Plasmid Society
@plasmidsociety.bsky.social
Reposted by Plasmid Society
We've come full circle! I began my postdoctoral career by identifying the peptidyl deformylase gene. Today, we show that half of bacterial species harbor multiple PDF genes (up to 7, for always a single Met-tRNA transformylase), and while the role of these PDFs ... academic.oup.com/mbe/article/...
Unraveling the Prevalence and Multifaceted Roles of Accessory Peptide Deformylases in Bacterial Adaptation and Resistance
Abstract. Peptide deformylases (PDFs) are enzymes that are essential for bacterial viability and attractive targets for antibiotic development. Yet, despit
academic.oup.com
December 12, 2025 at 8:57 AM
We've come full circle! I began my postdoctoral career by identifying the peptidyl deformylase gene. Today, we show that half of bacterial species harbor multiple PDF genes (up to 7, for always a single Met-tRNA transformylase), and while the role of these PDFs ... academic.oup.com/mbe/article/...
Reposted by Plasmid Society
Conjugative plasmids help spread AMR genes. @andrewmatthews.bsky.social @sonjalehtinen.bsky.social & @tatianadimitriu.bsky.social show that #AMR loss in evolving populations involves streamlined #plasmids that gain a transmission advantage by deleting AMR genes @plosbiology.org 🧪 plos.io/48NM0BL
December 12, 2025 at 1:55 PM
Conjugative plasmids help spread AMR genes. @andrewmatthews.bsky.social @sonjalehtinen.bsky.social & @tatianadimitriu.bsky.social show that #AMR loss in evolving populations involves streamlined #plasmids that gain a transmission advantage by deleting AMR genes @plosbiology.org 🧪 plos.io/48NM0BL
Reposted by Plasmid Society
Our story on plasmid streamlining is now published in PLoS Biology! With @andrewmatthews.bsky.social and @sonjalehtinen.bsky.social
#MicroSky #Mevosky
journals.plos.org/plosbiology/...
#MicroSky #Mevosky
journals.plos.org/plosbiology/...
Plasmid streamlining drives the extinction of antibiotic resistance plasmids under selection for horizontal transmission
Conjugative plasmids play an important role in the spread of antimicrobial resistance (AMR) genes among pathogenic bacteria. This study shows that AMR loss in evolving populations is associated with t...
journals.plos.org
December 12, 2025 at 12:09 PM
Our story on plasmid streamlining is now published in PLoS Biology! With @andrewmatthews.bsky.social and @sonjalehtinen.bsky.social
#MicroSky #Mevosky
journals.plos.org/plosbiology/...
#MicroSky #Mevosky
journals.plos.org/plosbiology/...
🐓 Bacteria trade resistance genes in the chicken gut, but the host may influence this exchange.
Small RNAs from chicken tissue modulate plasmid transfer between E. coli. 🧬
#Plasmid #Conjugation #miRNA
doi.org/10.1038/s442...
Small RNAs from chicken tissue modulate plasmid transfer between E. coli. 🧬
#Plasmid #Conjugation #miRNA
doi.org/10.1038/s442...
Host genetics regulate bacterial plasmid conjugation differentially in avian ceca explant co-culture through secretory miRNA - npj Antimicrobials and Resistance
npj Antimicrobials and Resistance - Host genetics regulate bacterial plasmid conjugation differentially in avian ceca explant co-culture through secretory miRNA
doi.org
December 8, 2025 at 9:34 AM
🐓 Bacteria trade resistance genes in the chicken gut, but the host may influence this exchange.
Small RNAs from chicken tissue modulate plasmid transfer between E. coli. 🧬
#Plasmid #Conjugation #miRNA
doi.org/10.1038/s442...
Small RNAs from chicken tissue modulate plasmid transfer between E. coli. 🧬
#Plasmid #Conjugation #miRNA
doi.org/10.1038/s442...
Reposted by Plasmid Society
New online: Structure and activation mechanism of a Lamassu phage and plasmid defense system
Structure and activation mechanism of a Lamassu phage and plasmid defense system
Nature Structural & Molecular Biology, Published online: 14 October 2025; doi:10.1038/s41594-025-01677-4Li et al. show that a Lamassu defense system protects bacteria from phage infection by activating a lethal tetrameric DNA-cutting enzyme. In the absence of phages, a protein clamp holds the enzyme as an inactive monomer, preventing self-damage.
go.nature.com
October 14, 2025 at 11:15 AM
New online: Structure and activation mechanism of a Lamassu phage and plasmid defense system
Reposted by Plasmid Society
Podcast with me and @turiking.bsky.social for the @milnerevolution.bsky.social series, on plasmid evolution over the last 100 years, talking about our ( @cazares-adr.bsky.social , Nick Thomson, @sarah1alexander.bsky.social & co) recent paper www.science.org/doi/10.1126/...
youtu.be/Mzr3TD4ijs0?...
youtu.be/Mzr3TD4ijs0?...
