Ricky Turgeon
@rickyturgeon.bsky.social
www.rickyturgeon.com
Cardiovascular pharmacist & Assistant Professor at UBC Faculty of Pharmaceutical Sciences.
EBM & shared decision making enthusiast, all-around nerd.
Cardiovascular pharmacist & Assistant Professor at UBC Faculty of Pharmaceutical Sciences.
EBM & shared decision making enthusiast, all-around nerd.
Reposted by Ricky Turgeon
🚨 Just published! This guideline provides multi-disciplinary clinical teams with practical recommendations for SGLT2is, MRAs, ARNI and drugs with GLP-1 receptor agonist activity.
Read the guideline here: onlinecjc.ca/article/S082...
#Cardiosky #HeartFailure
Read the guideline here: onlinecjc.ca/article/S082...
#Cardiosky #HeartFailure
October 20, 2025 at 2:00 PM
🚨 Just published! This guideline provides multi-disciplinary clinical teams with practical recommendations for SGLT2is, MRAs, ARNI and drugs with GLP-1 receptor agonist activity.
Read the guideline here: onlinecjc.ca/article/S082...
#Cardiosky #HeartFailure
Read the guideline here: onlinecjc.ca/article/S082...
#Cardiosky #HeartFailure
Reposted by Ricky Turgeon
Also check out @hildabast.bsky.social post on PubMed alternatives
absolutelymaybe.plos.org/2025/02/14/w...
absolutelymaybe.plos.org/2025/02/14/w...
What if We Can't Rely on PubMed? - Absolutely Maybe
PubMed is incredibly reliable. And a lot depends on it. It’s an ecosystem built around MEDLINE, the steady feed of new publications…
absolutelymaybe.plos.org
October 1, 2025 at 11:00 PM
Also check out @hildabast.bsky.social post on PubMed alternatives
absolutelymaybe.plos.org/2025/02/14/w...
absolutelymaybe.plos.org/2025/02/14/w...
Comparison of Quadruple Therapy Sequencing Strategies for Heart Failure With Reduced Ejection Fraction | Journal of the American Heart Association www.ahajournals.org/doi/10.1161/...
Comparison of Quadruple Therapy Sequencing Strategies for Heart Failure With Reduced Ejection Fraction | Journal of the American Heart Association
www.ahajournals.org
September 12, 2025 at 12:18 AM
Comparison of Quadruple Therapy Sequencing Strategies for Heart Failure With Reduced Ejection Fraction | Journal of the American Heart Association www.ahajournals.org/doi/10.1161/...
DIGIT-HF + DIG pooled
(DIG: composite of all-cause death & HF hospitalization calculated using IPD since this endpoint was not originally reported in the trial manuscript):
(DIG: composite of all-cause death & HF hospitalization calculated using IPD since this endpoint was not originally reported in the trial manuscript):
August 29, 2025 at 11:22 PM
DIGIT-HF + DIG pooled
(DIG: composite of all-cause death & HF hospitalization calculated using IPD since this endpoint was not originally reported in the trial manuscript):
(DIG: composite of all-cause death & HF hospitalization calculated using IPD since this endpoint was not originally reported in the trial manuscript):
DIGIT-HF trial - more to say on this later, but my initial thoughts can be summarized in a classic gif. www.nejm.org/doi/full/10....
a woman is wearing a santa hat and saying gretchen stop trying to make fetch happen it 's not going to happen
ALT: a woman is wearing a santa hat and saying gretchen stop trying to make fetch happen it 's not going to happen
media.tenor.com
August 29, 2025 at 8:45 PM
DIGIT-HF trial - more to say on this later, but my initial thoughts can be summarized in a classic gif. www.nejm.org/doi/full/10....
