Richard Unwin
@rdunwin.bsky.social
Mass Spectrometry and proteomics at Uni of Manchester. Analysis of primary samples for biomarker discovery. Development of targeted assays for clinical use.
Co-founder, Complement Therapeutics
Also football (SWFC), cricket and politics.
Co-founder, Complement Therapeutics
Also football (SWFC), cricket and politics.
Reposted by Richard Unwin
An opportunity for someone to join our team! We're looking for a 50% Technical Assistant from Feb. 2026 - Dec. 2030
Application deadline 15th Jan 2026! Please see
Application deadline 15th Jan 2026! Please see
Technical Assistant
The Institute for Ophthalmic Research (IOR), part of the Centre for Ophthalmology at the University Medical Centre Tübingen, offers excellent infrastructure and a dynamic basic and clinical research…
buff.ly
January 9, 2026 at 9:39 AM
An opportunity for someone to join our team! We're looking for a 50% Technical Assistant from Feb. 2026 - Dec. 2030
Application deadline 15th Jan 2026! Please see
Application deadline 15th Jan 2026! Please see
Yup. In theory, they surely know that you need money, investment in facilities and hire good people to make any business work. They've built successful businesses (unlike DC). In practice, I'm OK with the analytics stuff but I don't want us to be an experiment in 'can AI run a football club?'.
January 6, 2026 at 7:42 PM
Yup. In theory, they surely know that you need money, investment in facilities and hire good people to make any business work. They've built successful businesses (unlike DC). In practice, I'm OK with the analytics stuff but I don't want us to be an experiment in 'can AI run a football club?'.
Said it 100 times. We were mid-table at best last year, lost most of our first team so now we've got all players who weren't good enough to be 1st choice last year and kids. Bannan the only exception?
Good game-time for boys like Bailey, Thornton, Fusire, Weaver etc but it's too much. #swfc
Good game-time for boys like Bailey, Thornton, Fusire, Weaver etc but it's too much. #swfc
January 1, 2026 at 11:11 PM
Said it 100 times. We were mid-table at best last year, lost most of our first team so now we've got all players who weren't good enough to be 1st choice last year and kids. Bannan the only exception?
Good game-time for boys like Bailey, Thornton, Fusire, Weaver etc but it's too much. #swfc
Good game-time for boys like Bailey, Thornton, Fusire, Weaver etc but it's too much. #swfc
Reposted by Richard Unwin
Reposted by Richard Unwin
Twas the night before Christmas, and throughout the land
The sleeping arrangements were carefully planned
Down in the kitchen, a picturesque scene
A mattress, a pillow, a washing machine
The sleeping arrangements were carefully planned
Down in the kitchen, a picturesque scene
A mattress, a pillow, a washing machine
December 24, 2025 at 7:30 PM
Twas the night before Christmas, and throughout the land
The sleeping arrangements were carefully planned
Down in the kitchen, a picturesque scene
A mattress, a pillow, a washing machine
The sleeping arrangements were carefully planned
Down in the kitchen, a picturesque scene
A mattress, a pillow, a washing machine
No I agree. He'll increase our value. Which means sorting stadium, infrastructure and the team. His minimum aim will be to make us a yo-yo Prem team. No bad thing and Ashley's got experience to do it. But I think he'll do the minimum to get us there and I'd like it to be more - sustainable.
December 24, 2025 at 1:24 PM
No I agree. He'll increase our value. Which means sorting stadium, infrastructure and the team. His minimum aim will be to make us a yo-yo Prem team. No bad thing and Ashley's got experience to do it. But I think he'll do the minimum to get us there and I'd like it to be more - sustainable.
Hmmm...
Seems to say all the right things (long term, investment in facilities etc), but then again I guess you never know.
Rather a punt with him than Ashley, who I suspect will be in it to paper over enough cracks to sell us on for a profit. This is fine, but stability is key for us, now. #swfc
Seems to say all the right things (long term, investment in facilities etc), but then again I guess you never know.
Rather a punt with him than Ashley, who I suspect will be in it to paper over enough cracks to sell us on for a profit. This is fine, but stability is key for us, now. #swfc
December 24, 2025 at 1:08 PM
Hmmm...
Seems to say all the right things (long term, investment in facilities etc), but then again I guess you never know.
Rather a punt with him than Ashley, who I suspect will be in it to paper over enough cracks to sell us on for a profit. This is fine, but stability is key for us, now. #swfc
Seems to say all the right things (long term, investment in facilities etc), but then again I guess you never know.
