Pépin Lab
@pepinlab.bsky.social
Pépin Lab at MGH/Harvard Medical School. Studies ovarian biology, AMH, and women’s health.
Well done Josephine! Talk about multitalented…
Serving looks and sequ(in)ences at the same time. ✨🧬
September 22, 2025 at 3:14 PM
Well done Josephine! Talk about multitalented…
Reposted by Pépin Lab
The SRB, SRF and SSR have announced that A/Prof. David Pépin of the Massachusetts General Hospital and Harvard Medical School is the 2025 Recipient of the RV Short Medal and Lecture.
A/Prof. Pépin has made significant contributions to understanding the role of AMH in fertility.
A/Prof. Pépin has made significant contributions to understanding the role of AMH in fertility.
September 4, 2025 at 10:11 PM
The SRB, SRF and SSR have announced that A/Prof. David Pépin of the Massachusetts General Hospital and Harvard Medical School is the 2025 Recipient of the RV Short Medal and Lecture.
A/Prof. Pépin has made significant contributions to understanding the role of AMH in fertility.
A/Prof. Pépin has made significant contributions to understanding the role of AMH in fertility.
We're looking for a Postdoctoral Fellow in Machine Learning & Women’s Health in partnership with MIT’s Female Medicine through Machine Learning (FMML fmml.mit.edu ) to build multi-modal ML models related to ovarian aging and its impact on overall health using large, real-world datasets.
Postdoc Research Fellow Pepin Lab
Site: Massachusetts General Physicians Organization, Inc. Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and syste...
massgeneralbrigham.wd1.myworkdayjobs.com
August 8, 2025 at 3:49 PM
We're looking for a Postdoctoral Fellow in Machine Learning & Women’s Health in partnership with MIT’s Female Medicine through Machine Learning (FMML fmml.mit.edu ) to build multi-modal ML models related to ovarian aging and its impact on overall health using large, real-world datasets.
Reposted by Pépin Lab
This is incredible.
A lipid nanoparticle–delivered base-editing therapy was custom designed for an infant with a ureacycle disorder. The affected infant was treated at approximately 7 and 8 months of age. Read the Brief Report: nej.md/42XF03F
#ASGCT2025 #MedSky @asgct.bsky.social
#ASGCT2025 #MedSky @asgct.bsky.social
Patient-Specific In Vivo Gene Editing to Treat a Rare Genetic Disease | NEJM
Base editors can correct disease-causing genetic variants. After a neonate had received
a diagnosis of severe carbamoyl-phosphate synthetase 1 deficiency, a disease with
an estimated 50% mortality ...
nej.md
May 15, 2025 at 7:00 PM
This is incredible.
Reposted by Pépin Lab
Director of the Nat'l Institute of Child Health and Human Development (NICHD) was summarily dismissed yesterday. So here's your reminder that birth defects kill twice as many American kids as cancer. But there is no St. Jude's for birth defects. Only the NICHD.
www.nature.com/articles/d41...
www.nature.com/articles/d41...
‘One of the darkest days’: NIH purges agency leadership amid mass layoffs
In shock move, four institute directors at the US biomedical agency are removed from their posts.
www.nature.com
April 2, 2025 at 3:38 PM
Director of the Nat'l Institute of Child Health and Human Development (NICHD) was summarily dismissed yesterday. So here's your reminder that birth defects kill twice as many American kids as cancer. But there is no St. Jude's for birth defects. Only the NICHD.
www.nature.com/articles/d41...
www.nature.com/articles/d41...
So proud of our brilliant PhD student Alana Mermin-Bunnell, and thankful for all her work to implement a machine learning follicle counting pipeline.
March 28, 2025 at 3:05 PM
So proud of our brilliant PhD student Alana Mermin-Bunnell, and thankful for all her work to implement a machine learning follicle counting pipeline.
Reposted by Pépin Lab
I’m excited to share the latest work from our lab, led by a group of three amazing scientists: Junbing Zhang, Yousuf Ali and Harrison Chong, who describe @nature the discovery of a ROS sensor, VPS35, which links cytosolic H2O2 levels to regulation of mitochondrial translation and
Oxidation of retromer complex controls mitochondrial translation - Nature
Systematic base-editing and computational screens identify specific cysteine residues on VPS35 in the retromer complex as key sensors that decrease mitochondrial translation in response to reactive ox...
www.nature.com
March 26, 2025 at 5:33 PM
I’m excited to share the latest work from our lab, led by a group of three amazing scientists: Junbing Zhang, Yousuf Ali and Harrison Chong, who describe @nature the discovery of a ROS sensor, VPS35, which links cytosolic H2O2 levels to regulation of mitochondrial translation and
Reposted by Pépin Lab
Universities aren't doing enough to come to each others' defense, and industry isn't standing up for academia, says @hollylynchez.bsky.social:
March 20, 2025 at 6:07 PM
Universities aren't doing enough to come to each others' defense, and industry isn't standing up for academia, says @hollylynchez.bsky.social:
A great summary on the war against academia and the root of the rising anti-intellectualism open.substack.com/pub/paulwald...
