Juan C. Sanchez-Arcila (he/ele/él)
@rhodnius.bsky.social
Assistant project scientist at University of California, Merced.
Immunology of infectious diseases, mice genetic diversity, Data Science, Open Science, foo(d, tball).
South American Rocker 🇨🇴🇧🇷
Posts in SPA/POR/ENG.
Immunology of infectious diseases, mice genetic diversity, Data Science, Open Science, foo(d, tball).
South American Rocker 🇨🇴🇧🇷
Posts in SPA/POR/ENG.
Reposted by Juan C. Sanchez-Arcila (he/ele/él)
Quando Lula // Quando o bostô
foi preso // foi preso
foi preso // foi preso
November 22, 2025 at 3:28 PM
Quando Lula // Quando o bostô
foi preso // foi preso
foi preso // foi preso
Reposted by Juan C. Sanchez-Arcila (he/ele/él)
@duolingo is one of the biggest scams I have seen recently. Very expensive annual fee and zero, zero, zero support. Most probably it is all AI now. At the end, they don't really care about people learning, just about $$$.
November 20, 2025 at 6:54 PM
@duolingo is one of the biggest scams I have seen recently. Very expensive annual fee and zero, zero, zero support. Most probably it is all AI now. At the end, they don't really care about people learning, just about $$$.
Who was the evil person that invented the yearly paid subscription model for academic software?
November 18, 2025 at 7:09 PM
Who was the evil person that invented the yearly paid subscription model for academic software?
Me: I want to see the Aurora Borealis
Pachamama: 🖕
Pachamama: 🖕
November 13, 2025 at 6:48 AM
Me: I want to see the Aurora Borealis
Pachamama: 🖕
Pachamama: 🖕
Reposted by Juan C. Sanchez-Arcila (he/ele/él)
it's wild that R, the ubiquitous statistical computing language, was co-created by a Māori prof (Ross Ihaka) — and yet the vast majority of scientists who use R don't know
this is like inventing the toaster. possibly the largest impact of a single member of an indigenous community on modern science
this is like inventing the toaster. possibly the largest impact of a single member of an indigenous community on modern science
December 14, 2023 at 10:35 AM
it's wild that R, the ubiquitous statistical computing language, was co-created by a Māori prof (Ross Ihaka) — and yet the vast majority of scientists who use R don't know
this is like inventing the toaster. possibly the largest impact of a single member of an indigenous community on modern science
this is like inventing the toaster. possibly the largest impact of a single member of an indigenous community on modern science
Reposted by Juan C. Sanchez-Arcila (he/ele/él)
1/ A longtime Wired editor just wrote a mush-brained essay about how he totally missed the political rot of Silicon Valley (& still doesn't get it).
But in the late 1990s, a Wired journalist warned of a toxic ideology bubbling up from tech. Paulina Borsook has largely been erased. Let's change that
But in the late 1990s, a Wired journalist warned of a toxic ideology bubbling up from tech. Paulina Borsook has largely been erased. Let's change that
September 24, 2025 at 6:36 PM
1/ A longtime Wired editor just wrote a mush-brained essay about how he totally missed the political rot of Silicon Valley (& still doesn't get it).
But in the late 1990s, a Wired journalist warned of a toxic ideology bubbling up from tech. Paulina Borsook has largely been erased. Let's change that
But in the late 1990s, a Wired journalist warned of a toxic ideology bubbling up from tech. Paulina Borsook has largely been erased. Let's change that
It is a shame... @duolingo became an app probably manages through AI. They never answer one email, they have a horrible costumer service. And still they want to ask and ask to subscribe to their services. I won't renew my plan for sure.
September 12, 2025 at 12:02 AM
It is a shame... @duolingo became an app probably manages through AI. They never answer one email, they have a horrible costumer service. And still they want to ask and ask to subscribe to their services. I won't renew my plan for sure.
Reposted by Juan C. Sanchez-Arcila (he/ele/él)
Al Hilal x Fluminense vai ser basicamente o poder do dinheiro infinito vs. o poder da amizade
July 1, 2025 at 4:04 AM
Al Hilal x Fluminense vai ser basicamente o poder do dinheiro infinito vs. o poder da amizade
Reposted by Juan C. Sanchez-Arcila (he/ele/él)
No evidence of immune exhaustion after repeated SARS-CoV-2 vaccination in vulnerable and healthy populations
Does repeated vaccination cause "immune exhaustion"? No, the immune system can handle multiple hits from similar or different stimuli. It evolved to do so!
www.nature.com/artic...
