A user-friendly, shelf-stable protonated betaine reagent (BEHT triflate), derived from Mitsunobu reagents, has been developed to enable the direct displacement of alcohols using primary and secondary...

Pseudomonas aeruginosa is a critical priority pathogen and causes life-threatening acute and biofilm-associated chronic infections. The choice of suitable treatment for complicated infections requires...

More than 100 years after Staudinger's seminal reports on the reaction of iminophosphoranes with aldehydes, an alternative path, the so-called “Azide-Wittig Reaction” has been uncovered. We describe ...

Death notices for chemists suggest perhaps not, despite the hazards found in many labs

N,N-Dimethylformamide (DMF) is frequently used as a solvent because of its unique physical properties that allow it to solubilize both organic and inorganic substances. It has also found broad applications as a catalyst for a variety of chemical transformations and as a donor for many functional groups in synthetic organic chemistry. However, DMF is incompatible with a wide variety of substances and has resulted in many incidents over the years. Analysis of literature information indicates that those incompatible substances can be categorized as acids, bases, halogenated reagents, oxidants, and reductants. This comprehensive review of the potential hazards of using DMF in chemical reactions will serve as an educational resource to promote awareness of such safety hazards in the broader chemistry community and encourage scientists to develop appropriate control strategies to mitigate the potential safety risks associated with the use of DMF in chemical reactions.

Glycan recognition by lectins mediates important biological events. This Tutorial Review aims to introduce lectin–ligand interactions and show how these molecular recognition events inspire innovation...