Differences in indications, contraindications, and prescribing patterns for heart failure between specialties: the VancOuver CoastAL Acute Heart Failure (VOCAL-AHF) registry
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Differences in indications, contraindications, and prescribing patterns for heart failure between specialties: the VancOuver CoastAL Acute Heart Failure (VOCAL-AHF) registry
www.sciencedirect.com
August 27, 2025 at 5:57 PM
Differences in indications, contraindications, and prescribing patterns for heart failure between specialties: the VancOuver CoastAL Acute Heart Failure (VOCAL-AHF) registry
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Our meta-analysis that I presented at ESC last year now published & available open-access: Evening Blood Pressure Medication Administration and Cardiovascular Events: Systematic Review and Meta-Analysis - Canadian Journal of Cardiology onlinecjc.ca/article/S082...
Evening Blood Pressure Medication Administration and Cardiovascular Events: Systematic Review and Meta-Analysis
Controversy persists whether evening administration of antihypertensive medications
reduces cardiovascular events. We aimed to synthesize the randomized evidence comparing
the risk of cardiovascular e...
onlinecjc.ca
August 27, 2025 at 5:47 PM
Our meta-analysis that I presented at ESC last year now published & available open-access: Evening Blood Pressure Medication Administration and Cardiovascular Events: Systematic Review and Meta-Analysis - Canadian Journal of Cardiology onlinecjc.ca/article/S082...
Reposted by Ricky Turgeon
🧠 In @nejm.org, Raja-Elie Abdulnour et al. warn: AI in medical training risks deskilling & mis-skilling. They propose DEFT-AI to teach critical thinking & safe human-AI collaboration. Verify, then trust.
📖 doi.org/10.1056/NEJM...
#ResearchEthics #MedicalEducation
📖 doi.org/10.1056/NEJM...
#ResearchEthics #MedicalEducation
Educational Strategies for Clinical Supervision of Artificial Intelligence Use | NEJM
Many learners are more facile with the use of large language models in medicine than
their supervisors are. The authors provide an approach to clinical supervision that
can mitigate the perils and ...
doi.org
August 24, 2025 at 6:00 PM
🧠 In @nejm.org, Raja-Elie Abdulnour et al. warn: AI in medical training risks deskilling & mis-skilling. They propose DEFT-AI to teach critical thinking & safe human-AI collaboration. Verify, then trust.
📖 doi.org/10.1056/NEJM...
#ResearchEthics #MedicalEducation
📖 doi.org/10.1056/NEJM...
#ResearchEthics #MedicalEducation
Apropos of nothing today ;)
(One potential / my) Shared decision-making approach to type 2 diabetes management
www.cfp.ca/content/70/5...
(One potential / my) Shared decision-making approach to type 2 diabetes management
www.cfp.ca/content/70/5...
Shared decision-making approach to type 2 diabetes management
Objective To provide an online interactive decision aid to facilitate shared decision making in the context of medication choices for patients with type 2 diabetes mellitus (T2DM).
Sources of informa...
www.cfp.ca
August 15, 2025 at 4:31 PM
Apropos of nothing today ;)
(One potential / my) Shared decision-making approach to type 2 diabetes management
www.cfp.ca/content/70/5...
(One potential / my) Shared decision-making approach to type 2 diabetes management
www.cfp.ca/content/70/5...
We made a new decision aid! Introducing CR-DECIDE: decisionaid.ca/cr-decide/
A brief 🧵 on how we developed it & how it can be used 1/7
A brief 🧵 on how we developed it & how it can be used 1/7
July 14, 2025 at 5:03 PM
We made a new decision aid! Introducing CR-DECIDE: decisionaid.ca/cr-decide/
A brief 🧵 on how we developed it & how it can be used 1/7
A brief 🧵 on how we developed it & how it can be used 1/7
Development and Validation of the CR-DECIDE Models to Predict Major Adverse Cardiovascular Events and Health Status in Stable Coronary Artery Disease - CJC Open www.cjcopen.ca/article/S258...
Development and Validation of the CR-DECIDE Models to Predict Major Adverse Cardiovascular Events and Health Status in Stable Coronary Artery Disease
Guidelines emphasize individualized care in the management of stable coronary artery
disease (CAD). We aimed to develop and validate clinical prediction models for major
adverse cardiovascular events ...
www.cjcopen.ca
July 11, 2025 at 6:48 PM
Development and Validation of the CR-DECIDE Models to Predict Major Adverse Cardiovascular Events and Health Status in Stable Coronary Artery Disease - CJC Open www.cjcopen.ca/article/S258...