1/5
Does repeated vaccination cause "immune exhaustion"? No, the immune system can handle multiple hits from similar or different stimuli. It evolved to do so!
www.nature.com/artic...
1/5
No evidence of immune exhaustion after repeated SARS-CoV-2 vaccination in vulnerable and healthy populations
Nature Communications - Repeated vaccination is needed to maintain high levels of SARS-CoV-2 immunity in vulnerable populations, but there is concern that it could lead to immune exhaustion. Here,...
www.nature.com
June 6, 2025 at 11:20 AM
No evidence of immune exhaustion after repeated SARS-CoV-2 vaccination in vulnerable and healthy populations
Does repeated vaccination cause "immune exhaustion"? No, the immune system can handle multiple hits from similar or different stimuli. It evolved to do so!
www.nature.com/artic...
1/5
Does repeated vaccination cause "immune exhaustion"? No, the immune system can handle multiple hits from similar or different stimuli. It evolved to do so!
www.nature.com/artic...
1/5
Reposted by Juan C. Sanchez-Arcila (he/ele/él)
We're not the first to use IL-12 as an adjuvant - but having worked on IL-12 for >30 years this was still a surprise at how much this study taught us about mRNA vaccines and their utility. Here are two others below:
www.science.org/doi/10.1126/...
@cytokinesociety.bsky.social
www.science.org/doi/10.1126/...
@cytokinesociety.bsky.social
An Il12 mRNA-LNP adjuvant enhances mRNA vaccine–induced CD8 T cell responses
IL-12 is dispensable for CD8 T cell responses to mRNA vaccination, but an Il12 mRNA-LNP enhances CD8 T cell memory and protection.
www.science.org
June 9, 2025 at 11:22 AM
We're not the first to use IL-12 as an adjuvant - but having worked on IL-12 for >30 years this was still a surprise at how much this study taught us about mRNA vaccines and their utility. Here are two others below:
www.science.org/doi/10.1126/...
@cytokinesociety.bsky.social
www.science.org/doi/10.1126/...
@cytokinesociety.bsky.social
Reposted by Juan C. Sanchez-Arcila (he/ele/él)
Registration and Abstract submission for MPMXXXVI are now open! Abstract submission deadline is June 27th, get yours in quickly. @rmc9z.bsky.social @mjgubbels.bsky.social @omarharb.org
🔗https://www.parasitesrule.com/mpm-xxxvi
🔗https://www.parasitesrule.com/mpm-xxxvi
June 5, 2025 at 1:51 PM
Registration and Abstract submission for MPMXXXVI are now open! Abstract submission deadline is June 27th, get yours in quickly. @rmc9z.bsky.social @mjgubbels.bsky.social @omarharb.org
🔗https://www.parasitesrule.com/mpm-xxxvi
🔗https://www.parasitesrule.com/mpm-xxxvi
Reposted by Juan C. Sanchez-Arcila (he/ele/él)
Happy to share that our work "Amyloid-β induces lipid droplet-mediated microglial dysfunction via the enzyme DGAT2 in Alzheimer’s disease" is out now @cp-immunity.bsky.social! ➡️ www.cell.com/immunity/ful...
Amyloid-β induces lipid droplet-mediated microglial dysfunction via the enzyme DGAT2 in Alzheimer’s disease
Why microglia stop reducing amyloid deposits from Alzheimer’s disease (AD) brains
is unknown. Prakash, Manchanda, et al. show that microglia increase their lipid droplets
and lose their phagocytic cap...
www.cell.com
May 19, 2025 at 6:14 PM
Happy to share that our work "Amyloid-β induces lipid droplet-mediated microglial dysfunction via the enzyme DGAT2 in Alzheimer’s disease" is out now @cp-immunity.bsky.social! ➡️ www.cell.com/immunity/ful...
@elespectador.com miren, aprendan a hacer periodismo así.
O legado histórico de Mojica
www.bbc.com/portuguese/a...
www.bbc.com/portuguese/a...
Morre José Mujica, o ousado político uruguaio que foi o 'presidente mais pobre do mundo' - BBC News Brasil
O ex-presidente do Uruguai ganhou popularidade a nível mundial pelo seu estilo de vida austero, suas críticas ao consumismo e por liderar reformas sociais, como a legalização da maconha
www.bbc.com
May 14, 2025 at 3:55 AM
@elespectador.com miren, aprendan a hacer periodismo así.
