Jake
@rannmann.bsky.social
Caregiver, Software engineer, Hiker, Photographer, Dog dad. Always on the lookout for ways to help my spouse recover from ME/CFS.
Pacific Northwest.
Pacific Northwest.
Pinned
Jake
@rannmann.bsky.social
· Apr 26
📌 Here's a three-tiered list of treatments for MCAS. Personalize with your doctor.
1️⃣ Tier 1 #MCAS Treatments: OTC low-risk
* H1 blockers (e.g., Fexofenadine)
* H2 blockers (e.g., Famotidine)
* Quercetin
* DAO
* Vitamin C
* Magnesium glycinate
#ME/CFS #LongCovid
1️⃣ Tier 1 #MCAS Treatments: OTC low-risk
* H1 blockers (e.g., Fexofenadine)
* H2 blockers (e.g., Famotidine)
* Quercetin
* DAO
* Vitamin C
* Magnesium glycinate
#ME/CFS #LongCovid
Reposted by Jake
From a new @thelancet.com article today entitled "Health care in the USA: money has become the mission" www.thelancet.com/journals/lan...
October 21, 2025 at 10:49 PM
From a new @thelancet.com article today entitled "Health care in the USA: money has become the mission" www.thelancet.com/journals/lan...
@batemanhornecenter.bsky.social Is the BioMapAI protocol something that providers outside of the BHC can run?
July 28, 2025 at 6:00 PM
@batemanhornecenter.bsky.social Is the BioMapAI protocol something that providers outside of the BHC can run?
Are any #ME/CFS doctors out there recommending #Butyrate to patients? A mast-cell stabilizer + immune regulator + anti-inflammatory combo, while studies show many ME patients have low gut butyrate levels, it *sounds* promising but I see no studies or data on PEM. Any side effects?
#MedSky
#MedSky
July 8, 2025 at 7:18 PM
"There are studies showing berberine also blocks mast cells; it is an antioxidant, antifungal, antibacterial, and it's as good as #Ozempic at stimulating #GLP-1. If anyone wants Ozempic, just take 1g/day of berberine and you'll do better."
A big claim from *the* expert on #MCAS (MCAD) 👀
A big claim from *the* expert on #MCAS (MCAD) 👀
Mast Cells: Friend or Foe? with Dr. Theoharis Theoharides (Ep 151)
In this episode, Dr. Pradeep Chopra co-hosts a revealing conversation with Dr. Theoharis Theoharides, the scientist who first discovered that mast cells communicate with microglia in the brain.
www.bendybodiespodcast.com
June 28, 2025 at 6:10 PM
🚨 A mechanical cause for #ME/CFS symptoms may be hiding in plain sight: Thoracic Outlet Syndrome (TOS).
New findings suggest many patients have compressed nerves/blood vessels between their neck and shoulder—potentially explaining fatigue, #brainfog, and autonomic dysfunction.
#MedSky 1/3
New findings suggest many patients have compressed nerves/blood vessels between their neck and shoulder—potentially explaining fatigue, #brainfog, and autonomic dysfunction.
#MedSky 1/3
Thoracic Outlet Syndrome (TOS) Commonly Found in ME/CFS and Chronic Fatigue - Health Rising
Thoracic outlet syndrome could be contributing to the symptoms in a considerable number of people with ME/CFS and similar diseases.
www.healthrising.org
June 3, 2025 at 6:22 PM
Reposted by Jake
How do you fight for visibility when you’re too sick to leave your bed?
This May, individuals around the world used their limited energy to share powerful messages, completing the sentence “ME/CFS is…”
Explore community voices on our website: www.omf.ngo/community-vo...
This May, individuals around the world used their limited energy to share powerful messages, completing the sentence “ME/CFS is…”
Explore community voices on our website: www.omf.ngo/community-vo...
Community Voices - “ME/CFS Is..” - Open Medicine Foundation
For ME/CFS Awareness Day, individuals shared powerful messages about the reality of living with ME/CFS. Explore the gallery of voices and help raise awareness.
www.omf.ngo
May 12, 2025 at 4:19 PM
How do you fight for visibility when you’re too sick to leave your bed?