Reposted by Ricky Turgeon
ICE killed a Canadian man.
A 49 year old Canadian has died while in ICE custody.
June 26, 2025 at 6:49 PM
ICE killed a Canadian man.
Reposted by Ricky Turgeon
It's been a long journey but today we can share the methods and rationale for the #ACHIEVEtrial (Spiro vs placebo for patients with kidney failure receiving maintenance dialysis) and tomorrow we share the results at #era25
journals.sagepub.com/doi/10.1177/...
journals.sagepub.com/doi/10.1177/...
The Aldosterone Blockade for Health Improvement Evaluation in End-Stage Renal Disease (ACHIEVE) Trial: Rationale and Clinical Research Protocol - Michael Walsh, David Collister, Martin Gallagher, Patr...
Background: The mineralocorticoid aldosterone may contribute to the risk of cardiovascular morbidity and mortality in patients receiving maintenance dialysis. W...
journals.sagepub.com
June 5, 2025 at 7:44 AM
It's been a long journey but today we can share the methods and rationale for the #ACHIEVEtrial (Spiro vs placebo for patients with kidney failure receiving maintenance dialysis) and tomorrow we share the results at #era25
journals.sagepub.com/doi/10.1177/...
journals.sagepub.com/doi/10.1177/...
Reposted by Ricky Turgeon
There you have it: BEDMED published in @jama.com
jamanetwork.com/journals/jam...
h/t @drjmluther.bsky.social
No difference in bedtime versus morning BP meds - as expected
#NephSky #Hypertension
1/
jamanetwork.com/journals/jam...
h/t @drjmluther.bsky.social
No difference in bedtime versus morning BP meds - as expected
#NephSky #Hypertension
1/
May 12, 2025 at 9:46 PM
There you have it: BEDMED published in @jama.com
jamanetwork.com/journals/jam...
h/t @drjmluther.bsky.social
No difference in bedtime versus morning BP meds - as expected
#NephSky #Hypertension
1/
jamanetwork.com/journals/jam...
h/t @drjmluther.bsky.social
No difference in bedtime versus morning BP meds - as expected
#NephSky #Hypertension
1/
Reposted by Ricky Turgeon
Also summarized in the @ahajournals.bsky.social HT journal here
www.ahajournals.org/doi/10.1161/...
feat @rickyturgeon.bsky.social @mikejohansenmd.medsky.social @jordybc.bsky.social @boback.bsky.social and more!
4/
www.ahajournals.org/doi/10.1161/...
feat @rickyturgeon.bsky.social @mikejohansenmd.medsky.social @jordybc.bsky.social @boback.bsky.social and more!
4/
Lowering Nighttime Blood Pressure With Bedtime Dosing of Antihypertensive Medications: Controversies in Hypertension - Con Side of the Argument | Hypertension
www.ahajournals.org
May 12, 2025 at 9:46 PM
Also summarized in the @ahajournals.bsky.social HT journal here
www.ahajournals.org/doi/10.1161/...
feat @rickyturgeon.bsky.social @mikejohansenmd.medsky.social @jordybc.bsky.social @boback.bsky.social and more!
4/
www.ahajournals.org/doi/10.1161/...
feat @rickyturgeon.bsky.social @mikejohansenmd.medsky.social @jordybc.bsky.social @boback.bsky.social and more!
4/
Reposted by Ricky Turgeon
No need to accuse anyone of fraud - focus on trustworthiness of data. I suggest following Cochrane policy for managing potentially problematic studies: www.cochranelibrary.com/cdsr/editori...
Policy for managing potentially problematic studies: implementation guidance | Cochrane Library
Select your preferred language for Cochrane reviews and other content. Sections without translation will be in English.
www.cochranelibrary.com
April 11, 2025 at 1:36 PM
No need to accuse anyone of fraud - focus on trustworthiness of data. I suggest following Cochrane policy for managing potentially problematic studies: www.cochranelibrary.com/cdsr/editori...
