Rupert Faraway
@rupertfaraway.bsky.social
RNA biologist. Post-doc in the Plaschka and Ameres labs. PhD with Jernej Ule.
Reposted by Rupert Faraway
How does messenger RNA (mRNA) get out of the nucleus to become a protein? Eukaryotic mRNA is packaged, exported, and then translated in the cytoplasm. But how do these steps work? And what are open questions? Check out our new review for our take: www.annualreviews.org/content/jour... (1/3)
November 21, 2025 at 5:37 PM
How does messenger RNA (mRNA) get out of the nucleus to become a protein? Eukaryotic mRNA is packaged, exported, and then translated in the cytoplasm. But how do these steps work? And what are open questions? Check out our new review for our take: www.annualreviews.org/content/jour... (1/3)
Reposted by Rupert Faraway
Finally out in @nature.com! We uncovered a mechanistic framework for a general and conserved mRNA nuclear export pathway. www.nature.com/articles/s41.... 1/
November 19, 2025 at 11:22 PM
Finally out in @nature.com! We uncovered a mechanistic framework for a general and conserved mRNA nuclear export pathway. www.nature.com/articles/s41.... 1/
If you, or anyone you know, is looking for a PhD position, I have no doubt that Ulrich's lab is a fantastic choice! I'm tempted to do a second PhD in this lab.
Thrilled to share that I’ll be joining @imbmainz.bsky.social in February 2026 to start my own group!
We will explore new mechanisms in eukaryotic gene expression, leveraging ‘evolutionary play’ to uncover how regulation, repurposing, and hijacking shape RNA biology.
PhD positions available!
We will explore new mechanisms in eukaryotic gene expression, leveraging ‘evolutionary play’ to uncover how regulation, repurposing, and hijacking shape RNA biology.
PhD positions available!
October 13, 2025 at 5:07 AM
If you, or anyone you know, is looking for a PhD position, I have no doubt that Ulrich's lab is a fantastic choice! I'm tempted to do a second PhD in this lab.
Reposted by Rupert Faraway
Thrilled to share that I’ll be joining @imbmainz.bsky.social in February 2026 to start my own group!
We will explore new mechanisms in eukaryotic gene expression, leveraging ‘evolutionary play’ to uncover how regulation, repurposing, and hijacking shape RNA biology.
PhD positions available!
We will explore new mechanisms in eukaryotic gene expression, leveraging ‘evolutionary play’ to uncover how regulation, repurposing, and hijacking shape RNA biology.
PhD positions available!
October 12, 2025 at 8:19 PM
Thrilled to share that I’ll be joining @imbmainz.bsky.social in February 2026 to start my own group!
We will explore new mechanisms in eukaryotic gene expression, leveraging ‘evolutionary play’ to uncover how regulation, repurposing, and hijacking shape RNA biology.
PhD positions available!
We will explore new mechanisms in eukaryotic gene expression, leveraging ‘evolutionary play’ to uncover how regulation, repurposing, and hijacking shape RNA biology.
PhD positions available!
Reposted by Rupert Faraway
This is a fascinating paper that particular types of RNA binding proteins with IDRs that target nuclear speckles also can recruit their own RNAs to nuclear speckles as a negative feedback mechanism for condensation the authors call "interstasis" www.nature.com/articles/s41...
Collective homeostasis of condensation-prone proteins via their mRNAs - Nature
The authors discover a homeostatic process termed interstasis, in which an increased concentration of proteins within RNA–protein condensates induces the sequestration of their own mRNAs.
www.nature.com
September 25, 2025 at 8:24 PM
This is a fascinating paper that particular types of RNA binding proteins with IDRs that target nuclear speckles also can recruit their own RNAs to nuclear speckles as a negative feedback mechanism for condensation the authors call "interstasis" www.nature.com/articles/s41...
Reposted by Rupert Faraway
How are RNAs sorted for export vs. degradation in the nucleus? In collaboration with @heick.bsky.social’s lab we (@clemensplaschka.bsky.social and @juliusbrennecke.bsky.social labs) discovered a direct mechanistic link between the export and decay machineries: www.biorxiv.org/content/10.1... (1/x)
Molecular basis of polyadenylated RNA fate determination in the nucleus
Eukaryotic genomes generate a plethora of polyadenylated (pA+) RNAs[1][1],[2][2], that are packaged into ribonucleoprotein particles (RNPs). To ensure faithful gene expression, functional pA+ RNPs, in...
www.biorxiv.org
September 22, 2025 at 11:23 PM
How are RNAs sorted for export vs. degradation in the nucleus? In collaboration with @heick.bsky.social’s lab we (@clemensplaschka.bsky.social and @juliusbrennecke.bsky.social labs) discovered a direct mechanistic link between the export and decay machineries: www.biorxiv.org/content/10.1... (1/x)
Reposted by Rupert Faraway
I am thrilled to share the first manuscript from my group on identifying sequence and structural features promoting the condensation of RNAs that are organising highly interconnected RNA networks, thereby expanding our understanding of higher-order transcriptome assemblage.
