Rodrigo Senovilla-Ganzo
@rodrisenovilla.bsky.social
This profile will be changing: call it evolution, development or both!
I do omics to understand early development and vertebrate evolution.
PhD at @PhyloBrain
Postdoc at @denisduboule.bsky.social
I do omics to understand early development and vertebrate evolution.
PhD at @PhyloBrain
Postdoc at @denisduboule.bsky.social
Reposted by Rodrigo Senovilla-Ganzo
Interested in understanding how new cell types evolve? Consider joining our group for a PhD!
2026 PhD recruitment is now open.
As well as our main PhD recruitment, which is open to all, we are pleased to be offering scholarships for candidates of Black or mixed Black heritage. Learn more and apply on our website:
www.crick.ac.uk/careers-stud...
As well as our main PhD recruitment, which is open to all, we are pleased to be offering scholarships for candidates of Black or mixed Black heritage. Learn more and apply on our website:
www.crick.ac.uk/careers-stud...
PhD student recruitment
PhD recruitment information.
www.crick.ac.uk
October 7, 2025 at 4:43 PM
Interested in understanding how new cell types evolve? Consider joining our group for a PhD!
Reposted by Rodrigo Senovilla-Ganzo
How to represent genomes in 3D?
In this paper (and video), we propose Geometric Diagrams of Genomes (GDG)—a visual grammar that aims at emulating the effect ribbon diagrams (Richardson et al 1981) had in protein structural biology. Time will tell.😅
👉🏼 genomebiology.biomedcentral.com/articles/10....
In this paper (and video), we propose Geometric Diagrams of Genomes (GDG)—a visual grammar that aims at emulating the effect ribbon diagrams (Richardson et al 1981) had in protein structural biology. Time will tell.😅
👉🏼 genomebiology.biomedcentral.com/articles/10....
June 27, 2025 at 8:13 AM
How to represent genomes in 3D?
In this paper (and video), we propose Geometric Diagrams of Genomes (GDG)—a visual grammar that aims at emulating the effect ribbon diagrams (Richardson et al 1981) had in protein structural biology. Time will tell.😅
👉🏼 genomebiology.biomedcentral.com/articles/10....
In this paper (and video), we propose Geometric Diagrams of Genomes (GDG)—a visual grammar that aims at emulating the effect ribbon diagrams (Richardson et al 1981) had in protein structural biology. Time will tell.😅
👉🏼 genomebiology.biomedcentral.com/articles/10....
Reposted by Rodrigo Senovilla-Ganzo
Are digits modified fins, or evolutionary innovations? Read how we tackled this old question from a new angle🧪
A story with @chasebolt.bsky.social, @homeobox.bsky.social and myself, coordinated by @denisduboule.bsky.social from @college-de-france.fr and published in @nature.com today!
#InHoxWeTrust
A story with @chasebolt.bsky.social, @homeobox.bsky.social and myself, coordinated by @denisduboule.bsky.social from @college-de-france.fr and published in @nature.com today!
#InHoxWeTrust
September 17, 2025 at 5:26 PM
Are digits modified fins, or evolutionary innovations? Read how we tackled this old question from a new angle🧪
A story with @chasebolt.bsky.social, @homeobox.bsky.social and myself, coordinated by @denisduboule.bsky.social from @college-de-france.fr and published in @nature.com today!
#InHoxWeTrust
A story with @chasebolt.bsky.social, @homeobox.bsky.social and myself, coordinated by @denisduboule.bsky.social from @college-de-france.fr and published in @nature.com today!
#InHoxWeTrust
Reposted by Rodrigo Senovilla-Ganzo
We're looking for a PhD student!
Join the team to develop new technologies for targeted spatial omics.
More info and instruction on how to apply at the following link:
su.varbi.com/what:job/job...
Join the team to develop new technologies for targeted spatial omics.
More info and instruction on how to apply at the following link:
su.varbi.com/what:job/job...
Doktorand i biokemi
Institutionen för biokemi och biofysik. SciLifeLab ( SciLifeLab ) är ett nationellt center för molekylära biovetenskaper med fokus på forskning inom hälsa och miljö. Centret kombinerar ledande
su.varbi.com
September 15, 2025 at 6:36 PM
We're looking for a PhD student!
Join the team to develop new technologies for targeted spatial omics.