This May, individuals around the world used their limited energy to share powerful messages, completing the sentence “ME/CFS is…”
Explore community voices on our website: www.omf.ngo/community-vo...
This May, individuals around the world used their limited energy to share powerful messages, completing the sentence “ME/CFS is…”
Explore community voices on our website: www.omf.ngo/community-vo...
Reposted by Jake
New PLRC-funded work out from Rob Wust & team!
Skeletal muscles in #LongCovid and ME *differ* from skeletal muscles induced by bedrest.
LC and ME is not deconditioning! 1/
www.medrxiv.org/content/10.1...
Skeletal muscles in #LongCovid and ME *differ* from skeletal muscles induced by bedrest.
LC and ME is not deconditioning! 1/
www.medrxiv.org/content/10.1...
Skeletal muscle properties in long COVID and ME/CFS differ from those induced by bed rest
Patients with long COVID and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) suffer from a reduced exercise capacity, skeletal muscle abnormalities and post-exertional malaise (PEM), where...
www.medrxiv.org
May 7, 2025 at 2:46 AM
New PLRC-funded work out from Rob Wust & team!
Skeletal muscles in #LongCovid and ME *differ* from skeletal muscles induced by bedrest.
LC and ME is not deconditioning! 1/
www.medrxiv.org/content/10.1...
Skeletal muscles in #LongCovid and ME *differ* from skeletal muscles induced by bedrest.
LC and ME is not deconditioning! 1/
www.medrxiv.org/content/10.1...
The #ME/CFS Clinician Coalition's document on testing was written in 2021. With all the #LongCovid research, our understanding of the illness feels like it's updating daily. Is anyone working on an updated test list? What would you add/remove?
@ruhoy.bsky.social @kaufmanmd.bsky.social
@ruhoy.bsky.social @kaufmanmd.bsky.social
mecfscliniciancoalition.org
May 7, 2025 at 3:53 AM
The #ME/CFS Clinician Coalition's document on testing was written in 2021. With all the #LongCovid research, our understanding of the illness feels like it's updating daily. Is anyone working on an updated test list? What would you add/remove?
@ruhoy.bsky.social @kaufmanmd.bsky.social
@ruhoy.bsky.social @kaufmanmd.bsky.social
Reposted by Jake
✨Please share! My newsletter is out.
In this issue:
🧫COVID and Mast Cells
🛌Long COVID POTS and P-synuclein deposits in skin
🫁COVID, H5N1, Measles, Pertussis updates
🤰Preeclampsia protein signature seen for decades
🦠Gut and nasal microbiomes
and much more buff.ly/qzUjKeW
#medsky 🛟😷🧪 🧠📈
In this issue:
🧫COVID and Mast Cells
🛌Long COVID POTS and P-synuclein deposits in skin
🫁COVID, H5N1, Measles, Pertussis updates
🤰Preeclampsia protein signature seen for decades
🦠Gut and nasal microbiomes
and much more buff.ly/qzUjKeW
#medsky 🛟😷🧪 🧠📈
COVID & Health News, 5/4/25
Acute respiratory illness levels are now LOW across America.
buff.ly
May 5, 2025 at 5:57 AM
✨Please share! My newsletter is out.
In this issue:
🧫COVID and Mast Cells
🛌Long COVID POTS and P-synuclein deposits in skin
🫁COVID, H5N1, Measles, Pertussis updates
🤰Preeclampsia protein signature seen for decades
🦠Gut and nasal microbiomes
and much more buff.ly/qzUjKeW
#medsky 🛟😷🧪 🧠📈
In this issue:
🧫COVID and Mast Cells
🛌Long COVID POTS and P-synuclein deposits in skin
🫁COVID, H5N1, Measles, Pertussis updates
🤰Preeclampsia protein signature seen for decades
🦠Gut and nasal microbiomes
and much more buff.ly/qzUjKeW
#medsky 🛟😷🧪 🧠📈
📌 Here's a three-tiered list of treatments for MCAS. Personalize with your doctor.
