Patrick Zanon
@pzanon.bsky.social
Exploring and expanding non-conventional druggable space
NEOsphere Biotech. Previously Hacker & Disney labs
NEOsphere Biotech. Previously Hacker & Disney labs
Reposted by Patrick Zanon
This project started 5 years ago. It led us to add isotope-labeling support to #FragPipe/#IonQuant. Since then, the tools have grown so much and are now widely used in #Chemoproteomics.
Huge thanks to everyone, and special thanks to @stephanhacker2.bsky.social and @pzanon.bsky.social
Huge thanks to everyone, and special thanks to @stephanhacker2.bsky.social and @pzanon.bsky.social
How can we study target engagement and selectivity of covalent inhibitors? Which electrophilic probes are best suited to study a certain amino acid?
Our study on "Profiling the proteome-wide selectivity of diverse electrophiles" is published in Nature Chemistry.(1/7)
www.nature.com/articles/s41...
Our study on "Profiling the proteome-wide selectivity of diverse electrophiles" is published in Nature Chemistry.(1/7)
www.nature.com/articles/s41...
Profiling the proteome-wide selectivity of diverse electrophiles - Nature Chemistry
Covalent inhibitors are powerful entities in drug discovery. Now the amino acid selectivity and reactivity of a diverse electrophile library have been assessed proteome-wide using an unbiased workflow...
www.nature.com
October 30, 2025 at 2:15 PM
This project started 5 years ago. It led us to add isotope-labeling support to #FragPipe/#IonQuant. Since then, the tools have grown so much and are now widely used in #Chemoproteomics.
Huge thanks to everyone, and special thanks to @stephanhacker2.bsky.social and @pzanon.bsky.social
Huge thanks to everyone, and special thanks to @stephanhacker2.bsky.social and @pzanon.bsky.social
I am thrilled to see the paper out now and grateful to all coauthors for their contributions to this work!
Among a number of changes, we included additional probes as well as experiments in live bacterial cells. So be sure to check it out even if you are already familiar with the preprint!
Among a number of changes, we included additional probes as well as experiments in live bacterial cells. So be sure to check it out even if you are already familiar with the preprint!
How can we study target engagement and selectivity of covalent inhibitors? Which electrophilic probes are best suited to study a certain amino acid?
Our study on "Profiling the proteome-wide selectivity of diverse electrophiles" is published in Nature Chemistry.(1/7)
www.nature.com/articles/s41...
Our study on "Profiling the proteome-wide selectivity of diverse electrophiles" is published in Nature Chemistry.(1/7)
www.nature.com/articles/s41...
Profiling the proteome-wide selectivity of diverse electrophiles - Nature Chemistry
Covalent inhibitors are powerful entities in drug discovery. Now the amino acid selectivity and reactivity of a diverse electrophile library have been assessed proteome-wide using an unbiased workflow...
www.nature.com
October 31, 2025 at 4:38 PM
I am thrilled to see the paper out now and grateful to all coauthors for their contributions to this work!
Among a number of changes, we included additional probes as well as experiments in live bacterial cells. So be sure to check it out even if you are already familiar with the preprint!
Among a number of changes, we included additional probes as well as experiments in live bacterial cells. So be sure to check it out even if you are already familiar with the preprint!
Reposted by Patrick Zanon
New powerful article up in the New York Times on cancelled and delayed grants
www.nytimes.com/interactive/...
www.nytimes.com/interactive/...
Here Are the Nearly 2,500 Medical Research Grants Canceled or Delayed by Trump (Gift Article)
Some cuts have been starkly visible, but the country’s medical grant-making machinery has also radically transformed outside the public eye.
www.nytimes.com
June 4, 2025 at 3:01 PM
New powerful article up in the New York Times on cancelled and delayed grants
www.nytimes.com/interactive/...
www.nytimes.com/interactive/...
Reposted by Patrick Zanon
We are looking for a PhD candidate in medicinal / organic chemistry with a passion for drug discovery to join our young and enthusiastic team @univie.ac.at. For details, visit: jobs.univie.ac.at/job/Universi.... Reposts are very much appreciated!
May 14, 2025 at 5:01 PM
We are looking for a PhD candidate in medicinal / organic chemistry with a passion for drug discovery to join our young and enthusiastic team @univie.ac.at. For details, visit: jobs.univie.ac.at/job/Universi.... Reposts are very much appreciated!