Raúl Cosentino
@raulcosentino.bsky.social
Reposted by Raúl Cosentino
Our new paper is out in Nature Communications! 🎉
We explore how Toxoplasma gondii organizes parasite development, combining cell biology and expansion microscopy to reveal new structural insights.
#Toxoplasma @meissnerlab.bsky.social @natcomms.nature.com
www.nature.com/articles/s41...
We explore how Toxoplasma gondii organizes parasite development, combining cell biology and expansion microscopy to reveal new structural insights.
#Toxoplasma @meissnerlab.bsky.social @natcomms.nature.com
www.nature.com/articles/s41...
November 28, 2025 at 11:41 AM
Our new paper is out in Nature Communications! 🎉
We explore how Toxoplasma gondii organizes parasite development, combining cell biology and expansion microscopy to reveal new structural insights.
#Toxoplasma @meissnerlab.bsky.social @natcomms.nature.com
www.nature.com/articles/s41...
We explore how Toxoplasma gondii organizes parasite development, combining cell biology and expansion microscopy to reveal new structural insights.
#Toxoplasma @meissnerlab.bsky.social @natcomms.nature.com
www.nature.com/articles/s41...
Reposted by Raúl Cosentino
What an absolute pleasure to work with Lena and Chahat! The application of our CRISPR screens to their custom splitGFP system allowed the identification of parasite proteins needed to tether host organelles. Host-pathogen interaction at its best! www.nature.com/articles/s41...
Toxoplasma effector TgROP1 establishes membrane contact sites with the endoplasmic reticulum during infection - Nature Microbiology
The Toxoplasma gondii effector TgROP1 mimics host factors to bind VAPA/B, thereby establishing parasite–host ER contact sites.
www.nature.com
November 25, 2025 at 6:49 PM
What an absolute pleasure to work with Lena and Chahat! The application of our CRISPR screens to their custom splitGFP system allowed the identification of parasite proteins needed to tether host organelles. Host-pathogen interaction at its best! www.nature.com/articles/s41...
Reposted by Raúl Cosentino
Exciting news!!
I’ve been awarded an #SNSFStartingGrant and will join the Institute of Parasitology, University of Zurich as an Assistant Professor in summer 2026.
A dream come true! 🥺
October 31, 2025 at 2:39 PM
Exciting news!!
I’ve been awarded an #SNSFStartingGrant and will join the Institute of Parasitology, University of Zurich as an Assistant Professor in summer 2026.
A dream come true! 🥺
Reposted by Raúl Cosentino
We have a 3+ year post doc available in our lab to study trypanosome transmission and virulence. Combined wet lab and bioinformatics expertise preferred. Please apply via the HR link (elxw.fa.em3.oraclecloud.com/hcmUI/Candid...). Find out more about us in the link below.
The Matthews Lab | Biology
The Matthews Lab
biology.ed.ac.uk
October 17, 2025 at 12:06 PM
We have a 3+ year post doc available in our lab to study trypanosome transmission and virulence. Combined wet lab and bioinformatics expertise preferred. Please apply via the HR link (elxw.fa.em3.oraclecloud.com/hcmUI/Candid...). Find out more about us in the link below.
Reposted by Raúl Cosentino
🔬 We are currently seeking a #Postdoc in #Gene #Regulation & #Chromatin #Metabolism (m/f/x) - Deadline: 31/05/2025!
➡️ More details about this job offer: job-portal.lmu.de/jobposting/0...
#Postdoc #AcademicJobs #LMUMunich #BiomedicalResearch #Hiring #LifeScienceJobs #Bioinformatics #US #research
➡️ More details about this job offer: job-portal.lmu.de/jobposting/0...
#Postdoc #AcademicJobs #LMUMunich #BiomedicalResearch #Hiring #LifeScienceJobs #Bioinformatics #US #research
May 27, 2025 at 9:17 AM
🔬 We are currently seeking a #Postdoc in #Gene #Regulation & #Chromatin #Metabolism (m/f/x) - Deadline: 31/05/2025!
➡️ More details about this job offer: job-portal.lmu.de/jobposting/0...
#Postdoc #AcademicJobs #LMUMunich #BiomedicalResearch #Hiring #LifeScienceJobs #Bioinformatics #US #research
➡️ More details about this job offer: job-portal.lmu.de/jobposting/0...
