Paula
@paururo.bsky.social
Decoding #TB 🦠 mysteries at @pathogenomics.bsky.social | Bioinformagician wielding data to unlock genetic secrets 🧬💻 | Check out my code on GitHub https://github.com/paururo
Reposted by Paula
New paper out in PNAS!!! 🎉
Do more plasmid copies mean faster evolution?
🧵 Dive into the story
www.pnas.org/doi/10.1073/...
Do more plasmid copies mean faster evolution?
🧵 Dive into the story
www.pnas.org/doi/10.1073/...
Plasmid mutation rates scale with copy number | PNAS
Plasmids are extrachromosomal DNA molecules that spread by horizontal transfer and
shape bacterial evolution. Plasmids are typically present at mul...
www.pnas.org
January 27, 2026 at 12:02 PM
New paper out in PNAS!!! 🎉
Do more plasmid copies mean faster evolution?
🧵 Dive into the story
www.pnas.org/doi/10.1073/...
Do more plasmid copies mean faster evolution?
🧵 Dive into the story
www.pnas.org/doi/10.1073/...
Reposted by Paula
New paper out in @pnas.org, and it made the cover! 👁️
We represent plasmids as circles and mutations as dots, resembling an eye, because in this paper we literally 𝑤𝑎𝑡𝑐ℎ plasmids evolve.
‼️Check Paula’s 🧵 and the paper👇
𝗣𝗹𝗮𝘀𝗺𝗶𝗱 𝗺𝘂𝘁𝗮𝘁𝗶𝗼𝗻 𝗿𝗮𝘁𝗲𝘀 𝘀𝗰𝗮𝗹𝗲 𝘄𝗶𝘁𝗵 𝗰𝗼𝗽𝘆 𝗻𝘂𝗺𝗯𝗲𝗿
www.pnas.org/doi/10.1073/...
We represent plasmids as circles and mutations as dots, resembling an eye, because in this paper we literally 𝑤𝑎𝑡𝑐ℎ plasmids evolve.
‼️Check Paula’s 🧵 and the paper👇
𝗣𝗹𝗮𝘀𝗺𝗶𝗱 𝗺𝘂𝘁𝗮𝘁𝗶𝗼𝗻 𝗿𝗮𝘁𝗲𝘀 𝘀𝗰𝗮𝗹𝗲 𝘄𝗶𝘁𝗵 𝗰𝗼𝗽𝘆 𝗻𝘂𝗺𝗯𝗲𝗿
www.pnas.org/doi/10.1073/...
January 27, 2026 at 8:23 PM
New paper out in @pnas.org, and it made the cover! 👁️
We represent plasmids as circles and mutations as dots, resembling an eye, because in this paper we literally 𝑤𝑎𝑡𝑐ℎ plasmids evolve.
‼️Check Paula’s 🧵 and the paper👇
𝗣𝗹𝗮𝘀𝗺𝗶𝗱 𝗺𝘂𝘁𝗮𝘁𝗶𝗼𝗻 𝗿𝗮𝘁𝗲𝘀 𝘀𝗰𝗮𝗹𝗲 𝘄𝗶𝘁𝗵 𝗰𝗼𝗽𝘆 𝗻𝘂𝗺𝗯𝗲𝗿
www.pnas.org/doi/10.1073/...
We represent plasmids as circles and mutations as dots, resembling an eye, because in this paper we literally 𝑤𝑎𝑡𝑐ℎ plasmids evolve.
‼️Check Paula’s 🧵 and the paper👇
𝗣𝗹𝗮𝘀𝗺𝗶𝗱 𝗺𝘂𝘁𝗮𝘁𝗶𝗼𝗻 𝗿𝗮𝘁𝗲𝘀 𝘀𝗰𝗮𝗹𝗲 𝘄𝗶𝘁𝗵 𝗰𝗼𝗽𝘆 𝗻𝘂𝗺𝗯𝗲𝗿
www.pnas.org/doi/10.1073/...
Reposted by Paula
🎥El investigador @fgonzalef.bsky.social lidera el grupo de Epidemiología Molecular en el #I2SysBio (@csic.es- @uv.es)
➡️Mira esta breve presentación si quieres saber más sobre su trayectoria y sus principales líneas de investigación.
@dicv.csic.es
www.youtube.com/watch?v=W4Ja...
➡️Mira esta breve presentación si quieres saber más sobre su trayectoria y sus principales líneas de investigación.