Reposted by Ricky Turgeon
This brings us to the "simplified" risk-of-bias tool that doesn't have an actual problem to solve, nor add anything. But why not gather friends, throw opinions around, load up the CV, and then lament the continued explosion of low quality systematic reviews.
www.bmj.com/content/388/...
end/
www.bmj.com/content/388/...
end/
Development of ROBUST-RCT: Risk Of Bias instrument for Use in SysTematic reviews-for Randomised Controlled Trials
Recent innovations in evidence based medicine methods, in particular instruments assessing risk of bias in randomised trials, have focused on methodological rigour at the expense of simplicity and pra...
www.bmj.com
April 10, 2025 at 12:23 PM
This brings us to the "simplified" risk-of-bias tool that doesn't have an actual problem to solve, nor add anything. But why not gather friends, throw opinions around, load up the CV, and then lament the continued explosion of low quality systematic reviews.
www.bmj.com/content/388/...
end/
www.bmj.com/content/388/...
end/
FRESH-UP is my favorite trial of 2025 so far (despite some superiority design limitations). My takeaway:
In patients with chronic HF, liberalizing fluid intake vs restricting <1.5L doesn't worsen HF symptoms or require higher diuretic doses, among euvolemic patients on good GDMT
1/
rdcu.be/efInN
In patients with chronic HF, liberalizing fluid intake vs restricting <1.5L doesn't worsen HF symptoms or require higher diuretic doses, among euvolemic patients on good GDMT
1/
rdcu.be/efInN
Liberal fluid intake versus fluid restriction in chronic heart failure: a randomized clinical trial
Nature Medicine - While fluid restriction is typically recommended for patients with chronic heart failure, this randomized clinical trial showed no difference in health status, as assessed by...
rdcu.be
March 30, 2025 at 4:10 PM
FRESH-UP is my favorite trial of 2025 so far (despite some superiority design limitations). My takeaway:
In patients with chronic HF, liberalizing fluid intake vs restricting <1.5L doesn't worsen HF symptoms or require higher diuretic doses, among euvolemic patients on good GDMT
1/
rdcu.be/efInN
In patients with chronic HF, liberalizing fluid intake vs restricting <1.5L doesn't worsen HF symptoms or require higher diuretic doses, among euvolemic patients on good GDMT
1/
rdcu.be/efInN
Reposted by Ricky Turgeon
Limiting fluid intake may have no benefit for patients with #HeartFailure, according to findings from the FRESH-UP study presented during a Late-Breaking Clinical Trial session at #ACC25.
Check out the key findings ➡️ bit.ly/3DYGHEl
#CardioSky #MedSky
Check out the key findings ➡️ bit.ly/3DYGHEl
#CardioSky #MedSky
March 30, 2025 at 1:59 PM
Limiting fluid intake may have no benefit for patients with #HeartFailure, according to findings from the FRESH-UP study presented during a Late-Breaking Clinical Trial session at #ACC25.
Check out the key findings ➡️ bit.ly/3DYGHEl
#CardioSky #MedSky
Check out the key findings ➡️ bit.ly/3DYGHEl
#CardioSky #MedSky
Reposted by Ricky Turgeon
In clinical research, you will often receive feedback on study design, stats, and/or data analysis from an editor or reviewer that is simply wrong. Here is a list of common "statistical myths" and references you can use to push back.
discourse.datamethods.org/t/reference-...
discourse.datamethods.org/t/reference-...
Reference Collection to push back against "Common Statistical Myths"
Note: This topic is a wiki, meaning that this main body of the topic can be edited by others. Use the Reply button only to post questions or comments about material contained in the body, or to sugge...
discourse.datamethods.org
November 12, 2024 at 6:19 AM
In clinical research, you will often receive feedback on study design, stats, and/or data analysis from an editor or reviewer that is simply wrong. Here is a list of common "statistical myths" and references you can use to push back.
discourse.datamethods.org/t/reference-...
discourse.datamethods.org/t/reference-...