The Real Goal of Trump's War on Universities
It isn't about stopping antisemitism. It's about power.
open.substack.com
March 19, 2025 at 2:33 PM
A great summary on the war against academia and the root of the rising anti-intellectualism open.substack.com/pub/paulwald...
Reposted by Pépin Lab
Nothing will kill more children than the ongoing decimation of CDC, NIH, and USAID work to lift vaccine uptake in the US and world.
Child survival rose 75% in the last 50 years. Vaccines account for 40% of that. Measles vax alone was 60% of the benefit. www.thelancet.com/journals/lan...
Child survival rose 75% in the last 50 years. Vaccines account for 40% of that. Measles vax alone was 60% of the benefit. www.thelancet.com/journals/lan...
Contribution of vaccination to improved survival and health: modelling 50 years of the Expanded Programme on Immunization
Since 1974 substantial gains in childhood survival have occurred in every global region.
We estimate that EPI has provided the single greatest contribution to improved infant
survival over the past 50...
www.thelancet.com
March 13, 2025 at 12:05 PM
Nothing will kill more children than the ongoing decimation of CDC, NIH, and USAID work to lift vaccine uptake in the US and world.
Child survival rose 75% in the last 50 years. Vaccines account for 40% of that. Measles vax alone was 60% of the benefit. www.thelancet.com/journals/lan...
Child survival rose 75% in the last 50 years. Vaccines account for 40% of that. Measles vax alone was 60% of the benefit. www.thelancet.com/journals/lan...
Reposted by Pépin Lab
The House of Representatives just passed a CR that includes devastating cuts to the Congressionally Directed Medical Research Program (CDMRP) – 57% cut.
It is absolutely critical that we reach out to our Senators now and urge them NOT to include these cuts.
Call them!
It is absolutely critical that we reach out to our Senators now and urge them NOT to include these cuts.
Call them!
March 13, 2025 at 1:48 AM
The House of Representatives just passed a CR that includes devastating cuts to the Congressionally Directed Medical Research Program (CDMRP) – 57% cut.
It is absolutely critical that we reach out to our Senators now and urge them NOT to include these cuts.
Call them!
It is absolutely critical that we reach out to our Senators now and urge them NOT to include these cuts.
Call them!
This is a useful resource if you’re trying to keep track of NIH study section meetings, a google doc kept up to date by Dr Barber. docs.google.com/spreadsheets...
2025 Study section tracking
docs.google.com
March 11, 2025 at 4:51 PM
This is a useful resource if you’re trying to keep track of NIH study section meetings, a google doc kept up to date by Dr Barber. docs.google.com/spreadsheets...
You know it’s bad when the scientists go outside.
March 7, 2025 at 7:13 PM
You know it’s bad when the scientists go outside.
For those in the Boston area, the stand up for science demonstration will be at the capitol this Friday 3/7 12-4. i0.wp.com/standupforsc...
March 5, 2025 at 6:49 PM
For those in the Boston area, the stand up for science demonstration will be at the capitol this Friday 3/7 12-4. i0.wp.com/standupforsc...
Reposted by Pépin Lab
I am not going to call this a Bluetorial, because I do not want to sully that term (which, at least I, find joyful).
Let’s call it a Orwellial.
Let’s call it a Orwellial.
a cartoon of homer simpson holding a card
ALT: a cartoon of homer simpson holding a card
media.tenor.com
March 2, 2025 at 1:57 PM
I am not going to call this a Bluetorial, because I do not want to sully that term (which, at least I, find joyful).
Let’s call it a Orwellial.
Let’s call it a Orwellial.
Senior investigators are now on the chopping block. We could all suffer the same fate if we can’t unite to stop the willful dismantling of scientific research. www.science.org/content/arti...
NIH ban on renewing senior scientists adds to assaults on its in-house research
Policy follows firings of tenure-track scientists and suspension of training programs
www.science.org
February 27, 2025 at 1:14 PM
Senior investigators are now on the chopping block. We could all suffer the same fate if we can’t unite to stop the willful dismantling of scientific research. www.science.org/content/arti...
Reposted by Pépin Lab
If you are worried about science there IS something that you can do! Join us next Friday in DC to make your voice heard. Come and stand up for science! Show that science is for everyone. I’ll be there and I can’t wait to see you there too!
