Patrick Howlett
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phowlett.bsky.social
Patrick Howlett
@phowlett.bsky.social
He/him | MRC Clinical Research Fellow at
@imperialcollege
| Occupational lung disease and infection | Decarbonising health | ❤️🚴‍♂️🏔️ | Tweets are my own ...
Reposted by Patrick Howlett
Is an ‘exodus’ of clinical researchers threatening the future of UK healthcare?

“For young NHS clinicians coming through they are often not rewarded for what they’ve done in science whereas they used to be." – Prof Graham Cooke spoke to @financialtimes.com

www.ft.com/content/c4fa...
‘Exodus’ of clinical researchers sparks concern over future of UK healthcare
Lack of incentives is driving down the number of clinical researchers in Britain
www.ft.com
April 1, 2025 at 11:12 AM
A day late for #worldtbday and published a couple of weeks ago...

www.thelancet.com/journals/lan...

We argue that we are failing to engage with a growing problem of lung disease - TB and silicosis mainly - in small-scale and informal miners

1/4
Confronting the growing epidemic of silicosis and tuberculosis among small-scale miners
An estimated 49·5 million small-scale miners worldwide are exposed to high concentrations of silica during their work. The substantial morbidity and mortality of silicosis and tuberculosis among worke...
www.thelancet.com
March 25, 2025 at 2:05 PM
@abdullahbashir.bsky.social grateful to be your first follower 🙏😌
January 10, 2025 at 7:50 AM
Reposted by Patrick Howlett
I've only just noticed that BlueSky is being reported by Altmetric: www.altmetric.com/details/1709...

Feels like a significant development.
Report for: Altered IL-6 signalling and risk of tuberculosis: a multi-ancestry mendelian randomisation study
In the top 5% of all research outputs scored by Altmetric
www.altmetric.com
December 2, 2024 at 2:07 PM
#BTSWinter2024 two of the best talks I’ve heard in a long time from Esther Robinson and Gerry Davies at the TB Symposium… looking forward to the next by Celso Khosa
November 29, 2024 at 11:34 AM
#BTSWinter2024

Fascinating stuff from Prof Ducharme at BPRS joint session - ongoing airway subclinical disease in those with asthma remission in childhood. Could this be the small airways disease subgroup…?
November 27, 2024 at 2:59 PM
Reposted by Patrick Howlett
I constantly hear people say we need a prevention first approach. But I see no action or investment. Will this change? I could implement evidence based lifestyle medicine interventions tomorrow that would make a massive difference to my patients. But I'm told there's no time or money. #BTSWinter2024
November 27, 2024 at 1:44 PM
One thing I would say missed in the possible future - @thekingsfund.bsky.social - no mention of preventing people’s respiratory illness affected by work. Often overlooked despite attributable fraction often 10-20% of all Resp diseases
On now #BTSWinter2024

Sarah Woolnough from @thekingsfund.bsky.social showing us a possible future for the respiratory world

Telling us health inequalities have the greatest effect on respiratory diseases among all health outcomes - this is our problem to own
November 27, 2024 at 1:39 PM
On now #BTSWinter2024

Sarah Woolnough from @thekingsfund.bsky.social showing us a possible future for the respiratory world

Telling us health inequalities have the greatest effect on respiratory diseases among all health outcomes - this is our problem to own
November 27, 2024 at 1:32 PM
Closely followed by more silicosis…

Silicosis is under diagnosed on CXR - sensitivity 0.76 compared to HRCT and 0.50 compared to autopsy on meta-analysis

Silicosis and TB screening among small scale miners is achievable at a cost of £17-21 per person
November 27, 2024 at 1:30 PM
Welcome to the #BTSWinter2024!

So far this morning from occupational lung disease world

Journal club
- artificial stone silicosis in the uk
- high prevalences with dose response of autoimmune markers in Silica exposures
- organic exposures lead to HP and ILDs in the enviable Danish work cohort
November 27, 2024 at 1:27 PM
Reposted by Patrick Howlett
That’s it! I hope to see you at #BTSWinter2024 Come and say hi!
21/21 /end brit-thoracic.org.uk/education-an...
BTS Winter Meeting
The Winter Meeting will be held in London from Wednesday 24th to Friday 26th November 2021.
brit-thoracic.org.uk
November 27, 2024 at 7:17 AM
Strong recommend on this!
Birnam Wood by Eleanor Catton
November 25, 2024 at 3:20 PM
Reposted by Patrick Howlett
NEW PAPER! Work led by @gushamilton.bsky.social and @gpollara.bsky.social finds reduced IL-6 signalling may REDUCE risk of TB disease

Challenges idea that IL-6 plays essential role in immunity to Mtb, and suggests that IL-6 drives immunopathology

Great use of data from ITHGC

#IDSky #EpiSky
Altered IL-6 signalling and risk of tuberculosis: a multi-ancestry mendelian randomisation study
Our findings propose a causal relationship between reduced IL-6 signalling and lower risk of tuberculosis, akin to the effect seen in other IL-6 mediated diseases. This study suggests that IL-6 antago...
www.thelancet.com
November 21, 2024 at 9:20 AM
Reposted by Patrick Howlett
Very important finding from Joowhan Sung and Emily Kendall, presented at the Asymptomatic TB session at the #TBUnion conference last week!
2/
Implications of a trace Xpert Ultra (Joowhan Sung)
- 129 pts with trace Ultra were thoroughly investigated at baseline + followed up for 2 yrs
- ½ of pts diagnosed w/ prevalent or incident TB
- Incident TB strongly associated w/ abnormal CXR but NOT symptoms - supports symptom-agnostic testing
November 19, 2024 at 7:52 PM
Reposted by Patrick Howlett
We host monthly online international journal clubs on the latest #tuberculosis literature. We welcome researchers, clinicians, and anyone else interested in #TB - eepurl.com/hO4D79 to join the mailing list & hear about future meetings.
TB Journal Club
TB Journal Club Email Forms
eepurl.com
November 18, 2024 at 10:27 AM
My first proper Bluesky post…

Has anyone (ever?) submitted an article and not had it returned for some small change to be made before processing?

#MedSky
#Academiclyf
November 14, 2024 at 8:55 PM