Read this in a paper and it was totally new to me (after 18 years in biochemistry research): “Peptides translated from the sense and antisense strands of DNA interact specifically, analogous to the complementary interactions between DNA double strands.” Is this widely studied/actually true?? 🤯

Faculty opening in Cornell Chemistry at the Assistant Professor level in the area of chemical biology, broadly defined! academicjobsonline.org/ajo/jobs/30338 #chemjobs

Last day at #ENDO2025 was great! Amazing symposium on bone and calcium disorders 🦴 by @rche54.bsky.social @MichailLionakis @MichaelMannstadt with great talks on GPCRs and nanobodies, JAK inhibitors in APECED syndrome & new PTH therapies 🤩

This Wednesday and Thursday is the VIRTUAL Nebraska Drug Discovery and Development Pipeline Symposium! Registration is still open! Plenary speakers include Brian Kobilka and Virginia Man-Yee Lee.

#chemsky, you should attend!

research.unl.edu/blog/annual-...

Check out the final published product in Journal of Biological Chemistry! www.jbc.org/article/S002...

Excited to see this out in @science.org today!! www.science.org/doi/10.1126/...

Next up, a collaboration with Ross Cheloha's group (@rche54 <a href="https://bsky.app/profile/did:plc:ycxfqyv32syaeu347y4xquiw" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky-mention">@rche54.bsky.social) and @MitchellHo leveraging a novel self-labeling approach for site-specific modification of nanobodies for biological applications.

doi.org/10.1002/advs...
3/5

It's been a while since I posted on some of the ☢️ #radiopharmaceuticals ☢️ work we've been brewing.

Let's fix that...

🧵👇
1/5

Great news: NIH postbac program is recruiting again! If your grad school plans were affected by program cutbacks or admissions freezes this year I highly encourage you to apply, this could be a perfect opportunity. Please repost.

www.training.nih.gov/research-tra...

Check out our new review on induced proximity modalities (#TPD and a lot more!) aimed cell surface targets @naturebiotech.bsky.social, spearheaded by postdocs Nick Till and "Rahm" Ramanathan

www.nature.com/articles/s41...

The findings suggest that optimizing input parameters and refining competition-based modeling approaches may enhance predictive accuracy for antibody-antigen interactions. Intriguing.

Excited to share a preprint covering a collaborative project from my group, the Bewley lab (NIDDK), and the Pierce lab (University of Maryland) describing our first foray into assessing Alphafold for predicting peptide-nanobody interactions (1/n) www.biorxiv.org/content/10.1...

Proud to share this work from my group in the intramural research program at NIH! We describe a new kind of conjugate made from a small molecule adenosine analog linked to a GPCR targeting nanobody to make antibody drug conjugates that potently and specifically activate signaling (1/n) 🧪 #chembio

Nanobody-based conjugates targeting small molecule-binding GPCRs and exhibiting logic-gated signaling https://www.biorxiv.org/content/10.1101/2025.03.07.642093v1

One good thing I saw today

Proud to share this publication about the development of a new method for visualizing tumors! This work resulted from a close collaboration among 3 groups. (1/n) 🧪@freddyeescorcia.bsky.social
advanced.onlinelibrary.wiley.com/doi/10.1002/...

Our NCATS research program has a history of collaborating and partnering to get treatments to patients. One of my first goals as SD was to capture and share our success in one place - and here it is!

4 approvals and 56 INDs to date - not bad for 12 years old!

ncats.nih.gov/research/our...

Overjoyed and honestly relieved to share a Chem Rev magnum opus from Brian Chen & Julia Li titled Synthetic Lipid Biology! In it, we organize efforts across numerous fields to create, manipulate, and analyze lipids and biomembranes. Check it out! doi.org/10.1021/acs.... #lipidtime #chemsky #chembio

🎄Xmas gift!🎁Joint work with #OliverHantschel in @naturecomms.bsky.social 💥! Huge kudos 💪🏼😻 Nina 👩‍🔬 for leading as 1st author & Frank 👨🏼‍🔬 for training her like a pro❤️
Small delay😅 -my👵broke her hip🤦🏼‍♀️-loved ones always come first❤️surgery went good💪🏼🤩Let's celebrate🥳🥂! #ChemBio
www.nature.com/articles/s41...

1/ In two back-to-back papers, we present our de novo TRACeR platform for targeting MHC-I and MHC-II antigens

TRACeR for MHC-I: go.nature.com/4gcLzn5
TRACeR for MHC-II: go.nature.com/4gj5OQk

A thought provoking scenario: what would happen if "mirror" (reverse chirality) microbe were created and released? The time estimate (10 years) seems long to me as there's been incredible progress in making mirror enzymes. You don't need much of a few mirror enzymes for a self sustaining cascade..🧪

Are you a senior PhD student or postdoc? Do you have a cool science story to tell? Do you want to visit Buffalo when the weather is perfect? Then apply for the Emerging Leaders Seminar Series at Roswell Park! DM or email me with questions. (RT please!)

www.roswellpark.org/education/pr...

#Chembio #Chemsky 🧪

Very nice work using nanobodies, sortagging, click chemistry, and multivalent conjugates--right up my alley! Congrats to the authors

www.cell.com/cell/fulltex...

Could one envision a synthetic receptor technology that is fully programmable, able to detect diverse extracellular antigens – both soluble and cell-attached – and convert that recognition into a wide range of intracellular responses, from gene expression and real-time fluorescence to modulation..