Rather a punt with him than Ashley, who I suspect will be in it to paper over enough cracks to sell us on for a profit. This is fine, but stability is key for us, now. #swfc
This remains one of the BEST social media threads of the year. If you've never seen it, check it out (and if you're a long-time duvet-er, enjoy!) 😁
Tomorrow evening it’ll be my annual duty to vaguely shepherd the activity on the #duvetknowitschristmas hashtag and urge people to give small sums to charity. 7.30pm? Something like that?
December 23, 2025 at 9:00 PM
This remains one of the BEST social media threads of the year. If you've never seen it, check it out (and if you're a long-time duvet-er, enjoy!) 😁
Sad news about #ChrisRea. Was a bit of a fan when I was growing up.
Predictable focus on 'Driving home for Christmas'. But it's not even his best Christmas song lol.
If you've not heard it, check this. The Intro is 🔥, and the lyrics are top drawer
Thanks, Chris. RiP
youtu.be/nYz21xcJxTs?...
Predictable focus on 'Driving home for Christmas'. But it's not even his best Christmas song lol.
If you've not heard it, check this. The Intro is 🔥, and the lyrics are top drawer
Thanks, Chris. RiP
youtu.be/nYz21xcJxTs?...
Joys of Christmas
YouTube video by Chris Rea - Topic
youtu.be
December 22, 2025 at 7:50 PM
Sad news about #ChrisRea. Was a bit of a fan when I was growing up.
Predictable focus on 'Driving home for Christmas'. But it's not even his best Christmas song lol.
If you've not heard it, check this. The Intro is 🔥, and the lyrics are top drawer
Thanks, Chris. RiP
youtu.be/nYz21xcJxTs?...
Predictable focus on 'Driving home for Christmas'. But it's not even his best Christmas song lol.
If you've not heard it, check this. The Intro is 🔥, and the lyrics are top drawer
Thanks, Chris. RiP
youtu.be/nYz21xcJxTs?...
I'm marking UG essays. Glad of the distraction lolol
December 22, 2025 at 3:31 PM
I'm marking UG essays. Glad of the distraction lolol
Aw, Ben. Its christmas. You can hang baubles off those branches...
December 22, 2025 at 3:17 PM
Aw, Ben. Its christmas. You can hang baubles off those branches...
2 adjacent papers in my timeline with 'deep' in the title.
What was deep 5 years ago isn't now. In 5 years time, these will not be 'deep' either.
I've said this before, but its soooooo annoying. Tempted to spend 2026 highlighting all the 'deep' and 'ultra' papers but fear it'd be a full-time job lol
What was deep 5 years ago isn't now. In 5 years time, these will not be 'deep' either.
I've said this before, but its soooooo annoying. Tempted to spend 2026 highlighting all the 'deep' and 'ultra' papers but fear it'd be a full-time job lol
December 22, 2025 at 12:55 PM
2 adjacent papers in my timeline with 'deep' in the title.
What was deep 5 years ago isn't now. In 5 years time, these will not be 'deep' either.
I've said this before, but its soooooo annoying. Tempted to spend 2026 highlighting all the 'deep' and 'ultra' papers but fear it'd be a full-time job lol
What was deep 5 years ago isn't now. In 5 years time, these will not be 'deep' either.
I've said this before, but its soooooo annoying. Tempted to spend 2026 highlighting all the 'deep' and 'ultra' papers but fear it'd be a full-time job lol
Reposted by Richard Unwin
Just a gentle reminder to anyone who needs this...
Please share with your followers. You might be surprised who it could help...
Please share with your followers. You might be surprised who it could help...
December 21, 2025 at 10:39 PM
Just a gentle reminder to anyone who needs this...
Please share with your followers. You might be surprised who it could help...
Please share with your followers. You might be surprised who it could help...
There's a concerning 'drift' in AD biomarkers, in my view.
Started off with 'amyloid-PET is not a good diagnostic biomarker for AD'.
pTau correlates with amyloid-PET, but is now a 'good' biomarker (true for ~50% of people with v. high or v. low levels).
Now 'pTau in healthy people = early AD'. 🤔
Started off with 'amyloid-PET is not a good diagnostic biomarker for AD'.
pTau correlates with amyloid-PET, but is now a 'good' biomarker (true for ~50% of people with v. high or v. low levels).
Now 'pTau in healthy people = early AD'. 🤔
December 21, 2025 at 3:37 PM
There's a concerning 'drift' in AD biomarkers, in my view.