1️⃣ Tier 1 #MCAS Treatments: OTC low-risk
* H1 blockers (e.g., Fexofenadine)
* H2 blockers (e.g., Famotidine)
* Quercetin
* DAO
* Vitamin C
* Magnesium glycinate
#ME/CFS #LongCovid
1️⃣ Tier 1 #MCAS Treatments: OTC low-risk
* H1 blockers (e.g., Fexofenadine)
* H2 blockers (e.g., Famotidine)
* Quercetin
* DAO
* Vitamin C
* Magnesium glycinate
#ME/CFS #LongCovid
April 26, 2025 at 4:17 PM
📌 Here's a three-tiered list of treatments for MCAS. Personalize with your doctor.
1️⃣ Tier 1 #MCAS Treatments: OTC low-risk
* H1 blockers (e.g., Fexofenadine)
* H2 blockers (e.g., Famotidine)
* Quercetin
* DAO
* Vitamin C
* Magnesium glycinate
#ME/CFS #LongCovid
1️⃣ Tier 1 #MCAS Treatments: OTC low-risk
* H1 blockers (e.g., Fexofenadine)
* H2 blockers (e.g., Famotidine)
* Quercetin
* DAO
* Vitamin C
* Magnesium glycinate
#ME/CFS #LongCovid
📌 New studies in the #ScienceOfAging suggest biological clocks and AI could predict disease onset. Proteomic clocks, epigenetic tests, and blood tests aim to estimate risk for Alzheimer's, cancer, and heart disease, guiding proactive health changes.
#MedSky #ChronicIllness
#MedSky #ChronicIllness
April 26, 2025 at 12:01 AM
📌 New studies in the #ScienceOfAging suggest biological clocks and AI could predict disease onset. Proteomic clocks, epigenetic tests, and blood tests aim to estimate risk for Alzheimer's, cancer, and heart disease, guiding proactive health changes.
#MedSky #ChronicIllness
#MedSky #ChronicIllness
📌 Viruses play a significant role in #LongCovid and #ME/CFS, with reactivation impacting these conditions. Drs. Ruhoy & Kaufman discuss antivirals like Valtrex & Valcyte, while highlighting immune modulation options like thymosin alpha-1 and LDN.
#ChronicIllness #HealthResearch #Peptides
#ChronicIllness #HealthResearch #Peptides
Viruses: Why Do They Matter
Our conversation focuses on all things viral including especially reactivated herpes family viruses, Covid, and the role of viral activity in complex illness.
www.youtube.com
April 25, 2025 at 11:46 PM
📌 Viruses play a significant role in #LongCovid and #ME/CFS, with reactivation impacting these conditions. Drs. Ruhoy & Kaufman discuss antivirals like Valtrex & Valcyte, while highlighting immune modulation options like thymosin alpha-1 and LDN.
#ChronicIllness #HealthResearch #Peptides
#ChronicIllness #HealthResearch #Peptides
Reposted by Jake
🩺 "At last! A program where I can put what I learn into practice with my patients!" MERC is transforming #MECFS care with expert-led training & real-world tools.
❗May 9: Clinical Care Guide launches!
💙 Support MERC: ow.ly/ooPI50VHMhy
@batemanhornecenter.bsky.social #pwME #LongCOVID
❗May 9: Clinical Care Guide launches!
💙 Support MERC: ow.ly/ooPI50VHMhy
@batemanhornecenter.bsky.social #pwME #LongCOVID
April 25, 2025 at 2:15 PM
🩺 "At last! A program where I can put what I learn into practice with my patients!" MERC is transforming #MECFS care with expert-led training & real-world tools.
❗May 9: Clinical Care Guide launches!
💙 Support MERC: ow.ly/ooPI50VHMhy
@batemanhornecenter.bsky.social #pwME #LongCOVID
❗May 9: Clinical Care Guide launches!
💙 Support MERC: ow.ly/ooPI50VHMhy
@batemanhornecenter.bsky.social #pwME #LongCOVID
Reposted by Jake
I've heard: "if I didn't eat JUST right, I felt awful", "I needed to keep to my exercise regimen or I felt physically & emotionally awful", etc. etc.