More info and instruction on how to apply at the following link:
su.varbi.com/what:job/job...
Join the team to develop new technologies for targeted spatial omics.
More info and instruction on how to apply at the following link:
su.varbi.com/what:job/job...
Such a great picture to announce that I am now postdoc in Denis Duboule's team at @college-de-france.fr 🥳🍾 Learning a lot about gene regulation and chromatin organization, lots of challenges ahead! What more could you ask for? Thank you for the opportunity @denisduboule.bsky.social 🤗
September 3, 2025 at 9:27 AM
Such a great picture to announce that I am now postdoc in Denis Duboule's team at @college-de-france.fr 🥳🍾 Learning a lot about gene regulation and chromatin organization, lots of challenges ahead! What more could you ask for? Thank you for the opportunity @denisduboule.bsky.social 🤗
Reposted by Rodrigo Senovilla-Ganzo
🧠🦈Excited to present our latest work🧠🦈Interested in brain evolution? And shark embryos? Then read on… Our work sheds light on the deep origins of our brain’s most complex regions.
September 2, 2025 at 5:51 PM
🧠🦈Excited to present our latest work🧠🦈Interested in brain evolution? And shark embryos? Then read on… Our work sheds light on the deep origins of our brain’s most complex regions.
Reposted by Rodrigo Senovilla-Ganzo
We are hiring! ✨
Several predoc and postdoc open positions, check them here:
www.achucarro.org/job-opportun...
Several predoc and postdoc open positions, check them here:
www.achucarro.org/job-opportun...
August 28, 2025 at 1:10 PM
We are hiring! ✨
Several predoc and postdoc open positions, check them here:
www.achucarro.org/job-opportun...
Several predoc and postdoc open positions, check them here:
www.achucarro.org/job-opportun...
Reposted by Rodrigo Senovilla-Ganzo
TIL the original paper describing CRISPR, by Francisco Mojica, was rejected by 4 journals and took 2 years to be published
![CRISPR as a microbial immune system
In 2003, Mojica wrote the first paper suggesting that CRISPR was an innate microbial immune system. The paper was rejected by a series of high-profile journals, including Nature, Proceedings of the National Academy of Sciences, Molecular Microbiology and Nucleic Acids Research, before finally being accepted by Journal of Molecular Evolution in February, 2005.[3][4]](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:73aicoale2mqwrap63rdzwep/bafkreibu3dburfn527r3sbu2ov6y7gebv6zopaznagnfytjtsn6y4k7cs4@jpeg)
August 17, 2025 at 4:00 AM
TIL the original paper describing CRISPR, by Francisco Mojica, was rejected by 4 journals and took 2 years to be published
Reposted by Rodrigo Senovilla-Ganzo
Our study on a male-essential microRNA and the evolution of other dosage compensation mechanisms in birds is now out in Nature! www.nature.com/articles/s41...
A male-essential miRNA is key for avian sex chromosome dosage compensation - Nature
Birds have evolved a unique sex chromosome dosage compensation mechanism involving the male-biased microRNA (miR-2954), which is essential for male survival by regulating the expression of dosage-sens...
www.nature.com
July 16, 2025 at 3:23 PM
Our study on a male-essential microRNA and the evolution of other dosage compensation mechanisms in birds is now out in Nature! www.nature.com/articles/s41...
Reposted by Rodrigo Senovilla-Ganzo
Excited to launch our AlphaGenome API goo.gle/3ZPUeFX along with the preprint goo.gle/45AkUyc describing and evaluating our latest DNA sequence model powering the API. Looking forward to seeing how scientists use it! @googledeepmind
June 25, 2025 at 2:29 PM
Excited to launch our AlphaGenome API goo.gle/3ZPUeFX along with the preprint goo.gle/45AkUyc describing and evaluating our latest DNA sequence model powering the API. Looking forward to seeing how scientists use it! @googledeepmind
Rigor and objectivity are essential in Science 🧪—but Science is also driven by creative humans, whose personalities reflect their unique perspectives and reasoning. This is a wonderful talk, and I couldn’t help but smile at each of Fer’s reflections! 🥳 Great human, better science 😎
🎙️ Just out: my interview on The Creative Process podcast!
A surprising conversation where we went way beyond the usual: cultural evolution, the language-psychology link, AI legislation and brain constraints, the beauty of dev biology… and creativity in research!