@standupforscience.bsky.social
@standupforscience.bsky.social
February 26, 2025 at 4:31 AM
If you are worried about science there IS something that you can do! Join us next Friday in DC to make your voice heard. Come and stand up for science! Show that science is for everyone. I’ll be there and I can’t wait to see you there too!
@standupforscience.bsky.social
@standupforscience.bsky.social
Reposted by Pépin Lab
Medical research funding is usually both public (NIH) and private (pharma), i.e. the TV drug ads
Preterm birth & preeclampsia research is almost entirely non-industry
Most pharmaceutical companies avoid pregnant patients like the plague.
So freezing NIH essentially freezes our field
#MedSky
Preterm birth & preeclampsia research is almost entirely non-industry
Most pharmaceutical companies avoid pregnant patients like the plague.
So freezing NIH essentially freezes our field
#MedSky
February 21, 2025 at 11:11 AM
Medical research funding is usually both public (NIH) and private (pharma), i.e. the TV drug ads
Preterm birth & preeclampsia research is almost entirely non-industry
Most pharmaceutical companies avoid pregnant patients like the plague.
So freezing NIH essentially freezes our field
#MedSky
Preterm birth & preeclampsia research is almost entirely non-industry
Most pharmaceutical companies avoid pregnant patients like the plague.
So freezing NIH essentially freezes our field
#MedSky
Reposted by Pépin Lab
Get ready to #standupforscience in 2.5 weeks!
February 16, 2025 at 7:16 PM
Get ready to #standupforscience in 2.5 weeks!
Reposted by Pépin Lab
#BREAKING - 22 states sue to block Trump administration cuts to NIH research payments
22 states sue to block Trump administration cuts to NIH research payments
Attorneys general sued the Trump administration to block a NIH decision that would slash grant payments for research overhead
buff.ly
February 10, 2025 at 5:26 PM
#BREAKING - 22 states sue to block Trump administration cuts to NIH research payments
Reposted by Pépin Lab
#BREAKING - NIH plans to slash support for indirect research costs, sending shockwaves through science
NIH plans to slash support for indirect research costs, sending shockwaves through science
The NIH said Friday night that it would slash support for indirect costs on all existing and future grants to 15%
buff.ly
February 8, 2025 at 1:20 AM
#BREAKING - NIH plans to slash support for indirect research costs, sending shockwaves through science
Reposted by Pépin Lab
The Ovarian Cancer Research Syndicate schedule is out from the @pennmedicine.bsky.social Ovarian Cancer Research Center. Great line up!
January 24, 2025 at 6:19 AM
The Ovarian Cancer Research Syndicate schedule is out from the @pennmedicine.bsky.social Ovarian Cancer Research Center. Great line up!
Congrats to Dr Godin who did a great job presenting our work on cat contraception at #Fertility2025. We’ve shown that we can treat kittens with AMH gene therapy before puberty and they will be contracepted at maturity with no adverse effects on hormones! Finally, a non-surgical alternative for pets.
January 9, 2025 at 6:25 PM
Congrats to Dr Godin who did a great job presenting our work on cat contraception at #Fertility2025. We’ve shown that we can treat kittens with AMH gene therapy before puberty and they will be contracepted at maturity with no adverse effects on hormones! Finally, a non-surgical alternative for pets.
Preprint alert 🚨 www.biorxiv.org/content/10.1... . I’m pleased to tease this story regarding FSTL3 as a potential biomarker and therapeutic target in #ovariancancer. A thread 🧵1/n .
December 14, 2024 at 8:49 PM
Preprint alert 🚨 www.biorxiv.org/content/10.1... . I’m pleased to tease this story regarding FSTL3 as a potential biomarker and therapeutic target in #ovariancancer. A thread 🧵1/n .
Reposted by Pépin Lab
Research supported by NIH has led more than 100 Nobel Prizes and has supported more than 99% of drugs approved by federal regulators from 2010 to 2019.
But come January, NIH may face a wrecking ball
nytimes.com/2024/12/01/h...
But come January, NIH may face a wrecking ball
nytimes.com/2024/12/01/h...
Long a ‘Crown Jewel’ of Government, N.I.H. Is Now a Target
nytimes.com
December 1, 2024 at 11:47 PM
Research supported by NIH has led more than 100 Nobel Prizes and has supported more than 99% of drugs approved by federal regulators from 2010 to 2019.
But come January, NIH may face a wrecking ball
nytimes.com/2024/12/01/h...
But come January, NIH may face a wrecking ball
nytimes.com/2024/12/01/h...