If you NEED to take care of your health to this degree or you tip over into feeling frankly sick, you have a chronic illness at the tipping point.
If you NEED to take care of your health to this degree or you tip over into feeling frankly sick, you have a chronic illness at the tipping point.
April 25, 2025 at 1:46 PM
I've heard: "if I didn't eat JUST right, I felt awful", "I needed to keep to my exercise regimen or I felt physically & emotionally awful", etc. etc.
If you NEED to take care of your health to this degree or you tip over into feeling frankly sick, you have a chronic illness at the tipping point.
If you NEED to take care of your health to this degree or you tip over into feeling frankly sick, you have a chronic illness at the tipping point.
The NASA Lean Test can help identify #POTS at home, offering a first step toward understanding symptoms like dizziness and palpitations. As a common comorbidity, it provides valuable information for discussions with #ME/CFS healthcare providers.
All you need is a blood pressure monitor!
All you need is a blood pressure monitor!
NASA 10 Minute Lean Test | Instructions
Bateman Horne Center
batemanhornecenter.org
April 25, 2025 at 6:55 PM
Reposted by Jake
Urgent Appeal to Preserve & Strengthen the CDC’s ME/CFS Program
solvecfs.quorum.us/campaign/120...
#MyalgicEncephalomyelitis #ChronicFatigueSyndrome
solvecfs.quorum.us/campaign/120...
#MyalgicEncephalomyelitis #ChronicFatigueSyndrome
April 25, 2025 at 12:07 AM
Urgent Appeal to Preserve & Strengthen the CDC’s ME/CFS Program
solvecfs.quorum.us/campaign/120...
#MyalgicEncephalomyelitis #ChronicFatigueSyndrome
solvecfs.quorum.us/campaign/120...
#MyalgicEncephalomyelitis #ChronicFatigueSyndrome
New global clinical trial explores anti-inflammatory drugs for #LongCovid treatment. Led by Western & SILC, it tests upadacitinib & pirfenidone to reduce symptoms. Spanning 7 countries with 348 participants, it aims for faster relief.
🔍 ClinicalTrials.gov NCT06928272
#ME/CFS #HealthResearch
🔍 ClinicalTrials.gov NCT06928272
#ME/CFS #HealthResearch
Global clinical trial to test existing drugs as long COVID treatments
Western and Schmidt Initiative for Long Covid will test two existing drugs as treatments for long COVID in a clinical trial with patients worldwide.
news.westernu.ca
April 24, 2025 at 7:59 PM
New global clinical trial explores anti-inflammatory drugs for #LongCovid treatment. Led by Western & SILC, it tests upadacitinib & pirfenidone to reduce symptoms. Spanning 7 countries with 348 participants, it aims for faster relief.
🔍 ClinicalTrials.gov NCT06928272
#ME/CFS #HealthResearch
🔍 ClinicalTrials.gov NCT06928272
#ME/CFS #HealthResearch
Surgical intervention in #ME/CFS and #LongCovid: Cranio-cervical fusion may be a viable option for those with #CCI, a condition linked to connective tissue disorders like #EDS. Though controversial, some patients experience significant symptom relief.
At-Home Trial: Over-the-door traction?
At-Home Trial: Over-the-door traction?
This surgery fuses people’s skulls to their spines to treat a condition overlapping with myalgic encephalomyelitis - The Sick Times
A growing number of doctors agree that a minority of people with severe ME are like Brea: Some of their symptoms are caused by cranio-cervical instability linked to connective tissue disorders. Viruse...
thesicktimes.org
April 24, 2025 at 5:09 PM
Surgical intervention in #ME/CFS and #LongCovid: Cranio-cervical fusion may be a viable option for those with #CCI, a condition linked to connective tissue disorders like #EDS. Though controversial, some patients experience significant symptom relief.
At-Home Trial: Over-the-door traction?
At-Home Trial: Over-the-door traction?
📌 Recent study reveals SARS-CoV-2 can persist in semen, possibly impacting #LongCovid research. In 55% of male COVID-19 patients, viral RNA was detected up to 8 months after infection, especially in moderate cases (91%). More research needed on its reproductive implications.