🧠✨ Listen here: shorturl.at/Sjqo7
A surprising conversation where we went way beyond the usual: cultural evolution, the language-psychology link, AI legislation and brain constraints, the beauty of dev biology… and creativity in research!
🧠✨ Listen here: shorturl.at/Sjqo7
The Evolutionary Brain - DR. FERNANDO GARCÍA-MORENO on Creativity & Survival
The Creative Process · Arts, Culture & Society: Books, Film, Music, TV, Art, Writing, Creativity, Education, Environment, Theatre, Dance, LGBTQ, Climate Change, Social Justice, Spirituality, Feminism,...
shorturl.at
June 22, 2025 at 3:23 PM
Rigor and objectivity are essential in Science 🧪—but Science is also driven by creative humans, whose personalities reflect their unique perspectives and reasoning. This is a wonderful talk, and I couldn’t help but smile at each of Fer’s reflections! 🥳 Great human, better science 😎
Reposted by Rodrigo Senovilla-Ganzo
We are delighted to share our new preprint “The evolution of gene regulatory programs controlling gonadal development in primates” www.biorxiv.org/content/10.1...
June 20, 2025 at 8:13 AM
We are delighted to share our new preprint “The evolution of gene regulatory programs controlling gonadal development in primates” www.biorxiv.org/content/10.1...
Reposted by Rodrigo Senovilla-Ganzo
🎙️ Just out: my interview on The Creative Process podcast!
A surprising conversation where we went way beyond the usual: cultural evolution, the language-psychology link, AI legislation and brain constraints, the beauty of dev biology… and creativity in research!
🧠✨ Listen here: shorturl.at/Sjqo7
A surprising conversation where we went way beyond the usual: cultural evolution, the language-psychology link, AI legislation and brain constraints, the beauty of dev biology… and creativity in research!
🧠✨ Listen here: shorturl.at/Sjqo7
The Evolutionary Brain - DR. FERNANDO GARCÍA-MORENO on Creativity & Survival
The Creative Process · Arts, Culture & Society: Books, Film, Music, TV, Art, Writing, Creativity, Education, Environment, Theatre, Dance, LGBTQ, Climate Change, Social Justice, Spirituality, Feminism,...
shorturl.at
June 18, 2025 at 3:49 PM
🎙️ Just out: my interview on The Creative Process podcast!
A surprising conversation where we went way beyond the usual: cultural evolution, the language-psychology link, AI legislation and brain constraints, the beauty of dev biology… and creativity in research!
🧠✨ Listen here: shorturl.at/Sjqo7
A surprising conversation where we went way beyond the usual: cultural evolution, the language-psychology link, AI legislation and brain constraints, the beauty of dev biology… and creativity in research!
🧠✨ Listen here: shorturl.at/Sjqo7
Reposted by Rodrigo Senovilla-Ganzo
The research team at the Atapuerca archaeological sites in Burgos, Spain, has just broken its own record by discovering, for the third time, the oldest human in Western Europe.
👇 @mmartinont.bsky.social in @mapignorance.bsky.social
mappingignorance.org/2025/03/19/w...
👇 @mmartinont.bsky.social in @mapignorance.bsky.social
mappingignorance.org/2025/03/19/w...
Western Europe’s oldest human face discovered in Spain
The research team at the Atapuerca archaeological sites in Burgos, Spain, has just discovered the oldest human in Western Europe.
mappingignorance.org
March 19, 2025 at 4:39 PM
The research team at the Atapuerca archaeological sites in Burgos, Spain, has just broken its own record by discovering, for the third time, the oldest human in Western Europe.
👇 @mmartinont.bsky.social in @mapignorance.bsky.social
mappingignorance.org/2025/03/19/w...
👇 @mmartinont.bsky.social in @mapignorance.bsky.social
mappingignorance.org/2025/03/19/w...