@dicv.csic.es
www.youtube.com/watch?v=W4Ja...
Interview of Fernando González, Principal Investigator of the Molecular Epidemiology group
YouTube video by Institute for Integrative Systems Biology I2SysBio
www.youtube.com
December 19, 2025 at 9:05 AM
🎥El investigador @fgonzalef.bsky.social lidera el grupo de Epidemiología Molecular en el #I2SysBio (@csic.es- @uv.es)
➡️Mira esta breve presentación si quieres saber más sobre su trayectoria y sus principales líneas de investigación.
@dicv.csic.es
www.youtube.com/watch?v=W4Ja...
➡️Mira esta breve presentación si quieres saber más sobre su trayectoria y sus principales líneas de investigación.
@dicv.csic.es
www.youtube.com/watch?v=W4Ja...
Reposted by Paula
Come and join us in Valencia next January for the meeting of the Spanish Society of Evolutionary Biology. Deadline for abstracts October 22nd. sesbe2026.es/registration/
October 16, 2025 at 11:10 AM
Come and join us in Valencia next January for the meeting of the Spanish Society of Evolutionary Biology. Deadline for abstracts October 22nd. sesbe2026.es/registration/
Reposted by Paula
Then, we Mireia Coscollà ( @pathogenomics.bsky.social ), from I2SysBio ( @i2sysbio.es ) talked about compatibility between hosts in bacterial infections.
October 12, 2025 at 3:12 PM
Then, we Mireia Coscollà ( @pathogenomics.bsky.social ), from I2SysBio ( @i2sysbio.es ) talked about compatibility between hosts in bacterial infections.
Back from #MycoVLC2025 after presenting our M. tuberculosis work. Huge thanks to Mireia for stellar mentorship. Proud of my @pathogenomics.bsky.social mycolegas for standout posters. Energized to turn ideas into results. #TB #TBResearch @i2sysbio.es
October 10, 2025 at 8:04 PM
Back from #MycoVLC2025 after presenting our M. tuberculosis work. Huge thanks to Mireia for stellar mentorship. Proud of my @pathogenomics.bsky.social mycolegas for standout posters. Energized to turn ideas into results. #TB #TBResearch @i2sysbio.es
Reposted by Paula
Preprint out for myloasm, our new nanopore / HiFi metagenome assembler!
Nanopore's getting accurate, but
1. Can this lead to better metagenome assemblies?
2. How, algorithmically, to leverage them?
with co-author Max Marin @mgmarin.bsky.social, supervised by Heng Li @lh3lh3.bsky.social
1 / N
Nanopore's getting accurate, but
1. Can this lead to better metagenome assemblies?
2. How, algorithmically, to leverage them?
with co-author Max Marin @mgmarin.bsky.social, supervised by Heng Li @lh3lh3.bsky.social
1 / N
High-resolution metagenome assembly for modern long reads with myloasm https://www.biorxiv.org/content/10.1101/2025.09.05.674543v1
September 7, 2025 at 11:35 PM
Preprint out for myloasm, our new nanopore / HiFi metagenome assembler!
Nanopore's getting accurate, but
1. Can this lead to better metagenome assemblies?
2. How, algorithmically, to leverage them?
with co-author Max Marin @mgmarin.bsky.social, supervised by Heng Li @lh3lh3.bsky.social
1 / N
Nanopore's getting accurate, but
1. Can this lead to better metagenome assemblies?
2. How, algorithmically, to leverage them?
with co-author Max Marin @mgmarin.bsky.social, supervised by Heng Li @lh3lh3.bsky.social
1 / N
From fàstic to fantastic population genetics with @pathogenomics.bsky.social :announcing Fstic a high-performance Rust CLI that computes N×N genetic distance matrices from VCFs or allele-frequency tables at scale. (fàstic=Valencian/Catalan for annoyance)Code: github.com/PathoGenOmic... @i2sysbio.es
GitHub - PathoGenOmics-Lab/fstic: Calculates pairwise distances between samples using alelle frequencies
Calculates pairwise distances between samples using alelle frequencies - PathoGenOmics-Lab/fstic
github.com
August 13, 2025 at 7:21 AM
From fàstic to fantastic population genetics with @pathogenomics.bsky.social :announcing Fstic a high-performance Rust CLI that computes N×N genetic distance matrices from VCFs or allele-frequency tables at scale. (fàstic=Valencian/Catalan for annoyance)Code: github.com/PathoGenOmic... @i2sysbio.es
Reposted by Paula
🎉The EVBC Newsletter 95 - July/Aug 2025 - includes the newest EVBC publications, virus bioinformatics tools, members, upcoming events and more!