#ME/CFS #HealthResearch
#ME/CFS #HealthResearch
PD06-09 SARS-COV-2 PERSISTENCE IN SEMEN AS A WINDOW TO STUDY LONG COVID
www.auajournals.org
April 24, 2025 at 5:02 PM
📌 Recent study reveals SARS-CoV-2 can persist in semen, possibly impacting #LongCovid research. In 55% of male COVID-19 patients, viral RNA was detected up to 8 months after infection, especially in moderate cases (91%). More research needed on its reproductive implications.
#ME/CFS #HealthResearch
#ME/CFS #HealthResearch
📌 #LongCovid's economic burden could soar up to $31 billion, lasting 1–3 years per case, due to medical costs and productivity losses. With rising cases, the financial impact on employers, insurers, and healthcare will likely grow. 🔬
#ME/CFS #HealthResearch #ChronicIllness
#ME/CFS #HealthResearch #ChronicIllness
Significant economic burden of long COVID will only continue to grow, experts say
The economic burden of long COVID may exceed $2 billion and reach nearly $31 billion when symptoms last between 1 and 3 years, and researchers say these numbers will likely continue to grow as COVID-1...
www.healio.com
April 22, 2025 at 7:53 PM
📌 #LongCovid's economic burden could soar up to $31 billion, lasting 1–3 years per case, due to medical costs and productivity losses. With rising cases, the financial impact on employers, insurers, and healthcare will likely grow. 🔬
#ME/CFS #HealthResearch #ChronicIllness
#ME/CFS #HealthResearch #ChronicIllness
(1/2) 📌 Small fiber neuropathy (#SFN) in #LongCovid and #ME/CFS is tightly linked to #dysautonomia, with symptoms like numbness, tingling, altered sweat, and digestive issues. Diagnosis via skin biopsy has limits. 🔬 #ChronicIllness
🔗
🔗
Small Fiber Neuropathy
We have a conversation about this quite common and very painful neurologic condition so often found in our patients with Complex Illness. --- ## Small Fiber Neuropathy (SFN) in Chronic and Complex Illness: Podcast Summary ### What is Small Fiber Neuropathy? - SFN is a condition affecting small nerve fibers, leading to symptoms like burning pain, tingling, numbness, and autonomic dysfunction (e.g., sweating problems, GI symptoms, dry eyes/mouth, and more). - It’s common in chronic illnesses such as ME/CFS, long COVID, and was also seen in HIV. ### Diagnosis - **Symptoms:** Numbness, tingling, burning, electric shock-like pain, crawling sensations, and various autonomic issues. - **Testing:** Standard nerve tests (EMG/NCS) are usually normal. Skin biopsy is the main diagnostic test but can miss cases due to sampling error. Diagnosis is often clinical. - **Associated conditions:** Autoimmune diseases, diabetes, vitamin deficiencies, medication side effects, amyloidosis. ### Why Test? - Skin biopsy is...
www.youtube.com
April 21, 2025 at 8:46 PM
(1/2) 📌 Small fiber neuropathy (#SFN) in #LongCovid and #ME/CFS is tightly linked to #dysautonomia, with symptoms like numbness, tingling, altered sweat, and digestive issues. Diagnosis via skin biopsy has limits. 🔬 #ChronicIllness
🔗
🔗
Reposted by Jake
✨Please share! My newsletter is out.
In this issue:
🚗Mild COVID infection increases car accidents 25%
🧒Kids higher risk of CV (heart) and kidney disease after COVID
🫀HRV and VT1 for Long COVID pacing
🔴Measles: 800 cases, 11% hosp., 3 deaths, so far
& much more buff.ly/RGDj1ct
#medsky #pedsky 🛟😷🧪
In this issue:
🚗Mild COVID infection increases car accidents 25%
🧒Kids higher risk of CV (heart) and kidney disease after COVID
🫀HRV and VT1 for Long COVID pacing
🔴Measles: 800 cases, 11% hosp., 3 deaths, so far
& much more buff.ly/RGDj1ct
#medsky #pedsky 🛟😷🧪
COVID & Health News, 4/19/25
The CDC reports that respiratory illnesses are decreasing overall, with the exception of Pertussis (Whooping Cough) which continues to be elevated nationally.
buff.ly
April 20, 2025 at 5:30 AM
✨Please share! My newsletter is out.