How the Vectors of Antibiotic Resistance Have Evolved - Professor Zamin Iqbal
YouTube video by Milner Centre for Evolution
youtu.be
October 17, 2025 at 11:48 AM
Podcast with me and @turiking.bsky.social for the @milnerevolution.bsky.social series, on plasmid evolution over the last 100 years, talking about our ( @cazares-adr.bsky.social , Nick Thomson, @sarah1alexander.bsky.social & co) recent paper www.science.org/doi/10.1126/...
youtu.be/Mzr3TD4ijs0?...
youtu.be/Mzr3TD4ijs0?...
Reposted by Plasmid Society
Dissecting the fitness effects of a carbapenem resistance plasmid in clinical Enterobacterales using plasmid-wide CRISPRi screens
@aliciapcv.bsky.social @jorgesastred.bsky.social @sanmillan.bsky.social @cnb-csic.bsky.social
#bacteria #plasmids
@aliciapcv.bsky.social @jorgesastred.bsky.social @sanmillan.bsky.social @cnb-csic.bsky.social
#bacteria #plasmids
Dissecting pOXA-48 fitness effects in clinical Enterobacterales using plasmid-wide CRISPRi screens - Nature Communications
This study investigates the effects of the carbapenem resistance plasmid pOXA-48 in clinical enterobacteria. Using CRISPRi screens, the authors revealed that the carbapenemase OXA-48 has a role in the plasmid-associated fitness costs.
bit.ly
October 17, 2025 at 4:56 PM
Dissecting the fitness effects of a carbapenem resistance plasmid in clinical Enterobacterales using plasmid-wide CRISPRi screens
@aliciapcv.bsky.social @jorgesastred.bsky.social @sanmillan.bsky.social @cnb-csic.bsky.social
#bacteria #plasmids
@aliciapcv.bsky.social @jorgesastred.bsky.social @sanmillan.bsky.social @cnb-csic.bsky.social
#bacteria #plasmids
Reposted by Plasmid Society
New paper with my (amazing) friend and mentor @jrpenades.bsky.social
Really looking forward to see what plasmid aficionados think of this one!!
With @asantoslopez.bsky.social @wfigueroac3.bsky.social Akshay Sabins and others
www.cell.com/cell-reports...
Really looking forward to see what plasmid aficionados think of this one!!
With @asantoslopez.bsky.social @wfigueroac3.bsky.social Akshay Sabins and others
www.cell.com/cell-reports...
Non-conjugative plasmids limit their mobility to persist in nature
Sabnis et al. explain why non-conjugative plasmids move at a low rate in nature. While
increased mobility can easily evolve by incorporating phage DNA into plasmids, this
is disadvantageous because it...
www.cell.com
October 22, 2025 at 1:12 PM
New paper with my (amazing) friend and mentor @jrpenades.bsky.social
Really looking forward to see what plasmid aficionados think of this one!!
With @asantoslopez.bsky.social @wfigueroac3.bsky.social Akshay Sabins and others
www.cell.com/cell-reports...
Really looking forward to see what plasmid aficionados think of this one!!
With @asantoslopez.bsky.social @wfigueroac3.bsky.social Akshay Sabins and others
www.cell.com/cell-reports...
📢 Postdoctoral research position
A 2-year postdoctoral position on bacteriophages research is available at the Institut Pasteur in Paris in the Plasticity of the Genomes Unit.
🧐 Those interested can now send their applications!
A 2-year postdoctoral position on bacteriophages research is available at the Institut Pasteur in Paris in the Plasticity of the Genomes Unit.
🧐 Those interested can now send their applications!
July 28, 2025 at 9:06 AM
📢 Postdoctoral research position
A 2-year postdoctoral position on bacteriophages research is available at the Institut Pasteur in Paris in the Plasticity of the Genomes Unit.
🧐 Those interested can now send their applications!
A 2-year postdoctoral position on bacteriophages research is available at the Institut Pasteur in Paris in the Plasticity of the Genomes Unit.
🧐 Those interested can now send their applications!
Must-Read Paper 👀
Check out this latest review on plasmid mobility and how interactions between MGEs shape and affect plasmid stability and transfer:
doi.org/10.1093/nar/...
#Plasmid #MGE #Mobility
Check out this latest review on plasmid mobility and how interactions between MGEs shape and affect plasmid stability and transfer:
doi.org/10.1093/nar/...
