Paul Lapios 🧘♂️
@paulosh.bsky.social
synapse structure and curious man
Reposted by Paul Lapios 🧘♂️
Learn principles of image processing to determine macromolecular structures by #cryoEM: Sign up for EMBO Practical Course on Image processing for cryo-electron microscopy in London, UK, 9–16 September
Deadline: 25 April
meetings.embo.org/event/25-cry...
#EMBOcryoEM #EMBOevents 🧪
Deadline: 25 April
meetings.embo.org/event/25-cry...
#EMBOcryoEM #EMBOevents 🧪
Image processing for cryo-electron microscopy
Cryo electron microscopy (cryo EM) is a major structural biology method for studying macromolecular complexes and cellular structures in their native states. Stable high resolution cryo microscopes, …
meetings.embo.org
March 26, 2025 at 8:54 AM
Learn principles of image processing to determine macromolecular structures by #cryoEM: Sign up for EMBO Practical Course on Image processing for cryo-electron microscopy in London, UK, 9–16 September
Deadline: 25 April
meetings.embo.org/event/25-cry...
#EMBOcryoEM #EMBOevents 🧪
Deadline: 25 April
meetings.embo.org/event/25-cry...
#EMBOcryoEM #EMBOevents 🧪
Reposted by Paul Lapios 🧘♂️
A new chapter has begun for two of the world’s most popular preprint platforms, bioRxiv and medRxiv, with the launch of a non-profit organization that will manage them
https://go.nature.com/4iCVnHL
https://go.nature.com/4iCVnHL
Preprint sites bioRxiv and medRxiv launch new era of independence
The popular repositories, where scientists post research before peer review, will be managed by a new organization called openRxiv.
go.nature.com
March 11, 2025 at 2:03 PM
A new chapter has begun for two of the world’s most popular preprint platforms, bioRxiv and medRxiv, with the launch of a non-profit organization that will manage them
https://go.nature.com/4iCVnHL
https://go.nature.com/4iCVnHL
Reposted by Paul Lapios 🧘♂️
another piece, covering our work! Thanks to Laura Tran at the Scientist!!
www.the-scientist.com/challenging-...
www.the-scientist.com/challenging-...
Challenging the Axon’s Classic Shape
Forget the traditional tubular shape—researchers are investigating a pearl-on-a-string formation for axons, unlocking new insights into neural signaling in health and disease.
www.the-scientist.com
January 27, 2025 at 9:15 PM
another piece, covering our work! Thanks to Laura Tran at the Scientist!!
www.the-scientist.com/challenging-...
www.the-scientist.com/challenging-...
Reposted by Paul Lapios 🧘♂️
Excited to share our new preprint "Dynamic nanoscale architecture of synaptic vesicle fusion in mouse hippocampal neurons" www.biorxiv.org/content/10.1...
We combine optogenetic stimulation of neurons with in situ cryo-ET to characterize membrane dynamics during synaptic vesicle fusion ❄️🔬⏱️
We combine optogenetic stimulation of neurons with in situ cryo-ET to characterize membrane dynamics during synaptic vesicle fusion ❄️🔬⏱️
February 12, 2025 at 10:05 PM
Excited to share our new preprint "Dynamic nanoscale architecture of synaptic vesicle fusion in mouse hippocampal neurons" www.biorxiv.org/content/10.1...
We combine optogenetic stimulation of neurons with in situ cryo-ET to characterize membrane dynamics during synaptic vesicle fusion ❄️🔬⏱️
We combine optogenetic stimulation of neurons with in situ cryo-ET to characterize membrane dynamics during synaptic vesicle fusion ❄️🔬⏱️
Reposted by Paul Lapios 🧘♂️
New preprint from the MemTraS team ! www.biorxiv.org/content/10.1...
Great collaboration with @fronzeslab.bsky.social and Vladan Lucic to determine the first cryo electron tomography images of dopamine "synapses" extracted from adult mouse brain.
Great collaboration with @fronzeslab.bsky.social and Vladan Lucic to determine the first cryo electron tomography images of dopamine "synapses" extracted from adult mouse brain.
February 10, 2025 at 4:39 PM
New preprint from the MemTraS team ! www.biorxiv.org/content/10.1...
Great collaboration with @fronzeslab.bsky.social and Vladan Lucic to determine the first cryo electron tomography images of dopamine "synapses" extracted from adult mouse brain.
Great collaboration with @fronzeslab.bsky.social and Vladan Lucic to determine the first cryo electron tomography images of dopamine "synapses" extracted from adult mouse brain.
Reposted by Paul Lapios 🧘♂️
This study was key to establishing #cryoCLEM and #cryoET in Bordeaux.
It is an important milestone.
@davidp-bdx.bsky.social,
Étienne Herzog and @paulosh.bsky.social took the risk to be the first to use this approach with us.
🙏🙏🙏
It is an important milestone.
@davidp-bdx.bsky.social,
Étienne Herzog and @paulosh.bsky.social took the risk to be the first to use this approach with us.
🙏🙏🙏
New preprint from the MemTraS team ! www.biorxiv.org/content/10.1...
Great collaboration with @fronzeslab.bsky.social and Vladan Lucic to determine the first cryo electron tomography images of dopamine "synapses" extracted from adult mouse brain.
Great collaboration with @fronzeslab.bsky.social and Vladan Lucic to determine the first cryo electron tomography images of dopamine "synapses" extracted from adult mouse brain.
February 10, 2025 at 5:20 PM
This study was key to establishing #cryoCLEM and #cryoET in Bordeaux.
It is an important milestone.
@davidp-bdx.bsky.social,
Étienne Herzog and @paulosh.bsky.social took the risk to be the first to use this approach with us.
🙏🙏🙏
It is an important milestone.
@davidp-bdx.bsky.social,
Étienne Herzog and @paulosh.bsky.social took the risk to be the first to use this approach with us.
🙏🙏🙏
Very happy to share our last preprint where we investigated the vesicular organization of dopamine hub synapses with cryo-CLEM. It is a brain structure that emerges as an important regulator of striatal activity. Many thanks to David Perrais, Etienne Herzog and the lab of @fronzeslab.bsky.social !
Cryo-correlative light and electron tomography of dopaminergic axonal varicosities reveals non-synaptic modulation of cortico-striatal synapses https://www.biorxiv.org/content/10.1101/2025.02.07.637058v1
February 12, 2025 at 8:27 AM
Very happy to share our last preprint where we investigated the vesicular organization of dopamine hub synapses with cryo-CLEM. It is a brain structure that emerges as an important regulator of striatal activity. Many thanks to David Perrais, Etienne Herzog and the lab of @fronzeslab.bsky.social !
Reposted by Paul Lapios 🧘♂️
Cryo-correlative light and electron tomography of dopaminergic axonal varicosities reveals non-synaptic modulation of cortico-striatal synapses https://www.biorxiv.org/content/10.1101/2025.02.07.637058v1
February 8, 2025 at 10:16 AM
Cryo-correlative light and electron tomography of dopaminergic axonal varicosities reveals non-synaptic modulation of cortico-striatal synapses https://www.biorxiv.org/content/10.1101/2025.02.07.637058v1