Last Friday, I became a PhD! 💐 I could not be more thankful to my supervisor @PhyloBrain, the thesis committee @margaridamcm.bsky.social @AinaraCastellanos @JoseLuisFerrán and everyone who made possible this journey (colleagues @achucarro.bsky.social and collaborators @kaessmannlab.bsky.social ) 🥰
March 18, 2025 at 2:48 PM
Last Friday, I became a PhD! 💐 I could not be more thankful to my supervisor @PhyloBrain, the thesis committee @margaridamcm.bsky.social @AinaraCastellanos @JoseLuisFerrán and everyone who made possible this journey (colleagues @achucarro.bsky.social and collaborators @kaessmannlab.bsky.social ) 🥰
Reposted by Rodrigo Senovilla-Ganzo
How does gene regulation shape brain evolution? Our new preprint dives into this question in the context of mammalian cerebellum development! rb.gy/dbcxjz
Led by @ioansarr.bsky.social, @marisepp.bsky.social and @tyamadat.bsky.social, in collaboration with @steinaerts.bsky.social
Led by @ioansarr.bsky.social, @marisepp.bsky.social and @tyamadat.bsky.social, in collaboration with @steinaerts.bsky.social
March 16, 2025 at 10:31 AM
How does gene regulation shape brain evolution? Our new preprint dives into this question in the context of mammalian cerebellum development! rb.gy/dbcxjz
Led by @ioansarr.bsky.social, @marisepp.bsky.social and @tyamadat.bsky.social, in collaboration with @steinaerts.bsky.social
Led by @ioansarr.bsky.social, @marisepp.bsky.social and @tyamadat.bsky.social, in collaboration with @steinaerts.bsky.social
Reposted by Rodrigo Senovilla-Ganzo
Last week, I successfully defended my PhD thesis Microglia Development: From Proliferative Progenitors to Functional Phagocytes, under the supervision of Amanda Sierra. I am deeply grateful to Amanda, my amazing labmates, and everyone in attendance for their incredible support! 🧠🔬
March 10, 2025 at 9:59 AM
Last week, I successfully defended my PhD thesis Microglia Development: From Proliferative Progenitors to Functional Phagocytes, under the supervision of Amanda Sierra. I am deeply grateful to Amanda, my amazing labmates, and everyone in attendance for their incredible support! 🧠🔬
Extremely proud of @martapiglesias.bsky.social 🎉🎉 Huge amount of work carried out these four years, I am sure it will pay off ✈️ Congrats, new PhD in the house 🍾💐
March 10, 2025 at 10:11 PM
Extremely proud of @martapiglesias.bsky.social 🎉🎉 Huge amount of work carried out these four years, I am sure it will pay off ✈️ Congrats, new PhD in the house 🍾💐
Reposted by Rodrigo Senovilla-Ganzo
This paper here is the product of one of my funniest collaboration ever. Developmental biology, evolution, tech development, memes, gifs, improvised brainstorming sessions via WhatsApp, and so much more... Crazy things can happen when people with different skill sets have fun together!
Our article on the evolution of pallial circuits is out www.science.org/doi/10.1126/... 🥳
Eneritz Rueda-Alaña & Fernando García-Moreno led this study that proves how similar adult pallial neurons are generated in different regions and timepoints. Evolutionary CONVERGENCE of neurons & circuits! 🦎🐤🐭
Eneritz Rueda-Alaña & Fernando García-Moreno led this study that proves how similar adult pallial neurons are generated in different regions and timepoints. Evolutionary CONVERGENCE of neurons & circuits! 🦎🐤🐭
Evolutionary convergence of sensory circuits in the pallium of amniotes
The amniote pallium contains sensory circuits that are structurally and functionally equivalent, yet their evolutionary relationship remains unresolved. We used birthdating analysis, single-cell RNA a...
www.science.org
February 14, 2025 at 12:46 PM
This paper here is the product of one of my funniest collaboration ever. Developmental biology, evolution, tech development, memes, gifs, improvised brainstorming sessions via WhatsApp, and so much more... Crazy things can happen when people with different skill sets have fun together!
Reposted by Rodrigo Senovilla-Ganzo
Just very happy to have our paper out today! A big thanks to all our co-authors, and to Nikolai and @steinaerts.bsky.social for the teamwork over the past years. If you are interested in using our models for cross-species enhancer studies, check out crested.readthedocs.io/en/stable/mo... 🙂
In a new study, Nikolai Hecker, Niklas Kempynck et al. in the team of @steinaerts.bsky.social explore 300 million years of brain evolution through the lens of enhancer codes.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Enhancer-driven cell type comparison reveals similarities between the mammalian and bird pallium
Combinations of transcription factors govern the identity of cell types, which is reflected by genomic enhancer codes. We used deep learning to characterize these enhancer codes and devised three metr...