#Plasmid #MGE #Mobility
The extended mobility of plasmids
Abstract. Plasmids play key roles in the spreading of many traits, ranging from antibiotic resistance to varied secondary metabolism, from virulence to mut
doi.org
July 24, 2025 at 12:52 PM
Must-Read Paper 👀
Check out this latest review on plasmid mobility and how interactions between MGEs shape and affect plasmid stability and transfer:
doi.org/10.1093/nar/...
#Plasmid #MGE #Mobility
Check out this latest review on plasmid mobility and how interactions between MGEs shape and affect plasmid stability and transfer:
doi.org/10.1093/nar/...
#Plasmid #MGE #Mobility
Heads up! 📢
The 5th Session of the ISPB Virtual Seminars is tomorrow, from 8:00 to 9:00 UTC. Hope to see you there virtually!
#Plasmid #ISPB #VirtualSeminar
The 5th Session of the ISPB Virtual Seminars is tomorrow, from 8:00 to 9:00 UTC. Hope to see you there virtually!
#Plasmid #ISPB #VirtualSeminar
July 14, 2025 at 10:56 AM
Heads up! 📢
The 5th Session of the ISPB Virtual Seminars is tomorrow, from 8:00 to 9:00 UTC. Hope to see you there virtually!
#Plasmid #ISPB #VirtualSeminar
The 5th Session of the ISPB Virtual Seminars is tomorrow, from 8:00 to 9:00 UTC. Hope to see you there virtually!
#Plasmid #ISPB #VirtualSeminar
Kicking off the week with exciting news:
🧐 There is still time to register and submit your abstract until 30th May for the 2nd edition of "Secretion Days" (October 2-3, Marseille).
💻Registration:
docs.google.com/forms/d/e/1FAI…
📩 More info: secretion@imm.cnrs.fr
🧐 There is still time to register and submit your abstract until 30th May for the 2nd edition of "Secretion Days" (October 2-3, Marseille).
💻Registration:
docs.google.com/forms/d/e/1FAI…
📩 More info: secretion@imm.cnrs.fr
May 26, 2025 at 7:56 AM
Kicking off the week with exciting news:
🧐 There is still time to register and submit your abstract until 30th May for the 2nd edition of "Secretion Days" (October 2-3, Marseille).
💻Registration:
docs.google.com/forms/d/e/1FAI…
📩 More info: secretion@imm.cnrs.fr
🧐 There is still time to register and submit your abstract until 30th May for the 2nd edition of "Secretion Days" (October 2-3, Marseille).
💻Registration:
docs.google.com/forms/d/e/1FAI…
📩 More info: secretion@imm.cnrs.fr
Heey! ✋
If you missed the live session of the ISPB Virtual Seminar Series, there's still time to catch up and enjoy the great work of Zhengqing Zhou and Alicia Calvo Villamañán.
Huge thanks to the speakers and the organizers!! 🫂
If you missed the live session of the ISPB Virtual Seminar Series, there's still time to catch up and enjoy the great work of Zhengqing Zhou and Alicia Calvo Villamañán.
Huge thanks to the speakers and the organizers!! 🫂
May 14, 2025 at 8:31 PM
Heey! ✋
If you missed the live session of the ISPB Virtual Seminar Series, there's still time to catch up and enjoy the great work of Zhengqing Zhou and Alicia Calvo Villamañán.
Huge thanks to the speakers and the organizers!! 🫂
If you missed the live session of the ISPB Virtual Seminar Series, there's still time to catch up and enjoy the great work of Zhengqing Zhou and Alicia Calvo Villamañán.
Huge thanks to the speakers and the organizers!! 🫂
Must-Read Paper 👀
Wrap up the week exploring how mobile genetic elements (MGEs) drive pangenome structure: Salmonella enterica serovar Typhi.
journals.asm.org/doi/full/10....
#Plasmid #MGEs #Salmonella
Wrap up the week exploring how mobile genetic elements (MGEs) drive pangenome structure: Salmonella enterica serovar Typhi.
journals.asm.org/doi/full/10....
#Plasmid #MGEs #Salmonella
Mobile genetic elements define the non-random structure of the Salmonella enterica serovar Typhi pangenome | mSystems
Given bacterial evolution occurs in both vertical and horizontal dimensions, inclusion
of both core and accessory genetic material (i.e., the pangenome) is a logical step
toward a more thorough unders...
journals.asm.org
April 25, 2025 at 10:06 AM
Must-Read Paper 👀
Wrap up the week exploring how mobile genetic elements (MGEs) drive pangenome structure: Salmonella enterica serovar Typhi.
journals.asm.org/doi/full/10....