shorturl.at/pmLIj #RNASky
shorturl.at/pmLIj #RNASky
Integrative profiling of condensation-prone RNAs during early development
Complex RNA–protein networks play a pivotal role in the formation of many types of biomolecular condensates. How intrinsic RNA features contribute to condensate formation however remains unclear. Here...
www.biorxiv.org
February 6, 2025 at 9:44 AM
I am thrilled to share the first manuscript from my group on identifying sequence and structural features promoting the condensation of RNAs that are organising highly interconnected RNA networks, thereby expanding our understanding of higher-order transcriptome assemblage.
shorturl.at/pmLIj #RNASky
shorturl.at/pmLIj #RNASky
Has anyone spiked in a fluorescent or clickable ATP into an in-vitro poly-adenylation reaction to label some RNA? Or anything similar (e.g. clickable nucleotide)? Preferably using E. coli PAP. I don't care if it acts as a chain terminator - that might actually be preferred.
January 10, 2025 at 2:23 PM
Has anyone spiked in a fluorescent or clickable ATP into an in-vitro poly-adenylation reaction to label some RNA? Or anything similar (e.g. clickable nucleotide)? Preferably using E. coli PAP. I don't care if it acts as a chain terminator - that might actually be preferred.
Reposted by Rupert Faraway
We are very excited to share our recent preprint on the nuclear import mechanism of the proteasome, driven by the multivalent adaptor AKIRIN2! www.biorxiv.org/content/10.1... 🧵 1/6
A multivalent adaptor mechanism drives the nuclear import of proteasomes
Nuclear protein homeostasis, including the turnover of transcription factors, critically depends on nuclear proteasomes. After each cell division, proteasomes need to be re-imported into the newly for...
www.biorxiv.org
December 5, 2024 at 8:11 PM
We are very excited to share our recent preprint on the nuclear import mechanism of the proteasome, driven by the multivalent adaptor AKIRIN2! www.biorxiv.org/content/10.1... 🧵 1/6
Reposted by Rupert Faraway
1/10
Thrilled to share our latest research on 3′UTR-derived RNAs, now published in BMC Biology! doi.org/10.1186/s129...
Here’s what we found:
Thrilled to share our latest research on 3′UTR-derived RNAs, now published in BMC Biology! doi.org/10.1186/s129...
Here’s what we found:
November 15, 2024 at 5:03 PM
1/10
Thrilled to share our latest research on 3′UTR-derived RNAs, now published in BMC Biology! doi.org/10.1186/s129...
Here’s what we found:
Thrilled to share our latest research on 3′UTR-derived RNAs, now published in BMC Biology! doi.org/10.1186/s129...
Here’s what we found:
Can MS2 loops stall reverse transcription? Does anyone know? I'm using Superscript IV at 50C.
February 13, 2024 at 12:25 PM
Can MS2 loops stall reverse transcription? Does anyone know? I'm using Superscript IV at 50C.
Reposted by Rupert Faraway
Created an #RNAbiology feed to talk RNA science! Let's use it.
@onamy.bsky.social @mgblango.bsky.social @graveley.bsky.social @nickingolia.bsky.social @hogglab.bsky.social @quaidmorris.bsky.social @snf.bsky.social @lucksmith.bsky.social
@onamy.bsky.social @mgblango.bsky.social @graveley.bsky.social @nickingolia.bsky.social @hogglab.bsky.social @quaidmorris.bsky.social @snf.bsky.social @lucksmith.bsky.social
October 17, 2023 at 12:23 PM
Created an #RNAbiology feed to talk RNA science! Let's use it.
@onamy.bsky.social @mgblango.bsky.social @graveley.bsky.social @nickingolia.bsky.social @hogglab.bsky.social @quaidmorris.bsky.social @snf.bsky.social @lucksmith.bsky.social
@onamy.bsky.social @mgblango.bsky.social @graveley.bsky.social @nickingolia.bsky.social @hogglab.bsky.social @quaidmorris.bsky.social @snf.bsky.social @lucksmith.bsky.social
Reposted by Rupert Faraway
I'll be looking to hire another research associate (>$100k/year + benefits & retirement) shortly. Experience in molecular biology and pharmacology would be ideal, but not essential. Job ad will go up in a bit, but if anyone knows anyone looking I would be happy to chat with them.
September 13, 2023 at 2:19 AM
I'll be looking to hire another research associate (>$100k/year + benefits & retirement) shortly. Experience in molecular biology and pharmacology would be ideal, but not essential. Job ad will go up in a bit, but if anyone knows anyone looking I would be happy to chat with them.