#Postdoc #AcademicJobs #LMUMunich #BiomedicalResearch #Hiring #LifeScienceJobs #Bioinformatics #US #research
Reposted by Raúl Cosentino
Specialised RNA decay fine-tunes monogenic antigen expression in African trypanosomes https://www.biorxiv.org/content/10.1101/2025.05.24.654301v1
May 26, 2025 at 5:17 AM
Specialised RNA decay fine-tunes monogenic antigen expression in African trypanosomes https://www.biorxiv.org/content/10.1101/2025.05.24.654301v1
Reposted by Raúl Cosentino
Exploring the chromatin proteome of Trypanosoma brucei repetitive elements (telomeres, centromeres, 70bp repeats, 177bp repeats) using TALEs. Another great collaboration with @allshire-lab.bsky.social
www.biorxiv.org/cgi/content/...
www.biorxiv.org/cgi/content/...
Defining the chromatin-associated protein landscapes on Trypanosoma brucei repetitive elements using synthetic TALE proteins
Kinetoplastids, such as Trypansoma brucei, are eukaryotes that likely separated from the main lineage at an exceptionally early point in evolution. Consequently, many aspects of kinetoplastid biology ...
www.biorxiv.org
April 24, 2025 at 8:30 AM
Exploring the chromatin proteome of Trypanosoma brucei repetitive elements (telomeres, centromeres, 70bp repeats, 177bp repeats) using TALEs. Another great collaboration with @allshire-lab.bsky.social
www.biorxiv.org/cgi/content/...
www.biorxiv.org/cgi/content/...
Reposted by Raúl Cosentino
🎉 Finally online 🎉 GRA12, the first identified common virulence factor across Toxoplasma strains and murine subspecies! Check this improved manuscript after reviewers’ helpful suggestions www.nature.com/articles/s41...
GRA12 is a common virulence factor across Toxoplasma gondii strains and mouse subspecies - Nature Communications
CRISPR screens reveal Toxoplasma’s GRA12 as a strain- and mouse species-transcendent virulence factor. GRA12 protects parasites from IFNγ-activated macrophage clearance and parasitophorous vacuole col...
www.nature.com
April 16, 2025 at 9:57 AM
🎉 Finally online 🎉 GRA12, the first identified common virulence factor across Toxoplasma strains and murine subspecies! Check this improved manuscript after reviewers’ helpful suggestions www.nature.com/articles/s41...
Reposted by Raúl Cosentino
Thrilled to share my first paper, now out in
@natmicrobiol.nature.com! Huge thanks to my amazing supervisor @hakimi.bsky.social and everyone who contributed to this work!
www.nature.com/articles/s41...
@natmicrobiol.nature.com! Huge thanks to my amazing supervisor @hakimi.bsky.social and everyone who contributed to this work!
www.nature.com/articles/s41...
An ISWI-related chromatin remodeller regulates stage-specific gene expression in Toxoplasma gondii - Nature Microbiology
Toxoplasma gondii evolved two ISWI remodellers, TgSNF2h and TgSNF2L. TgSNF2h forms a complex that insulates active genes, regulates MORC-driven sexual commitment and ensures precise gene expression, s...
www.nature.com
April 13, 2025 at 11:03 AM
Thrilled to share my first paper, now out in
@natmicrobiol.nature.com! Huge thanks to my amazing supervisor @hakimi.bsky.social and everyone who contributed to this work!
www.nature.com/articles/s41...
@natmicrobiol.nature.com! Huge thanks to my amazing supervisor @hakimi.bsky.social and everyone who contributed to this work!
www.nature.com/articles/s41...
Reposted by Raúl Cosentino
Delighted to have been part of this great work driven by @marketanovotna.bsky.social in the Horn lab, showing the power of precision editing to study the direct role of histone modifications on gene expression regulation! Check it out!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Precision-edited histone tails disrupt polycistronic gene expression controls in trypanosomes
Transcription of protein coding genes in trypanosomatids is atypical and almost exclusively polycistronic. In Trypanosoma brucei, approximately 150 polycistrons, and 8000 genes, are constitutively tra...
www.biorxiv.org
March 24, 2025 at 8:35 AM
Delighted to have been part of this great work driven by @marketanovotna.bsky.social in the Horn lab, showing the power of precision editing to study the direct role of histone modifications on gene expression regulation! Check it out!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Our paper sheding light on the antigenic selection mechanism in Trypanosoma brucei is out! 🥳
Check it out!🤓
Check it out!🤓
If you are interested in antigenic variation, you may have wondered how parasites ‘select’ which antigen to express next.
Our manuscript, just published in Nature, provides some answers!
www.nature.com/articles/s41...
@lmumuenchen.bsky.social
@erc.europa.eu a.eu
@nature.com
Our manuscript, just published in Nature, provides some answers!
www.nature.com/articles/s41...
@lmumuenchen.bsky.social
@erc.europa.eu a.eu
@nature.com
March 12, 2025 at 6:14 PM
Our paper sheding light on the antigenic selection mechanism in Trypanosoma brucei is out! 🥳
Check it out!🤓
Check it out!🤓