Started off with 'amyloid-PET is not a good diagnostic biomarker for AD'.
pTau correlates with amyloid-PET, but is now a 'good' biomarker (true for ~50% of people with v. high or v. low levels).
Now 'pTau in healthy people = early AD'. 🤔
Started off with 'amyloid-PET is not a good diagnostic biomarker for AD'.
pTau correlates with amyloid-PET, but is now a 'good' biomarker (true for ~50% of people with v. high or v. low levels).
Now 'pTau in healthy people = early AD'. 🤔
December 20, 2025 at 8:17 PM
Dear the entire USA. You guys know that this is not normal, right? 🤦♂️😬
December 18, 2025 at 8:45 AM
Dear the entire USA. You guys know that this is not normal, right? 🤦♂️😬
Same as usual. Second to every loose ball, lack of quality all
over the park, stupid mistakes. Is it May yet?
over the park, stupid mistakes. Is it May yet?
December 15, 2025 at 8:54 PM
Same as usual. Second to every loose ball, lack of quality all
over the park, stupid mistakes. Is it May yet?
over the park, stupid mistakes. Is it May yet?
Reposted by Richard Unwin
I have a PhD position available with start date September 2026 at the University of Manchester.
Proteomics analysis of flow cytometry-based isolated pathogen-containing phagosomes
Due to funding requirements, this position is for UK home students only.
www.findaphd.com/phds/project...
Proteomics analysis of flow cytometry-based isolated pathogen-containing phagosomes
Due to funding requirements, this position is for UK home students only.
www.findaphd.com/phds/project...
Proteomics analysis of flow cytometry-based isolated pathogen-containing phagosomes at The University of Manchester on FindAPhD.com
PhD Project - Proteomics analysis of flow cytometry-based isolated pathogen-containing phagosomes at The University of Manchester, listed on FindAPhD.com
www.findaphd.com
December 15, 2025 at 12:15 PM
I have a PhD position available with start date September 2026 at the University of Manchester.
Proteomics analysis of flow cytometry-based isolated pathogen-containing phagosomes
Due to funding requirements, this position is for UK home students only.
www.findaphd.com/phds/project...
Proteomics analysis of flow cytometry-based isolated pathogen-containing phagosomes
Due to funding requirements, this position is for UK home students only.
www.findaphd.com/phds/project...
Love thy neighbour.
No, Not THAT neighbour.... 🤦♂️😡
No, Not THAT neighbour.... 🤦♂️😡
December 13, 2025 at 6:38 PM
Love thy neighbour.
No, Not THAT neighbour.... 🤦♂️😡
No, Not THAT neighbour.... 🤦♂️😡
That's not to say the science isn't good. They're big cohorts, data seems well presented, there's some interesting biology potentially.
But - and this is a regular whinge from me on here - this constant trend towards over-claiming does nobody any good.
But - and this is a regular whinge from me on here - this constant trend towards over-claiming does nobody any good.
December 11, 2025 at 8:57 AM
That's not to say the science isn't good. They're big cohorts, data seems well presented, there's some interesting biology potentially.
But - and this is a regular whinge from me on here - this constant trend towards over-claiming does nobody any good.
But - and this is a regular whinge from me on here - this constant trend towards over-claiming does nobody any good.
2 adjacent papers in my timeline with new AD biomarkers.
First claims 'accurate prediction'. Second claims 'prognosic value'.
First has an AUC of 0.769. Second has AUC 0.71 [95%CI 0.57–0.85]. Both values from the discovery cohort only.
Is it just me, or are these neither accurate or valuable?
First claims 'accurate prediction'. Second claims 'prognosic value'.
First has an AUC of 0.769. Second has AUC 0.71 [95%CI 0.57–0.85]. Both values from the discovery cohort only.
Is it just me, or are these neither accurate or valuable?
December 11, 2025 at 8:41 AM
2 adjacent papers in my timeline with new AD biomarkers.
First claims 'accurate prediction'. Second claims 'prognosic value'.
First has an AUC of 0.769. Second has AUC 0.71 [95%CI 0.57–0.85]. Both values from the discovery cohort only.
Is it just me, or are these neither accurate or valuable?
First claims 'accurate prediction'. Second claims 'prognosic value'.
First has an AUC of 0.769. Second has AUC 0.71 [95%CI 0.57–0.85]. Both values from the discovery cohort only.
Is it just me, or are these neither accurate or valuable?