🔗 evbc.uni-jena.de/evbc-newslet...
🔗 evbc.uni-jena.de/evbc-newslet...
August 8, 2025 at 11:08 AM
🎉The EVBC Newsletter 95 - July/Aug 2025 - includes the newest EVBC publications, virus bioinformatics tools, members, upcoming events and more!
🔗 evbc.uni-jena.de/evbc-newslet...
🔗 evbc.uni-jena.de/evbc-newslet...
Our R package, mycolorsTB, has officially landed on CRAN!
We created mycolorsTB to provide easy-to-use, standardized color palettes for visualizing Mycobacterium tuberculosis complex data. install.packages("mycolorsTB")
@pathogenomics.bsky.social
github.com/PathoGenOmic...
We created mycolorsTB to provide easy-to-use, standardized color palettes for visualizing Mycobacterium tuberculosis complex data. install.packages("mycolorsTB")
@pathogenomics.bsky.social
github.com/PathoGenOmic...
GitHub - PathoGenOmics-Lab/mycolorsTB: R Color package for Mycobacterium tuberculosis complex
R Color package for Mycobacterium tuberculosis complex - PathoGenOmics-Lab/mycolorsTB
github.com
August 1, 2025 at 12:30 PM
Our R package, mycolorsTB, has officially landed on CRAN!
We created mycolorsTB to provide easy-to-use, standardized color palettes for visualizing Mycobacterium tuberculosis complex data. install.packages("mycolorsTB")
@pathogenomics.bsky.social
github.com/PathoGenOmic...
We created mycolorsTB to provide easy-to-use, standardized color palettes for visualizing Mycobacterium tuberculosis complex data. install.packages("mycolorsTB")
@pathogenomics.bsky.social
github.com/PathoGenOmic...
Reposted by Paula
🚨 Abstract submission is open for Pangenome2025 in Valencia! #microsky #bioinformatics 🧪🦠🧬🖥️ I’m one of the invited speakers. Looking forward to the talks by my @i2sysbio.es colleague Pilar Domingo-Calap @pilardomingoc.bsky.social, and many other great researchers. www.alocongress.com/pangenome2025 🧵
PANGENOME2025
The biology of prokaryotic cells is directly dependent on the differential gene pools that characterize each cell or strain. This has been a fundamental aspect of epidemiology for delimiting outbreaks...
www.alocongress.com
July 30, 2025 at 10:05 AM
🚨 Abstract submission is open for Pangenome2025 in Valencia! #microsky #bioinformatics 🧪🦠🧬🖥️ I’m one of the invited speakers. Looking forward to the talks by my @i2sysbio.es colleague Pilar Domingo-Calap @pilardomingoc.bsky.social, and many other great researchers. www.alocongress.com/pangenome2025 🧵
Reposted by Paula
Reposted by Paula
Some great new features and updates from the awesome Pathoplexus project. This is a new open pathogen genome database that can provide access to your sequences under a use-restricted license but also feed directly in to INSDC (EBI, Genbank etc) when you are ready. pathoplexus.org/news/2025-07...
Pathoplexus | Pathoplexus July Update
Pathoplexus is a new, open-source database dedicated to the efficient sharing of human viral pathogen genomic data, fostering global collaboration and public health response.
pathoplexus.org
July 15, 2025 at 2:05 PM
Some great new features and updates from the awesome Pathoplexus project. This is a new open pathogen genome database that can provide access to your sequences under a use-restricted license but also feed directly in to INSDC (EBI, Genbank etc) when you are ready. pathoplexus.org/news/2025-07...
Reposted by Paula
🗓️As we close in on 11 months of Pathoplexus, we’re pleased to announce many new direct sequence uploads and some exciting new features that expand Pathoplexus’ utility!
📰 You can see our full News Item here: pathoplexus.org/news/2025-07-14-july-update
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📰 You can see our full News Item here: pathoplexus.org/news/2025-07-14-july-update
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July 15, 2025 at 10:13 AM
🗓️As we close in on 11 months of Pathoplexus, we’re pleased to announce many new direct sequence uploads and some exciting new features that expand Pathoplexus’ utility!