Reposted by Ricky Turgeon
What a journey this paper took.
Hydroxychloroquine was the first (false) hope of the pandemic. Trump touted it and took it himself. Even my hospital at the time, Yale, jumped on the bandwagon, briefly using it.
But researchers and patients generated RCT data showing it doesn’t work for COVID.
Hydroxychloroquine was the first (false) hope of the pandemic. Trump touted it and took it himself. Even my hospital at the time, Yale, jumped on the bandwagon, briefly using it.
But researchers and patients generated RCT data showing it doesn’t work for COVID.
December 17, 2024 at 7:43 PM
What a journey this paper took.
Hydroxychloroquine was the first (false) hope of the pandemic. Trump touted it and took it himself. Even my hospital at the time, Yale, jumped on the bandwagon, briefly using it.
But researchers and patients generated RCT data showing it doesn’t work for COVID.
Hydroxychloroquine was the first (false) hope of the pandemic. Trump touted it and took it himself. Even my hospital at the time, Yale, jumped on the bandwagon, briefly using it.
But researchers and patients generated RCT data showing it doesn’t work for COVID.
Reposted by Ricky Turgeon
Stumbled upon a neat website from @rickyturgeon.bsky.social, with guides on analyzing clinical trials and useful summaries mostly in heart failure #cardiosky
nerdcat.org
nerdcat.org
NERDCAT
nerdcat.org
December 8, 2024 at 6:36 PM
Stumbled upon a neat website from @rickyturgeon.bsky.social, with guides on analyzing clinical trials and useful summaries mostly in heart failure #cardiosky
nerdcat.org
nerdcat.org
Reposted by Ricky Turgeon
"In randomized experiments, the effects of this variable are distributed among the groups by the randomization in a way that is taken into account in the standard tests of significance. ."
Cochran 1957. NB "distributed". He does not say "balanced."
See also errorstatistics.com/2020/04/20/s...
Cochran 1957. NB "distributed". He does not say "balanced."
See also errorstatistics.com/2020/04/20/s...
S. Senn: Randomisation is not about balance, nor about homogeneity but about randomness (Guest Post)
Stephen Senn Consultant Statistician Edinburgh The intellectual illness of clinical drug evaluation that I have discussed here can be cured, and it will be cured when we restore intellectual primac…
errorstatistics.com
December 4, 2024 at 7:36 PM
"In randomized experiments, the effects of this variable are distributed among the groups by the randomization in a way that is taken into account in the standard tests of significance. ."
Cochran 1957. NB "distributed". He does not say "balanced."
See also errorstatistics.com/2020/04/20/s...
Cochran 1957. NB "distributed". He does not say "balanced."
See also errorstatistics.com/2020/04/20/s...
Updated prior NERDCAT summary of GLP1 receptor agonists in HFpEF with data from SUMMIT: nerdcat.org/studysummari...
#cardiosky #nephsky #medsky
How do people feel about the "incretin analog" terminology? Still feels clumsy to me
#cardiosky #nephsky #medsky
How do people feel about the "incretin analog" terminology? Still feels clumsy to me
STEP-HFpEF & SUMMIT: Incretin analogs (semaglutide & tirzepatide) in patients with HF & ejection fraction >=45% & obesity, with or without diabetes — NERDCAT
Semaglutide articles Pooled analysis of STEP-HFpEF & STEP-HFpEF DM. Lancet 2024 STEP-HFpEF main paper. NEJM 2023;389:1069-84. STEP-HFpEF DM main paper. NEJM 2024;390:1394-407. S...
nerdcat.org
December 4, 2024 at 3:00 AM
Updated prior NERDCAT summary of GLP1 receptor agonists in HFpEF with data from SUMMIT: nerdcat.org/studysummari...
#cardiosky #nephsky #medsky
How do people feel about the "incretin analog" terminology? Still feels clumsy to me
#cardiosky #nephsky #medsky
How do people feel about the "incretin analog" terminology? Still feels clumsy to me