Supervised by @dongwon-lee.bsky.social we're excited to share our preprint on the landscape of allele-specific expression (ASE) in human kidneys. Using paired WGS and RNA-seq from kidney biopsies, we mapped ASE in proteinuric kidney disease in the #NEPTUNE study www.biorxiv.org/content/10.6...

An in vivo imaging technique can track the way molecules move through the nuclear pore complex

go.nature.com/3KODM4A

We mapped the whole human fallopian tube in 3D and at single-cell resolution via our CODA workflow.

More about this work here: biorxiv.org/content/10.1...

Our recent observations are distinct from conventional active matter. Self-propelled colloidal particles neither secrete inhibitory molecules, nor actively modulate adhesion molecules, which are two key ingredients leading to our observed patterned aggregates.

Here: www.nature.com/articles/s41...

Ahead of #KidneyWk25,
I’m recruiting 2-3 folks to help us map the genomics of pediatric kidney diseases toward treatments & cures. Please reach out if you’d like to connect in Houston @bostonchildrens.bsky.social @asnkidney.bsky.social @harvardmed.bsky.social @broadinstitute.org
sampsonlab.org

Thrilled to share that a part of my Ph.D. work from
@dukeubme.bsky.social @stemcellengineer.bsky.social Lab is now out in @natbiomedeng.nature.com!
We investigated the impact of CHD-linked SMAD2 variants on kidney development using engineered human iPS cells in a microphysiological system.

New research published in @science.org led by @danafarber.bsky.social’s Doug Wassarman and @kranzuschlab.bsky.social reveals new protein chemistry named deazaguanylation that controls activation of immunity.

Read more: bit.ly/3WeKsLb

Get by with a little help from my friends (esp @rohanbme.bsky.social) 💕💕

Thanks to @stemcellengineer.bsky.social for visiting us at Cedars-Sinai last week! She’s doing amazing work developing advanced kidney-on-chip systems and much more.