📰 You can see our full News Item here: pathoplexus.org/news/2025-07-14-july-update
1/9
📰 You can see our full News Item here: pathoplexus.org/news/2025-07-14-july-update
1/9
Reposted by Paula
Spanish Society Evolutionary Biology meeting January 2026 in the botanical Garden @uv.es in Spain. Registration 200-350€. Preliminary program with confirmed keynote speakers: sesbe2026.es/programme/. Abstract submission until September 15th. sesbe2026.es/abstract/. Come to Valencia and join us!
July 14, 2025 at 11:05 AM
Spanish Society Evolutionary Biology meeting January 2026 in the botanical Garden @uv.es in Spain. Registration 200-350€. Preliminary program with confirmed keynote speakers: sesbe2026.es/programme/. Abstract submission until September 15th. sesbe2026.es/abstract/. Come to Valencia and join us!
Stop searching, start researching! My new 3D printable slide holder keeps your samples safe, accessible, and perfectly organized. It's a cost-effective and eco-friendly solution for any lab.
Download the files for free!
makerworld.com/en/models/15...
#Scicomm #Lab #3Ddesign #Freebie #DIYscience
Download the files for free!
makerworld.com/en/models/15...
#Scicomm #Lab #3Ddesign #Freebie #DIYscience
Slide Into Organization: Microscope Slide Box by paula MakerWorld: Download Free 3D Models
Enhance Your Lab Organization EffortlesslyPerfect for any laboratory, this design is available for free download to help you keep your slides safe, accessible, and well-organized.Key FeaturesDurable a...
makerworld.com
July 12, 2025 at 3:49 PM
Stop searching, start researching! My new 3D printable slide holder keeps your samples safe, accessible, and perfectly organized. It's a cost-effective and eco-friendly solution for any lab.
Download the files for free!
makerworld.com/en/models/15...
#Scicomm #Lab #3Ddesign #Freebie #DIYscience
Download the files for free!
makerworld.com/en/models/15...
#Scicomm #Lab #3Ddesign #Freebie #DIYscience
Reposted by Paula
El #I2SysBio (@csic.es-@uv.es) ha lanzado una serie de vídeos sobre los diferentes grupos de investigación en este centro. El nuevo video es sobre el grupo PatoGenÓmica @pathogenomics.bsky.social de Mireia Coscolla
🌐 youtu.be/0jj9iCCw3ww?...
🧪🧬🖥️ 🦠👩🔬 #microsky #WomenInSTEM #tuberculosis
🌐 youtu.be/0jj9iCCw3ww?...
🧪🧬🖥️ 🦠👩🔬 #microsky #WomenInSTEM #tuberculosis
Interview of Mireia Coscolla, Principal Investigator of the Pathogenomics group
YouTube video by Institute for Integrative Systems Biology I2SysBio
youtu.be
July 11, 2025 at 11:38 AM
El #I2SysBio (@csic.es-@uv.es) ha lanzado una serie de vídeos sobre los diferentes grupos de investigación en este centro. El nuevo video es sobre el grupo PatoGenÓmica @pathogenomics.bsky.social de Mireia Coscolla
🌐 youtu.be/0jj9iCCw3ww?...
🧪🧬🖥️ 🦠👩🔬 #microsky #WomenInSTEM #tuberculosis
🌐 youtu.be/0jj9iCCw3ww?...
🧪🧬🖥️ 🦠👩🔬 #microsky #WomenInSTEM #tuberculosis
Reposted by Paula
BEAST X v10.5.0 finally released – you can't just do beta releases forever. github.com/beast-dev/be...
Details and instructions for installing on the BEAST website: beast.community
Details and instructions for installing on the BEAST website: beast.community
July 2, 2025 at 8:32 PM
BEAST X v10.5.0 finally released – you can't just do beta releases forever. github.com/beast-dev/be...
Details and instructions for installing on the BEAST website: beast.community
Details and instructions for installing on the BEAST website: beast.community
A huge moment for our lab at #ESM2025, with Mireia Coscolla presenting our work on host-pathogen interactions. She did a brilliant job—fantastic science from a fantastic scientist! So proud of her and the entire team. @pathogenomics.bsky.social @i2sysbio.es @esmyco.bsky.social 👏✨
June 24, 2025 at 12:54 PM
A huge moment for our lab at #ESM2025, with Mireia Coscolla presenting our work on host-pathogen interactions. She did a brilliant job—fantastic science from a fantastic scientist! So proud of her and the entire team. @pathogenomics.bsky.social @i2sysbio.es @esmyco.bsky.social 👏✨
Nuestro 4to año superado con creces, #expociencia2025 @pathogenomics.bsky.social @i2sysbio.bsky.social
May 10, 2025 at 7:17 PM
Nuestro 4to año superado con creces, #expociencia2025 @pathogenomics.bsky.social @i2sysbio.bsky.social
Reposted by Paula
"Conèixer els màsters" is an informational event of the @uv.es 😀
Representing the Master's in Bioinformatics its director @vicentarnau.bsky.social and PhD student Celeste Moya attended.
