Sayan Das (he/him)
@s4yandas.bsky.social
Coffee mug humorist | #scicomm enthusiast|
UMN BMBB grad student| Hafenstein Lab| Cryo-EM ❄️ | Structural virology 🦠 | Opinions of my own
UMN BMBB grad student| Hafenstein Lab| Cryo-EM ❄️ | Structural virology 🦠 | Opinions of my own
Pinned
Atomic-resolution structure of a chimeric Powassan tick-borne flavivirus
The 2.8-Å resolution structure is presented for a chimeric construct of an emerging tick-borne flavivirus, Powassan virus.
www.science.org
New in @science.org
We built a safe, atomic-resolution version of the Powassan virus—a deadly tick-borne #flavivirus with no vaccine.
✅ First structure ever
✅ Safe to handle (BSL-2)
✅ Platform for vaccines & antivirals
Let me show you 🧵 (1/5)
Link: www.science.org/doi/10.1126/...
We built a safe, atomic-resolution version of the Powassan virus—a deadly tick-borne #flavivirus with no vaccine.
✅ First structure ever
✅ Safe to handle (BSL-2)
✅ Platform for vaccines & antivirals
Let me show you 🧵 (1/5)
Link: www.science.org/doi/10.1126/...
Reposted by Sayan Das (he/him)
Have you ever looked at the night sky and wondered if there’s a chlorophyll f in the reaction centre of Photosystem I from far-red light adapted cyanobacteria? 🦠
Well, we did (don’t judge) and the work that followed is now out as a First Release in @science.org
www.science.org/doi/10.1126/...
Well, we did (don’t judge) and the work that followed is now out as a First Release in @science.org
www.science.org/doi/10.1126/...
Locating the missing chlorophylls f in far-red photosystem I
The discovery of chlorophyll f-containing photosystems, with their long-wavelength photochemistry, represented a distinct, low-energy paradigm for oxygenic photosynthesis. Structural studies on chloro...
www.science.org
October 11, 2025 at 10:37 AM
Have you ever looked at the night sky and wondered if there’s a chlorophyll f in the reaction centre of Photosystem I from far-red light adapted cyanobacteria? 🦠
Well, we did (don’t judge) and the work that followed is now out as a First Release in @science.org
www.science.org/doi/10.1126/...
Well, we did (don’t judge) and the work that followed is now out as a First Release in @science.org
www.science.org/doi/10.1126/...
Reposted by Sayan Das (he/him)
Out in Science Advances: Our #cryoEM structure of HFTV1, a virus infecting the halophile #archaea. *First full atomic structure (containing all structural proteins) of any tailed virus!* Congrats and thanks to all co-authors and our fantastic collaborators! www.science.org/doi/10.1126/...
Cryo-EM resolves the structure of the archaeal dsDNA virus HFTV1 from head to tail
This structure of an archaeal tailed virus (arTV) provides detailed insights into arTV assembly and infection mechanisms.
www.science.org
October 6, 2025 at 11:31 AM
Out in Science Advances: Our #cryoEM structure of HFTV1, a virus infecting the halophile #archaea. *First full atomic structure (containing all structural proteins) of any tailed virus!* Congrats and thanks to all co-authors and our fantastic collaborators! www.science.org/doi/10.1126/...
Reposted by Sayan Das (he/him)
A laser flash melting procedure, followed by rapid revitrification, provides a simple approach to help mitigate the preferred orientation problem that plagues cryo-EM analysis.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Laser flash melting cryo-EM samples to overcome preferred orientation - Nature Methods
Individual proteins tend to adopt preferred orientations when subjected to vitrification for cryo-electron microscopy analysis. A laser flash melting procedure followed by rapid revitrification provid...
www.nature.com
August 29, 2025 at 6:44 PM
A laser flash melting procedure, followed by rapid revitrification, provides a simple approach to help mitigate the preferred orientation problem that plagues cryo-EM analysis.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Sayan Das (he/him)
Interested in our recent norovirus NS3 work? 👇
Join us to dig deeper!
I'm recruiting a PhD candidate to investigate NS3's role in viral replication and assembly using #cryoEM, #cryoET, and other complementary techniques.
🔗 tinyurl.com/4f3t3aae
Please share! 🙏
Join us to dig deeper!
I'm recruiting a PhD candidate to investigate NS3's role in viral replication and assembly using #cryoEM, #cryoET, and other complementary techniques.
🔗 tinyurl.com/4f3t3aae
Please share! 🙏
July 15, 2025 at 3:42 PM
Interested in our recent norovirus NS3 work? 👇
Join us to dig deeper!
I'm recruiting a PhD candidate to investigate NS3's role in viral replication and assembly using #cryoEM, #cryoET, and other complementary techniques.
🔗 tinyurl.com/4f3t3aae
Please share! 🙏
Join us to dig deeper!
I'm recruiting a PhD candidate to investigate NS3's role in viral replication and assembly using #cryoEM, #cryoET, and other complementary techniques.
🔗 tinyurl.com/4f3t3aae
Please share! 🙏
Reposted by Sayan Das (he/him)
Powassan virus is a scary emerging tick-borne virus that causes neurological disease. It is great to see that my @ciddpsu.bsky.social colleagues are on top of it.
www.psu.edu/news/researc...
www.psu.edu/news/researc...
Structure of tick-borne virus revealed at atomic resolution for the first time | Penn State University
Rates of the Powassan virus infections — which can cause seizures and paralysis — are increasing across North America. Researchers from Penn State, the University of Minnesota and the U.S. Department ...
www.psu.edu
July 9, 2025 at 6:52 PM
Powassan virus is a scary emerging tick-borne virus that causes neurological disease. It is great to see that my @ciddpsu.bsky.social colleagues are on top of it.
www.psu.edu/news/researc...
www.psu.edu/news/researc...
New in @science.org
We built a safe, atomic-resolution version of the Powassan virus—a deadly tick-borne #flavivirus with no vaccine.
✅ First structure ever
✅ Safe to handle (BSL-2)
✅ Platform for vaccines & antivirals
Let me show you 🧵 (1/5)
Link: www.science.org/doi/10.1126/...
We built a safe, atomic-resolution version of the Powassan virus—a deadly tick-borne #flavivirus with no vaccine.
✅ First structure ever
✅ Safe to handle (BSL-2)
✅ Platform for vaccines & antivirals
Let me show you 🧵 (1/5)
Link: www.science.org/doi/10.1126/...
Atomic-resolution structure of a chimeric Powassan tick-borne flavivirus
The 2.8-Å resolution structure is presented for a chimeric construct of an emerging tick-borne flavivirus, Powassan virus.
www.science.org
July 9, 2025 at 8:11 PM
New in @science.org
We built a safe, atomic-resolution version of the Powassan virus—a deadly tick-borne #flavivirus with no vaccine.
✅ First structure ever
✅ Safe to handle (BSL-2)
✅ Platform for vaccines & antivirals
Let me show you 🧵 (1/5)
Link: www.science.org/doi/10.1126/...
We built a safe, atomic-resolution version of the Powassan virus—a deadly tick-borne #flavivirus with no vaccine.
✅ First structure ever
✅ Safe to handle (BSL-2)
✅ Platform for vaccines & antivirals
Let me show you 🧵 (1/5)
Link: www.science.org/doi/10.1126/...