#Plasmid #MGEs #Salmonella
Wrap up the week exploring how mobile genetic elements (MGEs) drive pangenome structure: Salmonella enterica serovar Typhi.
journals.asm.org/doi/full/10....
#Plasmid #MGEs #Salmonella
The ISPB Virtual Seminars 2025 continue tomorrow with the second session:
📅 Tuesday, April 15
🕢 07:00–08:00 (UTC) (everytimezone.com)
Make sure you don't miss it! 🤠
#Plasmid #ISPBVirtualSeries
📅 Tuesday, April 15
🕢 07:00–08:00 (UTC) (everytimezone.com)
Make sure you don't miss it! 🤠
#Plasmid #ISPBVirtualSeries
Every Time Zone Converter
Easily find the exact time difference with the visual Time Zone Converter. Find meeting times for your contacts, locations and places around the world. Never warp your brain with time zone math again.
everytimezone.com
April 14, 2025 at 1:43 PM
The ISPB Virtual Seminars 2025 continue tomorrow with the second session:
📅 Tuesday, April 15
🕢 07:00–08:00 (UTC) (everytimezone.com)
Make sure you don't miss it! 🤠
#Plasmid #ISPBVirtualSeries
📅 Tuesday, April 15
🕢 07:00–08:00 (UTC) (everytimezone.com)
Make sure you don't miss it! 🤠
#Plasmid #ISPBVirtualSeries
Imagine resistance genes as stickers, and plasmids as the sticker albums where they're collected and swapped. 🤔🧩
Now, You should check this amazing work from Wang et al.! 👇
doi.org/10.1093/isme...
#Plasmid #MGEs #AntimicrobialResistance #ARGs
Now, You should check this amazing work from Wang et al.! 👇
doi.org/10.1093/isme...
#Plasmid #MGEs #AntimicrobialResistance #ARGs
doi.org
April 9, 2025 at 5:47 PM
Imagine resistance genes as stickers, and plasmids as the sticker albums where they're collected and swapped. 🤔🧩
Now, You should check this amazing work from Wang et al.! 👇
doi.org/10.1093/isme...
#Plasmid #MGEs #AntimicrobialResistance #ARGs
Now, You should check this amazing work from Wang et al.! 👇
doi.org/10.1093/isme...
#Plasmid #MGEs #AntimicrobialResistance #ARGs
Cigarettes: bad for your health… and for antibiotic resistance, too? 🚭🚭
Fang, Konyali and colleagues have demonstrated that smoking-derived compounds promote the conjugation rates in different environments (artificial lung sputum medium and environmental medium).
Fang, Konyali and colleagues have demonstrated that smoking-derived compounds promote the conjugation rates in different environments (artificial lung sputum medium and environmental medium).
March 17, 2025 at 5:21 PM
Cigarettes: bad for your health… and for antibiotic resistance, too? 🚭🚭
Fang, Konyali and colleagues have demonstrated that smoking-derived compounds promote the conjugation rates in different environments (artificial lung sputum medium and environmental medium).
Fang, Konyali and colleagues have demonstrated that smoking-derived compounds promote the conjugation rates in different environments (artificial lung sputum medium and environmental medium).
Updates are back! We’ll be sharing papers and reviews relevant to our community. Please, feel free to contact us if you’d like us to feature your work. Thanks!! 🧬
March 15, 2025 at 1:15 PM
Updates are back! We’ll be sharing papers and reviews relevant to our community. Please, feel free to contact us if you’d like us to feature your work. Thanks!! 🧬
IT'S TODAY! IT'S TODAY!
📣 Don't miss the start of the ISPB Virtual Seminars and join the first session!
⏱️ 09:00 (GMT-7) / 17:00 (GMT+1)
See you soon!
📣 Don't miss the start of the ISPB Virtual Seminars and join the first session!
⏱️ 09:00 (GMT-7) / 17:00 (GMT+1)
See you soon!
a pink starfish with a face and the words `` today 's the daaaay '' written on it .
ALT: a pink starfish with a face and the words `` today 's the daaaay '' written on it .
media.tenor.com
March 11, 2025 at 2:28 PM
IT'S TODAY! IT'S TODAY!
📣 Don't miss the start of the ISPB Virtual Seminars and join the first session!
⏱️ 09:00 (GMT-7) / 17:00 (GMT+1)
See you soon!
📣 Don't miss the start of the ISPB Virtual Seminars and join the first session!
⏱️ 09:00 (GMT-7) / 17:00 (GMT+1)
See you soon!
The International Society for Plasmid Biology and other Mobile Genetic Elements are finally in Bluesky!! 😎😎😎
March 11, 2025 at 2:21 PM
The International Society for Plasmid Biology and other Mobile Genetic Elements are finally in Bluesky!! 😎😎😎