroxybutyrate (βHB) across a range of models. βHB exposure
rescues cell-based and C. ele...
www.cell.com
December 2, 2024 at 9:53 PM
Sidharth Madhavan, et al show ketone body β-hydroxybutyrate alters solubility of misfolded proteins, facilitating their removal & reducing pathological aggregation @buckinstitute.bsky.social @ucsfgeriatrics.bsky.social @ithacacollege.bsky.social @cellchembiol.bsky.social www.cell.com/cell-chemica...
Reposted by Samuele Laudani
20 years ago, #Akkermansia muciniphila was discovered 🦠🎈.
To celebrate two decades of science on this unique bacterium, we reviewed its role in the human gut, some special biological features and potential applications. t.co/UpIHJyIVoQ
#microbiology #microbiota
To celebrate two decades of science on this unique bacterium, we reviewed its role in the human gut, some special biological features and potential applications. t.co/UpIHJyIVoQ
#microbiology #microbiota
November 29, 2024 at 11:58 AM
20 years ago, #Akkermansia muciniphila was discovered 🦠🎈.
To celebrate two decades of science on this unique bacterium, we reviewed its role in the human gut, some special biological features and potential applications. t.co/UpIHJyIVoQ
#microbiology #microbiota
To celebrate two decades of science on this unique bacterium, we reviewed its role in the human gut, some special biological features and potential applications. t.co/UpIHJyIVoQ
#microbiology #microbiota
Reposted by Samuele Laudani
Large language models surpass human experts in predicting neuroscience results www.nature.com/articles/s41...
Large language models surpass human experts in predicting neuroscience results - Nature Human Behaviour
Large language models (LLMs) can synthesize vast amounts of information. Luo et al. show that LLMs—especially BrainGPT, an LLM the authors tuned on the neuroscience literature—outperform experts in pr...
www.nature.com
November 27, 2024 at 10:49 PM
Large language models surpass human experts in predicting neuroscience results www.nature.com/articles/s41...
Reposted by Samuele Laudani
🔵 blue spot alert: Anita Luethi's team reports a dual role of #locuscoeruleus in #sleep in Nature Neuroscience @natureportfolio.bsky.social
1) high LC activity facilitates cortical microarousals
2) low LC activity is required for NREMS-to-REMS transitions
doi.org/10.1038/s415...
1) high LC activity facilitates cortical microarousals
2) low LC activity is required for NREMS-to-REMS transitions
doi.org/10.1038/s415...
Infraslow noradrenergic locus coeruleus activity fluctuations are gatekeepers of the NREM–REM sleep cycle - Nature Neuroscience
Lüthi and colleagues show that activity of the locus coeruleus (LC) is crucial for the cyclic alternation between non-rapid-eye-movement and rapid-eye-movement sleep. Stressful experiences during waki...
doi.org
November 28, 2024 at 7:40 AM
🔵 blue spot alert: Anita Luethi's team reports a dual role of #locuscoeruleus in #sleep in Nature Neuroscience @natureportfolio.bsky.social
1) high LC activity facilitates cortical microarousals
2) low LC activity is required for NREMS-to-REMS transitions
doi.org/10.1038/s415...
1) high LC activity facilitates cortical microarousals
2) low LC activity is required for NREMS-to-REMS transitions
doi.org/10.1038/s415...
Reposted by Samuele Laudani
Exciting new discovery from colleagues @stanfordmedicine.bsky.social, astrocyte metabolism compromised by amyloid and tau oligomers leading to insufficient support for neurons. Possible new target for treating AD.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Restoring hippocampal glucose metabolism rescues cognition across Alzheimer’s disease pathologies
Impaired cerebral glucose metabolism is a pathologic feature of Alzheimer’s disease (AD), with recent proteomic studies highlighting disrupted glial metabolism in AD. We report that inhibition of indo...
www.science.org
November 26, 2024 at 5:31 PM
Exciting new discovery from colleagues @stanfordmedicine.bsky.social, astrocyte metabolism compromised by amyloid and tau oligomers leading to insufficient support for neurons. Possible new target for treating AD.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Coffee consumption is associated with intestinal Lawsonibacter asaccharolyticus abundance and prevalence across multiple cohorts
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Coffee consumption is associated with intestinal Lawsonibacter asaccharolyticus abundance and prevalence across multiple cohorts - Nature Microbiology
Coffee consumption is associated with the presence and abundance of a specific member of the human gut microbiome, Lawsonibacter asaccharolyticus, and changes to the plasma metabolome.
www.nature.com
November 23, 2024 at 8:37 AM
Coffee consumption is associated with intestinal Lawsonibacter asaccharolyticus abundance and prevalence across multiple cohorts
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Samuele Laudani
Like ‘old Twitter’: The scientific community finds a new home on Bluesky
www.science.org/content/arti...
www.science.org/content/arti...
Like ‘old Twitter’: The scientific community finds a new home on Bluesky
After recent changes to Elon Musk’s X, a gradual migration turns into a stampede
www.science.org
November 20, 2024 at 10:49 PM
Like ‘old Twitter’: The scientific community finds a new home on Bluesky
www.science.org/content/arti...
www.science.org/content/arti...
Reposted by Samuele Laudani
“Bluesky seems to be the app where you post about being on Bluesky”
@jasonadamk.bsky.social for @newyorker.com
@jasonadamk.bsky.social for @newyorker.com
November 20, 2024 at 10:19 PM
“Bluesky seems to be the app where you post about being on Bluesky”
@jasonadamk.bsky.social for @newyorker.com
@jasonadamk.bsky.social for @newyorker.com