Registration for UV master's programs is open until June 13.
Sign up now! @i2sysbio.bsky.social #bioinformatics
Representing the Master's in Bioinformatics its director @vicentarnau.bsky.social and PhD student Celeste Moya attended.
Registration for UV master's programs is open until June 13.
Sign up now! @i2sysbio.bsky.social #bioinformatics
April 24, 2025 at 8:55 AM
"Conèixer els màsters" is an informational event of the @uv.es 😀
Representing the Master's in Bioinformatics its director @vicentarnau.bsky.social and PhD student Celeste Moya attended.
Registration for UV master's programs is open until June 13.
Sign up now! @i2sysbio.bsky.social #bioinformatics
Representing the Master's in Bioinformatics its director @vicentarnau.bsky.social and PhD student Celeste Moya attended.
Registration for UV master's programs is open until June 13.
Sign up now! @i2sysbio.bsky.social #bioinformatics
Reposted by Paula
Pathoplexus News Updates always feel like 💃 !
So many cool things to report, including amazing uploads from users! 🕺
So many cool things to report, including amazing uploads from users! 🕺
🗓️ Pathoplexus has now been around for 7 months!
And both we and our users have been busy - so we wanted to share some updates & highlights!
📰 You can see our full News Item here: pathoplexus.org/news/2025-04-16-spring-update
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And both we and our users have been busy - so we wanted to share some updates & highlights!
📰 You can see our full News Item here: pathoplexus.org/news/2025-04-16-spring-update
1/9
Pathoplexus | Pathoplexus Spring Update
Pathoplexus is a new, open-source database dedicated to the efficient sharing of human viral pathogen genomic data, fostering global collaboration and public health response.
pathoplexus.org
April 16, 2025 at 3:54 PM
Pathoplexus News Updates always feel like 💃 !
So many cool things to report, including amazing uploads from users! 🕺
So many cool things to report, including amazing uploads from users! 🕺
Reposted by Paula
Iñaki Comas del @ibv-csic.bsky.social junto a Mariana López y su grupo, ganadores del Premio en la categoría de Transferencia de conocimiento, con mención especial a la candidatura Genómica para políticas públicas: control de pandemias, epidemias y enfermedades del Sur Global
@csic.es
¡Enhorabuena!
@csic.es
¡Enhorabuena!
🏅 El #CSIC anuncia los ganadores de los II Premios de Transferencia y Emprendimiento
➡️ Los galardones reconocen las actividades del personal investigador y centros e institutos del Consejo para promover estos ámbitos y fomentar la cultura emprendedora
👉 http://tiny.cc/yvlg001
➡️ Los galardones reconocen las actividades del personal investigador y centros e institutos del Consejo para promover estos ámbitos y fomentar la cultura emprendedora
👉 http://tiny.cc/yvlg001
April 15, 2025 at 10:26 AM
Iñaki Comas del @ibv-csic.bsky.social junto a Mariana López y su grupo, ganadores del Premio en la categoría de Transferencia de conocimiento, con mención especial a la candidatura Genómica para políticas públicas: control de pandemias, epidemias y enfermedades del Sur Global
@csic.es
¡Enhorabuena!
@csic.es
¡Enhorabuena!
Reposted by Paula
By mining GISAID, researchers from I2SysBio uncover sequencing artifacts in SARS-CoV-2. Many repair mutations in the spike protein were due to errors in data processing. #covid19 #viruses #microsky🧪🦠💻🧬 More info: www.i2sysbio.es/communicatio... ⬇️
April 3, 2025 at 8:35 AM
By mining GISAID, researchers from I2SysBio uncover sequencing artifacts in SARS-CoV-2. Many repair mutations in the spike protein were due to errors in data processing. #covid19 #viruses #microsky🧪🦠💻🧬 More info: www.i2sysbio.es/communicatio... ⬇️