Reposted by Juan C. Sanchez-Arcila (he/ele/él)
One of the most powerful revelations for your personal and political growth is this: if you live long enough, you’ll become disabled.
No one is immune to illness, injury, or aging.
If you’re not committed to disability justice for altruistic reasons, commit for selfish ones. And guard your health.
No one is immune to illness, injury, or aging.
If you’re not committed to disability justice for altruistic reasons, commit for selfish ones. And guard your health.
May 10, 2025 at 1:43 PM
One of the most powerful revelations for your personal and political growth is this: if you live long enough, you’ll become disabled.
No one is immune to illness, injury, or aging.
If you’re not committed to disability justice for altruistic reasons, commit for selfish ones. And guard your health.
No one is immune to illness, injury, or aging.
If you’re not committed to disability justice for altruistic reasons, commit for selfish ones. And guard your health.
Reposted by Juan C. Sanchez-Arcila (he/ele/él)
I don’t remember when was the last time I saw an excellent TV show such as The Pitt
April 24, 2025 at 6:28 AM
I don’t remember when was the last time I saw an excellent TV show such as The Pitt
Reposted by Juan C. Sanchez-Arcila (he/ele/él)
👶🏼 Many #vaccines are not effective in newborns. So how do we protect them from infectious disease?
🤰🏽 By vaccination in #pregnancy!
Here we review…
💉 Established campaigns vs whooping cough, flu, COVID
💡 New approaches to RSV, GBS
🌈 Future challenges, opportunities
#ReproSky #ImmunoSky #IDSky
🤰🏽 By vaccination in #pregnancy!
Here we review…
💉 Established campaigns vs whooping cough, flu, COVID
💡 New approaches to RSV, GBS
🌈 Future challenges, opportunities
#ReproSky #ImmunoSky #IDSky
Vaccination in pregnancy to protect the newborn - Nature Reviews Immunology
In this Review, Male and Jones provide an overview of the current vaccines that are offered during pregnancy and to newborns, explaining the rationale behind the different vaccination programmes and t...
www.nature.com
April 24, 2025 at 6:21 AM
👶🏼 Many #vaccines are not effective in newborns. So how do we protect them from infectious disease?
🤰🏽 By vaccination in #pregnancy!
Here we review…
💉 Established campaigns vs whooping cough, flu, COVID
💡 New approaches to RSV, GBS
🌈 Future challenges, opportunities
#ReproSky #ImmunoSky #IDSky
🤰🏽 By vaccination in #pregnancy!
Here we review…
💉 Established campaigns vs whooping cough, flu, COVID
💡 New approaches to RSV, GBS
🌈 Future challenges, opportunities
#ReproSky #ImmunoSky #IDSky
Reposted by Juan C. Sanchez-Arcila (he/ele/él)
Please see the new tour de force from @danaaghabi.bsky.social PhD! We think that we have finally found the major Toxoplasma iron/zinc importer. Thanks to ID21 at the @esrf.fr, and help from UGs and the lab.
This is what I wanted to find when I started my lab, and thanks to Dana we have it!
This is what I wanted to find when I started my lab, and thanks to Dana we have it!
New preprint alert 🔔🎉 We are so happy to share that our latest work “ZFT is the major iron and zinc transporter in Toxoplasma gondii” is now available online! www.biorxiv.org/content/10.1...
ZFT is the major iron and zinc transporter in Toxoplasma gondii
Transition metals, such as iron and zinc, are indispensable trace elements for eukaryotic life, acting as co-factors in essential processes ranging from respiration and metabolism to DNA replication. ...
www.biorxiv.org
April 22, 2025 at 11:35 AM
Please see the new tour de force from @danaaghabi.bsky.social PhD! We think that we have finally found the major Toxoplasma iron/zinc importer. Thanks to ID21 at the @esrf.fr, and help from UGs and the lab.
This is what I wanted to find when I started my lab, and thanks to Dana we have it!
This is what I wanted to find when I started my lab, and thanks to Dana we have it!
Reposted by Juan C. Sanchez-Arcila (he/ele/él)
In the silence of chromatin, Toxoplasma whispers change.
TgSNF2h sculpts the genome - MORC in the backseat.
Some genes wake. Others sleep.
A dance of nucleosomes shaping space for life parasite stages to unfold.