www.science.org
February 14, 2025 at 10:08 AM
Just very happy to have our paper out today! A big thanks to all our co-authors, and to Nikolai and @steinaerts.bsky.social for the teamwork over the past years. If you are interested in using our models for cross-species enhancer studies, check out crested.readthedocs.io/en/stable/mo... 🙂
Our article on the evolution of pallial circuits is out www.science.org/doi/10.1126/... 🥳
Eneritz Rueda-Alaña & Fernando García-Moreno led this study that proves how similar adult pallial neurons are generated in different regions and timepoints. Evolutionary CONVERGENCE of neurons & circuits! 🦎🐤🐭
Eneritz Rueda-Alaña & Fernando García-Moreno led this study that proves how similar adult pallial neurons are generated in different regions and timepoints. Evolutionary CONVERGENCE of neurons & circuits! 🦎🐤🐭
Evolutionary convergence of sensory circuits in the pallium of amniotes
The amniote pallium contains sensory circuits that are structurally and functionally equivalent, yet their evolutionary relationship remains unresolved. We used birthdating analysis, single-cell RNA a...
www.science.org
February 14, 2025 at 10:19 AM
Our article on the evolution of pallial circuits is out www.science.org/doi/10.1126/... 🥳
Eneritz Rueda-Alaña & Fernando García-Moreno led this study that proves how similar adult pallial neurons are generated in different regions and timepoints. Evolutionary CONVERGENCE of neurons & circuits! 🦎🐤🐭
Eneritz Rueda-Alaña & Fernando García-Moreno led this study that proves how similar adult pallial neurons are generated in different regions and timepoints. Evolutionary CONVERGENCE of neurons & circuits! 🦎🐤🐭
Reposted by Rodrigo Senovilla-Ganzo
So excited to announce that our study on the development and evolution of pallial cell types and structures in birds, led by @bassi-z.bsky.social, is now out in @science.org!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Developmental origins and evolution of pallial cell types and structures in birds
Innovations in the pallium likely facilitated the evolution of advanced cognitive abilities in birds. We therefore scrutinized its cellular composition and evolution using cell type atlases from chick...
www.science.org
February 13, 2025 at 10:17 PM
So excited to announce that our study on the development and evolution of pallial cell types and structures in birds, led by @bassi-z.bsky.social, is now out in @science.org!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Rodrigo Senovilla-Ganzo
For my first post on 🦋, I am incredibly excited to share that my PhD paper has been published in #ScienceAdvances!
We compared the development of the anterior neuroectoderm to uncover how the chordate #forebrain evolved 🧠. Have a look at the summary 🧵 below!
www.science.org/doi/10.1126/...
We compared the development of the anterior neuroectoderm to uncover how the chordate #forebrain evolved 🧠. Have a look at the summary 🧵 below!
www.science.org/doi/10.1126/...
An ancient apical patterning system sets the position of the forebrain in chordates
A conserved Wnt-regulated molecular signature sets forebrain position and identity in chordates.
www.science.org
January 27, 2025 at 5:22 PM
For my first post on 🦋, I am incredibly excited to share that my PhD paper has been published in #ScienceAdvances!
We compared the development of the anterior neuroectoderm to uncover how the chordate #forebrain evolved 🧠. Have a look at the summary 🧵 below!
www.science.org/doi/10.1126/...
We compared the development of the anterior neuroectoderm to uncover how the chordate #forebrain evolved 🧠. Have a look at the summary 🧵 below!
www.science.org/doi/10.1126/...
Reposted by Rodrigo Senovilla-Ganzo
🚨New Perspective on microglia pruning 🚨 Thrilled to share our latest publication, where we propose a novel framework to distinguish between two potential mechanisms of synapse elimination: culling and scavenging. Check it out and let us know what you think! 🔬🧠
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Microglia as hunters or gatherers of brain synapses - Nature Neuroscience
How microglia sculpt brain circuits is not clear. Here, the authors propose that their contribution to synapse removal may occur by severing synapses (culling) or collecting synapses shed off by neuro...
www.nature.com
December 11, 2024 at 3:32 PM
🚨New Perspective on microglia pruning 🚨 Thrilled to share our latest publication, where we propose a novel framework to distinguish between two potential mechanisms of synapse elimination: culling and scavenging. Check it out and let us know what you think! 🔬🧠
www.nature.com/articles/s41...
www.nature.com/articles/s41...