In this issue:
🚗Mild COVID infection increases car accidents 25%
🧒Kids higher risk of CV (heart) and kidney disease after COVID
🫀HRV and VT1 for Long COVID pacing
🔴Measles: 800 cases, 11% hosp., 3 deaths, so far
& much more buff.ly/RGDj1ct
#medsky #pedsky 🛟😷🧪
In this issue:
🚗Mild COVID infection increases car accidents 25%
🧒Kids higher risk of CV (heart) and kidney disease after COVID
🫀HRV and VT1 for Long COVID pacing
🔴Measles: 800 cases, 11% hosp., 3 deaths, so far
& much more buff.ly/RGDj1ct
#medsky #pedsky 🛟😷🧪
Reposted by Jake
"Approximately 5%of annual cancer diagnoses or
100,000 cancers were projected to result from [U.S.] CT utilization in 2023.
"https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2832778
100,000 cancers were projected to result from [U.S.] CT utilization in 2023.
"https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2832778
April 14, 2025 at 3:07 PM
"Approximately 5%of annual cancer diagnoses or
100,000 cancers were projected to result from [U.S.] CT utilization in 2023.
"https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2832778
100,000 cancers were projected to result from [U.S.] CT utilization in 2023.
"https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2832778
📌 Up to 80% of people with #LongCovid or #ME/CFS may have undiagnosed mast cell activation syndrome ( #MCAS )—and it often starts long before they get sick. 🧬
#ChronicIllness
🔗 www.youtube.com/watch?v=nisu...
#ChronicIllness
🔗 www.youtube.com/watch?v=nisu...
Mast Cell Activation Syndrome--A Deeper Dive
YouTube video by Unraveled: Understanding Complex Illness
www.youtube.com
April 14, 2025 at 5:05 PM
📌 Up to 80% of people with #LongCovid or #ME/CFS may have undiagnosed mast cell activation syndrome ( #MCAS )—and it often starts long before they get sick. 🧬
#ChronicIllness
🔗 www.youtube.com/watch?v=nisu...
#ChronicIllness
🔗 www.youtube.com/watch?v=nisu...
Reposted by Jake
✨Please share! My Health Newsletter is out.
In this issue
🧠Mild COVID causes changes in kids' brains
💊15 days Paxlovid did not help Long COVID
🔴Measles updates
🧒CDC has no team to help MN schools w/LEAD poisoning
🫘Mitochondria can move between cells
& much more buff.ly/uLSYRz4
#medsky #Pedsky 🛟😷🧪
In this issue
🧠Mild COVID causes changes in kids' brains
💊15 days Paxlovid did not help Long COVID
🔴Measles updates
🧒CDC has no team to help MN schools w/LEAD poisoning
🫘Mitochondria can move between cells
& much more buff.ly/uLSYRz4
#medsky #Pedsky 🛟😷🧪
Health news, COVID & more, 4/13/25
The CDC reports low levels of respiratory illness overall with COVID, RSV, and flu trending downward nationally.
buff.ly
April 14, 2025 at 5:42 AM
✨Please share! My Health Newsletter is out.
In this issue
🧠Mild COVID causes changes in kids' brains
💊15 days Paxlovid did not help Long COVID
🔴Measles updates
🧒CDC has no team to help MN schools w/LEAD poisoning
🫘Mitochondria can move between cells
& much more buff.ly/uLSYRz4
#medsky #Pedsky 🛟😷🧪
In this issue
🧠Mild COVID causes changes in kids' brains
💊15 days Paxlovid did not help Long COVID
🔴Measles updates
🧒CDC has no team to help MN schools w/LEAD poisoning
🫘Mitochondria can move between cells
& much more buff.ly/uLSYRz4
#medsky #Pedsky 🛟😷🧪