Now in Nature Microbiology:
rdcu.be/ehkWp
TgSNF2h sculpts the genome - MORC in the backseat.
Some genes wake. Others sleep.
A dance of nucleosomes shaping space for life parasite stages to unfold.
Now in Nature Microbiology:
rdcu.be/ehkWp
An ISWI-related chromatin remodeller regulates stage-specific gene expression in Toxoplasma gondii
Nature Microbiology - Toxoplasma gondii evolved two ISWI remodellers, TgSNF2h and TgSNF2L. TgSNF2h forms a complex that insulates active genes, regulates MORC-driven sexual commitment and ensures...
rdcu.be
April 11, 2025 at 11:07 AM
In the silence of chromatin, Toxoplasma whispers change.
TgSNF2h sculpts the genome - MORC in the backseat.
Some genes wake. Others sleep.
A dance of nucleosomes shaping space for life parasite stages to unfold.
Now in Nature Microbiology:
rdcu.be/ehkWp
TgSNF2h sculpts the genome - MORC in the backseat.
Some genes wake. Others sleep.
A dance of nucleosomes shaping space for life parasite stages to unfold.
Now in Nature Microbiology:
rdcu.be/ehkWp
Reposted by Juan C. Sanchez-Arcila (he/ele/él)
Your yearly reminder to acknowledge the core facilities you use and their staff scientists in your papers. These scientists are a crucial part of the scientific ecosystem and to continue to exist they need tangible credit for their work. Plus their associated expertise adds credibility to your work.
April 10, 2025 at 1:38 PM
Your yearly reminder to acknowledge the core facilities you use and their staff scientists in your papers. These scientists are a crucial part of the scientific ecosystem and to continue to exist they need tangible credit for their work. Plus their associated expertise adds credibility to your work.
Reposted by Juan C. Sanchez-Arcila (he/ele/él)
A natural experiment on the effect of herpes zoster vaccination on dementia
Neurotropic herpes viruses may be implicated in the development of dementia. Can vaccines reduce this risk? Yes, they can!
www.nature.com/artic...
1/10
Neurotropic herpes viruses may be implicated in the development of dementia. Can vaccines reduce this risk? Yes, they can!
www.nature.com/artic...
1/10
A natural experiment on the effect of herpes zoster vaccination on dementia
Nature - Using a natural experiment that avoids common bias concerns, this study finds that the live-attenuated shingles vaccine reduced the probability of a new dementia diagnosis within a...
www.nature.com
April 3, 2025 at 9:55 AM
A natural experiment on the effect of herpes zoster vaccination on dementia
Neurotropic herpes viruses may be implicated in the development of dementia. Can vaccines reduce this risk? Yes, they can!
www.nature.com/artic...
1/10
Neurotropic herpes viruses may be implicated in the development of dementia. Can vaccines reduce this risk? Yes, they can!
www.nature.com/artic...
1/10
Reposted by Juan C. Sanchez-Arcila (he/ele/él)
Striking new study from @archaeon-alex.bsky.social's lab just out in @science.org on multicellular development induced by compression in Archaea: www.science.org/doi/10.1126/...
Tissue-like multicellular development triggered by mechanical compression in archaea
The advent of clonal multicellularity is a critical evolutionary milestone, seen often in eukaryotes, rarely in bacteria, and only once in archaea. We show that uniaxial compression induces clonal mul...
www.science.org
April 3, 2025 at 6:24 PM
Striking new study from @archaeon-alex.bsky.social's lab just out in @science.org on multicellular development induced by compression in Archaea: www.science.org/doi/10.1126/...
Reposted by Juan C. Sanchez-Arcila (he/ele/él)
Reposted by Juan C. Sanchez-Arcila (he/ele/él)
Why AI won’t replace scientists capable of making disruptive conceptual breakthroughs - they pose questions that challenge, rather than align with, the training data set
thomwolf.io/blog/scienti...
thomwolf.io/blog/scienti...
🔭 The Einstein AI model
I shared a controversial take the other day at an event and I decided to write it down in a longer format: I’m afraid AI won't give us a compressed 21st century.
thomwolf.io
March 22, 2025 at 4:06 PM
Why AI won’t replace scientists capable of making disruptive conceptual breakthroughs - they pose questions that challenge, rather than align with, the training data set
thomwolf.io/blog/scienti...
thomwolf.io/blog/scienti...